NZ594420A - Methods of creating and screening dna-encoded libraries - Google Patents
Methods of creating and screening dna-encoded librariesInfo
- Publication number
- NZ594420A NZ594420A NZ594420A NZ59442010A NZ594420A NZ 594420 A NZ594420 A NZ 594420A NZ 594420 A NZ594420 A NZ 594420A NZ 59442010 A NZ59442010 A NZ 59442010A NZ 594420 A NZ594420 A NZ 594420A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methods
- creating
- compounds
- screening dna
- encoded libraries
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B20/00—Methods specially adapted for identifying library members
- C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ611886A NZ611886A (en) | 2009-02-13 | 2010-02-16 | Methods of creating and screening dna-encoded libraries |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15250809P | 2009-02-13 | 2009-02-13 | |
| PCT/US2010/024314 WO2010094036A1 (en) | 2009-02-13 | 2010-02-16 | Methods of creating and screening dna-encoded libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ594420A true NZ594420A (en) | 2013-06-28 |
Family
ID=42562099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ594420A NZ594420A (en) | 2009-02-13 | 2010-02-16 | Methods of creating and screening dna-encoded libraries |
| NZ611886A NZ611886A (en) | 2009-02-13 | 2010-02-16 | Methods of creating and screening dna-encoded libraries |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ611886A NZ611886A (en) | 2009-02-13 | 2010-02-16 | Methods of creating and screening dna-encoded libraries |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9359601B2 (https=) |
| EP (3) | EP2396459B1 (https=) |
| JP (6) | JP5770641B2 (https=) |
| KR (4) | KR20170119729A (https=) |
| CN (2) | CN102317513B (https=) |
| AP (1) | AP3396A (https=) |
| BR (1) | BRPI1008429A2 (https=) |
| CA (2) | CA2752543A1 (https=) |
| DK (2) | DK2396459T3 (https=) |
| EA (4) | EA202090636A3 (https=) |
| ES (2) | ES2638324T3 (https=) |
| IL (3) | IL214399B (https=) |
| MX (1) | MX2011008563A (https=) |
| NZ (2) | NZ594420A (https=) |
| SG (3) | SG2014011381A (https=) |
| WO (1) | WO2010094036A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2396459T3 (en) | 2009-02-13 | 2017-08-28 | X-Chem Inc | Method for preparing and screening DNA-encoded libraries |
| WO2011127933A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| DK2748357T3 (en) | 2011-09-07 | 2018-07-16 | X Chem Inc | Methods for labeling DNA-encoded libraries |
| EA201992285A1 (ru) * | 2012-07-13 | 2020-05-31 | Икс-Чем, Инк. | Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами |
| CN104181221B (zh) | 2013-05-21 | 2017-02-01 | 成都先导药物开发有限公司 | 一种药物靶标捕获方法 |
| GB201322692D0 (en) * | 2013-12-20 | 2014-02-05 | Philochem Ag | Production of encoded chemical libraries |
| GB201404552D0 (en) * | 2014-03-14 | 2014-04-30 | Philochem Ag | Purification of dna-conjugate products |
| EP3218479A1 (en) | 2014-11-11 | 2017-09-20 | Nanocore ApS | Method for identification of molecules with desired characteristics |
| US10900065B2 (en) | 2014-11-14 | 2021-01-26 | University Of Washington | Methods and kits for labeling cellular molecules |
| NL2013857B1 (en) | 2014-11-21 | 2016-10-11 | Piculet Biosciences Tech B V | Self-assembled bivalent ligand complex (SABLC) libraries and methods for screening such libraries. |
| CN106048736B (zh) * | 2015-04-14 | 2019-09-03 | 成都先导药物开发股份有限公司 | 一种固相合成dna编码化合物库的方法 |
| US11186836B2 (en) | 2016-06-16 | 2021-11-30 | Haystack Sciences Corporation | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| CN107130300A (zh) * | 2016-10-08 | 2017-09-05 | 深圳劲宇生物科技有限公司 | 一种dna编码分子库的合成方法及dna模板 |
| IL266197B2 (en) | 2016-10-24 | 2024-03-01 | Geneinfosec Inc | Hiding information contained within nucleic acids |
| AU2017357638B2 (en) * | 2016-11-08 | 2023-11-16 | Nanna Therapeutics Limited | Tagless encoded chemical library |
| CN108149325A (zh) * | 2016-12-02 | 2018-06-12 | 杭州阿诺生物医药科技股份有限公司 | Dna编码动态分子库的合成与筛选方法 |
| WO2018151810A1 (en) | 2017-02-17 | 2018-08-23 | The Scripps Research Institute | Defining rna-small molecule affinity landscapes enables design of a small molecular inhibitor of an oncogenic non-coding rna |
| JP6911248B2 (ja) | 2017-03-17 | 2021-07-28 | 成都先導薬物開発股▲フン▼有限公司Hitgen Inc. | エンコードライブラリの合成方法及び組成物 |
| EP3619340A4 (en) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES |
| CN108070009B (zh) * | 2017-12-12 | 2021-04-13 | 上海药明康德新药开发有限公司 | 一种制备dna编码化合物文库的方法及起始头片段化合物和制得的dna编码化合物 |
| WO2020001560A1 (zh) * | 2018-06-29 | 2020-01-02 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
| US20220017471A1 (en) * | 2018-07-18 | 2022-01-20 | Shanghai Tech University | Functionality independent labeling of organic compounds |
| CN109338477A (zh) * | 2018-10-25 | 2019-02-15 | 深圳劲宇生物科技有限公司 | 基于环形模板的dna编码分子库及其合成方法和应用 |
| EP3914704B9 (en) | 2019-01-22 | 2023-10-04 | Vipergen APS | A method for screening of an in vitro display library within a cell |
| CN111675744B (zh) * | 2019-03-11 | 2022-01-04 | 成都先导药物开发股份有限公司 | 一种可溶于有机溶剂的dna编码化合物及其中间体化合物 |
| EP3956467A1 (en) | 2019-04-16 | 2022-02-23 | F. Hoffmann-La Roche AG | Small molecule screening cellular assay using modified beads |
| WO2020259689A1 (zh) * | 2019-06-27 | 2020-12-30 | 成都先导药物开发股份有限公司 | 一种可识别混合物对复杂生物体系的鉴别方法 |
| KR102376443B1 (ko) | 2020-02-26 | 2022-03-17 | 포항공과대학교 산학협력단 | 나노구조체, 나노구조체를 포함하는 바이오센서, 및 스크리닝 방법 |
| KR20230015347A (ko) | 2020-05-25 | 2023-01-31 | 닛산 가가쿠 가부시키가이샤 | 절단 가능한 dna 코드화 라이브러리 |
| US20250215615A1 (en) * | 2021-11-24 | 2025-07-03 | Nissan Chemical Corporation | Method for evaluating dna-encoded library |
| WO2023108090A2 (en) * | 2021-12-09 | 2023-06-15 | University Of Florida Research Foundation, Incorporated | Platform using dna-encoded small molecule libraries and rna selection to design small molecules that target rna |
| CN114989229B (zh) * | 2022-03-25 | 2025-02-11 | 康龙化成(宁波)科技发展有限公司 | 一种寡聚核酸-吡唑类化合物及其合成方法 |
| JP7204026B1 (ja) | 2022-03-31 | 2023-01-13 | 大阪ガスケミカル株式会社 | 不織布及びその製造方法、それを用いた有機溶剤回収方法、並びに有機溶剤回収装置 |
| CN114920791B (zh) * | 2022-04-28 | 2024-06-18 | 康龙化成(宁波)科技发展有限公司 | 一种寡聚核酸-琥珀酰亚胺化合物的合成方法 |
| WO2024069235A2 (en) | 2022-09-30 | 2024-04-04 | Sixfold Bioscience Ltd. | Compositions containing oligonucleotides with theranostic applications |
| CN116590798A (zh) * | 2023-05-10 | 2023-08-15 | 中科苏州药物研究院 | 含有三嗪骨架的dna编码化合物及其合成方法、dna编码化合物库 |
| WO2025217391A1 (en) * | 2024-04-12 | 2025-10-16 | Insitro, Inc. | Methods of preparing oligonucleotide-directed combinatorial libraries |
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