KR20100091191A - 항-ｐｃｓｋ9, 및 지질 및 콜레스테롤 질환의 치료 방법 - Google Patents
항-ｐｃｓｋ9, 및 지질 및 콜레스테롤 질환의 치료 방법 Download PDFInfo
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- KR20100091191A KR20100091191A KR1020107011280A KR20107011280A KR20100091191A KR 20100091191 A KR20100091191 A KR 20100091191A KR 1020107011280 A KR1020107011280 A KR 1020107011280A KR 20107011280 A KR20107011280 A KR 20107011280A KR 20100091191 A KR20100091191 A KR 20100091191A
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- Prior art keywords
- hydrochloride
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- 238000000034 method Methods 0.000 title claims abstract description 77
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- 150000002632 lipids Chemical class 0.000 title description 7
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 179
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 127
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- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 22
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 22
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- VGLGVJVUHYTIIU-UHFFFAOYSA-N 6-chloro-1,1-dioxo-3-[(prop-2-enylthio)methyl]-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(CSCC=C)NS2(=O)=O VGLGVJVUHYTIIU-UHFFFAOYSA-N 0.000 claims description 11
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- JXRAXHBVZQZSIC-JKVLGAQCSA-N Moexipril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 JXRAXHBVZQZSIC-JKVLGAQCSA-N 0.000 claims description 11
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| WO2021261906A1 (ko) * | 2020-06-24 | 2021-12-30 | 바이오스트림테크놀러지스(주) | 항 pcsk9 항체 및 이의 용도 |
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| US20100041102A1 (en) | 2006-11-07 | 2010-02-18 | Ayesha Sitlani | Antagonists of pcsk9 |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| EP2615114B1 (en) * | 2007-08-23 | 2022-04-06 | Amgen Inc. | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| AR070315A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Anticuerpos 1b20 antagonistas de pcsk9 |
| US9089522B2 (en) * | 2008-05-22 | 2015-07-28 | Merck Sharp & Dohme Corp. | Method of reducing total cholesterol level by administering matrilin-2 polypeptide |
| US8206943B1 (en) | 2008-06-30 | 2012-06-26 | Schering Corporation | Assay for PCSK9 inhibitors |
| TWI445716B (zh) * | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| AU2013200743B2 (en) * | 2008-09-12 | 2014-10-30 | Pfizer Inc. | PCSK9 antagonists |
| AU2015200427B2 (en) * | 2008-09-12 | 2016-11-10 | Pfizer Inc. | PCSK9 antagonists |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| US8357371B2 (en) | 2008-12-15 | 2013-01-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to PCSK9 |
| NZ620441A (en) * | 2009-09-03 | 2015-08-28 | Pfizer Vaccines Llc | Pcsk9 vaccine |
| EP2494355A4 (en) * | 2009-10-30 | 2013-05-01 | Merck Sharp & Dohme | PCSK9 IMMUNOASSAY |
| EP2493505A4 (en) * | 2009-10-30 | 2013-06-12 | Merck Sharp & Dohme | Ax1 and ax189 pcsk9 antagonists and variants |
| CA2777542A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Ax213 and ax132 pcsk9 antagonists and variants |
| GB201005005D0 (en) * | 2010-03-25 | 2010-05-12 | Angeletti P Ist Richerche Bio | New vaccine |
| EP2450382A1 (de) * | 2010-11-04 | 2012-05-09 | Affiris AG | Immunogenes Peptid |
| US8771696B2 (en) | 2010-11-23 | 2014-07-08 | Regeneron Pharmaceuticals, Inc. | Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor |
| JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
| MX2013007168A (es) * | 2010-12-22 | 2013-11-04 | Genentech Inc | Anticuerpo anti-pcsk9 y metodos de uso. |
| WO2012101252A2 (en) * | 2011-01-28 | 2012-08-02 | Sanofi | Human antibodies to pcsk9 for use in methods of treating particular groups of subjects |
| EA201391157A1 (ru) * | 2011-02-11 | 2014-02-28 | АйАрЭм ЭлЭлСи | Антагонисты pcsk9 |
| AR088782A1 (es) * | 2011-04-29 | 2014-07-10 | Sanofi Sa | Sistemas de ensayo y metodos para identificar y caracterizar farmacos hipolipemiantes |
| JOP20200043A1 (ar) * | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EP2756004B1 (en) | 2011-09-16 | 2019-12-25 | Regeneron Pharmaceuticals, Inc. | INHIBITOR OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN-9 (PCSK9) FOR USE IN REDUCING LIPOPROTEIN(a) LEVELS |
| AR087715A1 (es) | 2011-09-16 | 2014-04-09 | Lilly Co Eli | Anticuerpos anti pcsk9 y usos de los mismos |
| CA2858572C (en) | 2011-12-08 | 2023-01-17 | Amgen Inc. | Human lcat antigen binding proteins and their use in therapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021261906A1 (ko) * | 2020-06-24 | 2021-12-30 | 바이오스트림테크놀러지스(주) | 항 pcsk9 항체 및 이의 용도 |
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| BRPI0818765A8 (pt) | 2016-02-10 |
| BRPI0818765A2 (pt) | 2015-04-22 |
| JP2013091655A (ja) | 2013-05-16 |
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