NZ591134A - Cross-species-specific (human and primate) bispecific single chain antibody that binds both cd3 (epsilon) epitope and prostate specific membrane antigen (pmsa) - Google Patents
Cross-species-specific (human and primate) bispecific single chain antibody that binds both cd3 (epsilon) epitope and prostate specific membrane antigen (pmsa)Info
- Publication number
- NZ591134A NZ591134A NZ591134A NZ59113409A NZ591134A NZ 591134 A NZ591134 A NZ 591134A NZ 591134 A NZ591134 A NZ 591134A NZ 59113409 A NZ59113409 A NZ 59113409A NZ 591134 A NZ591134 A NZ 591134A
- Authority
- NZ
- New Zealand
- Prior art keywords
- epitope
- single chain
- chain antibody
- epsilon
- specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10185708P | 2008-10-01 | 2008-10-01 | |
| PCT/EP2009/062793 WO2010037836A2 (en) | 2008-10-01 | 2009-10-01 | Cross-species-specific psmaxcd3 bispecific single chain antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ591134A true NZ591134A (en) | 2012-08-31 |
Family
ID=42073956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ591134A NZ591134A (en) | 2008-10-01 | 2009-10-01 | Cross-species-specific (human and primate) bispecific single chain antibody that binds both cd3 (epsilon) epitope and prostate specific membrane antigen (pmsa) |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US20110293619A1 (OSRAM) |
| EP (3) | EP4180458A1 (OSRAM) |
| JP (4) | JP6126782B2 (OSRAM) |
| KR (1) | KR101820535B1 (OSRAM) |
| CN (1) | CN102171248B (OSRAM) |
| AU (1) | AU2009299792B2 (OSRAM) |
| BR (1) | BRPI0919841A2 (OSRAM) |
| CA (1) | CA2738565C (OSRAM) |
| CY (1) | CY1118303T1 (OSRAM) |
| DK (1) | DK2356153T3 (OSRAM) |
| ES (1) | ES2588155T3 (OSRAM) |
| HR (1) | HRP20160684T1 (OSRAM) |
| HU (1) | HUE030090T2 (OSRAM) |
| IL (1) | IL212099A (OSRAM) |
| ME (1) | ME02485B (OSRAM) |
| MX (1) | MX2011003502A (OSRAM) |
| NZ (1) | NZ591134A (OSRAM) |
| PL (1) | PL2356153T3 (OSRAM) |
| PT (1) | PT2356153T (OSRAM) |
| RS (1) | RS54900B1 (OSRAM) |
| RU (1) | RU2559531C2 (OSRAM) |
| SG (1) | SG194398A1 (OSRAM) |
| SI (1) | SI2356153T1 (OSRAM) |
| SM (1) | SMT201600256B (OSRAM) |
| WO (1) | WO2010037836A2 (OSRAM) |
| ZA (1) | ZA201101067B (OSRAM) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2520590T (pt) * | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| EP2352765B1 (en) * | 2008-10-01 | 2018-01-03 | Amgen Research (Munich) GmbH | Cross-species-specific single domain bispecific single chain antibody |
| DK2356153T3 (en) * | 2008-10-01 | 2016-07-04 | Amgen Res Munich Gmbh | Bispecific single CHAIN PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES |
| WO2010135313A1 (en) | 2009-05-19 | 2010-11-25 | Aic Blab Company | Composite current collector and methods therefor |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| TWI653333B (zh) | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
| CN103052649B (zh) | 2010-07-29 | 2015-12-16 | Xencor公司 | 具有修改的等电点的抗体 |
| UA112062C2 (uk) | 2010-10-04 | 2016-07-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Cd33-зв'язувальний агент |
| EP4279513A3 (en) | 2010-11-30 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| EP2699596A4 (en) | 2011-04-22 | 2015-01-14 | Emergent Product Dev Seattle | PROSTATE-SPECIFIC MEMBRANE-BINDING PROTEINS AND COMPOSITIONS AND METHOD THEREFOR |
| CN107903325B (zh) * | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| KR101681818B1 (ko) * | 2011-08-23 | 2016-12-01 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
| EP2820047B1 (en) * | 2012-03-01 | 2018-04-25 | Amgen Research (Munich) GmbH | Long life polypeptide binding molecules |
| US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| IN2015MN00139A (OSRAM) * | 2012-09-25 | 2015-10-16 | Glenmark Pharmaceuticals Sa | |
| JP6321667B2 (ja) * | 2012-11-06 | 2018-05-09 | バイエル・ファルマ・アクティエンゲゼルシャフト | 二重特異性T細胞エンゲージャー(BiTEs)のための配合物 |
| CN103087171B (zh) * | 2012-12-24 | 2015-01-14 | 中国人民解放军第四军医大学 | 一种用于前列腺癌早期诊断和治疗的抗psma/fitc双特异性抗体及其制备方法 |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| CN105051069B (zh) | 2013-01-14 | 2019-12-10 | Xencor股份有限公司 | 新型异二聚体蛋白 |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US9738722B2 (en) | 2013-01-15 | 2017-08-22 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| US10077315B2 (en) | 2013-02-05 | 2018-09-18 | Engmab Sàrl | Bispecific antibodies against CD3 and BCMA |
| EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
| EP2762497A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| WO2014143886A2 (en) * | 2013-03-15 | 2014-09-18 | Edimer Pharmaceuticals, Inc. | Anti-ectodysplasin antibodies |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| US10544187B2 (en) | 2013-03-15 | 2020-01-28 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| EP2970484B2 (en) * | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimeric bispecific antibodies |
| US9505849B2 (en) | 2013-03-15 | 2016-11-29 | Amgen Research (Munich) Gmbh | Antibody constructs for influenza M2 and CD3 |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| BR112016001611B1 (pt) | 2013-07-25 | 2024-01-09 | Cytomx Therapeutics, Inc | Anticorpo ativável multiespecífico, uso terapêutico do mesmo, molécula de ácido nucleico isolada, vetor e método para produzir um anticorpo ativável multiespecífico |
| EP3122781B1 (en) | 2014-03-28 | 2020-01-01 | Xencor, Inc. | Bispecific antibodies that bind to cd38 and cd3 |
| US9212225B1 (en) | 2014-07-01 | 2015-12-15 | Amphivena Therapeutics, Inc. | Bispecific CD33 and CD3 binding proteins |
| SG11201609707WA (en) | 2014-07-01 | 2017-01-27 | Pfizer | Bispecific heterodimeric diabodies and uses thereof |
| CA2955947A1 (en) * | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| AU2015353416C1 (en) | 2014-11-26 | 2022-01-27 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and CD38 |
| EP3223845B1 (en) | 2014-11-26 | 2021-05-19 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd20 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| EP3237449A2 (en) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Trispecific antibodies |
| CA2974453A1 (en) | 2015-01-23 | 2016-07-28 | Sanofi | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| WO2016130819A2 (en) * | 2015-02-11 | 2016-08-18 | Emergent Product Development Seattle Llc | Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| CN107849148B (zh) | 2015-05-21 | 2023-09-19 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| KR102537102B1 (ko) | 2015-05-29 | 2023-05-25 | 엠피베나 테라퓨틱스, 인크. | 이중특이적 cd33 및 cd3 결합 단백질을 사용하는 방법 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
| JOP20160154B1 (ar) * | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
| CA2992797A1 (en) | 2015-08-03 | 2017-02-09 | Engmab Sarl | Monoclonal antibodies against bcma |
| IL298041B2 (en) | 2015-08-17 | 2025-10-01 | Janssen Pharmaceutica Nv | Anti-BCMA antibodies, bispecific antigen-binding molecules that bind BCMA and CD3, and uses thereof |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| BR112018005573A2 (pt) | 2015-09-21 | 2019-01-22 | Aptevo Research And Development Llc | ?polipeptídeos de ligação a cd3? |
| CN105198992B (zh) * | 2015-10-16 | 2018-07-13 | 中国人民解放军海军总医院 | 一种人源抗创伤弧菌溶血素蛋白(vvh)抗体的制备方法与应用 |
| BR112018008908A2 (pt) | 2015-11-02 | 2018-11-27 | Janssen Pharmaceutica Nv | anticorpos anti-il1rap, moléculas de ligação ao antígeno biespecíficas que se ligam il1rap e cd3, e seus usos |
| WO2017100372A1 (en) | 2015-12-07 | 2017-06-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
| LT3411404T (lt) * | 2016-02-03 | 2022-12-27 | Amgen Research (Munich) Gmbh | Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai |
| CN109476756B (zh) | 2016-03-15 | 2022-05-31 | 埃泰美德(香港)有限公司 | 一种多特异性Fab融合蛋白及其用途 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| US10100106B2 (en) | 2016-05-20 | 2018-10-16 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
| WO2017218707A2 (en) | 2016-06-14 | 2017-12-21 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
| CA3029209A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
| US10316088B2 (en) | 2016-06-28 | 2019-06-11 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途 |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| UA126384C2 (uk) * | 2016-09-14 | 2022-09-28 | Тенеобіо, Інк. | Антитіло, яке зв'язує cd3 |
| AU2017331256B2 (en) | 2016-09-21 | 2024-11-07 | Aptevo Research And Development Llc | CD123 binding proteins and related compositions and methods |
| MA46534A (fr) | 2016-10-14 | 2019-08-21 | Xencor Inc | Protéines de fusion fc hétérodimères il15/il15r |
| CN110167964B (zh) | 2016-11-02 | 2023-12-01 | 百时美施贵宝公司 | 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物 |
| CA3044729A1 (en) * | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Psma targeting trispecific proteins and methods of use |
| WO2018098354A1 (en) | 2016-11-23 | 2018-05-31 | Harpoon Therapeutics, Inc. | Prostate specific membrane antigen binding protein |
| NZ795790A (en) | 2016-12-21 | 2025-11-28 | Teneobio Inc | Anti-BCMA heavy chain-only antibodies |
| EP3589662A4 (en) | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | INDUCTIBLE MONOVALENT ANTIGEN BINDING PROTEIN |
| JP7029822B2 (ja) * | 2017-03-29 | 2022-03-04 | タイペイ・メディカル・ユニバーシティ | 抗原特異的t細胞及びその使用 |
| CN113896792B (zh) | 2017-05-12 | 2025-08-22 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
| US11970540B2 (en) | 2017-06-20 | 2024-04-30 | Teneobio, Inc. | Anti-BCMA heavy chain-only antibodies |
| CA3065951A1 (en) | 2017-06-20 | 2018-12-27 | Teneoone, Inc. | Anti-bcma heavy chain-only antibodies |
| KR102324568B1 (ko) | 2017-06-21 | 2021-11-10 | 길리애드 사이언시즈, 인코포레이티드 | HIV gp120 및 CD3을 표적화하는 다중특이적 항체 |
| WO2019006472A1 (en) | 2017-06-30 | 2019-01-03 | Xencor, Inc. | TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS |
| PL3661954T3 (pl) | 2017-08-03 | 2022-05-16 | Amgen Inc. | Muteiny interleukiny 21 i sposoby leczenia |
| EP3679040B1 (en) | 2017-09-08 | 2022-08-03 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
| US12486325B2 (en) | 2017-09-21 | 2025-12-02 | WuXi Biologics Ireland Limited | Anti-CD3epsilon antibodies |
| CA3074130A1 (en) | 2017-09-21 | 2019-03-28 | WuXi Biologics Ireland Limited | Novel anti-cd3epsilon antibodies |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR102425983B1 (ko) | 2017-10-13 | 2022-07-29 | 하푼 테라퓨틱스, 인크. | 삼중특이적 단백질 및 사용 방법 |
| CN111247171A (zh) | 2017-10-14 | 2020-06-05 | 西托姆克斯治疗公司 | 抗体、可活化抗体、双特异性抗体和双特异性可活化抗体及其使用方法 |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| AU2018366199A1 (en) | 2017-11-08 | 2020-05-28 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-PD-1 sequences |
| US10426424B2 (en) | 2017-11-21 | 2019-10-01 | General Electric Company | System and method for generating and performing imaging protocol simulations |
| MA51291A (fr) | 2017-12-19 | 2020-10-28 | Xencor Inc | Protéines de fusion il-2 fc modifiées |
| MX2020006494A (es) | 2017-12-22 | 2020-11-24 | Teneobio Inc | Anticuerpos de cadena pesada que se unen a cd22. |
| TW201940518A (zh) | 2017-12-29 | 2019-10-16 | 美商安進公司 | 針對muc17和cd3之雙特異性抗體構建體 |
| CN111727197A (zh) | 2018-01-12 | 2020-09-29 | 美国安进公司 | 抗pd-1抗体和治疗方法 |
| CA3096052A1 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| EP3773913A1 (en) | 2018-04-11 | 2021-02-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| CA3097741A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| MX2020010910A (es) | 2018-04-18 | 2021-02-09 | Xencor Inc | Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos. |
| KR20210020903A (ko) | 2018-05-14 | 2021-02-24 | 하푼 테라퓨틱스, 인크. | 면역글로불린 분자의 조건부 활성화를 위한 결합 모이어티 |
| CA3100118A1 (en) | 2018-05-16 | 2019-11-21 | Janssen Biotech, Inc. | Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy |
| EP3802609A2 (en) * | 2018-05-24 | 2021-04-14 | Janssen Biotech, Inc. | Psma binding agents and uses thereof |
| JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
| CN118459594A (zh) | 2018-06-01 | 2024-08-09 | 诺华股份有限公司 | 针对bcma的结合分子及其用途 |
| KR20210029158A (ko) | 2018-06-03 | 2021-03-15 | 람카프 바이오 베타 엘티디. | Ceacam5 및 cd47에 대한 이중특이성 항체 |
| US12195533B2 (en) | 2018-07-24 | 2025-01-14 | Inhibrx Biosciences, Inc. | Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same |
| US11976131B2 (en) * | 2018-07-31 | 2024-05-07 | Heidelberg Pharma Research Gmbh | Humanized antibodies against PSMA |
| US12460000B2 (en) | 2018-09-07 | 2025-11-04 | Itabmed (Hk) Limited | Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| IL281683B2 (en) | 2018-09-25 | 2023-04-01 | Harpoon Therapeutics Inc | dll3 binding proteins and methods of use |
| CA3115096A1 (en) | 2018-10-03 | 2020-04-09 | Xencor, Inc. | Il-12 heterodimeric fc-fusion proteins |
| TW202028245A (zh) | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
| BR112021016955A2 (pt) | 2019-03-01 | 2021-11-23 | Xencor Inc | Composição, composição de ácido nucleico, composição de vetor de expressão, vetor de expressão, célula hospedeira, métodos de produção de um domínio de ligação de membro de família 3 de pirofosfatase/fosfodiesterase de ectonucleotídeo e de tratamento de um câncer, anticorpo anti-enpp3, e, anticorpo heterodimérico |
| KR20210149076A (ko) | 2019-04-05 | 2021-12-08 | 테네오바이오, 인코포레이티드 | Psma에 결합하는 중쇄 항체 |
| CA3136892A1 (en) * | 2019-04-19 | 2020-10-22 | Janssen Biotech, Inc. | Methods of treating renal cancer with an anti- psma/cd3 antibody |
| CA3136888A1 (en) | 2019-04-19 | 2020-10-22 | Janssen Biotech, Inc. | Methods of treating prostate cancer with an anti- psma/cd3 antibody |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Cd19結合分子及びその使用 |
| CR20210622A (es) | 2019-06-14 | 2022-06-27 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
| US20220372148A1 (en) | 2019-07-05 | 2022-11-24 | Ono Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating hematological cancer |
| US20220251562A1 (en) * | 2019-07-26 | 2022-08-11 | Ixaka France | Anti-CD3 Aptamers for Use in Cell Targeting and Labeling |
| WO2021053587A1 (en) | 2019-09-18 | 2021-03-25 | Klaus Strein | Bispecific antibodies against ceacam5 and cd3 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| EP3842461A1 (en) * | 2019-12-23 | 2021-06-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
| IL294458A (en) | 2020-01-13 | 2022-09-01 | Aptevo Res & Development Llc | Formulations for protein therapeutics |
| IL294461A (en) | 2020-01-13 | 2022-09-01 | Aptevo Res & Development Llc | Methods and compositions for preventing adsorption of therapeutic proteins to drug delivery system components |
| CA3170833A1 (en) | 2020-02-21 | 2021-08-26 | Harpoon Therapeutics, Inc. | Flt3 binding proteins and methods of use |
| JP7625007B2 (ja) | 2020-04-29 | 2025-01-31 | テネオバイオ, インコーポレイテッド | 重鎖定常領域が修飾された多重特異性重鎖抗体 |
| AU2021272291A1 (en) | 2020-05-11 | 2023-02-02 | Janssen Biotech, Inc. | Methods for treating multiple myeloma |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| AU2021329378A1 (en) | 2020-08-19 | 2023-03-23 | Xencor, Inc. | Anti-CD28 compositions |
| AU2021345124A1 (en) | 2020-09-16 | 2023-03-30 | Amgen Inc. | Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer |
| WO2022060878A1 (en) | 2020-09-16 | 2022-03-24 | Amgen Inc. | Methods for treating prostate cancer |
| WO2022081822A1 (en) * | 2020-10-15 | 2022-04-21 | Janux Therapeutics, Inc. | Antibodies targeting psma and cd3 and uses thereof |
| KR20230104256A (ko) | 2020-11-06 | 2023-07-07 | 암젠 인크 | 증가된 선택성의 다중표적화 이중특이적 항원 결합 분자 |
| CR20230235A (es) * | 2020-11-06 | 2023-10-05 | Amgen Res Munich Gmbh | Construcciones polipeptídicas que se unen selectivamente a cldn6 y cd3 |
| WO2022125576A1 (en) | 2020-12-09 | 2022-06-16 | Janux Therapeutics, Inc. | Compositions and methods related to tumor activated antibodies targeting psma and effector cell antigens |
| CR20230398A (es) | 2021-02-16 | 2023-11-15 | Janssen Pharmaceutica Nv | Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3 |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
| KR20230160874A (ko) | 2021-03-24 | 2023-11-24 | 얀센 바이오테크 인코포레이티드 | CD79b, CD20 및 CD3을 표적으로 하는 삼중특이적 항체 |
| EP4330281A1 (en) | 2021-04-29 | 2024-03-06 | Amgen Inc. | Methods for reducing low molecular weight species of recombinantly-produced proteins |
| WO2022234102A1 (en) | 2021-05-06 | 2022-11-10 | Amgen Research (Munich) Gmbh | Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases |
| JP2024519964A (ja) | 2021-05-21 | 2024-05-21 | アプティーボ リサーチ アンド デベロップメント エルエルシー | タンパク質治療薬のための投薬レジメン |
| CN115536740A (zh) * | 2021-06-30 | 2022-12-30 | 苏州方德门达新药开发有限公司 | 介导细胞内有效滞留cd3的空间构象表位及其应用 |
| JP7707834B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707828B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707827B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707823B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707831B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707833B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707822B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707821B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707824B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707835B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707825B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707836B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707820B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707830B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707832B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| JP7707829B2 (ja) * | 2021-10-06 | 2025-07-15 | 株式会社三洋物産 | 遊技機 |
| KR20240099376A (ko) | 2021-11-03 | 2024-06-28 | 얀센 바이오테크 인코포레이티드 | 암 치료 및 bcmaxcd3 이중특이성 항체의 효능을 향상시키는 방법 |
| AU2023238724A1 (en) | 2022-03-21 | 2024-09-05 | Amgen Inc. | Combination therapy methods with t-cell engaging molecules for treatment of prostate cancer |
| EP4522651A1 (en) | 2022-05-12 | 2025-03-19 | Amgen Research (Munich) GmbH | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
| WO2025134049A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of al amyloidosis |
| WO2025134050A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of multiple myeloma |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| GB9304200D0 (en) | 1993-03-02 | 1993-04-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JP3626187B2 (ja) | 1993-06-07 | 2005-03-02 | バイカル インコーポレイテッド | 遺伝子治療に適するプラスミド |
| WO1997000957A1 (en) | 1995-06-23 | 1997-01-09 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| WO1999054440A1 (en) | 1998-04-21 | 1999-10-28 | Micromet Gesellschaft Für Biomedizinische Forschung Mbh | CD19xCD3 SPECIFIC POLYPEPTIDES AND USES THEREOF |
| US20020142000A1 (en) * | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| SE524615C2 (sv) | 1999-06-30 | 2004-09-07 | Volvo Personvagnar Ab | Arrangemang för minskning av galvanisk korrosion mellan metallkomponenter |
| DK1210374T3 (da) * | 1999-07-29 | 2007-02-19 | Medarex Inc | Humane, monoklonale antistoffer over for prostataspecifikt membranantigen |
| JP4386776B2 (ja) * | 2000-05-18 | 2009-12-16 | 日本たばこ産業株式会社 | 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途 |
| RU2179862C1 (ru) * | 2000-12-26 | 2002-02-27 | Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" | Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки |
| AU2003224604B2 (en) * | 2002-01-28 | 2007-06-14 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (PSMA) |
| WO2004069876A2 (en) | 2003-02-06 | 2004-08-19 | Micromet Ag | Trimeric polypeptide construct to induce an enduring t cell response |
| CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| RU2005141512A (ru) * | 2003-05-31 | 2007-07-20 | Микромет Аг (De) | Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками |
| EP2292664B1 (en) | 2003-10-16 | 2016-11-23 | Amgen Research (Munich) GmbH | Multispecific deimmunized CD3-binders |
| US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| DE602005022830D1 (de) | 2004-02-16 | 2010-09-23 | Micromet Ag | Weniger immunogene bindungsmoleküle |
| WO2005118635A2 (en) | 2004-06-03 | 2005-12-15 | Novimmune S.A. | Anti-cd3 antibodies and methods of use thereof |
| CA2570990C (en) | 2004-07-16 | 2014-01-21 | Micromet Ag | Expression-enhanced polypeptides |
| JP2006040495A (ja) | 2004-07-30 | 2006-02-09 | Renesas Technology Corp | 半導体集積回路装置 |
| NO20064183L (no) | 2005-02-16 | 2006-11-08 | Micromet Ag | Mindre immunogene bindingsmolekyler |
| CA2598522A1 (en) * | 2005-02-18 | 2006-08-24 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (psma) |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| WO2007033230A2 (en) | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
| EP3770174A1 (en) * | 2005-10-11 | 2021-01-27 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
| PT2520590T (pt) * | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| WO2008119566A2 (en) * | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
| RU2561457C2 (ru) | 2007-04-03 | 2015-08-27 | Эмджен Рисерч (Мьюник) Гмбх | Cd3-эпсилон-связывающий домен с межвидовой специфичностью |
| JP4970211B2 (ja) * | 2007-10-18 | 2012-07-04 | ヘキサゴン・メトロジー株式会社 | 3次元形状測定器 |
| CA2738566C (en) | 2008-10-01 | 2024-04-30 | Micromet Ag | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| DK2356153T3 (en) * | 2008-10-01 | 2016-07-04 | Amgen Res Munich Gmbh | Bispecific single CHAIN PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES |
| TWI653333B (zh) * | 2010-04-01 | 2019-03-11 | 安進研究(慕尼黑)有限責任公司 | 跨物種專一性之PSMAxCD3雙專一性單鏈抗體 |
| LT3411404T (lt) * | 2016-02-03 | 2022-12-27 | Amgen Research (Munich) Gmbh | Psma ir cd3 bispecifiniai, t ląsteles aktyvuojantys antikūno konstruktai |
-
2009
- 2009-10-01 DK DK09783664.7T patent/DK2356153T3/en active
- 2009-10-01 SI SI200931452A patent/SI2356153T1/sl unknown
- 2009-10-01 WO PCT/EP2009/062793 patent/WO2010037836A2/en not_active Ceased
- 2009-10-01 PT PT97836647T patent/PT2356153T/pt unknown
- 2009-10-01 BR BRPI0919841-5A2A patent/BRPI0919841A2/pt not_active Application Discontinuation
- 2009-10-01 ES ES09783664.7T patent/ES2588155T3/es active Active
- 2009-10-01 SG SG2013073945A patent/SG194398A1/en unknown
- 2009-10-01 MX MX2011003502A patent/MX2011003502A/es active IP Right Grant
- 2009-10-01 RS RS20160506A patent/RS54900B1/sr unknown
- 2009-10-01 JP JP2011529563A patent/JP6126782B2/ja active Active
- 2009-10-01 ME MEP-2016-156A patent/ME02485B/me unknown
- 2009-10-01 RU RU2011108687/10A patent/RU2559531C2/ru active
- 2009-10-01 CA CA2738565A patent/CA2738565C/en active Active
- 2009-10-01 AU AU2009299792A patent/AU2009299792B2/en active Active
- 2009-10-01 EP EP22178586.8A patent/EP4180458A1/en not_active Withdrawn
- 2009-10-01 HU HUE09783664A patent/HUE030090T2/en unknown
- 2009-10-01 PL PL09783664.7T patent/PL2356153T3/pl unknown
- 2009-10-01 EP EP16167900.6A patent/EP3106468A1/en not_active Ceased
- 2009-10-01 EP EP09783664.7A patent/EP2356153B1/en active Active
- 2009-10-01 US US13/122,245 patent/US20110293619A1/en not_active Abandoned
- 2009-10-01 KR KR1020117009667A patent/KR101820535B1/ko active Active
- 2009-10-01 CN CN200980138646.3A patent/CN102171248B/zh active Active
- 2009-10-01 NZ NZ591134A patent/NZ591134A/xx unknown
- 2009-10-01 HR HRP20160684TT patent/HRP20160684T1/hr unknown
-
2011
- 2011-02-10 ZA ZA2011/01067A patent/ZA201101067B/en unknown
- 2011-04-03 IL IL212099A patent/IL212099A/en active IP Right Grant
-
2015
- 2015-07-03 JP JP2015134815A patent/JP6643822B2/ja active Active
-
2016
- 2016-08-02 CY CY20161100757T patent/CY1118303T1/el unknown
- 2016-08-02 SM SM201600256T patent/SMT201600256B/it unknown
-
2018
- 2018-06-27 US US16/020,558 patent/US20190169310A1/en not_active Abandoned
- 2018-07-05 JP JP2018128072A patent/JP2018198595A/ja active Pending
-
2021
- 2021-04-02 US US17/221,707 patent/US11472886B2/en active Active
- 2021-04-02 US US17/221,627 patent/US12281172B2/en active Active
- 2021-04-02 US US17/221,705 patent/US20210277143A1/en not_active Abandoned
- 2021-06-15 JP JP2021099390A patent/JP7273106B2/ja active Active
-
2025
- 2025-01-16 US US19/024,179 patent/US20250163179A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ591134A (en) | Cross-species-specific (human and primate) bispecific single chain antibody that binds both cd3 (epsilon) epitope and prostate specific membrane antigen (pmsa) | |
| NZ602209A (en) | Cross-species-specific psmaxcd3 bispecific single chain antibody | |
| IL177337A0 (en) | Less immunogenic binding molecules | |
| NZ591087A (en) | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody | |
| NZ597692A (en) | Anti-IGF antibodies | |
| JP2013509879A5 (OSRAM) | ||
| SI1629011T1 (sl) | Humane molekule za vezavo anti hu cd | |
| AU2006226733A8 (en) | Antibodies against CD38 for treatment of multiple myeloma | |
| ATE472557T1 (de) | Vl dab fc-fusion | |
| NZ623273A (en) | Sparc binding scfvs | |
| RU2013138469A (ru) | АНТИТЕЛА К ИНТЕРЛЕЙКИНУ-1α И СПОСОБЫ ПРИМЕНЕНИЯ | |
| NZ602780A (en) | Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
| NZ584838A (en) | Novel antibodies which bind alpha5beta1 (fibronectin receptor) and uses thereof | |
| WO2003072036A3 (en) | Treatment methods using anti-cd22 antibodies | |
| NZ602892A (en) | Antibodies that bind human cd27 and uses thereof | |
| MX2010005966A (es) | Conjugados de anticuerpo monoclonal-molecula asociada dirigidos a la proteina tirosina-cinasa 7 (ptk7). | |
| EP2826791A3 (en) | Humanized anti-C5aR antibodies | |
| WO2005103081A3 (en) | Human monoclonal antibodies against cd20 | |
| MY187263A (en) | Il-17 reception a antigen binding proteins | |
| MXPA06012601A (es) | Anticuerpos especificos de fcy riib humanizados y metodos de uso de los mismos. | |
| MX2010005830A (es) | Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo. | |
| UA95438C2 (ru) | Биспецифические антитела, которые замещают функциональные белки | |
| NZ731392A (en) | Monoclonal antibodies against tissue factor pathway inhibitor (tfp1) | |
| UA92580C2 (ru) | Антитело, которое специфически связывается с cd22, и его терапевтическое и диагностическое применение | |
| WO2011073954A3 (en) | Novel antagonist antibodies and their fab fragments against gpvi and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 OCT 2016 BY DENNEMEYER + CO Effective date: 20130926 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2017 BY CPA GLOBAL Effective date: 20160902 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2018 BY CPA GLOBAL Effective date: 20170831 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2019 BY CPA GLOBAL Effective date: 20180830 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2020 BY CPA GLOBAL Effective date: 20190829 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2021 BY CPA GLOBAL Effective date: 20200903 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2022 BY CPA GLOBAL Effective date: 20210902 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2023 BY ANAQUA SERVICES Effective date: 20220921 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2024 BY ANAQUA SERVICES Effective date: 20230921 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2025 BY ANAQUA SERVICES Effective date: 20240920 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 01 OCT 2026 BY ANAQUA SERVICES Effective date: 20250924 |