EA015848B1 - Производные 6,9-дизамещённого пурина и их применение для лечения кожи - Google Patents
Производные 6,9-дизамещённого пурина и их применение для лечения кожи Download PDFInfo
- Publication number
- EA015848B1 EA015848B1 EA200970110A EA200970110A EA015848B1 EA 015848 B1 EA015848 B1 EA 015848B1 EA 200970110 A EA200970110 A EA 200970110A EA 200970110 A EA200970110 A EA 200970110A EA 015848 B1 EA015848 B1 EA 015848B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- skin
- purine
- cells
- tetrahydropyranyl
- aging
- Prior art date
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- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
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- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
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- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- WOXKDUGGOYFFRN-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C(C4=CC=CC=C4N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 WOXKDUGGOYFFRN-IIBYNOLFSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
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- 150000003536 tetrazoles Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
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- 230000001988 toxicity Effects 0.000 description 1
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- 238000011269 treatment regimen Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US80687106P | 2006-07-10 | 2006-07-10 | |
| US11/774,652 US20080009508A1 (en) | 2006-07-10 | 2007-07-09 | 6,9-Disubstituted Purine Derivatives And Their Use For Treating Skin |
| PCT/US2007/073142 WO2008008770A2 (en) | 2006-07-10 | 2007-07-10 | 6, 9-disubstituted purine derivatives and their use for treating skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970110A1 EA200970110A1 (ru) | 2009-06-30 |
| EA015848B1 true EA015848B1 (ru) | 2011-12-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970110A EA015848B1 (ru) | 2006-07-10 | 2007-07-10 | Производные 6,9-дизамещённого пурина и их применение для лечения кожи |
Country Status (16)
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| US (4) | US20080009508A1 (enExample) |
| EP (1) | EP2043630B1 (enExample) |
| JP (1) | JP5309023B2 (enExample) |
| KR (1) | KR101478727B1 (enExample) |
| CN (1) | CN101646435B (enExample) |
| AU (1) | AU2007272576B2 (enExample) |
| BR (1) | BRPI0714161A2 (enExample) |
| CA (1) | CA2657516C (enExample) |
| EA (1) | EA015848B1 (enExample) |
| ES (1) | ES2603216T3 (enExample) |
| IL (1) | IL196442A (enExample) |
| MX (1) | MX2009000347A (enExample) |
| MY (1) | MY158100A (enExample) |
| NO (1) | NO20090598L (enExample) |
| NZ (1) | NZ574711A (enExample) |
| WO (1) | WO2008008770A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960397B2 (en) * | 2007-12-28 | 2011-06-14 | Institute Of Experimental Botany, Academy Of Sciences Of The Czech Republic | 6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions |
| AR077280A1 (es) | 2009-06-29 | 2011-08-17 | Incyte Corp | Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden |
| US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| AR079529A1 (es) * | 2009-12-18 | 2012-02-01 | Incyte Corp | Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k |
| US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
| ES2459143T3 (es) | 2010-06-09 | 2014-05-08 | Chanel Parfums Beauté | Inhibidores de varios microARN para usar en la prevención y/o atenuación del envejecimiento cutáneo y/o para hidratar la piel |
| EP2395086A1 (en) * | 2010-06-09 | 2011-12-14 | Chanel Parfums Beauté | Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| IL299533B2 (en) | 2011-09-02 | 2025-01-01 | Incyte Holdings Corp | Heterocycloamines as PI3K inhibitors |
| US20130072506A1 (en) | 2011-09-16 | 2013-03-21 | Lenka ZAHAJSKA | 6,8-disubstituted purine compositions |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| CZ306984B6 (cs) | 2014-12-15 | 2017-11-01 | Ústav experimentální botaniky AV ČR, v. v. i. | 6,8-Disubstituované-9-(heterocyklyl)puriny, přípravky obsahující tyto deriváty a jejich použití v kosmetických a medicínských aplikacích |
| SG11201706917WA (en) | 2015-02-27 | 2017-09-28 | Incyte Corp | Salts of pi3k inhibitor and processes for their preparation |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| CZ307722B6 (cs) * | 2015-08-28 | 2019-03-27 | Univerzita PalackĂ©ho v Olomouci | Adeninové deriváty a jejich použití |
| CZ307868B6 (cs) | 2017-04-28 | 2019-07-10 | Univerzita PalackĂ©ho v Olomouci | Deriváty 9-(2-oxacykloalkyl)-9H-purin-2,6-diaminu, přípravky obsahující tyto deriváty a jejich použití |
| SG11202011680YA (en) | 2018-06-01 | 2020-12-30 | Incyte Corp | Dosing regimen for the treatment of pi3k related disorders |
| WO2022012702A1 (en) | 2020-07-13 | 2022-01-20 | Univerzita Palackeho V Olomouci | Nitrogen heterocyclic cytokinin derivatives, compositions containing these derivatives and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602139A (en) * | 1987-02-26 | 1997-02-11 | Senetek Plc | Method for ameliorating the adverse effects of aging |
| US20050113340A1 (en) * | 2003-09-18 | 2005-05-26 | Conforma Therapeutics Corporation | 2-Aminopurine analogs having HSP90-inhibiting activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021422A (en) * | 1989-06-08 | 1991-06-04 | Senetek Plc | Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins |
| AU2003274652A1 (en) * | 2002-10-23 | 2004-05-13 | Obetherapy Biotechnology | Compounds, compositions and methods for modulating fat metabolism |
| WO2007007255A2 (en) * | 2005-07-08 | 2007-01-18 | The Procter & Gamble Company | Personal care compositions and methods for the beautification of mammalian skin and hair |
-
2007
- 2007-07-09 US US11/774,652 patent/US20080009508A1/en not_active Abandoned
- 2007-07-10 BR BRPI0714161-0A patent/BRPI0714161A2/pt not_active IP Right Cessation
- 2007-07-10 MY MYPI20090112A patent/MY158100A/en unknown
- 2007-07-10 EA EA200970110A patent/EA015848B1/ru not_active IP Right Cessation
- 2007-07-10 NZ NZ574711A patent/NZ574711A/en not_active IP Right Cessation
- 2007-07-10 WO PCT/US2007/073142 patent/WO2008008770A2/en not_active Ceased
- 2007-07-10 KR KR1020097002557A patent/KR101478727B1/ko not_active Expired - Fee Related
- 2007-07-10 ES ES07799439.0T patent/ES2603216T3/es active Active
- 2007-07-10 EP EP07799439.0A patent/EP2043630B1/en not_active Not-in-force
- 2007-07-10 CA CA2657516A patent/CA2657516C/en not_active Expired - Fee Related
- 2007-07-10 AU AU2007272576A patent/AU2007272576B2/en not_active Ceased
- 2007-07-10 CN CN200780031839XA patent/CN101646435B/zh not_active Expired - Fee Related
- 2007-07-10 JP JP2009519632A patent/JP5309023B2/ja not_active Expired - Fee Related
- 2007-07-10 MX MX2009000347A patent/MX2009000347A/es not_active Application Discontinuation
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2009
- 2009-01-11 IL IL196442A patent/IL196442A/en active IP Right Grant
- 2009-02-06 NO NO20090598A patent/NO20090598L/no not_active Application Discontinuation
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2010
- 2010-05-24 US US12/786,027 patent/US20100234401A1/en not_active Abandoned
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2011
- 2011-05-26 US US13/116,636 patent/US20110224238A1/en not_active Abandoned
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2012
- 2012-09-28 US US13/630,673 patent/US20130072505A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602139A (en) * | 1987-02-26 | 1997-02-11 | Senetek Plc | Method for ameliorating the adverse effects of aging |
| US20050113340A1 (en) * | 2003-09-18 | 2005-05-26 | Conforma Therapeutics Corporation | 2-Aminopurine analogs having HSP90-inhibiting activity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101646435B (zh) | 2012-08-22 |
| CA2657516A1 (en) | 2008-01-17 |
| US20080009508A1 (en) | 2008-01-10 |
| IL196442A0 (en) | 2009-11-18 |
| NZ574711A (en) | 2012-05-25 |
| KR20090047457A (ko) | 2009-05-12 |
| MX2009000347A (es) | 2009-03-20 |
| AU2007272576B2 (en) | 2012-05-17 |
| JP2009543799A (ja) | 2009-12-10 |
| EP2043630B1 (en) | 2016-09-07 |
| BRPI0714161A2 (pt) | 2012-12-25 |
| MY158100A (en) | 2016-08-30 |
| JP5309023B2 (ja) | 2013-10-09 |
| KR101478727B1 (ko) | 2015-01-02 |
| ES2603216T3 (es) | 2017-02-24 |
| CA2657516C (en) | 2016-05-10 |
| CN101646435A (zh) | 2010-02-10 |
| WO2008008770A3 (en) | 2008-04-10 |
| NO20090598L (no) | 2009-04-14 |
| WO2008008770A2 (en) | 2008-01-17 |
| AU2007272576A1 (en) | 2008-01-17 |
| EP2043630A2 (en) | 2009-04-08 |
| US20130072505A1 (en) | 2013-03-21 |
| US20100234401A1 (en) | 2010-09-16 |
| EP2043630A4 (en) | 2010-12-29 |
| US20110224238A1 (en) | 2011-09-15 |
| IL196442A (en) | 2015-10-29 |
| EA200970110A1 (ru) | 2009-06-30 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |