MX389866B - El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal. - Google Patents

El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal.

Info

Publication number
MX389866B
MX389866B MX2020000225A MX2020000225A MX389866B MX 389866 B MX389866 B MX 389866B MX 2020000225 A MX2020000225 A MX 2020000225A MX 2020000225 A MX2020000225 A MX 2020000225A MX 389866 B MX389866 B MX 389866B
Authority
MX
Mexico
Prior art keywords
cis
visual function
retinal
endogenous
loss
Prior art date
Application number
MX2020000225A
Other languages
English (en)
Inventor
Suzanne Cadden
Original Assignee
Retinagenix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Retinagenix LLC filed Critical Retinagenix LLC
Publication of MX389866B publication Critical patent/MX389866B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen regímenes terapéuticos para mejorar la función visual en un sujeto que tiene una deficiencia en 11-cis-retinal endógenamente producido, que comprenden administrar el derivado retinal sintético como una dosis dividida durante 2-7 días, después proporcionar un período de descanso de 7-28 días, después de lo cual se administra la segunda dosis del derivado retinal sintético. Los derivados retinal sintéticos preferidos son 9- u11-cis-retinil ésteres. Los trastornos asociados con la deficiencia en 11-cis-retinal endógenamente producido incluyen retinitis pigmentosa y amaurosis congénita de Leber.
MX2020000225A 2012-03-01 2013-03-01 El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal. MX389866B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261605729P 2012-03-01 2012-03-01
US201261642212P 2012-05-03 2012-05-03
US201261644360P 2012-05-08 2012-05-08
PCT/CA2013/050155 WO2013134867A1 (en) 2012-03-01 2013-03-01 Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency

Publications (1)

Publication Number Publication Date
MX389866B true MX389866B (es) 2025-03-20

Family

ID=49160185

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020000225A MX389866B (es) 2012-03-01 2013-03-01 El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal.
MX2014010457A MX370928B (es) 2012-03-01 2013-03-01 El uso de 9-cis-retinil acetato para mejorar la función visual de un sujeto que padece de pérdida de la función visual originada por una deficiencia retinoide endógena de 11-cis retinal.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014010457A MX370928B (es) 2012-03-01 2013-03-01 El uso de 9-cis-retinil acetato para mejorar la función visual de un sujeto que padece de pérdida de la función visual originada por una deficiencia retinoide endógena de 11-cis retinal.

Country Status (16)

Country Link
US (2) US20160296478A1 (es)
EP (1) EP2819667B8 (es)
JP (3) JP6576636B2 (es)
KR (1) KR102133608B1 (es)
CN (2) CN104470511A (es)
AU (3) AU2013232697B2 (es)
BR (1) BR112014021602A2 (es)
CA (1) CA2865935C (es)
DK (1) DK2819667T3 (es)
ES (1) ES2780357T3 (es)
IL (1) IL234306B (es)
MX (2) MX389866B (es)
NZ (1) NZ629267A (es)
PT (1) PT2819667T (es)
RU (1) RU2635536C2 (es)
WO (1) WO2013134867A1 (es)

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MX389866B (es) 2012-03-01 2025-03-20 Retinagenix LLC El uso de 9-cis-retinil acetato para mejorar la funcion visual de un sujeto que padece de perdida de la funcion visual originada por una deficiencia retinoide endogena de 11-cis retinal.
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US12029715B2 (en) * 2015-05-08 2024-07-09 University Of Debrecen Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof
WO2016181288A1 (en) * 2015-05-08 2016-11-17 University Of Debrecen Stereoselective synthesis of 9-cis.13,14-dihydroretinoic acid and its ethyl esters
ES2967076T3 (es) 2016-11-17 2024-04-25 Univ Of Debrecen Compuestos precursores para proporcionar retinoides de la vía de la vitamina a5 y sus usos
RU186184U1 (ru) * 2018-06-06 2019-01-11 Федеральное государственное бюджетное учреждение "33 Центральный научно-исследовательский испытательный институт" Министерства обороны Российской Федерации Устройство для оценки углов обзора и поля зрения испытателей в противогазе
AU2021289331A1 (en) * 2020-06-09 2022-12-15 Eluminex Biosciences (Suzhou) Limited Methods of treating visual disorders using daily low dosing of a retinoid compound
WO2024110625A1 (en) 2022-11-24 2024-05-30 Universität Bern Cralbp based therapeutics for retinal disorders

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Also Published As

Publication number Publication date
AU2019283995B2 (en) 2021-11-11
AU2019283995A1 (en) 2020-01-23
EP2819667B8 (en) 2020-03-04
EP2819667A4 (en) 2015-08-05
PT2819667T (pt) 2020-03-31
AU2018200415B2 (en) 2019-09-26
US20160296478A1 (en) 2016-10-13
MX370928B (es) 2020-01-08
HK1205469A1 (en) 2015-12-18
NZ629267A (en) 2016-11-25
US20190054039A1 (en) 2019-02-21
AU2018200415A1 (en) 2018-02-08
EP2819667A1 (en) 2015-01-07
AU2013232697A1 (en) 2014-09-18
WO2013134867A1 (en) 2013-09-19
EP2819667B1 (en) 2019-12-25
CN109248163A (zh) 2019-01-22
AU2013232697B2 (en) 2017-10-19
IL234306B (en) 2022-02-01
CA2865935C (en) 2021-12-14
JP2015508783A (ja) 2015-03-23
JP2017197588A (ja) 2017-11-02
JP2020073597A (ja) 2020-05-14
RU2635536C2 (ru) 2017-11-13
RU2014139666A (ru) 2016-04-20
KR102133608B1 (ko) 2020-07-13
DK2819667T3 (da) 2020-03-30
ES2780357T3 (es) 2020-08-25
CA2865935A1 (en) 2013-09-19
CN104470511A (zh) 2015-03-25
US10828267B2 (en) 2020-11-10
BR112014021602A2 (pt) 2021-06-08
KR20150000881A (ko) 2015-01-05
MX2014010457A (es) 2015-04-08
JP6576636B2 (ja) 2019-09-18

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