NO994364L - Dolastatin 15 derivater med karbonyl og heterocykliske funksjonaliteter ved C-terminal ende - Google Patents

Dolastatin 15 derivater med karbonyl og heterocykliske funksjonaliteter ved C-terminal ende

Info

Publication number
NO994364L
NO994364L NO994364A NO994364A NO994364L NO 994364 L NO994364 L NO 994364L NO 994364 A NO994364 A NO 994364A NO 994364 A NO994364 A NO 994364A NO 994364 L NO994364 L NO 994364L
Authority
NO
Norway
Prior art keywords
group
dolastatin
carbonyl
derivatives
terminal end
Prior art date
Application number
NO994364A
Other languages
English (en)
Norwegian (no)
Other versions
NO994364D0 (no
Inventor
Kurt Ritter
Wilhelm Amberg
Teresa Barlozzari
Andreas Haupt
Bernd Janssen
Andreas Kling
Original Assignee
Basf Ag
Basf Bioresearch Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Basf Bioresearch Corp filed Critical Basf Ag
Publication of NO994364D0 publication Critical patent/NO994364D0/no
Publication of NO994364L publication Critical patent/NO994364L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO994364A 1997-03-10 1999-09-09 Dolastatin 15 derivater med karbonyl og heterocykliske funksjonaliteter ved C-terminal ende NO994364L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/814,577 US5965537A (en) 1997-03-10 1997-03-10 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
PCT/US1998/004317 WO1998040400A1 (en) 1997-03-10 1998-03-05 Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus

Publications (2)

Publication Number Publication Date
NO994364D0 NO994364D0 (no) 1999-09-09
NO994364L true NO994364L (no) 1999-11-09

Family

ID=25215470

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994364A NO994364L (no) 1997-03-10 1999-09-09 Dolastatin 15 derivater med karbonyl og heterocykliske funksjonaliteter ved C-terminal ende

Country Status (17)

Country Link
US (1) US5965537A (zh)
EP (1) EP0981539A1 (zh)
JP (1) JP2001518084A (zh)
KR (1) KR20000076099A (zh)
CN (1) CN1252806A (zh)
AR (1) AR011957A1 (zh)
AU (1) AU744511B2 (zh)
BR (1) BR9808017A (zh)
CA (1) CA2297164A1 (zh)
CO (1) CO4950525A1 (zh)
HR (1) HRP980124A2 (zh)
HU (1) HUP0001758A3 (zh)
IL (1) IL131596A0 (zh)
NO (1) NO994364L (zh)
TW (1) TW505657B (zh)
WO (1) WO1998040400A1 (zh)
ZA (1) ZA981957B (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN101307046B (zh) 2000-10-30 2012-08-15 詹森药业有限公司 三肽酶抑制剂
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
DK1545613T3 (da) * 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
KR101520209B1 (ko) 2003-11-06 2015-05-13 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
CN111499748A (zh) 2007-07-16 2020-08-07 健泰科生物技术公司 抗cd79b抗体和免疫偶联物及使用方法
AR080154A1 (es) 2010-02-10 2012-03-14 Immunogen Inc Anticuerpos cd20 y su utilizacion
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
WO2016086357A1 (en) * 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Methyl oxazole orexin receptor antagonists
US9987255B2 (en) 2014-12-19 2018-06-05 Merck Sharp & Dohme Corp. 5,5-bicyclic oxazole orexin receptor antagonists
CN104952808A (zh) * 2015-06-12 2015-09-30 广州先艺电子科技有限公司 一种预置金锡盖板及其制造方法
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CN109776342A (zh) * 2019-02-26 2019-05-21 北京大学深圳研究生院 顺式β-氨基酸及其衍生物的合成方法
WO2021074281A1 (en) * 2019-10-17 2021-04-22 Givaudan Sa Substituted azacyles as trmp8 modulators
JPWO2023033129A1 (zh) 2021-09-03 2023-03-09

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
US5091368A (en) * 1990-08-08 1992-02-25 Harbor Branch Oceanographic Institution, Inc. Biologically active compounds from blue-green algae
SG87056A1 (en) * 1991-08-09 2002-03-19 Teikoku Hormone Mfg Co Ltd Novel tetrapeptide derivative
IL105651A (en) * 1992-05-20 1998-07-15 Basf Ag History of dolastatin preparation and pharmaceutical preparations containing them
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
ATE196296T1 (de) * 1992-12-16 2000-09-15 Basf Ag Dolastatin analog
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof

Also Published As

Publication number Publication date
WO1998040400A1 (en) 1998-09-17
CA2297164A1 (en) 1998-09-17
BR9808017A (pt) 2000-03-08
EP0981539A1 (en) 2000-03-01
AU744511B2 (en) 2002-02-28
CN1252806A (zh) 2000-05-10
CO4950525A1 (es) 2000-09-01
TW505657B (en) 2002-10-11
HUP0001758A2 (hu) 2001-05-28
US5965537A (en) 1999-10-12
IL131596A0 (en) 2001-01-28
HRP980124A2 (en) 1998-12-31
JP2001518084A (ja) 2001-10-09
NO994364D0 (no) 1999-09-09
AR011957A1 (es) 2000-09-13
KR20000076099A (ko) 2000-12-26
ZA981957B (en) 1999-09-09
AU6448298A (en) 1998-09-29
HUP0001758A3 (en) 2001-12-28

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