KR101478727B1 - 6,9-이치환 퓨린 유도체 및 피부 치료를 위한 그의 용도 - Google Patents

6,9-이치환 퓨린 유도체 및 피부 치료를 위한 그의 용도 Download PDF

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Publication number
KR101478727B1
KR101478727B1 KR1020097002557A KR20097002557A KR101478727B1 KR 101478727 B1 KR101478727 B1 KR 101478727B1 KR 1020097002557 A KR1020097002557 A KR 1020097002557A KR 20097002557 A KR20097002557 A KR 20097002557A KR 101478727 B1 KR101478727 B1 KR 101478727B1
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South Korea
Prior art keywords
skin
purine
cells
tetrahydropyranyl
percent
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KR1020097002557A
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English (en)
Korean (ko)
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KR20090047457A (ko
Inventor
루시에 스즈코바
마렉 자틀로우칼
루카스 스피칼
루덱 프로리히
카렐 돌레잘
미로슬라브 스트르나드
프랭크 제이 마씨노
Original Assignee
인스티튜트 오브 엑스페리멘탈 보타니, 아카데미 오브 사이언시즈 오브 더 체코 리퍼블릭
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Publication of KR20090047457A publication Critical patent/KR20090047457A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
KR1020097002557A 2006-07-10 2007-07-10 6,9-이치환 퓨린 유도체 및 피부 치료를 위한 그의 용도 Expired - Fee Related KR101478727B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80687106P 2006-07-10 2006-07-10
US60/806,871 2006-07-10
US11/774,652 2007-07-09
US11/774,652 US20080009508A1 (en) 2006-07-10 2007-07-09 6,9-Disubstituted Purine Derivatives And Their Use For Treating Skin
PCT/US2007/073142 WO2008008770A2 (en) 2006-07-10 2007-07-10 6, 9-disubstituted purine derivatives and their use for treating skin

Publications (2)

Publication Number Publication Date
KR20090047457A KR20090047457A (ko) 2009-05-12
KR101478727B1 true KR101478727B1 (ko) 2015-01-02

Family

ID=38919793

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KR1020097002557A Expired - Fee Related KR101478727B1 (ko) 2006-07-10 2007-07-10 6,9-이치환 퓨린 유도체 및 피부 치료를 위한 그의 용도

Country Status (16)

Country Link
US (4) US20080009508A1 (enExample)
EP (1) EP2043630B1 (enExample)
JP (1) JP5309023B2 (enExample)
KR (1) KR101478727B1 (enExample)
CN (1) CN101646435B (enExample)
AU (1) AU2007272576B2 (enExample)
BR (1) BRPI0714161A2 (enExample)
CA (1) CA2657516C (enExample)
EA (1) EA015848B1 (enExample)
ES (1) ES2603216T3 (enExample)
IL (1) IL196442A (enExample)
MX (1) MX2009000347A (enExample)
MY (1) MY158100A (enExample)
NO (1) NO20090598L (enExample)
NZ (1) NZ574711A (enExample)
WO (1) WO2008008770A2 (enExample)

Families Citing this family (23)

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US7960397B2 (en) * 2007-12-28 2011-06-14 Institute Of Experimental Botany, Academy Of Sciences Of The Czech Republic 6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions
PE20120493A1 (es) 2009-06-29 2012-05-20 Incyte Corp Pirimidinonas como inhibidores de pi3k
TW201130842A (en) * 2009-12-18 2011-09-16 Incyte Corp Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
EP2395086A1 (en) * 2010-06-09 2011-12-14 Chanel Parfums Beauté Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing and/or for hydrating skin
ES2459143T3 (es) * 2010-06-09 2014-05-08 Chanel Parfums Beauté Inhibidores de varios microARN para usar en la prevención y/o atenuación del envejecimiento cutáneo y/o para hidratar la piel
WO2011163195A1 (en) 2010-06-21 2011-12-29 Incyte Corporation Fused pyrrole derivatives as pi3k inhibitors
ES2764848T3 (es) 2010-12-20 2020-06-04 Incyte Holdings Corp N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR20230038593A (ko) 2011-09-02 2023-03-20 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
US20130072506A1 (en) 2011-09-16 2013-03-21 Lenka ZAHAJSKA 6,8-disubstituted purine compositions
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
CZ306984B6 (cs) 2014-12-15 2017-11-01 Ústav experimentální botaniky AV ČR, v. v. i. 6,8-Disubstituované-9-(heterocyklyl)puriny, přípravky obsahující tyto deriváty a jejich použití v kosmetických a medicínských aplikacích
PH12017501538B1 (en) 2015-02-27 2024-02-14 Incyte Holdings Corp Salts of p13k inhibitor and processes for their preparation
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CZ307722B6 (cs) * 2015-08-28 2019-03-27 Univerzita PalackĂ©ho v Olomouci Adeninové deriváty a jejich použití
CZ307868B6 (cs) 2017-04-28 2019-07-10 Univerzita PalackĂ©ho v Olomouci Deriváty 9-(2-oxacykloalkyl)-9H-purin-2,6-diaminu, přípravky obsahující tyto deriváty a jejich použití
CN112469418A (zh) 2018-06-01 2021-03-09 因赛特公司 治疗pi3k相关病症的给药方案
WO2022012702A1 (en) 2020-07-13 2022-01-20 Univerzita Palackeho V Olomouci Nitrogen heterocyclic cytokinin derivatives, compositions containing these derivatives and use thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5021422A (en) * 1989-06-08 1991-06-04 Senetek Plc Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins
US5602139A (en) * 1987-02-26 1997-02-11 Senetek Plc Method for ameliorating the adverse effects of aging

Family Cites Families (3)

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WO2004037159A2 (en) * 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
EP2145888A1 (en) * 2003-09-18 2010-01-20 Conforma Therapeutics Corporation Deazapurine derivatives as HSP90-Inhibitors
JP2009500394A (ja) * 2005-07-08 2009-01-08 ザ プロクター アンド ギャンブル カンパニー パーソナルケア組成物及び哺乳類の皮膚と毛髪を美化する方法

Patent Citations (2)

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US5602139A (en) * 1987-02-26 1997-02-11 Senetek Plc Method for ameliorating the adverse effects of aging
US5021422A (en) * 1989-06-08 1991-06-04 Senetek Plc Method and composition for treating hyperproliferative skin diseases using 6-aminopurine cytokinins

Non-Patent Citations (2)

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Title
Journal of the American Chemical Society, Vol. 83, pp. 2574-2570, 1961 *
Journal of the American Chemical Society, Vol. 83, pp. 2574-2570, 1961*

Also Published As

Publication number Publication date
MX2009000347A (es) 2009-03-20
AU2007272576A1 (en) 2008-01-17
EA200970110A1 (ru) 2009-06-30
US20130072505A1 (en) 2013-03-21
BRPI0714161A2 (pt) 2012-12-25
WO2008008770A2 (en) 2008-01-17
JP5309023B2 (ja) 2013-10-09
IL196442A0 (en) 2009-11-18
EP2043630B1 (en) 2016-09-07
MY158100A (en) 2016-08-30
WO2008008770A3 (en) 2008-04-10
US20080009508A1 (en) 2008-01-10
US20110224238A1 (en) 2011-09-15
NO20090598L (no) 2009-04-14
CN101646435A (zh) 2010-02-10
EP2043630A2 (en) 2009-04-08
JP2009543799A (ja) 2009-12-10
US20100234401A1 (en) 2010-09-16
EA015848B1 (ru) 2011-12-30
CN101646435B (zh) 2012-08-22
ES2603216T3 (es) 2017-02-24
KR20090047457A (ko) 2009-05-12
CA2657516C (en) 2016-05-10
CA2657516A1 (en) 2008-01-17
NZ574711A (en) 2012-05-25
AU2007272576B2 (en) 2012-05-17
EP2043630A4 (en) 2010-12-29
IL196442A (en) 2015-10-29

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