NZ197299A - N-(vinblastin-23-oyl)derivatives of aminoacids - Google Patents

N-(vinblastin-23-oyl)derivatives of aminoacids

Info

Publication number
NZ197299A
NZ197299A NZ197299A NZ19729981A NZ197299A NZ 197299 A NZ197299 A NZ 197299A NZ 197299 A NZ197299 A NZ 197299A NZ 19729981 A NZ19729981 A NZ 19729981A NZ 197299 A NZ197299 A NZ 197299A
Authority
NZ
New Zealand
Prior art keywords
deacetyl
vinblastin
oyl
ethyl
tryptophanate
Prior art date
Application number
NZ197299A
Other languages
English (en)
Inventor
A B L Trouet
J A A Hannart
K S B Rao
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of NZ197299A publication Critical patent/NZ197299A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
NZ197299A 1980-06-10 1981-06-03 N-(vinblastin-23-oyl)derivatives of aminoacids NZ197299A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique

Publications (1)

Publication Number Publication Date
NZ197299A true NZ197299A (en) 1985-10-11

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ197299A NZ197299A (en) 1980-06-10 1981-06-03 N-(vinblastin-23-oyl)derivatives of aminoacids

Country Status (21)

Country Link
US (1) US4388305A (https=)
EP (1) EP0041935B1 (https=)
AT (2) AT390793B (https=)
AU (1) AU541747B2 (https=)
CA (1) CA1196326A (https=)
DD (1) DD160417A5 (https=)
DE (2) DE3122479A1 (https=)
DK (1) DK160614C (https=)
ES (1) ES8203385A1 (https=)
FR (1) FR2483926A1 (https=)
GB (1) GB2078730A (https=)
GR (1) GR74565B (https=)
HU (1) HU185261B (https=)
IE (1) IE51403B1 (https=)
IL (1) IL63038A0 (https=)
IT (1) IT1144601B (https=)
NL (1) NL8102802A (https=)
NZ (1) NZ197299A (https=)
OA (1) OA06421A (https=)
PT (1) PT73161B (https=)
SE (1) SE8103594L (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
ATE64396T1 (de) * 1983-04-29 1991-06-15 Omnichem Sa Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPH075608B2 (ja) * 1986-01-13 1995-01-25 イ−ル−セルタ−ク ソシエテ アノニム ビンブラスチン誘導体
ES2045092T3 (es) * 1987-11-11 1994-01-16 Akzo Nv Un procedimiento de manufactura de un producto farmaceutico para tratamiento de cancer.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
JP4157600B2 (ja) * 1994-08-19 2008-10-01 ラ レフィオン バロンネ 化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2000006582A1 (en) * 1998-07-31 2000-02-10 Goldsmith Seeds, Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
JP2004510702A (ja) 2000-06-14 2004-04-08 メダレックス，インコーポレイティド イソロイシンを有するプロドラッグ化合物
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2005055943A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinorelbine derivatives
WO2005055939A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinca derivatives
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
PH12022553378A1 (en) 2020-06-10 2024-03-25 Univ Leuven Kath Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
JP2024525589A (ja) 2021-07-09 2024-07-12 アリゴス セラピューティクス インコーポレイテッド 抗ウイルス化合物
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (https=) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
DE3166150D1 (en) 1984-10-25
AU541747B2 (en) 1985-01-17
PT73161B (fr) 1982-07-16
GR74565B (https=) 1984-06-29
FR2483926B1 (https=) 1983-07-29
CA1196326A (en) 1985-11-05
ATE9475T1 (de) 1984-10-15
FR2483926A1 (fr) 1981-12-11
ES502644A0 (es) 1982-04-01
PT73161A (fr) 1981-07-01
ES8203385A1 (es) 1982-04-01
EP0041935A1 (fr) 1981-12-16
IL63038A0 (en) 1981-09-13
EP0041935B1 (fr) 1984-09-19
NL8102802A (nl) 1982-01-04
DK250181A (da) 1981-12-11
HU185261B (en) 1984-12-28
IE51403B1 (en) 1986-12-24
IT8167782A0 (it) 1981-06-08
SE8103594L (sv) 1981-12-11
ATA253881A (de) 1989-12-15
OA06421A (fr) 1981-09-30
DK160614B (da) 1991-04-02
DE3122479A1 (de) 1982-06-16
IT1144601B (it) 1986-10-29
GB2078730A (en) 1982-01-13
IE811275L (en) 1981-12-10
AT390793B (de) 1990-06-25
DD160417A5 (de) 1983-07-27
AU7126281A (en) 1981-12-17
US4388305A (en) 1983-06-14
DK160614C (da) 1991-09-23

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