NZ584902A - Anti-pcsk9 and methods for treating lipid and cholesterol disorders - Google Patents
Anti-pcsk9 and methods for treating lipid and cholesterol disordersInfo
- Publication number
- NZ584902A NZ584902A NZ584902A NZ58490208A NZ584902A NZ 584902 A NZ584902 A NZ 584902A NZ 584902 A NZ584902 A NZ 584902A NZ 58490208 A NZ58490208 A NZ 58490208A NZ 584902 A NZ584902 A NZ 584902A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hydrochloride
- antibody
- seq
- cdr
- amino acid
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims description 113
- 238000000034 method Methods 0.000 title claims description 64
- 235000012000 cholesterol Nutrition 0.000 title claims description 32
- 150000002632 lipids Chemical class 0.000 title description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 144
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 125
- 229920001184 polypeptide Polymers 0.000 claims abstract description 123
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract description 64
- 102000018358 immunoglobulin Human genes 0.000 claims abstract description 64
- 230000027455 binding Effects 0.000 claims description 107
- 239000012634 fragment Substances 0.000 claims description 106
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- 108091007433 antigens Proteins 0.000 claims description 83
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- 239000002157 polynucleotide Substances 0.000 claims description 56
- -1 nebivalol Chemical compound 0.000 claims description 54
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 48
- 150000001413 amino acids Chemical group 0.000 claims description 43
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 40
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- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 13
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 12
- ZNIFSRGNXRYGHF-UHFFFAOYSA-N Clonidine hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1 ZNIFSRGNXRYGHF-UHFFFAOYSA-N 0.000 claims description 11
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- DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 claims description 10
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- KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 claims description 9
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- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims description 9
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- XILWEASNBDKGSA-AWEZNQCLSA-N 1-(4-methylphenyl)sulfonyl-3-[(2s)-1-phenylpropan-2-yl]urea Chemical compound C([C@H](C)NC(=O)NS(=O)(=O)C=1C=CC(C)=CC=1)C1=CC=CC=C1 XILWEASNBDKGSA-AWEZNQCLSA-N 0.000 claims description 8
- VGLGVJVUHYTIIU-UHFFFAOYSA-N 6-chloro-1,1-dioxo-3-[(prop-2-enylthio)methyl]-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(CSCC=C)NS2(=O)=O VGLGVJVUHYTIIU-UHFFFAOYSA-N 0.000 claims description 8
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- DGFYECXYGUIODH-UHFFFAOYSA-N Guanfacine hydrochloride Chemical compound Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl DGFYECXYGUIODH-UHFFFAOYSA-N 0.000 claims description 8
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- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 8
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- XLFWDASMENKTKL-UHFFFAOYSA-N molsidomine Chemical compound O1C(N=C([O-])OCC)=C[N+](N2CCOCC2)=N1 XLFWDASMENKTKL-UHFFFAOYSA-N 0.000 claims description 8
- 229960001749 practolol Drugs 0.000 claims description 8
- FLSLEGPOVLMJMN-YSSFQJQWSA-N quinaprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)C(O)=O)CC1=CC=CC=C1 FLSLEGPOVLMJMN-YSSFQJQWSA-N 0.000 claims description 8
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims description 7
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- NDTSRXAMMQDVSW-UHFFFAOYSA-N benzthiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1N=C2CSCC1=CC=CC=C1 NDTSRXAMMQDVSW-UHFFFAOYSA-N 0.000 claims description 7
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- JXRAXHBVZQZSIC-JKVLGAQCSA-N Moexipril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 JXRAXHBVZQZSIC-JKVLGAQCSA-N 0.000 claims description 6
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- TVTJZMHAIQQZTL-WATAJHSMSA-M sodium;(2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-WATAJHSMSA-M 0.000 claims description 6
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- ZDZXCYHMVFLGMT-BTJKTKAUSA-N Monatepil maleate Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(F)=CC=C1N1CCN(CCCC(=O)NC2C3=CC=CC=C3SCC3=CC=CC=C32)CC1 ZDZXCYHMVFLGMT-BTJKTKAUSA-N 0.000 claims description 5
- XKLMZUWKNUAPSZ-UHFFFAOYSA-N N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide Chemical compound COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC=2C(=CC=CC=2C)C)CC1 XKLMZUWKNUAPSZ-UHFFFAOYSA-N 0.000 claims description 5
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Landscapes
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- Rheumatology (AREA)
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| MX2021003491A (es) | 2018-10-05 | 2021-06-18 | Amgen Inc | Dispositivo de administracion de farmacos con indicador de dosis. |
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| DK3911648T3 (da) * | 2019-01-18 | 2025-01-13 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf |
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| BR112023024278A2 (pt) | 2021-05-21 | 2024-01-30 | Amgen Inc | Método de otimizar uma receita de enchimento para um recipiente de fármacos |
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| US5817789A (en) * | 1995-06-06 | 1998-10-06 | Transkaryotic Therapies, Inc. | Chimeric proteins for use in transport of a selected substance into cells |
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| CA2667869A1 (en) | 2006-11-07 | 2008-05-15 | Merck & Co., Inc. | Antagonists of pcsk9 |
| CA2681428A1 (en) * | 2007-04-13 | 2008-10-23 | Novartis Ag | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9) |
-
2008
- 2008-10-27 SG SG2013014352A patent/SG2013014352A/en unknown
- 2008-10-27 US US12/739,761 patent/US8598320B2/en not_active Expired - Fee Related
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- 2008-10-27 CN CN2008801235736A patent/CN102232088A/zh active Pending
- 2008-10-27 SG SG2013014360A patent/SG188814A1/en unknown
- 2008-10-27 JP JP2010531314A patent/JP2011501952A/ja active Pending
- 2008-10-27 MX MX2010004454A patent/MX2010004454A/es active IP Right Grant
- 2008-10-27 AU AU2008316587A patent/AU2008316587B2/en not_active Ceased
- 2008-10-27 KR KR1020107011280A patent/KR20100091191A/ko not_active Ceased
- 2008-10-27 EP EP08841231.7A patent/EP2205639B1/en active Active
- 2008-10-27 BR BRPI0818765A patent/BRPI0818765A8/pt not_active IP Right Cessation
- 2008-10-27 NZ NZ584902A patent/NZ584902A/en not_active IP Right Cessation
- 2008-10-27 CA CA2703712A patent/CA2703712A1/en not_active Abandoned
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2013
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- 2013-12-02 US US14/094,560 patent/US20140161798A1/en not_active Abandoned
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| EP2205639A2 (en) | 2010-07-14 |
| EP2205639B1 (en) | 2015-12-23 |
| US8598320B2 (en) | 2013-12-03 |
| JP5692867B2 (ja) | 2015-04-01 |
| IL205323A0 (en) | 2010-12-30 |
| CA2703712A1 (en) | 2009-04-30 |
| US20110033465A1 (en) | 2011-02-10 |
| JP2011501952A (ja) | 2011-01-20 |
| SG188814A1 (en) | 2013-04-30 |
| SG2013014352A (en) | 2014-09-26 |
| AU2008316587B2 (en) | 2014-07-17 |
| US20140161798A1 (en) | 2014-06-12 |
| CN102232088A (zh) | 2011-11-02 |
| AU2008316587A1 (en) | 2009-04-30 |
| KR20100091191A (ko) | 2010-08-18 |
| MX2010004454A (es) | 2010-07-28 |
| JP2013213057A (ja) | 2013-10-17 |
| WO2009055783A3 (en) | 2009-09-17 |
| WO2009055783A2 (en) | 2009-04-30 |
| BRPI0818765A8 (pt) | 2016-02-10 |
| BRPI0818765A2 (pt) | 2015-04-22 |
| JP2013091655A (ja) | 2013-05-16 |
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