NZ596498A - Transdermal methods and systems for the delivery of anti-migraine compounds - Google Patents

Transdermal methods and systems for the delivery of anti-migraine compounds

Info

Publication number
NZ596498A
NZ596498A NZ596498A NZ59649807A NZ596498A NZ 596498 A NZ596498 A NZ 596498A NZ 596498 A NZ596498 A NZ 596498A NZ 59649807 A NZ59649807 A NZ 59649807A NZ 596498 A NZ596498 A NZ 596498A
Authority
NZ
New Zealand
Prior art keywords
delivery
transdermal patch
stage
systems
iontophoretic transdermal
Prior art date
Application number
NZ596498A
Other languages
English (en)
Inventor
Carter R Anderson
Original Assignee
Nupathe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nupathe Inc filed Critical Nupathe Inc
Priority to NZ610790A priority Critical patent/NZ610790A/en
Publication of NZ596498A publication Critical patent/NZ596498A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NZ596498A 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds NZ596498A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ610790A NZ610790A (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79181906P 2006-04-13 2006-04-13
US81413106P 2006-06-16 2006-06-16

Publications (1)

Publication Number Publication Date
NZ596498A true NZ596498A (en) 2013-05-31

Family

ID=38610170

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ596498A NZ596498A (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds
NZ610790A NZ610790A (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ610790A NZ610790A (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Country Status (13)

Country Link
US (4) US7973058B2 (cg-RX-API-DMAC7.html)
EP (1) EP2012871A4 (cg-RX-API-DMAC7.html)
JP (3) JP5580042B2 (cg-RX-API-DMAC7.html)
CN (2) CN101472644B (cg-RX-API-DMAC7.html)
AU (1) AU2007238685B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0709965C1 (cg-RX-API-DMAC7.html)
CA (2) CA2935569A1 (cg-RX-API-DMAC7.html)
EA (1) EA023147B1 (cg-RX-API-DMAC7.html)
HK (1) HK1203867A1 (cg-RX-API-DMAC7.html)
IL (1) IL194553A (cg-RX-API-DMAC7.html)
MX (1) MX2008012922A (cg-RX-API-DMAC7.html)
NZ (2) NZ596498A (cg-RX-API-DMAC7.html)
WO (1) WO2007120747A2 (cg-RX-API-DMAC7.html)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5580042B2 (ja) * 2006-04-13 2014-08-27 ヌパス インコーポレイテッド 抗片頭痛化合物の送達のための経皮的方法およびシステム
ES2604968T3 (es) * 2008-04-28 2017-03-10 Zogenix, Inc. Nuevas formulaciones para el tratamiento de la migraña
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
CN102046157A (zh) 2008-06-19 2011-05-04 Lts罗曼治疗方法有限公司 阳离子活性剂透皮输运组合物
US8155737B2 (en) 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US9913806B2 (en) * 2008-06-25 2018-03-13 Fe3 Medical, Inc. Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
JP5888645B2 (ja) 2008-12-30 2016-03-22 テバ・ファーマシューティカルズ・インターナショナル・ゲー・エム・ベー・ハー 薬物投与システムの電子制御
WO2010093472A2 (en) * 2009-02-12 2010-08-19 Incube Labs, Llc Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent
US8190252B2 (en) * 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US9008765B2 (en) 2009-02-12 2015-04-14 Incube Labs, Llc System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
US8423131B2 (en) * 2009-06-26 2013-04-16 Incube Labs, Llc Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use
CN102573489A (zh) * 2009-08-10 2012-07-11 纽帕特公司 用离子电渗疗法治疗恶心和偏头痛的方法
WO2011044175A2 (en) 2009-10-06 2011-04-14 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
US8986279B2 (en) 2010-02-10 2015-03-24 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
WO2012025239A1 (en) 2010-08-27 2012-03-01 Grünenthal GmbH Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as kcnq2/3 modulators
DK2609083T3 (da) 2010-08-27 2015-03-30 Gruenenthal Gmbh Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer
WO2012129576A2 (en) 2011-03-24 2012-09-27 Incube Labs, Llc System and method for biphasic transdermal iontophreotic delivery of therapeutic agents
US9744353B2 (en) 2012-11-14 2017-08-29 Teva Pharmaceuticals International Gmbh Detection of presence and alignment of a therapeutic agent in an iontophoretic drug delivery device
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
GB2554455A (en) 2016-09-29 2018-04-04 Feeligreen Sa Skin treatment device and method for delivery of an active ingredient into the human skin by means of iontophoresis, using an array of electrodes
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CN111278503B (zh) * 2017-09-12 2023-12-05 Lts勒曼治疗系统股份公司 离子电渗微针装置
US11318292B2 (en) * 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
WO2020264034A1 (en) * 2019-06-28 2020-12-30 Passport Technologies, Inc. Methods and systems for controlling energy delivery to filament devices
EP3989970B1 (en) 2019-06-28 2025-12-24 PassPort Technologies, Inc. Triptan microporation delivery system
US11364225B2 (en) 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557723A (en) 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4856188A (en) 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
US5605536A (en) 1983-08-18 1997-02-25 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5651768A (en) 1983-08-18 1997-07-29 Drug Delivery Systems, Inc. Transdermal drug applicator and electrodes therefor
US4883457A (en) 1983-08-18 1989-11-28 Drug Delivery Systems Inc. Disposable and/or replenishable transdermal drug applicators and methods of manufacturing same
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4822802A (en) 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
US5162042A (en) * 1988-07-05 1992-11-10 Alza Corporation Electrotransport transdermal system
US4927408A (en) 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
DE4014913C2 (de) 1990-05-10 1996-05-15 Lohmann Therapie Syst Lts Miniaturisiertes transdermales therapeutisches System für die Iontophorese
ATE160510T1 (de) * 1992-06-02 1997-12-15 Alza Corp Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
DE4314976C1 (de) * 1993-05-06 1994-10-06 Lohmann Therapie Syst Lts Transdermale therapeutische Systeme zur Verabreichung von Wirkstoffen, Verfahren zu ihrer Herstellung und ihre Verwendung
US5807571A (en) * 1993-05-06 1998-09-15 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic systems for administering indole serotonin agonists
US5458569A (en) 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
US5533971A (en) 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
JPH08317997A (ja) * 1995-03-17 1996-12-03 Takeda Chem Ind Ltd 経皮透過方法
US5700481A (en) * 1995-03-17 1997-12-23 Takeda Chemical Industries, Ltd. Transdermal drug delivery process
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
KR100453140B1 (ko) 1995-06-05 2005-02-28 앨자 코포레이션 펜타닐 및 수펜타닐의 경피 전기수송 전달을 위한 장치
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US5983130A (en) 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US5688232A (en) 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US5941843A (en) * 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US5882677A (en) * 1997-09-30 1999-03-16 Becton Dickinson And Company Iontophoretic patch with hydrogel reservoir
JP4290271B2 (ja) 1998-04-14 2009-07-01 久光製薬株式会社 経皮透過方法
SE9802864D0 (sv) * 1998-08-27 1998-08-27 Pharmacia & Upjohn Ab Transdermally administered tolterodine as antimuscarinic agent for the treatment of overactive bladder
JP4279992B2 (ja) 1999-04-12 2009-06-17 久光製薬株式会社 イオントフォレーシス用デバイス
US6312716B1 (en) * 1999-05-10 2001-11-06 Peierce Management Llc Patch and method for transdermal delivery of bupropion base
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
US6421561B1 (en) * 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
US8017627B2 (en) * 2000-07-31 2011-09-13 Nycomed Danmark Aps Fentanyl composition for nasal administration
US6653014B2 (en) 2001-05-30 2003-11-25 Birch Point Medical, Inc. Power sources for iontophoretic drug delivery systems
DE60228294D1 (en) * 2001-06-05 2008-09-25 Ronald Aung-Din Topische migränetherapie
US7979117B2 (en) * 2001-10-24 2011-07-12 Power Paper Ltd. Device and method for controlled delivery of active substance into the skin
WO2003072138A1 (en) * 2002-02-26 2003-09-04 Ortho-Mcneil Pharmaceutical Inc. Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
JP4191951B2 (ja) 2002-04-25 2008-12-03 ソントル ファルマペプティド 抗微生物剤投与装置および組立品
AU2003280136A1 (en) 2002-06-28 2004-01-19 Alza Corporation A reservoir for use in an electrotransport drug delivery device
US6745071B1 (en) 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system
RU2326893C2 (ru) 2003-04-16 2008-06-20 Кориум Интернэшнл Ковалентное и нековалентное сшивание гидрофильных полимеров и адгезивные композиции, полученные с ними
US8734421B2 (en) * 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US20050228336A1 (en) * 2004-04-07 2005-10-13 Preston Keusch Electrically assisted lidocaine and epinephrine delivery device having extended shelf-stability
UY28935A1 (es) 2004-06-03 2005-07-29 Alza Corp Sistema y metodo para la administracion transdermica de un anticoagulante
WO2006015299A2 (en) * 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US7856263B2 (en) 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
RU2008117167A (ru) 2005-09-30 2009-11-10 ТиТиАй ЭЛЛЕБО, ИНК. (JP) Способ и устройство для ионтофореза для системной доставки активных компонентов
JP5580042B2 (ja) 2006-04-13 2014-08-27 ヌパス インコーポレイテッド 抗片頭痛化合物の送達のための経皮的方法およびシステム

Also Published As

Publication number Publication date
US20110213294A1 (en) 2011-09-01
CN104138634B (zh) 2016-09-07
US20160317464A1 (en) 2016-11-03
CA2650412C (en) 2016-09-27
IL194553A (en) 2016-03-31
JP2009533451A (ja) 2009-09-17
CN104138634A (zh) 2014-11-12
EP2012871A2 (en) 2009-01-14
JP2016163723A (ja) 2016-09-08
JP5925844B2 (ja) 2016-05-25
BRPI0709965C2 (pt) 2011-12-20
US7973058B2 (en) 2011-07-05
BRPI0709965A2 (pt) 2011-08-02
US20080287497A1 (en) 2008-11-20
US9272137B2 (en) 2016-03-01
US20110213330A1 (en) 2011-09-01
EP2012871A4 (en) 2015-07-22
MX2008012922A (es) 2008-12-17
EA023147B1 (ru) 2016-04-29
HK1203867A1 (en) 2015-11-06
US8470853B2 (en) 2013-06-25
WO2007120747A2 (en) 2007-10-25
AU2007238685B2 (en) 2012-09-13
JP2014221798A (ja) 2014-11-27
BRPI0709965C1 (pt) 2011-12-20
AU2007238685A1 (en) 2007-10-25
JP5580042B2 (ja) 2014-08-27
CN101472644A (zh) 2009-07-01
CA2650412A1 (en) 2007-10-25
CN101472644B (zh) 2014-04-23
CA2935569A1 (en) 2007-10-25
NZ610790A (en) 2015-05-29
EA200802146A1 (ru) 2009-06-30
WO2007120747A3 (en) 2008-04-24

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