BRPI0709965C2 - formulações melhoradas de poliamina para a iontoforese do composto triptano - Google Patents

formulações melhoradas de poliamina para a iontoforese do composto triptano

Info

Publication number
BRPI0709965C2
BRPI0709965C2 BRC20709965-7A BRPI0709965A BRPI0709965C2 BR PI0709965 C2 BRPI0709965 C2 BR PI0709965C2 BR PI0709965 A BRPI0709965 A BR PI0709965A BR PI0709965 C2 BRPI0709965 C2 BR PI0709965C2
Authority
BR
Brazil
Prior art keywords
iontophoresis
tryptan
improved
formulations
polyamine formulations
Prior art date
Application number
BRC20709965-7A
Other languages
English (en)
Inventor
Carter R Anderson
Russell L Morris
Terri B Sebree
Original Assignee
Nupathe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nupathe Inc filed Critical Nupathe Inc
Publication of BRPI0709965A2 publication Critical patent/BRPI0709965A2/pt
Publication of BRPI0709965C2 publication Critical patent/BRPI0709965C2/pt
Publication of BRPI0709965C1 publication Critical patent/BRPI0709965C1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

FARMACOCINéTICA DA ADMINISTRAçãO IONTOFORéTICA DE SUMATRIPTANO. Perfis farmacocinétiçOS melhorados pra e composições para iontoforese dos compostos trão descritos.
BRC10709965-7A 2006-04-13 2007-04-12 farmacocinética da administração iontoforética de sumatriptano BRPI0709965C1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79181906P 2006-04-13 2006-04-13
US60/791.819 2006-04-13
US81413106P 2006-06-16 2006-06-16
US60/814.131 2006-06-16
PCT/US2007/009000 WO2007120747A2 (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Publications (3)

Publication Number Publication Date
BRPI0709965A2 BRPI0709965A2 (pt) 2011-08-02
BRPI0709965C2 true BRPI0709965C2 (pt) 2011-12-20
BRPI0709965C1 BRPI0709965C1 (pt) 2011-12-20

Family

ID=38610170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC10709965-7A BRPI0709965C1 (pt) 2006-04-13 2007-04-12 farmacocinética da administração iontoforética de sumatriptano

Country Status (13)

Country Link
US (4) US7973058B2 (pt)
EP (1) EP2012871A4 (pt)
JP (3) JP5580042B2 (pt)
CN (2) CN101472644B (pt)
AU (1) AU2007238685B2 (pt)
BR (1) BRPI0709965C1 (pt)
CA (2) CA2650412C (pt)
EA (1) EA023147B1 (pt)
HK (1) HK1203867A1 (pt)
IL (1) IL194553A (pt)
MX (1) MX2008012922A (pt)
NZ (2) NZ596498A (pt)
WO (1) WO2007120747A2 (pt)

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CA2650412C (en) * 2006-04-13 2016-09-27 Nupathe, Inc. Transdermal methods and systems for the delivery of anti-migraine compounds
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US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
US8155737B2 (en) 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
KR101656537B1 (ko) * 2008-06-19 2016-09-09 에르테에스 로만 테라피-시스테메 아게 양이온성 활성제의 경피 전달용 조성물
CN102159205A (zh) 2008-06-25 2011-08-17 Fe3医学有限公司 用于经皮递送治疗有效量的铁的贴片和方法
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US9095503B2 (en) 2009-02-12 2015-08-04 Incube Labs, Llc System and method for biphasic transdermal iontophreotic delivery of therapeutic agents
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US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
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US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CN111278503B (zh) * 2017-09-12 2023-12-05 Lts勒曼治疗系统股份公司 离子电渗微针装置
US11318292B2 (en) * 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
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US11364225B2 (en) 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same

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Also Published As

Publication number Publication date
CA2650412A1 (en) 2007-10-25
US9272137B2 (en) 2016-03-01
HK1203867A1 (en) 2015-11-06
CN101472644A (zh) 2009-07-01
US7973058B2 (en) 2011-07-05
US20080287497A1 (en) 2008-11-20
BRPI0709965A2 (pt) 2011-08-02
US20110213294A1 (en) 2011-09-01
NZ596498A (en) 2013-05-31
IL194553A (en) 2016-03-31
EA023147B1 (ru) 2016-04-29
CN104138634A (zh) 2014-11-12
JP2014221798A (ja) 2014-11-27
US20110213330A1 (en) 2011-09-01
WO2007120747A3 (en) 2008-04-24
AU2007238685A1 (en) 2007-10-25
EP2012871A4 (en) 2015-07-22
MX2008012922A (es) 2008-12-17
EA200802146A1 (ru) 2009-06-30
CN104138634B (zh) 2016-09-07
CN101472644B (zh) 2014-04-23
CA2935569A1 (en) 2007-10-25
WO2007120747A2 (en) 2007-10-25
JP5925844B2 (ja) 2016-05-25
EP2012871A2 (en) 2009-01-14
US8470853B2 (en) 2013-06-25
BRPI0709965C1 (pt) 2011-12-20
AU2007238685B2 (en) 2012-09-13
CA2650412C (en) 2016-09-27
JP5580042B2 (ja) 2014-08-27
JP2009533451A (ja) 2009-09-17
JP2016163723A (ja) 2016-09-08
NZ610790A (en) 2015-05-29
US20160317464A1 (en) 2016-11-03

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