MX337593B - Gemcabeno y derivados para tratar la pancreatitis. - Google Patents

Gemcabeno y derivados para tratar la pancreatitis.

Info

Publication number
MX337593B
MX337593B MX2013007310A MX2013007310A MX337593B MX 337593 B MX337593 B MX 337593B MX 2013007310 A MX2013007310 A MX 2013007310A MX 2013007310 A MX2013007310 A MX 2013007310A MX 337593 B MX337593 B MX 337593B
Authority
MX
Mexico
Prior art keywords
gemcabene
derivatives
treating pancreatitis
pancreatitis
free acid
Prior art date
Application number
MX2013007310A
Other languages
English (en)
Other versions
MX2013007310A (es
Inventor
Charles L Bisgaier
Original Assignee
Michigan Life Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan Life Therapeutics Llc filed Critical Michigan Life Therapeutics Llc
Publication of MX2013007310A publication Critical patent/MX2013007310A/es
Publication of MX337593B publication Critical patent/MX337593B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Gemcabeno, un carboxialquiléter, es eficaz en el tratamiento y la prevención de pancreatitis en pacientes. El compuesto puede ser administrado en una dosis eficaz como el ácido libre, una sal farmacéuticamente aceptable o un éster o profármaco que se hidroliza o metaboliza de otra forma in situ en gemcabeno como el ácido libre o la sal de este.
MX2013007310A 2010-12-27 2011-12-22 Gemcabeno y derivados para tratar la pancreatitis. MX337593B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061427236P 2010-12-27 2010-12-27
PCT/US2011/066736 WO2012092103A1 (en) 2010-12-27 2011-12-22 Gemcabene and derivatives for treating pancreatitis

Publications (2)

Publication Number Publication Date
MX2013007310A MX2013007310A (es) 2013-10-25
MX337593B true MX337593B (es) 2016-03-11

Family

ID=45498140

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007310A MX337593B (es) 2010-12-27 2011-12-22 Gemcabeno y derivados para tratar la pancreatitis.

Country Status (14)

Country Link
US (1) US8846761B2 (es)
EP (2) EP2658536B1 (es)
JP (3) JP2014509305A (es)
CN (2) CN103442707A (es)
AU (1) AU2011352449B2 (es)
CA (1) CA2822921C (es)
DK (1) DK2658536T3 (es)
ES (1) ES2608177T3 (es)
HK (1) HK1250484A1 (es)
HU (1) HUE031004T2 (es)
MX (1) MX337593B (es)
PL (1) PL2658536T3 (es)
PT (1) PT2658536T (es)
WO (1) WO2012092103A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170083535A (ko) 2014-11-14 2017-07-18 젬파이어 세러퓨틱스 인코포레이티드 α,ω-다이카복실산-말단 다이알케인 에터를 제조하기 위한 방법 및 중간체
BR112018007857A2 (pt) * 2015-11-06 2018-10-30 Gemphire Therapeutics Inc combinações de gemcabene para o tratamento de doença cardiovascular

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011852A1 (en) * 1988-06-06 1989-12-14 Showa Denko Kabushiki Kaisha Agent for treating pancreatitis or the like
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
US6861555B2 (en) 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
US20020103252A1 (en) 1997-12-12 2002-08-01 Bisgaier Charles Larry Statin-carboxyalkylether combinations
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
MXPA01009893A (es) * 1999-04-01 2003-07-28 Esperion Therapeutics Inc Compuestos con eter, composiciones y usos de estos.
IL155215A0 (en) 2000-10-11 2003-11-23 Esperion Therapeutics Inc Ether compounds and compositions for cholesterol management and related uses
US6645170B2 (en) 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
US7345190B2 (en) 2003-11-12 2008-03-18 Ssv Therapeutics, Inc. Carnitine conjugates as dual prodrugs and uses thereof

Also Published As

Publication number Publication date
EP2658536A1 (en) 2013-11-06
AU2011352449A1 (en) 2013-07-11
CA2822921A1 (en) 2012-07-05
DK2658536T3 (en) 2017-01-09
US20120165411A1 (en) 2012-06-28
CN103442707A (zh) 2013-12-11
MX2013007310A (es) 2013-10-25
HK1250484A1 (zh) 2018-12-21
JP2016028075A (ja) 2016-02-25
HUE031004T2 (en) 2017-06-28
PT2658536T (pt) 2016-12-22
PL2658536T3 (pl) 2017-04-28
AU2011352449B2 (en) 2015-06-18
JP6207560B2 (ja) 2017-10-04
WO2012092103A1 (en) 2012-07-05
JP2014509305A (ja) 2014-04-17
CA2822921C (en) 2018-07-17
CN107648210A (zh) 2018-02-02
EP3170495B1 (en) 2023-04-26
US8846761B2 (en) 2014-09-30
JP2018027953A (ja) 2018-02-22
EP2658536B1 (en) 2016-10-19
EP3170495A1 (en) 2017-05-24
ES2608177T3 (es) 2017-04-06

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