BRPI0709965C2 - formulações melhoradas de poliamina para a iontoforese do composto triptano - Google Patents

formulações melhoradas de poliamina para a iontoforese do composto triptano

Info

Publication number
BRPI0709965C2
BRPI0709965C2 BRC20709965-7A BRPI0709965A BRPI0709965C2 BR PI0709965 C2 BRPI0709965 C2 BR PI0709965C2 BR PI0709965 A BRPI0709965 A BR PI0709965A BR PI0709965 C2 BRPI0709965 C2 BR PI0709965C2
Authority
BR
Brazil
Prior art keywords
iontophoresis
tryptan
improved
formulations
polyamine formulations
Prior art date
Application number
BRC20709965-7A
Other languages
English (en)
Inventor
Carter R Anderson
Russell L Morris
Terri B Sebree
Original Assignee
Nupathe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nupathe Inc filed Critical Nupathe Inc
Publication of BRPI0709965A2 publication Critical patent/BRPI0709965A2/pt
Publication of BRPI0709965C1 publication Critical patent/BRPI0709965C1/pt
Publication of BRPI0709965C2 publication Critical patent/BRPI0709965C2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

FARMACOCINéTICA DA ADMINISTRAçãO IONTOFORéTICA DE SUMATRIPTANO. Perfis farmacocinétiçOS melhorados pra e composições para iontoforese dos compostos trão descritos.
BRC20709965-7A 2006-04-13 2007-04-12 formulações melhoradas de poliamina para a iontoforese do composto triptano BRPI0709965C2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79181906P 2006-04-13 2006-04-13
US60/791.819 2006-04-13
US81413106P 2006-06-16 2006-06-16
US60/814.131 2006-06-16
PCT/US2007/009000 WO2007120747A2 (en) 2006-04-13 2007-04-12 Transdermal methods and systems for the delivery of anti-migraine compounds

Publications (3)

Publication Number Publication Date
BRPI0709965A2 BRPI0709965A2 (pt) 2011-08-02
BRPI0709965C1 BRPI0709965C1 (pt) 2011-12-20
BRPI0709965C2 true BRPI0709965C2 (pt) 2011-12-20

Family

ID=38610170

Family Applications (1)

Application Number Title Priority Date Filing Date
BRC20709965-7A BRPI0709965C2 (pt) 2006-04-13 2007-04-12 formulações melhoradas de poliamina para a iontoforese do composto triptano

Country Status (13)

Country Link
US (4) US7973058B2 (pt)
EP (1) EP2012871A4 (pt)
JP (3) JP5580042B2 (pt)
CN (2) CN104138634B (pt)
AU (1) AU2007238685B2 (pt)
BR (1) BRPI0709965C2 (pt)
CA (2) CA2650412C (pt)
EA (1) EA023147B1 (pt)
HK (1) HK1203867A1 (pt)
IL (1) IL194553A (pt)
MX (1) MX2008012922A (pt)
NZ (2) NZ596498A (pt)
WO (1) WO2007120747A2 (pt)

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US8366600B2 (en) 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
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CN105748401A (zh) * 2009-08-10 2016-07-13 泰华制药国际有限公司 用离子电渗疗法治疗恶心和偏头痛的方法
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CN103826696B (zh) 2011-03-24 2017-03-22 因卡伯实验室有限责任公司 用于治疗剂的两阶段经皮离子电渗递送的系统及方法
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US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US11534589B2 (en) * 2017-09-12 2022-12-27 Lts Lohmann Therapie-Systeme Ag Iontophoretic microneedle device
US11318292B2 (en) * 2018-05-28 2022-05-03 Microneedles Inc. Microneedle patch for transdermal injections
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Also Published As

Publication number Publication date
CN104138634B (zh) 2016-09-07
US20110213294A1 (en) 2011-09-01
US7973058B2 (en) 2011-07-05
BRPI0709965A2 (pt) 2011-08-02
JP2014221798A (ja) 2014-11-27
US20110213330A1 (en) 2011-09-01
EA023147B1 (ru) 2016-04-29
NZ610790A (en) 2015-05-29
EP2012871A4 (en) 2015-07-22
CN104138634A (zh) 2014-11-12
US20160317464A1 (en) 2016-11-03
BRPI0709965C1 (pt) 2011-12-20
CA2935569A1 (en) 2007-10-25
WO2007120747A2 (en) 2007-10-25
WO2007120747A3 (en) 2008-04-24
JP2016163723A (ja) 2016-09-08
JP5925844B2 (ja) 2016-05-25
US9272137B2 (en) 2016-03-01
HK1203867A1 (en) 2015-11-06
NZ596498A (en) 2013-05-31
US8470853B2 (en) 2013-06-25
AU2007238685A1 (en) 2007-10-25
MX2008012922A (es) 2008-12-17
US20080287497A1 (en) 2008-11-20
CN101472644A (zh) 2009-07-01
AU2007238685B2 (en) 2012-09-13
CN101472644B (zh) 2014-04-23
JP5580042B2 (ja) 2014-08-27
IL194553A (en) 2016-03-31
CA2650412C (en) 2016-09-27
EA200802146A1 (ru) 2009-06-30
CA2650412A1 (en) 2007-10-25
JP2009533451A (ja) 2009-09-17
EP2012871A2 (en) 2009-01-14

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