CN104138634A - 递送抗偏头痛化合物的透皮方法和系统 - Google Patents
递送抗偏头痛化合物的透皮方法和系统 Download PDFInfo
- Publication number
- CN104138634A CN104138634A CN201410110715.2A CN201410110715A CN104138634A CN 104138634 A CN104138634 A CN 104138634A CN 201410110715 A CN201410110715 A CN 201410110715A CN 104138634 A CN104138634 A CN 104138634A
- Authority
- CN
- China
- Prior art keywords
- patch
- putan
- compound
- sumatriptan
- stage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Abstract
Description
药物 | Cmax ng/mL | AUC ng.hr/mL |
阿莫曲普坦 | 52 | 310 |
夫罗曲普坦 | 5 | 45 |
依来曲普坦 | 200 | 1,300 |
那拉曲普坦 | 8 | 75 |
利扎曲普坦 | 22 | 78 |
佐米曲普坦 | 4 | 20 |
分值 | 定义 |
0 | 无红斑 |
1 | 最小的红斑 |
2 | 中度的红斑,有清楚的边界 |
3 | 强烈的红斑,有或无浮肿 |
4 | 强烈的红斑,有浮肿和发疱/糜烂 |
Claims (148)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79181906P | 2006-04-13 | 2006-04-13 | |
US60/791819 | 2006-04-13 | ||
US81413106P | 2006-06-16 | 2006-06-16 | |
US60/814131 | 2006-06-16 | ||
CN200780022405.3A CN101472644B (zh) | 2006-04-13 | 2007-04-12 | 递送抗偏头痛化合物的透皮方法和系统 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780022405.3A Division CN101472644B (zh) | 2006-04-13 | 2007-04-12 | 递送抗偏头痛化合物的透皮方法和系统 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104138634A true CN104138634A (zh) | 2014-11-12 |
CN104138634B CN104138634B (zh) | 2016-09-07 |
Family
ID=38610170
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410110715.2A Expired - Fee Related CN104138634B (zh) | 2006-04-13 | 2007-04-12 | 递送抗偏头痛化合物的透皮方法和系统 |
CN200780022405.3A Expired - Fee Related CN101472644B (zh) | 2006-04-13 | 2007-04-12 | 递送抗偏头痛化合物的透皮方法和系统 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780022405.3A Expired - Fee Related CN101472644B (zh) | 2006-04-13 | 2007-04-12 | 递送抗偏头痛化合物的透皮方法和系统 |
Country Status (13)
Country | Link |
---|---|
US (4) | US7973058B2 (zh) |
EP (1) | EP2012871A4 (zh) |
JP (3) | JP5580042B2 (zh) |
CN (2) | CN104138634B (zh) |
AU (1) | AU2007238685B2 (zh) |
BR (1) | BRPI0709965C1 (zh) |
CA (2) | CA2935569A1 (zh) |
EA (1) | EA023147B1 (zh) |
HK (1) | HK1203867A1 (zh) |
IL (1) | IL194553A (zh) |
MX (1) | MX2008012922A (zh) |
NZ (2) | NZ610790A (zh) |
WO (1) | WO2007120747A2 (zh) |
Families Citing this family (30)
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NZ610790A (en) * | 2006-04-13 | 2015-05-29 | Nupathe Inc | Transdermal methods and systems for the delivery of anti-migraine compounds |
EP2756756B1 (en) * | 2008-04-28 | 2016-01-06 | Zogenix, Inc. | Novel formulations for treatment of migraine |
US8155737B2 (en) * | 2008-06-19 | 2012-04-10 | Nupathe, Inc. | Pharmacokinetics of iontophoretic sumatriptan administration |
US8366600B2 (en) | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
AU2009259601B2 (en) * | 2008-06-19 | 2014-09-18 | Lts Lohmann Therapie-Systeme Ag | Composition for transdermal delivery of cationic active agents |
US8996104B2 (en) * | 2008-06-25 | 2015-03-31 | Fe3 Medical, Inc. | Patches and method for the transdermal delivery of a therapeutically effective amount of iron |
NZ622157A (en) | 2008-12-30 | 2015-10-30 | Teva Pharmaceuticals Int Gmbh | Electronic control of drug delivery system |
US8190252B2 (en) * | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
WO2010093472A2 (en) * | 2009-02-12 | 2010-08-19 | Incube Labs, Llc | Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent |
US9095503B2 (en) | 2009-02-12 | 2015-08-04 | Incube Labs, Llc | System and method for biphasic transdermal iontophreotic delivery of therapeutic agents |
US9008765B2 (en) | 2009-02-12 | 2015-04-14 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
US8821945B2 (en) * | 2009-04-25 | 2014-09-02 | Fe3 Medical, Inc. | Method for transdermal iontophoretic delivery of chelated agents |
WO2010151845A2 (en) * | 2009-06-26 | 2010-12-29 | Incube Labs, Llc | Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use |
US8903485B2 (en) * | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
BR112012003111A8 (pt) * | 2009-08-10 | 2017-10-10 | Nupathe Inc | Métodos para tratar iontoforeticamente náusea e enxaqueca |
US20110087153A1 (en) * | 2009-10-13 | 2011-04-14 | Angelov Angel S | Transdermal Methods And Systems For The Delivery Of Rizatriptan |
US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
WO2011100376A2 (en) * | 2010-02-10 | 2011-08-18 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
CN103189357B (zh) | 2010-08-27 | 2015-11-25 | 格吕伦塔尔有限公司 | 作为kcnq2/3调节剂的取代的2-氧代-和2-硫代-二氢喹啉-3-甲酰胺 |
ES2537628T3 (es) | 2010-08-27 | 2015-06-10 | Grünenthal GmbH | 2-Oxiquinolin-3-carboxamidas sustituidas como moduladores de KCNQ2/3 |
US9744353B2 (en) | 2012-11-14 | 2017-08-29 | Teva Pharmaceuticals International Gmbh | Detection of presence and alignment of a therapeutic agent in an iontophoretic drug delivery device |
EP3416618A1 (en) | 2016-02-19 | 2018-12-26 | ZP Opco, Inc. | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines |
GB2554455A (en) | 2016-09-29 | 2018-04-04 | Feeligreen Sa | Skin treatment device and method for delivery of an active ingredient into the human skin by means of iontophoresis, using an array of electrodes |
US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
CA3074777A1 (en) * | 2017-09-12 | 2019-03-21 | Lts Lohmann Therapie-Systeme Ag | Iontophoretic microneedle device |
US11318292B2 (en) * | 2018-05-28 | 2022-05-03 | Microneedles Inc. | Microneedle patch for transdermal injections |
US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
WO2020264026A1 (en) * | 2019-06-28 | 2020-12-30 | Passport Technologies, Inc. | Triptan microporation delivery system |
US11364225B2 (en) | 2019-08-21 | 2022-06-21 | Bn Intellectual Properties, Inc. | Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same |
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-
2007
- 2007-04-12 NZ NZ610790A patent/NZ610790A/en not_active IP Right Cessation
- 2007-04-12 WO PCT/US2007/009000 patent/WO2007120747A2/en active Application Filing
- 2007-04-12 CN CN201410110715.2A patent/CN104138634B/zh not_active Expired - Fee Related
- 2007-04-12 MX MX2008012922A patent/MX2008012922A/es active IP Right Grant
- 2007-04-12 CA CA2935569A patent/CA2935569A1/en not_active Abandoned
- 2007-04-12 EP EP07755312.1A patent/EP2012871A4/en not_active Withdrawn
- 2007-04-12 EA EA200802146A patent/EA023147B1/ru not_active IP Right Cessation
- 2007-04-12 AU AU2007238685A patent/AU2007238685B2/en not_active Ceased
- 2007-04-12 BR BRC10709965-7A patent/BRPI0709965C1/pt not_active IP Right Cessation
- 2007-04-12 CN CN200780022405.3A patent/CN101472644B/zh not_active Expired - Fee Related
- 2007-04-12 JP JP2009505469A patent/JP5580042B2/ja not_active Expired - Fee Related
- 2007-04-12 CA CA2650412A patent/CA2650412C/en not_active Expired - Fee Related
- 2007-04-12 NZ NZ596498A patent/NZ596498A/xx unknown
-
2008
- 2008-07-28 US US12/181,142 patent/US7973058B2/en not_active Expired - Fee Related
- 2008-10-06 IL IL194553A patent/IL194553A/en active IP Right Grant
-
2011
- 2011-05-11 US US13/105,562 patent/US9272137B2/en not_active Expired - Fee Related
- 2011-05-11 US US13/105,585 patent/US8470853B2/en not_active Expired - Fee Related
-
2014
- 2014-07-10 JP JP2014141927A patent/JP5925844B2/ja not_active Expired - Fee Related
-
2015
- 2015-05-06 HK HK15104294.8A patent/HK1203867A1/zh unknown
-
2016
- 2016-02-26 US US15/055,312 patent/US20160317464A1/en not_active Abandoned
- 2016-04-20 JP JP2016084282A patent/JP2016163723A/ja not_active Ceased
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