NZ234564A - 1-substituted benzimidazoles and pharmaceutical compositions - Google Patents

1-substituted benzimidazoles and pharmaceutical compositions

Info

Publication number
NZ234564A
NZ234564A NZ234564A NZ23456487A NZ234564A NZ 234564 A NZ234564 A NZ 234564A NZ 234564 A NZ234564 A NZ 234564A NZ 23456487 A NZ23456487 A NZ 23456487A NZ 234564 A NZ234564 A NZ 234564A
Authority
NZ
New Zealand
Prior art keywords
compound
salt
nmr
compounds
acid
Prior art date
Application number
NZ234564A
Other languages
English (en)
Inventor
Tomas Borje Alminger
Rolf Axel Bergman
Hans Bundgaard
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8604998A external-priority patent/SE8604998D0/xx
Priority claimed from SE8605551A external-priority patent/SE8605551D0/xx
Priority claimed from SE8704049A external-priority patent/SE8704049D0/xx
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of NZ234564A publication Critical patent/NZ234564A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ234564A 1986-11-21 1987-11-10 1-substituted benzimidazoles and pharmaceutical compositions NZ234564A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8604998A SE8604998D0 (sv) 1986-11-21 1986-11-21 Novel pharmacological compounds
SE8605551A SE8605551D0 (sv) 1986-12-23 1986-12-23 Novel pharmacological compounds
SE8704049A SE8704049D0 (sv) 1987-10-16 1987-10-16 Novel pharmacological compounds
NZ222495A NZ222495A (en) 1986-11-21 1987-11-10 Benzimidazole derivatives and pharmaceutical compositions

Publications (1)

Publication Number Publication Date
NZ234564A true NZ234564A (en) 1991-04-26

Family

ID=27355365

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ234564A NZ234564A (en) 1986-11-21 1987-11-10 1-substituted benzimidazoles and pharmaceutical compositions
NZ222495A NZ222495A (en) 1986-11-21 1987-11-10 Benzimidazole derivatives and pharmaceutical compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ222495A NZ222495A (en) 1986-11-21 1987-11-10 Benzimidazole derivatives and pharmaceutical compositions

Country Status (24)

Country Link
EP (3) EP0332647A1 (https=)
JP (1) JPH02500744A (https=)
KR (1) KR890700125A (https=)
AT (1) ATE84032T1 (https=)
AU (1) AU612129B2 (https=)
DE (1) DE3783356T2 (https=)
DK (1) DK365488A (https=)
EG (1) EG18379A (https=)
ES (1) ES2052603T3 (https=)
FI (1) FI892454L (https=)
GR (1) GR3007385T3 (https=)
HU (1) HU204814B (https=)
IE (2) IE61178B1 (https=)
IL (1) IL84504A (https=)
IS (1) IS1565B (https=)
LV (1) LV10954B (https=)
MY (1) MY101784A (https=)
NO (1) NO173998C (https=)
NZ (2) NZ234564A (https=)
PL (1) PL157655B1 (https=)
PT (1) PT86186B (https=)
RU (1) RU2062778C1 (https=)
WO (1) WO1988003921A1 (https=)
YU (1) YU47116B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801907D0 (sv) * 1988-05-20 1988-05-20 Haessle Ab Novel pharmacological compounds
WO1990003373A1 (fr) * 1988-09-20 1990-04-05 Hisamitsu Pharmaceutical Co., Inc. NOUVEAUX DERIVES DE DIBENZ[b,e]OXEPINE
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
WO1991019712A1 (en) * 1990-06-20 1991-12-26 Aktiebolaget Astra Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
US5312824A (en) * 1990-10-17 1994-05-17 Takeda Chemical Industries, Ltd. Certain 2-[(4-difluoromethoxy-2-pyridyl)-methylthio or methylsulfinyl-5-benzimidazoles useful for treating peptic ulcers
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
DE69327572T2 (de) * 1992-05-21 2000-06-21 Otsuka Pharmaceutical Factory, Inc. Phosphonsäurediester-derivat
WO1994026279A1 (en) * 1993-05-18 1994-11-24 The Upjohn Company Bisphosphonate esters for treating gastric disorders
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
AU6551198A (en) * 1997-05-30 1998-12-30 Dr. Reddy's Research Foundation Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
AU754965B2 (en) * 1997-12-31 2002-11-28 University Of Kansas, The Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
AU2583901A (en) 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
CA2425363A1 (en) * 2000-10-12 2003-04-10 Fumihiko Sato Benzimidazole compounds, process for producing the same and use thereof
EP1437352A4 (en) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd BENZIMIDAZOLE COMPOUND, METHOD FOR THE PRODUCTION AND USE THEREOF
DE60304726T2 (de) * 2002-07-19 2007-08-09 Winston Pharmaceuticals Llc, Newport Beach Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
ATE520668T1 (de) * 2004-08-27 2011-09-15 Esteve Labor Dr Sigmarezeptor-inhibitoren
ES2344275T3 (es) * 2005-07-28 2010-08-23 Intervet International Bv Nuevos (tio) carbamatos de benzimidazol con actividad antiparasitaria y sintesis de ellos.
CA3000985C (en) 2014-10-14 2023-01-31 The Board Of Trustees Of The Leland Stanford Junior University Method for treating neurodegenerative diseases
AU2016371598B2 (en) 2015-12-15 2021-05-13 The Board Of Trustees Of The Leland Stanford Junior University Method for preventing and/or treating aging-associated cognitive impairment and neuroinflammation
KR20210068399A (ko) * 2018-08-06 2021-06-09 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 신경퇴행성 질병의 치료를 위한 피피에이알지씨1알파 활성제로서 2-아릴벤즈이미다졸
MX2022001820A (es) * 2019-08-20 2022-03-17 Ono Pharmaceutical Co Sal y forma cristalina de un compuesto que tiene actividad agonista para el receptor 5 de esfingosina-1-fosfato [acido (2s,3r,4e)-2-amino-3-hidroxioctadeca-4-enil-1-fosforico (s1p5).

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (https=) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS5836312B2 (ja) * 1978-08-21 1983-08-08 日本電信電話株式会社 通信用平衡ケ−ブル線路の障害位置測定方式
JPS5687818A (en) * 1979-12-19 1981-07-16 Ishikawajima Harima Heavy Ind Co Ltd Reflex type position detector
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
JPS57137860A (en) * 1981-02-20 1982-08-25 Sumitomo Electric Ind Ltd Optical tachometer
JPS5999597A (ja) * 1982-11-30 1984-06-08 株式会社東芝 光学測定装置
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
JPS6020051U (ja) * 1983-07-19 1985-02-12 三洋電機株式会社 カセツト収納装置
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds

Also Published As

Publication number Publication date
DE3783356D1 (de) 1993-02-11
MY101784A (en) 1992-01-17
FI892454A7 (fi) 1989-05-19
FI892454A0 (fi) 1989-05-19
IE873125L (en) 1988-05-21
EP0510719A1 (en) 1992-10-28
HUT51269A (en) 1990-04-28
IS3284A7 (is) 1988-05-22
EG18379A (en) 1992-11-30
ES2052603T3 (es) 1994-07-16
IE61178B1 (en) 1994-10-05
JPH02500744A (ja) 1990-03-15
PL268927A1 (en) 1989-01-23
EP0279149A2 (en) 1988-08-24
NO883229D0 (no) 1988-07-20
EP0279149A3 (en) 1988-08-31
NO173998B (no) 1993-11-22
DK365488D0 (da) 1988-07-01
FI892454L (fi) 1989-05-19
HU204814B (en) 1992-02-28
PL157655B1 (pl) 1992-06-30
DE3783356T2 (de) 1993-04-15
YU211087A (en) 1988-12-31
YU47116B (sh) 1994-12-28
EP0279149B1 (en) 1992-12-30
AU8330287A (en) 1988-06-16
KR890700125A (ko) 1989-03-02
NO883229L (no) 1988-09-16
DK365488A (da) 1988-07-01
ATE84032T1 (de) 1993-01-15
NO173998C (no) 1994-03-02
GR3007385T3 (https=) 1993-07-30
EP0332647A1 (en) 1989-09-20
IL84504A (en) 1994-10-07
IS1565B (is) 1994-12-13
NZ222495A (en) 1991-04-26
IE940326L (en) 1988-05-21
PT86186A (en) 1987-12-01
PT86186B (pt) 1990-08-31
LV10954B (en) 1996-08-20
AU612129B2 (en) 1991-07-04
LV10954A (lv) 1995-12-20
WO1988003921A1 (en) 1988-06-02
RU2062778C1 (ru) 1996-06-27

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