DE3484691D1 - Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
DE3484691D1
DE3484691D1 DE8484870057T DE3484691T DE3484691D1 DE 3484691 D1 DE3484691 D1 DE 3484691D1 DE 8484870057 T DE8484870057 T DE 8484870057T DE 3484691 T DE3484691 T DE 3484691T DE 3484691 D1 DE3484691 D1 DE 3484691D1
Authority
DE
Germany
Prior art keywords
derivatives
compounds
conjuged
vinblastin
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484870057T
Other languages
English (en)
Inventor
Andre Benoit Leon Trouet
Kandukuri Sivaprasada Bush Rao
Jean-Alfred Alphonse Hannart
Jonghe Jean-Paul De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU84784A external-priority patent/LU84784A1/fr
Priority claimed from LU85161A external-priority patent/LU85161A1/fr
Application filed by Omnichem SA filed Critical Omnichem SA
Application granted granted Critical
Publication of DE3484691D1 publication Critical patent/DE3484691D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
DE8484870057T 1983-04-29 1984-04-26 Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. Expired - Lifetime DE3484691D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU84784A LU84784A1 (fr) 1983-04-29 1983-04-29 Nouveaux conjugues proteiques de la vinblastine leur procede de preparation et leur utilisation therapeutique
LU85161A LU85161A1 (fr) 1983-12-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
DE3484691D1 true DE3484691D1 (de) 1991-07-18

Family

ID=26640299

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484870057T Expired - Lifetime DE3484691D1 (de) 1983-04-29 1984-04-26 Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (13)

Country Link
US (1) US4870162A (de)
EP (1) EP0124502B1 (de)
AT (1) ATE64396T1 (de)
AU (1) AU575819B2 (de)
CA (1) CA1234800A (de)
DE (1) DE3484691D1 (de)
DK (1) DK210784A (de)
ES (1) ES8600769A1 (de)
GR (1) GR81790B (de)
HU (1) HUT34212A (de)
NZ (1) NZ207992A (de)
OA (1) OA07711A (de)
PT (1) PT78508B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79898B (de) * 1983-03-30 1984-10-31 Lilly Industries Ltd
GB2181126B (en) * 1983-03-30 1987-08-26 Lilly Industries Ltd Novel pharmaceutical compounds
LU86157A1 (fr) * 1985-11-12 1987-06-26 Omnichem Sa Nouveau procede de fabrication de conjugues de la vinblastine et de ses derives
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FR2584293B1 (fr) * 1985-07-04 1989-03-17 Ire Celltarg Sa Anticorps utiles comme agents de pilotage et conjugues les incorporant
ATE89567T1 (de) * 1985-11-12 1993-06-15 Wallone Region Konjugate von vinblastin und seine derivate, verfahren zur herstellung derselben und diese konjugate enthaltende pharmazeutische zusammensetzungen.
EP0232693A3 (de) * 1985-12-16 1988-04-06 La Region Wallonne Konjugate des Vinblastins und seiner Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
FR2608158B2 (fr) * 1986-12-12 1992-03-27 Ire Celltarg Sa Nouveaux derives de vinblastine et composition pharmaceutique les contenant
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US4728183A (en) * 1986-10-01 1988-03-01 Ocular Instruments, Inc. Ophthalmic lens for observing the fundus of the eye
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US5322678A (en) * 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
US5094849A (en) * 1988-08-08 1992-03-10 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers
US5144012A (en) * 1988-08-08 1992-09-01 Eli Lilly And Company Cytotoxic drug conjugates
US5007729A (en) * 1989-10-27 1991-04-16 Ocular Instruments, Inc. Wide angle ophthalmic lens
US5189450A (en) * 1991-05-21 1993-02-23 Ocular Instruments, Inc. High magnification ophthalmic lens
US5309187A (en) * 1992-03-18 1994-05-03 Ocular Instruments, Inc. High magnification ophthalmic lens
DE69233126T2 (de) * 1992-09-25 2004-04-15 Neorx Corp., Seattle Therapeutischer inhibitor der vaskulären glatten muskelzellen
US5789189A (en) * 1993-09-24 1998-08-04 The Regents Of The University Of California Inhibition of cyst formation by cytoskeletal specific drugs
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
WO1996005863A1 (fr) * 1994-08-19 1996-02-29 La Region Wallonne Composes, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation
US5623323A (en) * 1994-10-26 1997-04-22 Ocular Instruments, Inc. Extra wide field ophthalmic lens
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20040081659A1 (en) * 1997-12-02 2004-04-29 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
CN1181092C (zh) * 1997-12-02 2004-12-22 麦克公司 可用于治疗前列腺癌的缀合物
ZA9810974B (en) * 1997-12-02 1999-06-03 Merck & Co Inc Conjugates useful in the treatment of prostate cancer
WO2000006582A1 (en) * 1998-07-31 2000-02-10 Goldsmith Seeds, Inc. Trimeric and polymeric alkaloids
US6174858B1 (en) * 1998-11-17 2001-01-16 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
GB0012718D0 (en) * 2000-05-24 2000-07-19 Angeletti P Ist Richerche Bio Conjugates of aminodrugs
AU6685301A (en) 2000-06-14 2001-12-24 Corixa Corp Prodrug compounds with isoleucine
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
EP1552002A4 (de) * 2002-06-18 2006-02-08 Archemix Corp Aptamer-toxinmoleküle sowie verfahren zu deren verwendung
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
NZ541846A (en) * 2003-01-27 2008-12-24 Endocyte Inc Vitamin receptor binding drug delivery conjugates
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
EP1789391B1 (de) 2004-07-23 2017-06-28 Endocyte, Inc. Zweiwertige linker und konjugate davon
WO2006096754A2 (en) * 2005-03-07 2006-09-14 Archemix Corp. Stabilized aptamers to psma and their use as prostate cancer therapeutics
EP2382995A3 (de) * 2005-08-19 2013-09-25 Endocyte, Inc. Ligandenkonjugate von Vincaalkaloiden, Analoga und Derivaten
ES2468240T3 (es) * 2005-08-19 2014-06-16 Endocyte, Inc. Conjugados de ligando de múltiples fármacos
US20100104626A1 (en) 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CA2680535C (en) 2007-03-14 2016-09-20 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
WO2009002993A1 (en) 2007-06-25 2008-12-31 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
MX2015004757A (es) 2012-10-16 2015-07-17 Endocyte Inc Conjugados de suministro de farmacos que contienen aminoacidos no naturales y metodo para usarlos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1037379A (en) * 1965-01-11 1966-07-27 Lilly Co Eli Desacetyl polynuclear indoles
FR2349335A1 (fr) * 1976-04-28 1977-11-25 Inst Int Pathologie Cellulaire Complexes d'alcaloides bis-indoliques du type vinblastine avec la tubuline, leur procede d'obtention et leur utilisation
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4357334A (en) * 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FI820020L (fi) * 1981-01-12 1982-07-13 Lilly Industries Ltd Immunoglobulinkonjugater
GR79898B (de) * 1983-03-30 1984-10-31 Lilly Industries Ltd
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates

Also Published As

Publication number Publication date
EP0124502A2 (de) 1984-11-07
EP0124502A3 (en) 1986-05-07
CA1234800A (en) 1988-04-05
GR81790B (de) 1984-12-12
ES531965A0 (es) 1985-11-01
AU575819B2 (en) 1988-08-11
PT78508A (en) 1984-05-01
PT78508B (en) 1986-05-20
NZ207992A (en) 1987-04-30
ES8600769A1 (es) 1985-11-01
ATE64396T1 (de) 1991-06-15
HUT34212A (en) 1985-02-28
AU2743484A (en) 1984-11-01
DK210784D0 (da) 1984-04-27
DK210784A (da) 1984-10-30
EP0124502B1 (de) 1991-06-12
US4870162A (en) 1989-09-26
OA07711A (fr) 1985-06-30

Similar Documents

Publication Publication Date Title
DE3484691D1 (de) Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EA200000592A1 (ru) Азаполициклические соединения, конденсированные с арилом
RU94042922A (ru) Новые соединения, способы их получения, фармацевтическая композиция
EA200400815A1 (ru) Контролируемый синтез зипразидона и его композиции
TR199900537T2 (xx) D�n��t�r�lm�� amino asitler, bunlar� i�eren farmas�tik preparatlar.
BR9509665A (pt) Composto composições e métodos
DE69432109T2 (de) Synthetische, vielfache tandemwiederholungen des mucinpeptides und seiner derivate und deren verwendung
OA06421A (fr) Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
TR199801594A2 (xx) CCR-3 resept�r antagonistleri.
TR199802518T2 (xx) 4-Diketon ikameli yeni tiazolidon-2 t�revleri.
NO930006D0 (no) Fremgangsmaate ved fremstilling av beta-laktamer
ES2174298T3 (es) Derivados de aminotiazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
ATE51617T1 (de) Verfahren zur herstellung von 4-phenyl-pyrrolderivaten.
FI97226C (fi) Menetelmä terapeuttisesti käyttökelpoisten 6-amino-substituoitujen oktahydro-1,7,8-indolitsiinitriolijohdannaisten valmistamiseksi
DE69637941D1 (de) Modifizierte hämoglobinähnliche verbindungen und verfahren zu deren reinigung
ATE89567T1 (de) Konjugate von vinblastin und seine derivate, verfahren zur herstellung derselben und diese konjugate enthaltende pharmazeutische zusammensetzungen.
EA199800368A1 (ru) Новые промежуточные продукты и их использование для получения n,n'-мостиковых бисиндолилмалеимидов
DK305184A (da) Hexahydropyrrolo(2,1-a)isoquinolin-derivater
ES447686A1 (es) Procedimiento para la preparacion de tripeptidos derivados de la l-prolina.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee