NZ595661A - Method for purifying recombinant follicle stimulating hormone (fsh) - Google Patents

Method for purifying recombinant follicle stimulating hormone (fsh)

Info

Publication number
NZ595661A
NZ595661A NZ595661A NZ59566110A NZ595661A NZ 595661 A NZ595661 A NZ 595661A NZ 595661 A NZ595661 A NZ 595661A NZ 59566110 A NZ59566110 A NZ 59566110A NZ 595661 A NZ595661 A NZ 595661A
Authority
NZ
New Zealand
Prior art keywords
fsh
stimulating hormone
follicle stimulating
chromatography
recombinant follicle
Prior art date
Application number
NZ595661A
Other languages
English (en)
Inventor
Christian Scheckermann
Dietmar Eichinger
Stefan Arnold
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NZ595661A publication Critical patent/NZ595661A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ595661A 2009-04-01 2010-04-01 Method for purifying recombinant follicle stimulating hormone (fsh) NZ595661A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09157133 2009-04-01
PCT/EP2010/002111 WO2010115586A2 (en) 2009-04-01 2010-04-01 Method for purifying recombinant fsh

Publications (1)

Publication Number Publication Date
NZ595661A true NZ595661A (en) 2013-07-26

Family

ID=42153744

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ595661A NZ595661A (en) 2009-04-01 2010-04-01 Method for purifying recombinant follicle stimulating hormone (fsh)

Country Status (26)

Country Link
US (3) US9096683B2 (https=)
EP (1) EP2414380B1 (https=)
JP (2) JP5845170B2 (https=)
KR (1) KR101761168B1 (https=)
CN (1) CN102448979B (https=)
AU (1) AU2010234028B2 (https=)
BR (1) BRPI1012647B1 (https=)
CA (1) CA2755927A1 (https=)
CY (1) CY1116963T1 (https=)
DK (1) DK2414380T3 (https=)
EA (1) EA028065B1 (https=)
ES (1) ES2552055T3 (https=)
HR (1) HRP20151086T1 (https=)
HU (1) HUE025959T2 (https=)
IL (1) IL215234A (https=)
ME (1) ME02277B (https=)
MX (1) MX2011010480A (https=)
NZ (1) NZ595661A (https=)
PL (1) PL2414380T3 (https=)
PT (1) PT2414380E (https=)
RS (1) RS54318B1 (https=)
SI (1) SI2414380T1 (https=)
SM (1) SMT201500276B (https=)
UA (1) UA106369C2 (https=)
WO (1) WO2010115586A2 (https=)
ZA (1) ZA201106800B (https=)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
JP5845170B2 (ja) * 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法
CN103570820B (zh) * 2012-08-06 2015-11-18 齐鲁制药有限公司 一种重组人促卵泡激素的纯化方法
KR101516054B1 (ko) * 2012-11-21 2015-05-06 씨제이헬스케어 주식회사 신규한 지속형 인간 성장호르몬 단량체를 제조하는 방법
CN103059125B (zh) * 2012-12-27 2015-08-12 浙江海正药业股份有限公司 重组人促卵泡激素的纯化方法
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
KR20160131113A (ko) * 2014-04-18 2016-11-15 카딜라 핼쓰캐어 리미티드 고나도트로핀의 신규한 정제 방법
CN104479005B (zh) * 2014-09-05 2017-10-31 上海丽珠制药有限公司 一种促性腺激素纯化的方法
CN105461799A (zh) * 2015-12-31 2016-04-06 哈药集团技术中心 一种重组人促卵泡生成素的纯化方法
CN106117342B (zh) * 2016-07-07 2020-01-03 江西浩然生物医药有限公司 一种高纯度尿促卵泡素的制备方法
RU2694598C1 (ru) * 2018-08-07 2019-07-16 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Клеточная линия huFSHKKc6 - продуцент рекомбинантного человеческого фолликулостимулирующего гормона (ФСГ) и способ получения ФСГ с использованием данной линии
CN114867741A (zh) * 2019-12-26 2022-08-05 株式会社Lg化学 纯化促卵泡激素的方法
KR102283871B1 (ko) * 2021-03-02 2021-08-02 한국원자력연구원 크로마토그래피를 이용한 무담체 홀뮴-166의 분리 방법, 분리 장치 및 이에 의하여 분리된 무담체 홀뮴-166
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法
CN114591414A (zh) * 2022-03-24 2022-06-07 江西浩然生物制药有限公司 一种人绒毛膜促性腺激素的制备方法

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US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4840896A (en) 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US6455282B1 (en) * 1983-11-02 2002-09-24 Genzyme Corporation Cells, vectors and methods for producing biologically active TSH
IT1206302B (it) 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
CA2018676C (en) 1989-06-20 2003-05-06 Christie A. Kelton Novel heteropolymeric protein production methods
US5021160A (en) * 1990-01-09 1991-06-04 Gelman Sciences, Inc. Strongly acidic microporous membranes for cation exchange
DE4440587A1 (de) 1994-11-14 1996-05-15 Fliether Karl Gmbh & Co Basquill-Schloß
US6261823B1 (en) * 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
ES2332931T3 (es) 1997-06-25 2010-02-15 Merck Serono Sa Analogos de hormonas glicoproteinicas entrelazadas por disulfuro, su preparacion y uso.
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
BRPI0010677B8 (pt) * 1999-04-16 2021-05-25 Inst Massone S A processo de purificação de gonadotropinas urinárias humanas a partir de gonadotropinas brutas.
WO2001058493A1 (en) 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
CA2483650A1 (en) 2002-05-31 2003-12-11 E.I. Du Pont De Nemours And Company Copolymers having tunable energy levels and color of emission
DK1610822T4 (en) 2003-04-02 2019-01-14 Ares Trading Sa Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant
EP1697412B1 (en) * 2003-12-22 2009-10-21 Ares Trading S.A. Method for purifying fsh
DE602005009856D1 (de) * 2004-11-09 2008-10-30 Ares Trading Sa Verfahren zur reinigung von fsh
ES2572629T3 (es) * 2005-12-09 2016-06-01 Ares Trading S.A. Método para purificar FSH o un mutante de FSH
EP1960419B1 (en) 2005-12-09 2016-03-16 Ares Trading S.A. Method for purifying fsh or a fsh mutant
DK2170942T3 (da) * 2007-06-28 2013-11-04 Biogenerix Ag Fsh-producerende celleklon
AR067536A1 (es) * 2007-07-17 2009-10-14 Hoffmann La Roche Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea
JP5845170B2 (ja) * 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法

Also Published As

Publication number Publication date
JP2016027050A (ja) 2016-02-18
BRPI1012647A2 (pt) 2020-08-11
PL2414380T3 (pl) 2016-01-29
JP5845170B2 (ja) 2016-01-20
EP2414380B1 (en) 2015-08-26
KR101761168B1 (ko) 2017-07-25
AU2010234028A1 (en) 2011-10-27
SI2414380T1 (sl) 2015-12-31
EP2414380A2 (en) 2012-02-08
ME02277B (me) 2016-02-20
AU2010234028B2 (en) 2013-11-14
KR20120013359A (ko) 2012-02-14
US20120135928A1 (en) 2012-05-31
US20150353599A1 (en) 2015-12-10
RS54318B1 (sr) 2016-02-29
UA106369C2 (ru) 2014-08-26
JP6231056B2 (ja) 2017-11-15
CA2755927A1 (en) 2010-10-14
HRP20151086T1 (hr) 2015-12-04
IL215234A0 (en) 2011-12-29
JP2012522736A (ja) 2012-09-27
ES2552055T3 (es) 2015-11-25
WO2010115586A3 (en) 2010-11-25
CY1116963T1 (el) 2017-04-05
HUE025959T2 (en) 2016-05-30
EA201171199A1 (ru) 2012-05-30
US20160304575A1 (en) 2016-10-20
IL215234A (en) 2016-09-29
DK2414380T3 (en) 2015-10-19
MX2011010480A (es) 2012-09-07
CN102448979A (zh) 2012-05-09
SMT201500276B (it) 2016-01-08
PT2414380E (pt) 2015-11-13
ZA201106800B (en) 2012-08-28
CN102448979B (zh) 2015-03-04
EA028065B1 (ru) 2017-10-31
WO2010115586A2 (en) 2010-10-14
US9096683B2 (en) 2015-08-04
BRPI1012647B1 (pt) 2022-05-17

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