KR101810381B1 - 연령-관련 망막 기능장애의 치료 및 예방 방법 - Google Patents

연령-관련 망막 기능장애의 치료 및 예방 방법 Download PDF

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Publication number
KR101810381B1
KR101810381B1 KR1020107019972A KR20107019972A KR101810381B1 KR 101810381 B1 KR101810381 B1 KR 101810381B1 KR 1020107019972 A KR1020107019972 A KR 1020107019972A KR 20107019972 A KR20107019972 A KR 20107019972A KR 101810381 B1 KR101810381 B1 KR 101810381B1
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cis
delete delete
retinyl
pharmaceutical composition
retinal
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Korean (ko)
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KR20100126358A (ko
Inventor
다다오 마에다
데이비드 사퍼스테인
크르지츠토프 팔체브스키
Original Assignee
유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107019972A 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법 Expired - Fee Related KR101810381B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2762508P 2008-02-11 2008-02-11
US61/027,625 2008-02-11
PCT/US2009/000824 WO2009102418A1 (en) 2008-02-11 2009-02-10 Methods for the treatment and prevention of age-related retinal dysfunction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167019984A Division KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

Publications (2)

Publication Number Publication Date
KR20100126358A KR20100126358A (ko) 2010-12-01
KR101810381B1 true KR101810381B1 (ko) 2017-12-19

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KR1020107019972A Expired - Fee Related KR101810381B1 (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법
KR1020167019984A Ceased KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

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KR1020167019984A Ceased KR20160092032A (ko) 2008-02-11 2009-02-10 연령-관련 망막 기능장애의 치료 및 예방 방법

Country Status (14)

Country Link
US (7) US8324270B2 (enExample)
EP (1) EP2252276B1 (enExample)
JP (3) JP6022746B2 (enExample)
KR (2) KR101810381B1 (enExample)
CN (1) CN101969938A (enExample)
AU (1) AU2009213138B2 (enExample)
BR (1) BRPI0908154A2 (enExample)
CA (2) CA3018374A1 (enExample)
IL (2) IL207220B (enExample)
MX (1) MX337656B (enExample)
NZ (3) NZ600498A (enExample)
RU (1) RU2565448C2 (enExample)
WO (1) WO2009102418A1 (enExample)
ZA (1) ZA201005434B (enExample)

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US8329938B2 (en) * 2011-02-21 2012-12-11 Eastman Chemical Company Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
US10226536B2 (en) 2011-11-28 2019-03-12 Case Western Reserve University Polysaccharide therapeutic conjugates
MX389866B (es) * 2012-03-01 2025-03-20 Retinagenix LLC El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal.
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WO2015184453A1 (en) 2014-05-30 2015-12-03 Case Western Reserve University Retinylamine derivitives for treatment of ocular disorders
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US12060318B2 (en) 2015-10-09 2024-08-13 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
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JP7311162B2 (ja) 2017-10-10 2023-07-19 アルデイラ セラピューティクス， インコーポレイテッド 炎症性障害の処置
CN112714762A (zh) 2018-08-06 2021-04-27 奥尔德拉医疗公司 多晶型化合物及其用途
WO2020223717A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
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US20230034053A1 (en) * 2019-09-25 2023-02-02 The Board Of Trustees Of The Leland Stanford Junior University Metabolic rescue of retinal degeneration
CA3175856A1 (en) 2020-05-13 2021-11-18 Todd Brady Pharmaceutical formulations and uses thereof
WO2021252421A1 (en) * 2020-06-09 2021-12-16 Retinagenix Holdings Llc Methods of treating visual disorders using daily low dosing of a retinoid compound

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Also Published As

Publication number Publication date
JP5934304B2 (ja) 2016-06-15
US20130072558A1 (en) 2013-03-21
CA2714530C (en) 2018-09-25
MX337656B (es) 2016-03-14
US8324270B2 (en) 2012-12-04
IL258356A (en) 2018-05-31
US9233091B2 (en) 2016-01-12
JP6022746B2 (ja) 2016-11-09
US20180098955A1 (en) 2018-04-12
CA2714530A1 (en) 2009-08-20
NZ617701A (en) 2015-06-26
US20190133986A1 (en) 2019-05-09
EP2252276B1 (en) 2019-03-27
EP2252276A1 (en) 2010-11-24
JP2016190852A (ja) 2016-11-10
MX2010008847A (es) 2010-11-30
JP2011511789A (ja) 2011-04-14
JP6272943B2 (ja) 2018-01-31
IL207220A0 (en) 2010-12-30
US20130072557A1 (en) 2013-03-21
JP2014221828A (ja) 2014-11-27
RU2565448C2 (ru) 2015-10-20
CN101969938A (zh) 2011-02-09
KR20160092032A (ko) 2016-08-03
US20130072561A1 (en) 2013-03-21
AU2009213138A1 (en) 2009-08-20
RU2010137842A (ru) 2012-03-20
KR20100126358A (ko) 2010-12-01
NZ587376A (en) 2012-06-29
US20160331713A1 (en) 2016-11-17
US20100035986A1 (en) 2010-02-11
ZA201005434B (en) 2011-11-30
BRPI0908154A2 (pt) 2015-08-11
AU2009213138B2 (en) 2014-11-06
CA3018374A1 (en) 2009-08-20
IL207220B (en) 2018-04-30
US9408821B2 (en) 2016-08-09
WO2009102418A1 (en) 2009-08-20
NZ600498A (en) 2014-01-31
US9855239B2 (en) 2018-01-02

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