NZ600498A - Methods for the treatment and prevention of age-related retinal dysfunction - Google Patents
Methods for the treatment and prevention of age-related retinal dysfunctionInfo
- Publication number
- NZ600498A NZ600498A NZ600498A NZ60049809A NZ600498A NZ 600498 A NZ600498 A NZ 600498A NZ 600498 A NZ600498 A NZ 600498A NZ 60049809 A NZ60049809 A NZ 60049809A NZ 600498 A NZ600498 A NZ 600498A
- Authority
- NZ
- New Zealand
- Prior art keywords
- prevention
- impairment
- formula
- treatment
- synthetic retinal
- Prior art date
Links
- 230000002265 prevention Effects 0.000 title abstract 2
- 230000004284 age-related retinal dysfunction Effects 0.000 title 1
- 230000006735 deficit Effects 0.000 abstract 3
- 150000003726 retinal derivatives Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000004300 dark adaptation Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000002763 monocarboxylic acids Chemical class 0.000 abstract 1
- 230000004297 night vision Effects 0.000 abstract 1
- WWDMJSSVVPXVSV-YCNIQYBTSA-N retinyl ester Chemical compound CC1CCCC(C)(C)C1\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O WWDMJSSVVPXVSV-YCNIQYBTSA-N 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ617701A NZ617701A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2762508P | 2008-02-11 | 2008-02-11 | |
| NZ587376A NZ587376A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ600498A true NZ600498A (en) | 2014-01-31 |
Family
ID=40521846
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ600498A NZ600498A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
| NZ617701A NZ617701A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
| NZ587376A NZ587376A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ617701A NZ617701A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
| NZ587376A NZ587376A (en) | 2008-02-11 | 2009-02-10 | Methods for the treatment and prevention of age-related retinal dysfunction |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8324270B2 (enExample) |
| EP (1) | EP2252276B1 (enExample) |
| JP (3) | JP6022746B2 (enExample) |
| KR (2) | KR101810381B1 (enExample) |
| CN (1) | CN101969938A (enExample) |
| AU (1) | AU2009213138B2 (enExample) |
| BR (1) | BRPI0908154A2 (enExample) |
| CA (2) | CA3018374A1 (enExample) |
| IL (2) | IL207220B (enExample) |
| MX (1) | MX337656B (enExample) |
| NZ (3) | NZ600498A (enExample) |
| RU (1) | RU2565448C2 (enExample) |
| WO (1) | WO2009102418A1 (enExample) |
| ZA (1) | ZA201005434B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082622A2 (en) | 2003-03-14 | 2004-09-30 | University Of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| ES2443194T3 (es) | 2004-06-18 | 2014-02-18 | University Of Washington | Derivados de retinal y métodos de uso de los mismos para el tratamiento de trastornos visuales |
| ES2393768T3 (es) | 2005-05-26 | 2012-12-27 | Neuron Systems, Inc | Derivado de quinolina para el tratamiento de enfermedades retinianas |
| MX337656B (es) * | 2008-02-11 | 2016-03-14 | Univ Washington | Metodos para el tratamiento y prevencion de disfuncion retinal relacionada con la edad. |
| US20120178806A1 (en) | 2009-09-15 | 2012-07-12 | Qlt Inc. | Pharmaceutical formulations comprising 9-cis-retinyl esters in a lipid vehicle |
| WO2011071995A2 (en) | 2009-12-08 | 2011-06-16 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| CA2796991A1 (en) * | 2010-04-19 | 2011-10-27 | Qlt Inc. | Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency |
| US8846723B2 (en) | 2010-07-29 | 2014-09-30 | Eastman Chemical Company | Esters of O-substituted hydroxy carboxylic acids and preparations thereof |
| US8613940B2 (en) | 2010-09-03 | 2013-12-24 | Eastman Chemical Company | Carbonate derivatives as skin care |
| US8329938B2 (en) * | 2011-02-21 | 2012-12-11 | Eastman Chemical Company | Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol |
| US10226536B2 (en) | 2011-11-28 | 2019-03-12 | Case Western Reserve University | Polysaccharide therapeutic conjugates |
| MX389866B (es) * | 2012-03-01 | 2025-03-20 | Retinagenix LLC | El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal. |
| CN117045653A (zh) | 2013-01-23 | 2023-11-14 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| WO2015184453A1 (en) | 2014-05-30 | 2015-12-03 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| US11129845B2 (en) | 2014-06-18 | 2021-09-28 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US10925980B2 (en) | 2014-08-04 | 2021-02-23 | Case Western Reserve University | Molecular probes and methods of use |
| US11407786B2 (en) | 2015-06-18 | 2022-08-09 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| JP6947406B2 (ja) | 2015-08-21 | 2021-10-13 | アルデイラ セラピューティクス, インコーポレイテッド | 重水素化化合物およびその使用 |
| US12060318B2 (en) | 2015-10-09 | 2024-08-13 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| WO2017196881A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| AU2018234919A1 (en) | 2017-03-16 | 2019-09-19 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス, インコーポレイテッド | 炎症性障害の処置 |
| CN112714762A (zh) | 2018-08-06 | 2021-04-27 | 奥尔德拉医疗公司 | 多晶型化合物及其用途 |
| WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| EP3962894A4 (en) | 2019-05-02 | 2023-01-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND USES THEREOF |
| US20230034053A1 (en) * | 2019-09-25 | 2023-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Metabolic rescue of retinal degeneration |
| CA3175856A1 (en) | 2020-05-13 | 2021-11-18 | Todd Brady | Pharmaceutical formulations and uses thereof |
| WO2021252421A1 (en) * | 2020-06-09 | 2021-12-16 | Retinagenix Holdings Llc | Methods of treating visual disorders using daily low dosing of a retinoid compound |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196076A (en) | 1961-12-20 | 1965-07-20 | Schering Corp | Anti-depressant 10-(3-dimethylaminopropyl)-3-azaphenothiazine |
| US3196078A (en) * | 1962-01-30 | 1965-07-20 | Ortho Pharma Corp | Process for combating retinits pigmentosa |
| US3517067A (en) | 1964-02-11 | 1970-06-23 | Eastman Kodak Co | Syntheses of quaternary phosphonium salts |
| DE2300107C2 (de) | 1973-01-03 | 1982-03-11 | Basf Ag, 6700 Ludwigshafen | Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen |
| DE2456959A1 (de) | 1974-12-03 | 1976-06-16 | Basf Ag | 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen |
| JPS61275266A (ja) | 1985-05-28 | 1986-12-05 | Taisho Pharmaceut Co Ltd | レチノイド誘導体 |
| US5310764A (en) | 1992-05-08 | 1994-05-10 | Steven Baranowitz | Treatment of age related macular degeneration with beta-carotene |
| JPH06340525A (ja) | 1993-06-02 | 1994-12-13 | Lion Corp | 安定な低眼刺激性ビタミンa類可溶化点眼剤 |
| CA2185699A1 (en) | 1994-04-04 | 1995-10-12 | William R. Freeman | Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure |
| RU2106843C1 (ru) | 1994-06-29 | 1998-03-20 | Красноярская государственная медицинская академия | Способ лечения близорукости |
| JPH08198746A (ja) | 1995-01-18 | 1996-08-06 | Lion Corp | 可溶化点眼剤 |
| US5837728A (en) | 1995-01-27 | 1998-11-17 | Molecular Design International | 9-cis retinoic acid esters and amides and uses thereof |
| US5489611A (en) | 1995-02-10 | 1996-02-06 | Warner-Lambert Company | Method for lowering plasma levels of lipoprotein (a) |
| US5620970A (en) | 1995-06-05 | 1997-04-15 | Alcon Laboratories, Inc. | Topical ophthalmic carbonic anhydrase inhibitor formulations |
| US5716627A (en) | 1996-04-25 | 1998-02-10 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester |
| EP0908179A1 (en) | 1997-08-23 | 1999-04-14 | Werner Bollag | Treatment of cell-mediated immune diseases |
| US6391924B1 (en) * | 1997-12-10 | 2002-05-21 | Hampar Karageozian | Taurine derivatives useable in the treatment of ophthalmic disorders |
| US6552009B2 (en) | 1998-07-16 | 2003-04-22 | Gentrix Llc | Compositions and methods of treating abnormal cell proliferation |
| US6372463B1 (en) | 1999-05-06 | 2002-04-16 | The President & Fellows Of Harvard College | Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof |
| WO2000068354A1 (en) | 1999-05-07 | 2000-11-16 | Chemlink Laboratories Llc | Window cleaner tablet |
| US6300328B1 (en) | 1999-08-06 | 2001-10-09 | Alcon Universal Ltd. | Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage |
| US20020028849A1 (en) | 2000-04-18 | 2002-03-07 | Godkin James D. | Use of retinol in assisted-reproduction protocols |
| US6696069B2 (en) | 2000-06-30 | 2004-02-24 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin care cosmetic compositions containing phosphates and/or sulfates of branched alcohols and/or ethoxylates thereof |
| WO2002055540A1 (en) | 2001-01-11 | 2002-07-18 | Chebigen Inc. | New retinol derivatives, the method of preparations and the uses thereof |
| CA2435410A1 (en) | 2001-01-26 | 2002-08-01 | Steven Baranowitz | Systemic formulations containing beta-carotene and derivatives thereof |
| GB0103998D0 (en) | 2001-02-19 | 2001-04-04 | King S College London | Method |
| CA2442670A1 (en) | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| JP2005524626A (ja) | 2002-01-18 | 2005-08-18 | タットン テクノロジーズ エルエルシー. | 眼疾患を治療するための方法 |
| US20030215413A1 (en) | 2002-03-22 | 2003-11-20 | L'oreal | Compositions containing stabilized retinoid |
| US20040097587A1 (en) | 2002-03-27 | 2004-05-20 | Arbiser Jack L | Compositions and methods of treatment of ulcerating diseases, burns, and related conditions |
| JP2006512279A (ja) | 2002-03-29 | 2006-04-13 | マキシム ファーマシューティカルス,インコーポレイテッド | 眼内損傷を治療および予防するためのrom生成および放出阻害剤の使用 |
| WO2004082622A2 (en) | 2003-03-14 | 2004-09-30 | University Of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| JP2007525496A (ja) * | 2004-02-17 | 2007-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 黄班変性症を含む眼科疾患の管理 |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| CA2555261A1 (en) * | 2004-02-17 | 2005-09-01 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| KR20070011379A (ko) | 2004-03-17 | 2007-01-24 | 라스 미카엘 라르센 | 시각 사이클 억제에 의한 망막증의 예방 |
| ES2443194T3 (es) | 2004-06-18 | 2014-02-18 | University Of Washington | Derivados de retinal y métodos de uso de los mismos para el tratamiento de trastornos visuales |
| PT1768657E (pt) | 2004-06-23 | 2008-11-25 | Sirion Therapeutics Inc | Métodos e composições para tratar condições oftálmicas com derivados de retinilo |
| CA2575265A1 (en) * | 2004-08-18 | 2006-03-30 | Sirion Therapeutics, Inc. | Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat ophthalmic disorders |
| WO2006039551A2 (en) | 2004-09-30 | 2006-04-13 | The Regents Of The University Of California | Local administration of retinoids to treat deficiencies in dark adaptation |
| EP2687208A1 (en) | 2007-09-12 | 2014-01-22 | The Trustees of Columbia University in the City of New York | Compositions and Methods for Treating Macular Degeneration |
| MX337656B (es) | 2008-02-11 | 2016-03-14 | Univ Washington | Metodos para el tratamiento y prevencion de disfuncion retinal relacionada con la edad. |
-
2009
- 2009-02-10 MX MX2010008847A patent/MX337656B/es active IP Right Grant
- 2009-02-10 BR BRPI0908154-2A patent/BRPI0908154A2/pt not_active Application Discontinuation
- 2009-02-10 NZ NZ600498A patent/NZ600498A/en not_active IP Right Cessation
- 2009-02-10 AU AU2009213138A patent/AU2009213138B2/en not_active Ceased
- 2009-02-10 CA CA3018374A patent/CA3018374A1/en not_active Abandoned
- 2009-02-10 RU RU2010137842/15A patent/RU2565448C2/ru not_active Application Discontinuation
- 2009-02-10 US US12/368,427 patent/US8324270B2/en active Active
- 2009-02-10 JP JP2010545893A patent/JP6022746B2/ja not_active Expired - Fee Related
- 2009-02-10 CA CA2714530A patent/CA2714530C/en active Active
- 2009-02-10 WO PCT/US2009/000824 patent/WO2009102418A1/en not_active Ceased
- 2009-02-10 EP EP09711491.2A patent/EP2252276B1/en active Active
- 2009-02-10 KR KR1020107019972A patent/KR101810381B1/ko not_active Expired - Fee Related
- 2009-02-10 NZ NZ617701A patent/NZ617701A/en not_active IP Right Cessation
- 2009-02-10 CN CN2009801053588A patent/CN101969938A/zh active Pending
- 2009-02-10 KR KR1020167019984A patent/KR20160092032A/ko not_active Ceased
- 2009-02-10 NZ NZ587376A patent/NZ587376A/en not_active IP Right Cessation
-
2010
- 2010-07-26 IL IL207220A patent/IL207220B/en active IP Right Grant
- 2010-07-29 ZA ZA2010/05434A patent/ZA201005434B/en unknown
-
2012
- 2012-09-14 US US13/620,051 patent/US20130072558A1/en not_active Abandoned
- 2012-09-14 US US13/620,303 patent/US9233091B2/en active Active
- 2012-09-14 US US13/619,947 patent/US9408821B2/en active Active
-
2014
- 2014-08-01 JP JP2014157921A patent/JP5934304B2/ja active Active
-
2016
- 2016-05-10 JP JP2016094767A patent/JP6272943B2/ja not_active Expired - Fee Related
- 2016-07-26 US US15/220,315 patent/US9855239B2/en active Active
-
2017
- 2017-12-12 US US15/839,784 patent/US20180098955A1/en not_active Abandoned
-
2018
- 2018-03-26 IL IL258356A patent/IL258356A/en unknown
-
2019
- 2019-01-04 US US16/240,578 patent/US20190133986A1/en not_active Abandoned
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