DE69432109T2 - Synthetische, vielfache tandemwiederholungen des mucinpeptides und seiner derivate und deren verwendung - Google Patents
Synthetische, vielfache tandemwiederholungen des mucinpeptides und seiner derivate und deren verwendungInfo
- Publication number
- DE69432109T2 DE69432109T2 DE69432109T DE69432109T DE69432109T2 DE 69432109 T2 DE69432109 T2 DE 69432109T2 DE 69432109 T DE69432109 T DE 69432109T DE 69432109 T DE69432109 T DE 69432109T DE 69432109 T2 DE69432109 T2 DE 69432109T2
- Authority
- DE
- Germany
- Prior art keywords
- muc
- synthetic
- peptides
- tandem repeats
- mucinpeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 101100346932 Mus musculus Muc1 gene Proteins 0.000 abstract 3
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
- F02B75/00—Other engines
- F02B75/02—Engines characterised by their cycles, e.g. six-stroke
- F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
- F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/099,354 US5744144A (en) | 1993-07-30 | 1993-07-30 | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
PCT/US1994/008477 WO1995003825A1 (en) | 1993-07-30 | 1994-07-29 | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432109D1 DE69432109D1 (de) | 2003-03-13 |
DE69432109T2 true DE69432109T2 (de) | 2003-11-20 |
Family
ID=22274597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432109T Expired - Fee Related DE69432109T2 (de) | 1993-07-30 | 1994-07-29 | Synthetische, vielfache tandemwiederholungen des mucinpeptides und seiner derivate und deren verwendung |
Country Status (7)
Country | Link |
---|---|
US (2) | US5744144A (de) |
EP (1) | EP0804231B1 (de) |
JP (1) | JPH09501159A (de) |
AT (1) | ATE232109T1 (de) |
CA (1) | CA2167730A1 (de) |
DE (1) | DE69432109T2 (de) |
WO (1) | WO1995003825A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPN568095A0 (en) * | 1995-09-27 | 1995-10-26 | Austin Research Institute, The | Anti-Galalpha(1,3)Gal antibody binding peptides |
US20080286228A1 (en) * | 1995-10-20 | 2008-11-20 | Tarantolo Stefano R | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells |
CA2232344C (en) | 1995-10-20 | 2005-04-05 | University Of Nebraska Board Of Regents | Compositions and methods for enhancing immune responses mediated by antigen-presenting cells |
WO1997028187A2 (en) * | 1996-01-31 | 1997-08-07 | The Population Council | Multivalent chimeric peptides as microbicides |
EP0923605A4 (de) * | 1996-03-20 | 2003-01-02 | Sloan Kettering Inst Cancer | Mucin enthaltende konjugierte impfstoffe |
AU2540897A (en) * | 1996-03-21 | 1997-10-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods and compositions of chimeric polypeptides for tumor antigen vaccines |
DE69734776T2 (de) * | 1996-05-24 | 2006-08-17 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Fusionsprotein mit multiplen Epitopen |
US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
WO1998010783A1 (en) * | 1996-09-10 | 1998-03-19 | Biomira Inc. | Muc-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions |
EP0964694A4 (de) * | 1996-10-25 | 2000-09-13 | Dana Farber Cancer Inst Inc | Mucin-vermittelte immunomodulation |
AU727308B2 (en) * | 1997-02-24 | 2000-12-07 | Dana-Farber Cancer Institute | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
GB9810040D0 (en) | 1998-05-11 | 1998-07-08 | Univ Nottingham | Blood borne tumour markers |
EP1090299A1 (de) | 1998-06-26 | 2001-04-11 | Biomira, Inc. | Methoden zum bestimmen der t-zellaktivität |
IL142971A0 (en) * | 1998-11-05 | 2002-04-21 | Univ Michigan | S100 proteins and autoantibodies as serum markers for cancer |
GB9827228D0 (en) * | 1998-12-10 | 1999-02-03 | Univ Nottingham | Cancer detection method and reagents |
DE19906615A1 (de) * | 1999-02-17 | 2000-09-28 | Hanisch Franz Georg | Peptid-Varianten des Tumormarkers MUC1 und ihre Verwendung |
GB9904695D0 (en) * | 1999-03-01 | 1999-04-21 | Imp Cancer Res Tech | Peptide |
GB9930359D0 (en) * | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Novel polypeptides |
CA2322057A1 (en) * | 2000-05-18 | 2001-11-18 | Dnavec Research Inc. | Paramyxovirus vectors used for transfer of foreign genes |
US20030232399A1 (en) * | 2000-06-14 | 2003-12-18 | Robertson John Forsyth Russell | Cancer detection methods and reagents |
ES2392943T3 (es) | 2000-10-18 | 2012-12-17 | Glaxosmithkline Biologicals S.A. | Vacunas antitumorales |
US20020142047A1 (en) * | 2001-01-19 | 2002-10-03 | Johnson Mark E. | Microsphere delivery of mucin peptides |
US8198400B2 (en) | 2001-03-27 | 2012-06-12 | Oncothyreon, Inc. | Vaccine for modulating between T1 and T2 immune responses |
US7183388B2 (en) * | 2001-03-30 | 2007-02-27 | The Regents Of The University Of California | Anti-MUC-1 single chain antibodies for tumor targeting |
CA2443138A1 (en) * | 2001-03-30 | 2002-10-10 | The Regents Of The University Of California | Anti-muc-1 single chain antibodies for tumor targeting |
GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
US7247297B2 (en) * | 2001-09-14 | 2007-07-24 | The University Of Chicago | Use of DF3/MUC1 regulated expression in gene therapy |
AU2002240734A1 (en) * | 2001-10-18 | 2003-04-28 | Zlatko Ademovic | Repetitive motifs from salivary proline rich proteins, mucin and collagen |
EP1465699A4 (de) * | 2001-12-12 | 2006-05-24 | Leon J Lewandowski | Photophoretische autoimmunstimulation |
AU2003203034A1 (en) * | 2002-01-14 | 2003-07-30 | Vertex Pharmaceuticals Incorporated | Mucin immobilized chromatography |
AU2003203079B9 (en) * | 2002-02-04 | 2009-01-15 | Oncothyreon Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
AU2003224878B2 (en) * | 2002-04-15 | 2009-07-09 | Oncothyreon Inc. | Synthetic glyco-lipo-peptides as vaccines |
KR100994748B1 (ko) | 2002-04-19 | 2010-11-17 | 더 가버닝 카운실 오브 더 유니버시티 오브 토론토 | 알쯔하이머병의 치료를 위한 면역학적 방법 및 조성물 |
GB0212036D0 (en) * | 2002-05-24 | 2002-07-03 | Glaxo Group Ltd | Vaccines |
EP1537143A2 (de) * | 2002-09-05 | 2005-06-08 | Cell Center Cologne GmbH | Immunogene muc1-glykopeptide |
GB2424070B (en) * | 2002-11-14 | 2007-06-27 | Univ Nottingham | Methods for preparing tumour marker proteins |
US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
BR0316758A (pt) * | 2002-12-16 | 2005-10-25 | Globeimmune Inc | Vacinas baseadas em levedura como imunoterapia |
US7696306B2 (en) * | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
AU2004286144A1 (en) | 2003-11-04 | 2005-05-12 | Dnavec Research Inc. | Method for producing gene transferred dendritic cells |
JP4995575B2 (ja) * | 2003-11-12 | 2012-08-08 | アメリカ合衆国 | 乳癌を処置および予防するためのシステム |
EP1687322B1 (de) * | 2003-11-12 | 2017-02-08 | The Government of the United States of America, represented by the Secretary, Department of Health and Human Services | Massgeschneiderte vektoren für die behandlung und prävention von bauchspeicheldrüsenkrebs |
JP5060134B2 (ja) * | 2003-12-12 | 2012-10-31 | ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ・アズ リプレゼンテッド バイ ザ セクレタリー・デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ヒト細胞傷害性Tリンパ球のエピトープ及びそのMUC−1の非VNTR(non−variablenumberoftandemrepeatsequence)由来のアゴニストエピトープ |
TWI395591B (zh) * | 2004-04-01 | 2013-05-11 | Oncothyreon Inc | 黏液性糖蛋白(muc-1)疫苗 |
MX2007009598A (es) * | 2005-02-08 | 2008-03-10 | Queensland Inst Med Res | Moleculas inmunogenicas. |
GB2426581A (en) * | 2005-05-27 | 2006-11-29 | Univ Nottingham | Immunoassay methods |
PT1889059E (pt) | 2005-05-27 | 2009-10-01 | Oncimmune Ltd | Métodos de imunoensaio melhorados |
ES2526344T3 (es) | 2005-06-28 | 2015-01-09 | Oncothyreon Inc. | Método para el tratamiento de pacientes con una vacuna de glicoproteína mucinosa (MUC-1) |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
EP2025762A3 (de) | 2006-01-17 | 2009-09-30 | Health Research Inc. | Heteroduplex-Trackingassay |
CN101405389A (zh) | 2006-01-17 | 2009-04-08 | 生物载体株式会社 | 新型蛋白质表达系统 |
CA2658266A1 (en) | 2006-07-13 | 2008-01-17 | Dnavec Corporation | Non-replicating paramyxoviridae virus vector |
US20090317414A1 (en) * | 2006-07-25 | 2009-12-24 | 4G Vaccines Pty Ltd | Cancer vaccine comprising a mucin 1 (muc1) t cell epitope-derived peptide |
CN101632020B (zh) | 2006-09-13 | 2013-11-27 | 昂西免疫有限公司 | 改进的免疫测定方法 |
WO2008127680A2 (en) * | 2007-04-11 | 2008-10-23 | The Jackson Laboratory | Diagnosis and treatment of diseases caused by misfolded proteins |
US20090124557A1 (en) * | 2007-04-16 | 2009-05-14 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating cancer |
DK2148697T3 (da) | 2007-05-24 | 2012-12-17 | Glaxosmithkline Biolog Sa | Lyofiliseret CPG indeholdende WT-1-sammensætning |
GB0725239D0 (en) * | 2007-12-24 | 2008-02-06 | Oncimmune Ltd | Calibrator for autoantibody assay |
EP2351599A4 (de) | 2008-11-14 | 2013-05-08 | Dnavec Corp | Verfahren zur herstellung dendritischer zellen |
WO2011140595A2 (en) | 2010-05-10 | 2011-11-17 | 4G Vaccines Pty Ltd | Immunostimulatory and vaccine compositions |
KR20140023903A (ko) | 2011-02-24 | 2014-02-27 | 온코타이레온, 인코포레이티드 | 항원보강제를 갖는 muc1 기초 당지질펩티드 백신 |
JP6523685B2 (ja) | 2012-01-03 | 2019-06-05 | アメリカ合衆国 | Muc1腫瘍抗原のネイティブ及びアゴニストctlエピトープ |
WO2016105536A2 (en) * | 2014-12-23 | 2016-06-30 | University Of Maryland, Baltimore | Muc1 decoy peptides for treatment and prevention of bacterial infections |
RU2756534C2 (ru) | 2016-09-28 | 2021-10-01 | Бавариан Нордик А/С | Композиции и способы для повышения стабильности трансгенов в поксвирусах |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0369816A3 (de) * | 1988-11-17 | 1990-09-12 | The University Of Melbourne | Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper |
WO1991008217A1 (en) * | 1989-12-05 | 1991-06-13 | The Regents Of The University Of California | Human intestinal mucins |
-
1993
- 1993-07-30 US US08/099,354 patent/US5744144A/en not_active Expired - Lifetime
-
1994
- 1994-07-29 JP JP7505945A patent/JPH09501159A/ja active Pending
- 1994-07-29 DE DE69432109T patent/DE69432109T2/de not_active Expired - Fee Related
- 1994-07-29 CA CA002167730A patent/CA2167730A1/en not_active Abandoned
- 1994-07-29 WO PCT/US1994/008477 patent/WO1995003825A1/en active IP Right Grant
- 1994-07-29 EP EP94925121A patent/EP0804231B1/de not_active Expired - Lifetime
- 1994-07-29 AT AT94925121T patent/ATE232109T1/de not_active IP Right Cessation
- 1994-08-10 US US08/288,059 patent/US5827666A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1995003825A1 (en) | 1995-02-09 |
EP0804231B1 (de) | 2003-02-05 |
US5827666A (en) | 1998-10-27 |
CA2167730A1 (en) | 1995-02-09 |
US5744144A (en) | 1998-04-28 |
EP0804231A4 (de) | 1999-08-18 |
ATE232109T1 (de) | 2003-02-15 |
EP0804231A1 (de) | 1997-11-05 |
JPH09501159A (ja) | 1997-02-04 |
DE69432109D1 (de) | 2003-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |