NZ563510A - Benzofuranyl derivatives as 5-HT6-receptor inhibitors - Google Patents

Benzofuranyl derivatives as 5-HT6-receptor inhibitors

Info

Publication number
NZ563510A
NZ563510A NZ563510A NZ56351006A NZ563510A NZ 563510 A NZ563510 A NZ 563510A NZ 563510 A NZ563510 A NZ 563510A NZ 56351006 A NZ56351006 A NZ 56351006A NZ 563510 A NZ563510 A NZ 563510A
Authority
NZ
New Zealand
Prior art keywords
body weight
disorders
treatment
compound according
prophylaxis
Prior art date
Application number
NZ563510A
Other languages
English (en)
Inventor
Patrizia Caldirola
Gary Johansson
Lori Sutin
Original Assignee
Proximagen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proximagen Ltd filed Critical Proximagen Ltd
Publication of NZ563510A publication Critical patent/NZ563510A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NZ563510A 2005-06-17 2006-06-15 Benzofuranyl derivatives as 5-HT6-receptor inhibitors NZ563510A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0501383 2005-06-17
US70652305P 2005-08-09 2005-08-09
PCT/EP2006/063249 WO2006134150A1 (en) 2005-06-17 2006-06-15 Benzofuranyl derivatives as 5-ht6-receptor inhibitors

Publications (1)

Publication Number Publication Date
NZ563510A true NZ563510A (en) 2011-01-28

Family

ID=36659956

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ563510A NZ563510A (en) 2005-06-17 2006-06-15 Benzofuranyl derivatives as 5-HT6-receptor inhibitors

Country Status (18)

Country Link
US (1) US7582767B2 (enExample)
EP (1) EP1896460B1 (enExample)
JP (1) JP2008543813A (enExample)
KR (1) KR20080017482A (enExample)
CN (1) CN101193885B (enExample)
AU (1) AU2006259082B2 (enExample)
BR (1) BRPI0612746A2 (enExample)
CA (1) CA2610383A1 (enExample)
DE (1) DE602006008002D1 (enExample)
DK (1) DK1896460T3 (enExample)
EA (1) EA015671B1 (enExample)
ES (1) ES2330145T3 (enExample)
IL (1) IL187575A (enExample)
MX (1) MX2007015988A (enExample)
NO (1) NO20080354L (enExample)
NZ (1) NZ563510A (enExample)
WO (1) WO2006134150A1 (enExample)
ZA (1) ZA200710468B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2014013014A1 (en) 2012-07-18 2014-01-23 Fundació Privada Centre De Regulació Genòmica (Crg) Jak inhibitors for activation of epidermal stem cell populations
CN103880797B (zh) * 2014-03-26 2015-12-02 沈阳大学 苯并呋喃类化合物及其医药用途
WO2018041989A1 (en) 2016-09-02 2018-03-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating refractory celiac disease type 2
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
EP3947737A2 (en) 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212395A1 (en) 2019-04-16 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
US20250283174A1 (en) 2022-05-16 2025-09-11 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
DK1149078T3 (da) 1998-12-11 2006-07-10 Univ Virginia Commonwealth Selektive 5-HT6-receptorligander
US7144883B2 (en) 2001-06-11 2006-12-05 Biovitrum Ab Bicyclic sulfonamide compounds
RS44204A (sr) * 2001-11-22 2007-06-04 Biovitrum Ab., Inhibitori 11-beta- hidroksistereoidne dehidrogenaze tipa 1
CN1662521A (zh) 2002-06-20 2005-08-31 比奥维特罗姆股份公司 可用于治疗肥胖、ii型糖尿病和cns障碍的新化合物
US7943639B2 (en) * 2002-06-20 2011-05-17 Proximagen Limited Compounds
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes

Also Published As

Publication number Publication date
AU2006259082A1 (en) 2006-12-21
HK1112918A1 (en) 2008-09-19
CN101193885B (zh) 2011-07-27
EA200800071A1 (ru) 2008-10-30
DE602006008002D1 (de) 2009-09-03
EP1896460A1 (en) 2008-03-12
KR20080017482A (ko) 2008-02-26
ZA200710468B (en) 2009-04-29
CN101193885A (zh) 2008-06-04
MX2007015988A (es) 2008-03-07
JP2008543813A (ja) 2008-12-04
AU2006259082B2 (en) 2011-07-14
IL187575A (en) 2012-12-31
WO2006134150A1 (en) 2006-12-21
CA2610383A1 (en) 2006-12-21
BRPI0612746A2 (pt) 2010-11-30
IL187575A0 (en) 2008-03-20
EP1896460B1 (en) 2009-07-22
NO20080354L (no) 2008-01-17
DK1896460T3 (da) 2009-11-16
EA015671B1 (ru) 2011-10-31
US20060293361A1 (en) 2006-12-28
ES2330145T3 (es) 2009-12-04
US7582767B2 (en) 2009-09-01

Similar Documents

Publication Publication Date Title
US20060142269A1 (en) New compounds
US20060148818A1 (en) Novel tetraydrospiro(piperdine-2,7'- pyrrolo{3,2-b}pyridine derivatives and novel in-dole derivatives useful in the treatment of 5-ht6 receptor-related disorders
Audinot et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors
ZA200403207B (en) Therapeutic quinolone compounds with 5-HT-antagonistic properties.
KR20090019894A (ko) 치환 술폰아미드 화합물, cns 장애, 비만 및 ⅱ 형 당뇨병 치료용 약제로서의 이들의 사용 방법
EP2567698B1 (en) GPR 17 agonists and screening assay
AU2006259082B2 (en) Benzofuranyl derivatives as 5-HT6-receptor inhibitors
NO180486B (no) Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater
US7820675B2 (en) Benzofuran compounds
US7960374B2 (en) Tricyclic compounds, compositions, and methods useful in the treatment or prophylaxis of 5-HT6 receptor-related disorders
JP2015214527A (ja) イミダゾール誘導体
TW568786B (en) A combination, pharmaceutical formulation, and kit for use in the treatment of affective disorders
WO2006062481A1 (en) New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders .
Chung et al. Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata
HK1112918B (en) Benzofuranyl derivatives as 5-ht6-receptor inhibitors
JP2003519229A (ja) 新規ヘテロアリール誘導体、その製造方法及びその使用方法
Wentland et al. Redefining the structure–activity relationships of 2, 6-methano-3-benzazocines. Part 7: Syntheses and opioid receptor properties of cyclic variants of cyclazocine
JP2000516629A (ja) 選択的ドーパミンd4受容体リガンドとしてのトロポニルピペラジン
ZA200602756B (en) Novel tetraydrospiro{piperidine-2,7'-pyrrolo[3,2-b]pyridine derivatives and novel indole derivatives useful in the treatment of 5-HT6 receptor-related disorders
Demopoulos et al. Kurzmitteilungen: Synthesis and Biological Evaluation of 3‐(2‐Aminoethyl) pyrrole Derivatives Synthese und biologische Bewertung von 3‐(2‐Aminoethyl) pyrrol‐Derivaten
KR20070020373A (ko) 5-HT6 수용체-관련 장애의 치료에 유용한 신규한 테트라히드로스피로{피페리딘-2,7'-피롤로[3,2-b]피리딘} 유도체 및 신규한 인돌 유도체
EP1897876A2 (en) Compounds useful for the treatment of obesity, type II diabetes and CNS disorders
NZ577103A (en) 8-Sulfonyl-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole derivatives and their use as 5-HT6 receptor ligands

Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: PROXIMAGEN LIMITED, GB

Free format text: OLD OWNER(S): BIOVITRUM AB

PSEA Patent sealed
RENW Renewal (renewal fees accepted)
LAPS Patent lapsed