NZ574711A - 6, 9-disubstituted purine derivatives and their use for treating skin - Google Patents
6, 9-disubstituted purine derivatives and their use for treating skinInfo
- Publication number
- NZ574711A NZ574711A NZ574711A NZ57471107A NZ574711A NZ 574711 A NZ574711 A NZ 574711A NZ 574711 A NZ574711 A NZ 574711A NZ 57471107 A NZ57471107 A NZ 57471107A NZ 574711 A NZ574711 A NZ 574711A
- Authority
- NZ
- New Zealand
- Prior art keywords
- purine derivative
- cells
- percent
- medicament
- purine
- Prior art date
Links
- -1 6, 9-disubstituted purine Chemical class 0.000 title claims abstract description 177
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title description 46
- 238000000034 method Methods 0.000 claims abstract description 47
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- 238000011161 development Methods 0.000 claims abstract description 8
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- 238000002845 discoloration Methods 0.000 claims abstract description 6
- 210000003491 skin Anatomy 0.000 claims description 108
- 150000001875 compounds Chemical class 0.000 claims description 44
- 150000003212 purines Chemical class 0.000 claims description 33
- FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 claims description 24
- QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 claims description 23
- 229960001669 kinetin Drugs 0.000 claims description 23
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- 150000003839 salts Chemical class 0.000 claims description 16
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 48
- VUEOUOLENQRIDI-UHFFFAOYSA-N n-(furan-2-ylmethyl)-9-(oxan-2-yl)purin-6-amine Chemical group C=1C=COC=1CNC(C=1N=C2)=NC=NC=1N2C1CCCCO1 VUEOUOLENQRIDI-UHFFFAOYSA-N 0.000 description 43
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- QSTASPNCKDPSAH-UHFFFAOYSA-N 6-chloro-9-(oxan-2-yl)purine Chemical compound C1=NC=2C(Cl)=NC=NC=2N1C1CCCCO1 QSTASPNCKDPSAH-UHFFFAOYSA-N 0.000 description 10
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- 235000011803 sesame oil Nutrition 0.000 description 1
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- 239000011781 sodium selenite Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
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- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80687106P | 2006-07-10 | 2006-07-10 | |
| US11/774,652 US20080009508A1 (en) | 2006-07-10 | 2007-07-09 | 6,9-Disubstituted Purine Derivatives And Their Use For Treating Skin |
| PCT/US2007/073142 WO2008008770A2 (en) | 2006-07-10 | 2007-07-10 | 6, 9-disubstituted purine derivatives and their use for treating skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ574711A true NZ574711A (en) | 2012-05-25 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ574711A NZ574711A (en) | 2006-07-10 | 2007-07-10 | 6, 9-disubstituted purine derivatives and their use for treating skin |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20080009508A1 (enExample) |
| EP (1) | EP2043630B1 (enExample) |
| JP (1) | JP5309023B2 (enExample) |
| KR (1) | KR101478727B1 (enExample) |
| CN (1) | CN101646435B (enExample) |
| AU (1) | AU2007272576B2 (enExample) |
| BR (1) | BRPI0714161A2 (enExample) |
| CA (1) | CA2657516C (enExample) |
| EA (1) | EA015848B1 (enExample) |
| ES (1) | ES2603216T3 (enExample) |
| IL (1) | IL196442A (enExample) |
| MX (1) | MX2009000347A (enExample) |
| MY (1) | MY158100A (enExample) |
| NO (1) | NO20090598L (enExample) |
| NZ (1) | NZ574711A (enExample) |
| WO (1) | WO2008008770A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7960397B2 (en) * | 2007-12-28 | 2011-06-14 | Institute Of Experimental Botany, Academy Of Sciences Of The Czech Republic | 6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions |
| PE20120493A1 (es) | 2009-06-29 | 2012-05-20 | Incyte Corp | Pirimidinonas como inhibidores de pi3k |
| TW201130842A (en) * | 2009-12-18 | 2011-09-16 | Incyte Corp | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| AR081823A1 (es) | 2010-04-14 | 2012-10-24 | Incyte Corp | DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd |
| EP2395086A1 (en) * | 2010-06-09 | 2011-12-14 | Chanel Parfums Beauté | Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin |
| ES2459143T3 (es) * | 2010-06-09 | 2014-05-08 | Chanel Parfums Beauté | Inhibidores de varios microARN para usar en la prevención y/o atenuación del envejecimiento cutáneo y/o para hidratar la piel |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| KR20230038593A (ko) | 2011-09-02 | 2023-03-20 | 인사이트 홀딩스 코포레이션 | Ｐｉ３ｋ 억제제로서 헤테로시클릴아민 |
| US20130072506A1 (en) | 2011-09-16 | 2013-03-21 | Lenka ZAHAJSKA | 6,8-disubstituted purine compositions |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| CZ306984B6 (cs) | 2014-12-15 | 2017-11-01 | Ústav experimentální botaniky AV ČR, v. v. i. | 6,8-Disubstituované-9-(heterocyklyl)puriny, přípravky obsahující tyto deriváty a jejich použití v kosmetických a medicínských aplikacích |
| PH12017501538B1 (en) | 2015-02-27 | 2024-02-14 | Incyte Holdings Corp | Salts of p13k inhibitor and processes for their preparation |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CZ307722B6 (cs) * | 2015-08-28 | 2019-03-27 | Univerzita PalackĂ©ho v Olomouci | Adeninové deriváty a jejich použití |
| CZ307868B6 (cs) | 2017-04-28 | 2019-07-10 | Univerzita PalackĂ©ho v Olomouci | Deriváty 9-(2-oxacykloalkyl)-9H-purin-2,6-diaminu, přípravky obsahující tyto deriváty a jejich použití |
| CN112469418A (zh) | 2018-06-01 | 2021-03-09 | 因赛特公司 | 治疗pi3k相关病症的给药方案 |
| WO2022012702A1 (en) | 2020-07-13 | 2022-01-20 | Univerzita Palackeho V Olomouci | Nitrogen heterocyclic cytokinin derivatives, compositions containing these derivatives and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5371089A (en) * | 1987-02-26 | 1994-12-06 | Senetek, Plc | Method and composition for ameliorating the adverse effects of aging |
| US5021422A (en) * | 1989-06-08 | 1991-06-04 | Senetek Plc | Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins |
| WO2004037159A2 (en) * | 2002-10-23 | 2004-05-06 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| EP2145888A1 (en) * | 2003-09-18 | 2010-01-20 | Conforma Therapeutics Corporation | Deazapurine derivatives as HSP90-Inhibitors |
| JP2009500394A (ja) * | 2005-07-08 | 2009-01-08 | ザ プロクター アンド ギャンブル カンパニー | パーソナルケア組成物及び哺乳類の皮膚と毛髪を美化する方法 |
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2007
- 2007-07-09 US US11/774,652 patent/US20080009508A1/en not_active Abandoned
- 2007-07-10 EA EA200970110A patent/EA015848B1/ru not_active IP Right Cessation
- 2007-07-10 MX MX2009000347A patent/MX2009000347A/es not_active Application Discontinuation
- 2007-07-10 BR BRPI0714161-0A patent/BRPI0714161A2/pt not_active IP Right Cessation
- 2007-07-10 MY MYPI20090112A patent/MY158100A/en unknown
- 2007-07-10 CN CN200780031839XA patent/CN101646435B/zh not_active Expired - Fee Related
- 2007-07-10 EP EP07799439.0A patent/EP2043630B1/en not_active Not-in-force
- 2007-07-10 ES ES07799439.0T patent/ES2603216T3/es active Active
- 2007-07-10 KR KR1020097002557A patent/KR101478727B1/ko not_active Expired - Fee Related
- 2007-07-10 WO PCT/US2007/073142 patent/WO2008008770A2/en not_active Ceased
- 2007-07-10 JP JP2009519632A patent/JP5309023B2/ja not_active Expired - Fee Related
- 2007-07-10 AU AU2007272576A patent/AU2007272576B2/en not_active Ceased
- 2007-07-10 NZ NZ574711A patent/NZ574711A/en not_active IP Right Cessation
- 2007-07-10 CA CA2657516A patent/CA2657516C/en not_active Expired - Fee Related
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2009
- 2009-01-11 IL IL196442A patent/IL196442A/en active IP Right Grant
- 2009-02-06 NO NO20090598A patent/NO20090598L/no not_active Application Discontinuation
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2010
- 2010-05-24 US US12/786,027 patent/US20100234401A1/en not_active Abandoned
-
2011
- 2011-05-26 US US13/116,636 patent/US20110224238A1/en not_active Abandoned
-
2012
- 2012-09-28 US US13/630,673 patent/US20130072505A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR101478727B1 (ko) | 2015-01-02 |
| MX2009000347A (es) | 2009-03-20 |
| AU2007272576A1 (en) | 2008-01-17 |
| EA200970110A1 (ru) | 2009-06-30 |
| US20130072505A1 (en) | 2013-03-21 |
| BRPI0714161A2 (pt) | 2012-12-25 |
| WO2008008770A2 (en) | 2008-01-17 |
| JP5309023B2 (ja) | 2013-10-09 |
| IL196442A0 (en) | 2009-11-18 |
| EP2043630B1 (en) | 2016-09-07 |
| MY158100A (en) | 2016-08-30 |
| WO2008008770A3 (en) | 2008-04-10 |
| US20080009508A1 (en) | 2008-01-10 |
| US20110224238A1 (en) | 2011-09-15 |
| NO20090598L (no) | 2009-04-14 |
| CN101646435A (zh) | 2010-02-10 |
| EP2043630A2 (en) | 2009-04-08 |
| JP2009543799A (ja) | 2009-12-10 |
| US20100234401A1 (en) | 2010-09-16 |
| EA015848B1 (ru) | 2011-12-30 |
| CN101646435B (zh) | 2012-08-22 |
| ES2603216T3 (es) | 2017-02-24 |
| KR20090047457A (ko) | 2009-05-12 |
| CA2657516C (en) | 2016-05-10 |
| CA2657516A1 (en) | 2008-01-17 |
| AU2007272576B2 (en) | 2012-05-17 |
| EP2043630A4 (en) | 2010-12-29 |
| IL196442A (en) | 2015-10-29 |
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