NL8102802A - N-(vinblastin-23-oyl)aminozuurderivaten. - Google Patents

N-(vinblastin-23-oyl)aminozuurderivaten. Download PDF

Info

Publication number
NL8102802A
NL8102802A NL8102802A NL8102802A NL8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A NL 8102802 A NL8102802 A NL 8102802A
Authority
NL
Netherlands
Prior art keywords
deacetyl
oyl
vinblastin
ethyl
tryptophanate
Prior art date
Application number
NL8102802A
Other languages
English (en)
Dutch (nl)
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU82514A external-priority patent/LU82514A1/fr
Priority claimed from LU83034A external-priority patent/LU83034A1/fr
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of NL8102802A publication Critical patent/NL8102802A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
NL8102802A 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten. NL8102802A (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU82514 1980-06-10
LU82514A LU82514A1 (fr) 1980-06-10 1980-06-10 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr) 1980-12-23 1980-12-23 Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
LU83034 1980-12-23

Publications (1)

Publication Number Publication Date
NL8102802A true NL8102802A (nl) 1982-01-04

Family

ID=26640267

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8102802A NL8102802A (nl) 1980-06-10 1981-06-10 N-(vinblastin-23-oyl)aminozuurderivaten.

Country Status (21)

Country Link
US (1) US4388305A (https=)
EP (1) EP0041935B1 (https=)
AT (2) AT390793B (https=)
AU (1) AU541747B2 (https=)
CA (1) CA1196326A (https=)
DD (1) DD160417A5 (https=)
DE (2) DE3122479A1 (https=)
DK (1) DK160614C (https=)
ES (1) ES8203385A1 (https=)
FR (1) FR2483926A1 (https=)
GB (1) GB2078730A (https=)
GR (1) GR74565B (https=)
HU (1) HU185261B (https=)
IE (1) IE51403B1 (https=)
IL (1) IL63038A0 (https=)
IT (1) IT1144601B (https=)
NL (1) NL8102802A (https=)
NZ (1) NZ197299A (https=)
OA (1) OA06421A (https=)
PT (1) PT73161B (https=)
SE (1) SE8103594L (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639456A (en) * 1980-06-10 1987-01-27 Omnichem S.A. Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
ATE64396T1 (de) * 1983-04-29 1991-06-15 Omnichem Sa Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
FI860456A7 (fi) * 1985-07-16 1987-01-17 Huhtamaeki Oy Laeaeketehdas Le Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) * 1985-12-16 1988-04-06 La Region Wallonne Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPH075608B2 (ja) * 1986-01-13 1995-01-25 イ−ル−セルタ−ク ソシエテ アノニム ビンブラスチン誘導体
ES2045092T3 (es) * 1987-11-11 1994-01-16 Akzo Nv Un procedimiento de manufactura de un producto farmaceutico para tratamiento de cancer.
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
JP4157600B2 (ja) * 1994-08-19 2008-10-01 ラ レフィオン バロンネ 化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6127333A (en) * 1997-07-10 2000-10-03 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2000006582A1 (en) * 1998-07-31 2000-02-10 Goldsmith Seeds, Inc. Trimeric and polymeric alkaloids
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
JP2004510702A (ja) 2000-06-14 2004-04-08 メダレックス，インコーポレイティド イソロイシンを有するプロドラッグ化合物
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
WO2005055943A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinorelbine derivatives
WO2005055939A2 (en) * 2003-12-04 2005-06-23 Amr Technology, Inc. Vinca derivatives
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
PH12022553378A1 (en) 2020-06-10 2024-03-25 Univ Leuven Kath Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
JP2024525589A (ja) 2021-07-09 2024-07-12 アリゴス セラピューティクス インコーポレイテッド 抗ウイルス化合物
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (https=) * 1976-09-08 1982-07-07 Lilly Co Eli
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Also Published As

Publication number Publication date
DE3166150D1 (en) 1984-10-25
AU541747B2 (en) 1985-01-17
PT73161B (fr) 1982-07-16
GR74565B (https=) 1984-06-29
FR2483926B1 (https=) 1983-07-29
CA1196326A (en) 1985-11-05
ATE9475T1 (de) 1984-10-15
FR2483926A1 (fr) 1981-12-11
ES502644A0 (es) 1982-04-01
PT73161A (fr) 1981-07-01
ES8203385A1 (es) 1982-04-01
EP0041935A1 (fr) 1981-12-16
IL63038A0 (en) 1981-09-13
EP0041935B1 (fr) 1984-09-19
DK250181A (da) 1981-12-11
HU185261B (en) 1984-12-28
IE51403B1 (en) 1986-12-24
NZ197299A (en) 1985-10-11
IT8167782A0 (it) 1981-06-08
SE8103594L (sv) 1981-12-11
ATA253881A (de) 1989-12-15
OA06421A (fr) 1981-09-30
DK160614B (da) 1991-04-02
DE3122479A1 (de) 1982-06-16
IT1144601B (it) 1986-10-29
GB2078730A (en) 1982-01-13
IE811275L (en) 1981-12-10
AT390793B (de) 1990-06-25
DD160417A5 (de) 1983-07-27
AU7126281A (en) 1981-12-17
US4388305A (en) 1983-06-14
DK160614C (da) 1991-09-23

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BV The patent application has lapsed