NZ504394A - Method of extracting undesirable materials from capsule surfaces by exposing the capsule to super critical fluid (SCF) - Google Patents

Method of extracting undesirable materials from capsule surfaces by exposing the capsule to super critical fluid (SCF)

Info

Publication number
NZ504394A
NZ504394A NZ504394A NZ50439498A NZ504394A NZ 504394 A NZ504394 A NZ 504394A NZ 504394 A NZ504394 A NZ 504394A NZ 50439498 A NZ50439498 A NZ 50439498A NZ 504394 A NZ504394 A NZ 504394A
Authority
NZ
New Zealand
Prior art keywords
capsule
exposing
scf
critical fluid
super critical
Prior art date
Application number
NZ504394A
Other languages
English (en)
Inventor
Stephen T Horhota
Said Saim
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26741866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ504394(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NZ504394A publication Critical patent/NZ504394A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/02—Equipment for testing the apparatus

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
NZ504394A 1997-10-14 1998-10-05 Method of extracting undesirable materials from capsule surfaces by exposing the capsule to super critical fluid (SCF) NZ504394A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6209997P 1997-10-14 1997-10-14
US09/157,267 US6228394B1 (en) 1997-10-14 1998-09-21 Supercritical fluid extraction of mould lubricant from hard shell capsules
PCT/US1998/020815 WO1999018939A1 (en) 1997-10-14 1998-10-05 Methods of treating capsules and dry, powdered pharmaceutical formulations

Publications (1)

Publication Number Publication Date
NZ504394A true NZ504394A (en) 2002-12-20

Family

ID=26741866

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ504394A NZ504394A (en) 1997-10-14 1998-10-05 Method of extracting undesirable materials from capsule surfaces by exposing the capsule to super critical fluid (SCF)

Country Status (23)

Country Link
US (1) US6228394B1 (da)
EP (1) EP1024794B1 (da)
JP (1) JP2001519380A (da)
KR (1) KR20010031097A (da)
CN (1) CN1306420A (da)
AT (1) ATE350019T1 (da)
AU (1) AU753076B2 (da)
BG (1) BG65169B1 (da)
BR (1) BR9814818A (da)
CA (1) CA2302276C (da)
CY (1) CY1106033T1 (da)
CZ (1) CZ299101B6 (da)
DE (1) DE69836822T2 (da)
DK (1) DK1024794T3 (da)
EE (1) EE200000292A (da)
ES (1) ES2281141T3 (da)
HU (1) HUP0003990A3 (da)
IL (1) IL134731A0 (da)
NZ (1) NZ504394A (da)
PL (1) PL195462B1 (da)
PT (1) PT1024794E (da)
TR (1) TR200001000T2 (da)
WO (1) WO1999018939A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109289249A (zh) * 2018-12-08 2019-02-01 内蒙合成化工研究所 一种高能推进剂中增塑剂和安定剂的回收方法

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US6294194B1 (en) 1997-10-14 2001-09-25 Boehringer Ingelheim Pharmaceuticals, Inc. Method for extraction and reaction using supercritical fluids
GB9804379D0 (en) * 1998-03-02 1998-04-22 Bradford Particle Design Ltd Method of particle formation
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
HU226982B1 (en) * 2000-10-12 2010-04-28 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder, process for its preperation and its use
US6544282B1 (en) 2001-02-21 2003-04-08 Radiant Medical, Inc. Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US20030181749A1 (en) * 2002-03-21 2003-09-25 Kunzler Jay F. Supercritical fluid extraction of vitreoretinal silicone tamponades
JP2005523951A (ja) * 2002-04-23 2005-08-11 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カルボマー中の残留有機溶媒の低減方法
JP2005530765A (ja) * 2002-05-07 2005-10-13 ネクター セラピューティクス 乾燥粉末吸入器のためのカプセル及びそれを製造及び使用する方法
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
WO2005018410A1 (de) * 2003-07-30 2005-03-03 BSH Bosch und Siemens Hausgeräte GmbH Verfahren zum betreiben eines gerätes mit wenigstens einem teilprogrammschritt 'trocknen'
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
DK1791542T3 (da) 2004-08-23 2015-06-15 Mannkind Corp Diketopiperazinsalte til lægemiddel-levering
DE102004060479A1 (de) * 2004-12-16 2006-06-29 Schaeffler Kg Verfahren und Vorrichtung zum Schmieren und Kühlen eines hochbelasteten Lagers
JP5339328B2 (ja) * 2005-07-21 2013-11-13 独立行政法人物質・材料研究機構 薬物吸入デバイス
CA2621806C (en) 2005-09-14 2016-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
CN101389348A (zh) 2006-02-22 2009-03-18 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (en) 2008-06-13 2022-09-21 MannKind Corporation Breath powered dry powder inhaler for drug delivery
ES2421385T3 (es) 2008-06-20 2013-09-02 Mannkind Corp Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
ES2943333T3 (es) 2009-06-12 2023-06-12 Mannkind Corp Micropartículas de dicetopiperazina con superficies específicas definidas
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN108451920A (zh) * 2018-03-14 2018-08-28 绍兴康可胶囊有限公司 一种吸雾式胶囊及其制备方法

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JPS61155265A (ja) 1984-12-26 1986-07-14 住友重機械工業株式会社 超臨界流体により成形体中のバインダ−を除去する方法
JPH0363232A (ja) 1989-07-10 1991-03-19 Syntex Usa Inc 溶剤抽出方法
ATE122248T1 (de) 1989-07-31 1995-05-15 Ciba Geigy Ag Extraktion organischer lösungsmittel aus geformten stoffen durch überkritische fluide und gase, nahe am kritischen punkt.
US5254335A (en) * 1990-10-10 1993-10-19 Clairol Incorporated Hair conditioning compounds containing reactive nonionic surfactants and isothiuronium compounds and method of use
US5198115A (en) * 1991-07-09 1993-03-30 Analytical Bio-Chemistry Laboratories, Inc. Integrated instrument for supercritical fluid sample extraction, sample separation and concentration
US5481058A (en) 1994-01-07 1996-01-02 Minnesota Mining And Manufacturing Company Supercritical fluid extraction involving hydrofluoroalkanes
US5641510A (en) 1994-07-01 1997-06-24 Genentech, Inc. Method for treating capsules used for drug storage

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109289249A (zh) * 2018-12-08 2019-02-01 内蒙合成化工研究所 一种高能推进剂中增塑剂和安定剂的回收方法

Also Published As

Publication number Publication date
AU9783898A (en) 1999-05-03
AU753076B2 (en) 2002-10-10
CA2302276A1 (en) 1999-04-22
CZ299101B6 (cs) 2008-04-23
PL342650A1 (en) 2001-06-18
KR20010031097A (ko) 2001-04-16
IL134731A0 (en) 2001-04-30
HUP0003990A3 (en) 2001-04-28
BG104317A (en) 2000-12-29
EP1024794A1 (en) 2000-08-09
PL195462B1 (pl) 2007-09-28
WO1999018939A1 (en) 1999-04-22
HUP0003990A2 (en) 2001-03-28
WO1999018939A9 (en) 1999-06-03
BR9814818A (pt) 2000-10-03
DE69836822T2 (de) 2007-04-26
PT1024794E (pt) 2007-02-28
ES2281141T3 (es) 2007-09-16
CN1306420A (zh) 2001-08-01
BG65169B1 (bg) 2007-05-31
US6228394B1 (en) 2001-05-08
EE200000292A (et) 2001-08-15
CZ20001365A3 (cs) 2000-09-13
DE69836822D1 (de) 2007-02-15
TR200001000T2 (tr) 2000-11-21
JP2001519380A (ja) 2001-10-23
CA2302276C (en) 2008-02-05
CY1106033T1 (el) 2011-04-06
DK1024794T3 (da) 2007-04-10
ATE350019T1 (de) 2007-01-15
EP1024794B1 (en) 2007-01-03

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