ITFI20050239A1 - Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono - Google Patents

Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono

Info

Publication number
ITFI20050239A1
ITFI20050239A1 IT000239A ITFI20050239A ITFI20050239A1 IT FI20050239 A1 ITFI20050239 A1 IT FI20050239A1 IT 000239 A IT000239 A IT 000239A IT FI20050239 A ITFI20050239 A IT FI20050239A IT FI20050239 A1 ITFI20050239 A1 IT FI20050239A1
Authority
IT
Italy
Prior art keywords
hydroxammed
istone
deacetylases
inhibitors
count
Prior art date
Application number
IT000239A
Other languages
English (en)
Inventor
Andrea Piero D
Daniela Fattori
Marina Porcelloni
Cristina Rossi
Original Assignee
Menarini Int Operations Lu Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT000041A priority Critical patent/ITFI20050041A1/it
Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa
Priority to IT000239A priority patent/ITFI20050239A1/it
Priority to TW095107569A priority patent/TW200724529A/zh
Priority to BRPI0606290-3A priority patent/BRPI0606290A2/pt
Priority to EP06708749A priority patent/EP1868997A1/en
Priority to AP2007004188A priority patent/AP2007004188A0/xx
Priority to US11/886,160 priority patent/US20080207694A1/en
Priority to ARP060100977A priority patent/AR058002A1/es
Priority to AU2006224624A priority patent/AU2006224624A1/en
Priority to PCT/EP2006/060687 priority patent/WO2006097460A1/en
Priority to KR1020077022763A priority patent/KR20070112240A/ko
Priority to CNA2006800066799A priority patent/CN101155780A/zh
Priority to MX2007011072A priority patent/MX2007011072A/es
Priority to JP2008501287A priority patent/JP2008533091A/ja
Priority to EA200701970A priority patent/EA012909B1/ru
Priority to CA002600528A priority patent/CA2600528A1/en
Priority to SA06270135A priority patent/SA06270135B1/ar
Publication of ITFI20050239A1 publication Critical patent/ITFI20050239A1/it
Priority to IL185882A priority patent/IL185882A0/en
Priority to CR9431A priority patent/CR9431A/es
Priority to MA30291A priority patent/MA29389B1/fr
Priority to ZA200708749A priority patent/ZA200708749B/xx
Priority to CO07107399A priority patent/CO6321134A2/es
Priority to NO20075281A priority patent/NO20075281L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT000239A 2005-03-15 2005-11-21 Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono ITFI20050239A1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT000041A ITFI20050041A1 (it) 2005-03-15 2005-03-15 Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono
IT000239A ITFI20050239A1 (it) 2005-03-15 2005-11-21 Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono
TW095107569A TW200724529A (en) 2005-03-15 2006-03-07 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
CNA2006800066799A CN101155780A (zh) 2005-03-15 2006-03-14 作为组蛋白去乙酰基酶抑制剂的异羟肟酸盐以及含有其的药物配方
EA200701970A EA012909B1 (ru) 2005-03-15 2006-03-14 Гидроксаматы как ингибиторы гистондеацетилазы и содержащие их фармацевтические композиции
AP2007004188A AP2007004188A0 (en) 2005-03-15 2006-03-14 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
US11/886,160 US20080207694A1 (en) 2005-03-15 2006-03-14 Hydroxamates as Histone Deacetylase Inhibitors and Pharmaceutical Formulations Containing Them
ARP060100977A AR058002A1 (es) 2005-03-15 2006-03-14 Hidroxamatos como inhibidores de la histona deacetilasa y formulaciones farmaceuticas que los contienen
AU2006224624A AU2006224624A1 (en) 2005-03-15 2006-03-14 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
PCT/EP2006/060687 WO2006097460A1 (en) 2005-03-15 2006-03-14 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
KR1020077022763A KR20070112240A (ko) 2005-03-15 2006-03-14 히스톤 탈아세틸화효소 저해제로서 하이드록사메이트 및이를 함유하는 약학적 제제
BRPI0606290-3A BRPI0606290A2 (pt) 2005-03-15 2006-03-14 hidroxamatos como inibidores de histona desacetilase e formulações farmacêuticas os contendo
MX2007011072A MX2007011072A (es) 2005-03-15 2006-03-14 Hidroxamatos como inhibidores de la histona deacetilasa y formulaciones farmaceuticas que los contienen.
JP2008501287A JP2008533091A (ja) 2005-03-15 2006-03-14 ヒストンデアセチラーゼ阻害剤としてのヒドロキサム酸及びこれを含有する医薬組成物
EP06708749A EP1868997A1 (en) 2005-03-15 2006-03-14 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
CA002600528A CA2600528A1 (en) 2005-03-15 2006-03-14 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
SA06270135A SA06270135B1 (ar) 2005-03-15 2006-05-08 مركبات هيدروكسامات بصفتها مثبطات هستون دياستيلاز وتركيبات صيدلية تحتوي عليها
IL185882A IL185882A0 (en) 2005-03-15 2007-09-10 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
CR9431A CR9431A (es) 2005-03-15 2007-10-11 Hidroxamatos como inhibidores de la histona deacetilasa y formulaciones farmaceuticas que los contienen
MA30291A MA29389B1 (fr) 2005-03-15 2007-10-11 Hydroxamates utilises en tant qu'inhibiteurs de desacetylase d'histones et formulations pharmaceutiques les contenant.
ZA200708749A ZA200708749B (en) 2005-03-15 2007-10-12 Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
CO07107399A CO6321134A2 (es) 2005-03-15 2007-10-12 Hidroxamatos como inhibidores de la histona deacetilasa y formulaciones farmaceuticas que los contienen
NO20075281A NO20075281L (no) 2005-03-15 2007-10-15 Hydroksamater som historiedeacetylasehemmere og farmasoytiske formuleringer inneholdende disse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000041A ITFI20050041A1 (it) 2005-03-15 2005-03-15 Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono
IT000239A ITFI20050239A1 (it) 2005-03-15 2005-11-21 Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono

Publications (1)

Publication Number Publication Date
ITFI20050239A1 true ITFI20050239A1 (it) 2007-05-22

Family

ID=36617217

Family Applications (2)

Application Number Title Priority Date Filing Date
IT000041A ITFI20050041A1 (it) 2005-03-15 2005-03-15 Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono
IT000239A ITFI20050239A1 (it) 2005-03-15 2005-11-21 Idrossammati come inibitori dell'istone deacetilasi e formulazioni farmaceutiche che li contegono

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IT000041A ITFI20050041A1 (it) 2005-03-15 2005-03-15 Idrossammati come inibitori dell'istone deacelitasi, loro preparazione e formulazioni farmaceutiche che li contengono

Country Status (22)

Country Link
US (1) US20080207694A1 (it)
EP (1) EP1868997A1 (it)
JP (1) JP2008533091A (it)
KR (1) KR20070112240A (it)
CN (1) CN101155780A (it)
AP (1) AP2007004188A0 (it)
AR (1) AR058002A1 (it)
AU (1) AU2006224624A1 (it)
BR (1) BRPI0606290A2 (it)
CA (1) CA2600528A1 (it)
CO (1) CO6321134A2 (it)
CR (1) CR9431A (it)
EA (1) EA012909B1 (it)
IL (1) IL185882A0 (it)
IT (2) ITFI20050041A1 (it)
MA (1) MA29389B1 (it)
MX (1) MX2007011072A (it)
NO (1) NO20075281L (it)
SA (1) SA06270135B1 (it)
TW (1) TW200724529A (it)
WO (1) WO2006097460A1 (it)
ZA (1) ZA200708749B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1996550A2 (en) * 2005-09-27 2008-12-03 Novartis AG Carboxyamine compounds and their use in the treatment of hdac dependent diseases
GB0523040D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
US20100261710A1 (en) * 2007-08-21 2010-10-14 Arqule, Inc. HDAC Inhibitors
CN102775368B (zh) 2011-05-10 2016-08-17 上海驺虞医药科技有限公司 一类噻唑类化合物及其制备方法和用途
US10654814B2 (en) * 2015-12-22 2020-05-19 Kancera Ab Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
DK3398598T3 (da) * 2015-12-31 2022-07-11 Hitgen Inc Sulfonamidderivat og fremstillingsmetode og anvendelse deraf
CN112325620B (zh) * 2020-11-13 2022-04-19 南阳中联水泥有限公司 一种水泥生产高效烘干设备
CN112516142B (zh) * 2020-12-11 2021-10-15 北京华氏精恒医药科技有限公司 一种具有hdac抑制活性的药物组合物、制备方法及其用途
WO2023003468A1 (en) * 2021-07-23 2023-01-26 Rijksuniversiteit Groningen Novel inhibitors of histone deacetylase (hdac), and methods, compositions and uses related thereto.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076438A1 (en) * 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
US7629343B2 (en) * 2002-04-03 2009-12-08 Topotarget Uk Limited Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors
US20040072802A1 (en) * 2002-10-09 2004-04-15 Jingwu Duan Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
US7723376B2 (en) * 2003-07-15 2010-05-25 Korea Research Institute Of Bioscience And Biotechnology 2-oxo-heterocyclic compounds and pharmaceutical compositions
CA2543570A1 (en) * 2003-10-27 2005-05-06 S*Bio Pte Ltd Acylurea connected and sulfonylurea connected hydroxamates

Also Published As

Publication number Publication date
US20080207694A1 (en) 2008-08-28
KR20070112240A (ko) 2007-11-22
EA012909B1 (ru) 2010-02-26
JP2008533091A (ja) 2008-08-21
WO2006097460A8 (en) 2007-11-01
ITFI20050041A1 (it) 2006-09-16
MA29389B1 (fr) 2008-04-01
WO2006097460A1 (en) 2006-09-21
EP1868997A1 (en) 2007-12-26
CO6321134A2 (es) 2011-09-20
TW200724529A (en) 2007-07-01
AU2006224624A1 (en) 2006-09-21
IL185882A0 (en) 2008-01-06
SA06270135B1 (ar) 2009-07-19
BRPI0606290A2 (pt) 2009-06-09
NO20075281L (no) 2007-10-15
CA2600528A1 (en) 2006-09-21
ZA200708749B (en) 2009-08-26
CN101155780A (zh) 2008-04-02
CR9431A (es) 2008-07-31
AR058002A1 (es) 2008-01-23
EA200701970A1 (ru) 2008-02-28
AP2007004188A0 (en) 2007-10-31
MX2007011072A (es) 2007-10-08

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