UY28935A1 - Sistema y metodo para la administracion transdermica de un anticoagulante - Google Patents
Sistema y metodo para la administracion transdermica de un anticoagulanteInfo
- Publication number
- UY28935A1 UY28935A1 UY28935A UY28935A UY28935A1 UY 28935 A1 UY28935 A1 UY 28935A1 UY 28935 A UY28935 A UY 28935A UY 28935 A UY28935 A UY 28935A UY 28935 A1 UY28935 A1 UY 28935A1
- Authority
- UY
- Uruguay
- Prior art keywords
- anticoagulant
- benzamidine
- derivative
- transdermal administration
- maintain
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 4
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 3
- 230000036470 plasma concentration Effects 0.000 abstract 2
- WVAYGXSZZDUNOS-UHFFFAOYSA-N 2-[3-(4-piperidin-4-yloxyanilino)prop-1-enyl]benzenecarboximidamide Chemical class NC(=N)C1=CC=CC=C1C=CCNC(C=C1)=CC=C1OC1CCNCC1 WVAYGXSZZDUNOS-UHFFFAOYSA-N 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003937 benzamidines Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- MELCHBVBYGSSOC-UHFFFAOYSA-N naphthalene-1-carboximidamide Chemical class C1=CC=C2C(C(=N)N)=CC=CC2=C1 MELCHBVBYGSSOC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Electrotherapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Un dispositivo para administrar en forma transdérmica un agente anticoagulante mediante electrotransporte. Preferentemente,el anticoagulante incluye una benzamidina o un derivado de naftamidina. Un derivado particularmente preferido de benzamidina es un derivado 2-(3-(4-(4-piperidimiloxi)anilino)-1-propenil)benzamidina. Los dispositivos se configuran para mantener una concentración plasmática de 20-80 ng/mL o para proporcionar un flujo en el rango de alrededor de 20-40 ng/día. Las densidades corrientes adecuadas incluyen 0,050 y 0,10 mA/cm2. Los métodos de la invención incluyen la administración de los anticoagulantes para mantener de manera precisa las concentraciones plasmáticas deseadas. La invención también incluye el tratamiento de enfermedades tromboemólicas y la inhibición del Factor Xa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57690504P | 2004-06-03 | 2004-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28935A1 true UY28935A1 (es) | 2005-07-29 |
Family
ID=35033286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28935A UY28935A1 (es) | 2004-06-03 | 2005-05-31 | Sistema y metodo para la administracion transdermica de un anticoagulante |
Country Status (18)
Country | Link |
---|---|
US (1) | US20050273047A1 (es) |
EP (1) | EP1758568A1 (es) |
JP (1) | JP2008501434A (es) |
KR (1) | KR20070027582A (es) |
CN (1) | CN1972681A (es) |
AR (1) | AR049434A1 (es) |
AU (1) | AU2005251772A1 (es) |
BR (1) | BRPI0511740A (es) |
CA (1) | CA2568625A1 (es) |
IL (1) | IL179675A0 (es) |
MX (1) | MXPA06014082A (es) |
NO (1) | NO20065985L (es) |
NZ (1) | NZ551359A (es) |
PE (1) | PE20060099A1 (es) |
RU (1) | RU2006147274A (es) |
UY (1) | UY28935A1 (es) |
WO (1) | WO2005120482A1 (es) |
ZA (1) | ZA200700051B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104138634B (zh) | 2006-04-13 | 2016-09-07 | 梯瓦制药国际有限责任公司 | 递送抗偏头痛化合物的透皮方法和系统 |
US20070249988A1 (en) * | 2006-04-21 | 2007-10-25 | Alza Corporation | Electrotransport Delivery of Nesiritide |
WO2009135896A1 (en) * | 2008-05-09 | 2009-11-12 | John Wetling | Ionized gas for medical treatment |
US8428708B1 (en) * | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
EP3342452A1 (en) * | 2017-01-03 | 2018-07-04 | L'oreal | Systems including association of ellagic acid and microcurrent |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US4340047A (en) * | 1978-10-18 | 1982-07-20 | Robert Tapper | Iontophoretic treatment apparatus |
US4250878A (en) * | 1978-11-22 | 1981-02-17 | Motion Control, Inc. | Non-invasive chemical species delivery apparatus and method |
US4382529A (en) * | 1980-12-15 | 1983-05-10 | Drdlik Frank J | Sanitary dispensing closure |
US4406658A (en) * | 1981-03-06 | 1983-09-27 | Medtronic, Inc. | Iontophoretic device with reversible polarity |
US4456012A (en) * | 1982-02-22 | 1984-06-26 | Medtronic, Inc. | Iontophoretic and electrical tissue stimulation device |
US4722726A (en) * | 1986-02-12 | 1988-02-02 | Key Pharmaceuticals, Inc. | Method and apparatus for iontophoretic drug delivery |
US5496266A (en) * | 1990-04-30 | 1996-03-05 | Alza Corporation | Device and method of iontophoretic drug delivery |
US5047007A (en) * | 1989-12-22 | 1991-09-10 | Medtronic, Inc. | Method and apparatus for pulsed iontophoretic drug delivery |
US5637599A (en) * | 1994-06-17 | 1997-06-10 | Corvas International, Inc. | Arginine mimic derivatives as enzyme inhibitors |
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US6322550B2 (en) * | 1998-04-14 | 2001-11-27 | Hisamitsu Pharmaceutical Co., Inc. | Method for transdermal administration of GP IIb/IIIa antagonist |
JP2001055332A (ja) * | 1999-06-07 | 2001-02-27 | Saitama Daiichi Seiyaku Kk | 芳香族アミジン誘導体類含有のイオントフォレ−シス用製剤 |
JP2003522613A (ja) * | 2000-02-18 | 2003-07-29 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | 交流を用いて物質を抽出する方法 |
US7137975B2 (en) * | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
US6775570B2 (en) * | 2002-02-04 | 2004-08-10 | Ceramatec, Inc. | Iontophoretic treatment device |
JP2007511617A (ja) | 2003-11-19 | 2007-05-10 | アルザ・コーポレーシヨン | 電気運搬適用のためのポリマーのバッファー調製物の調製法 |
-
2005
- 2005-05-31 UY UY28935A patent/UY28935A1/es unknown
- 2005-06-01 JP JP2007515621A patent/JP2008501434A/ja not_active Withdrawn
- 2005-06-01 KR KR1020067026295A patent/KR20070027582A/ko not_active Application Discontinuation
- 2005-06-01 CA CA002568625A patent/CA2568625A1/en not_active Abandoned
- 2005-06-01 AU AU2005251772A patent/AU2005251772A1/en not_active Abandoned
- 2005-06-01 CN CNA2005800182916A patent/CN1972681A/zh active Pending
- 2005-06-01 NZ NZ551359A patent/NZ551359A/en unknown
- 2005-06-01 PE PE2005000616A patent/PE20060099A1/es not_active Application Discontinuation
- 2005-06-01 US US11/144,005 patent/US20050273047A1/en not_active Abandoned
- 2005-06-01 RU RU2006147274/14A patent/RU2006147274A/ru not_active Application Discontinuation
- 2005-06-01 MX MXPA06014082A patent/MXPA06014082A/es unknown
- 2005-06-01 WO PCT/US2005/019576 patent/WO2005120482A1/en active Application Filing
- 2005-06-01 BR BRPI0511740-2A patent/BRPI0511740A/pt not_active IP Right Cessation
- 2005-06-01 EP EP05772746A patent/EP1758568A1/en not_active Withdrawn
- 2005-06-02 AR ARP050102264A patent/AR049434A1/es not_active Application Discontinuation
-
2006
- 2006-11-28 IL IL179675A patent/IL179675A0/en unknown
- 2006-12-22 NO NO20065985A patent/NO20065985L/no not_active Application Discontinuation
-
2007
- 2007-01-02 ZA ZA200700051A patent/ZA200700051B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MXPA06014082A (es) | 2007-05-09 |
RU2006147274A (ru) | 2008-07-20 |
NZ551359A (en) | 2009-03-31 |
WO2005120482A1 (en) | 2005-12-22 |
ZA200700051B (en) | 2008-04-30 |
AR049434A1 (es) | 2006-08-02 |
PE20060099A1 (es) | 2006-02-18 |
EP1758568A1 (en) | 2007-03-07 |
NO20065985L (no) | 2007-02-28 |
AU2005251772A1 (en) | 2005-12-22 |
JP2008501434A (ja) | 2008-01-24 |
IL179675A0 (en) | 2008-03-20 |
KR20070027582A (ko) | 2007-03-09 |
CA2568625A1 (en) | 2005-12-22 |
BRPI0511740A (pt) | 2008-01-08 |
US20050273047A1 (en) | 2005-12-08 |
CN1972681A (zh) | 2007-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY28935A1 (es) | Sistema y metodo para la administracion transdermica de un anticoagulante | |
Werner et al. | Erectile dysfunction in mice lacking the large‐conductance calcium‐activated potassium (BK) channel | |
AR058892A1 (es) | Metodos para tratar lupus cutaneo con el uso de compuestos de aminoisoindolina | |
CY1109732T1 (el) | Χρησις παραγωγων βενζο-συνενωμενου ετεροκυκλο σουλφαμιδιου δια την θεραπειαν πονου | |
NO20070855L (no) | Arylidener for behandling av estrogenrelaterte reseptor-alfamedierte sykdommer. | |
CL2010000616A1 (es) | Procedimiento para producir el polimorfo b de hidrocloruro de n-(3-etinilfenil)-6,7-bis(2-metoxietoxi)-4-quinazolinamina por recristalizacion del hidrocloruro de n-(3-etinilfenil)-6,7-bis(2-metoxietoxi)-4-quinazolinamina en un solvente que contiene etanol y agua (div. sol. n° 3107-00). | |
FI7341U1 (fi) | Transdermaalinen laastari fentanyylin antamiseksi | |
ECSP055669A (es) | Derivados de pirimidinona como agentes terapéuticos contra procesos de remodelación, isquemicos e inflamatorios agudos y cronicos | |
AR031766A1 (es) | Terapia | |
GT200900283A (es) | "terapia de combinación con un compuesto actuando como un inhibidor del receptor adp plaquetario". | |
DE602004027936D1 (de) | Tocopherolmodifizierte therapeutische arzneimittelverbindung | |
AR100772A1 (es) | Métodos para aumentar la inhibición tónica y tratar el insomnio secundario | |
CY1108932T1 (el) | Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων | |
AR074471A1 (es) | Compuesto 5(5-(2-(3-aminopropoxi) - 6 - metoxifenil) -1h- pirazol-3- ilamino ) pirazin -2-carbonitrilo , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para inhibir chk1 y para tratar cancer | |
DK1973541T3 (da) | Anvendelse af benzokondenserede heterocykliske sulfamidderivater til nedsættelse af lipid- og blodglucoseniveauer | |
DK1771155T3 (da) | Fremgangsmåde og sammensætning til behandling af rhinitis | |
AR072809A1 (es) | Compuesto de (3- piridinilcarbonil)-4-(fenilsulfonilpiperazina ), su uso para la elaboracion de unmedicamento para el tratamiento del dolor y composicion farmaceutica que lo comprende | |
RU2010148787A (ru) | Чрескожно абсорбируемый препарат | |
AR025449A1 (es) | Soluciones farmaceuticas de levosimendan | |
CO6361995A2 (es) | Derivados de isoquinolinona como antagonistas de nk3 | |
ATE399011T1 (de) | Substituierte diketopiperazine als oxytocin- antagonisten | |
AR055614A1 (es) | Combinacion de sustancias farmaceuticas para el tratamiento de enfermedades respiratorias | |
PA8525801A1 (es) | Compuestos de pirazol, composiciones farmacéuticas, y métodos para modular y/o inhibir la actividad de erab/hadh2 | |
ATE366601T1 (de) | Transdermales wirkstoffverabreichungssystem mit elektrodenraster | |
EA201990766A1 (ru) | Индазольные соединения для применения при повреждениях сухожилий и/или связок |