NO993806L - FremgangsmÕte for fremstilling av ioderte kontrastmidler og mellomprodukter for disse - Google Patents

FremgangsmÕte for fremstilling av ioderte kontrastmidler og mellomprodukter for disse

Info

Publication number
NO993806L
NO993806L NO993806A NO993806A NO993806L NO 993806 L NO993806 L NO 993806L NO 993806 A NO993806 A NO 993806A NO 993806 A NO993806 A NO 993806A NO 993806 L NO993806 L NO 993806L
Authority
NO
Norway
Prior art keywords
preparation
compound
intermediates
contrast agents
iodinated contrast
Prior art date
Application number
NO993806A
Other languages
English (en)
Other versions
NO993806D0 (no
Inventor
David Redick Lane
Janis Vasilevskis
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO993806D0 publication Critical patent/NO993806D0/no
Publication of NO993806L publication Critical patent/NO993806L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated

Abstract

Oppfinnelsen tilveiebringer en fremgangsmåte for fremstilling av en 2,3- dihydroksypropylamino-forbindelse, idet nevnte fremgangsmåte omfatter reak- sjonstrinnene: (i) oppnåelse av en allylaminoforbindelse; (ii) epoksydering av nevnte allylaminoforbindelse, hvilket gir en epoksypropy- lamino-forbindelse; og (iii hydrolysering av nevnte epoksypropylamino-forbindelse, hvilket gir en 2,3- dihydroksypropylamino-forbindelse. Denne prosessen kan anvendes for å produsere enkle 2,3-dihydroksy- propylamino-forbindelser så som APD, eller sammensatte så som BAPD (et mel- lomprodukt i fremstillingen av iohexol).
NO993806A 1997-02-07 1999-08-06 FremgangsmÕte for fremstilling av ioderte kontrastmidler og mellomprodukter for disse NO993806L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/796,212 US5824821A (en) 1997-02-07 1997-02-07 Process for the preparation of iodinated contrast agents and intermediates therefor
PCT/GB1998/000356 WO1998034905A1 (en) 1997-02-07 1998-02-05 Process for the preparation of iodinated contrast agents and intermediates therefor

Publications (2)

Publication Number Publication Date
NO993806D0 NO993806D0 (no) 1999-08-06
NO993806L true NO993806L (no) 1999-09-08

Family

ID=25167625

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993806A NO993806L (no) 1997-02-07 1999-08-06 FremgangsmÕte for fremstilling av ioderte kontrastmidler og mellomprodukter for disse

Country Status (15)

Country Link
US (2) US5824821A (no)
EP (1) EP0968173B1 (no)
JP (1) JP2001511173A (no)
CN (1) CN1246844A (no)
AT (1) ATE237578T1 (no)
AU (1) AU5996498A (no)
BR (1) BR9807154A (no)
CA (1) CA2280235A1 (no)
DE (1) DE69813534D1 (no)
HU (1) HUP0000845A3 (no)
IL (1) IL131423A0 (no)
NO (1) NO993806L (no)
PL (1) PL334954A1 (no)
SK (1) SK106799A3 (no)
WO (1) WO1998034905A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100358855B1 (ko) * 2000-02-29 2002-10-31 광주과학기술원 사이클로덱스트린 또는 그 유도체와 조영제의 포접 착체형성 방법
KR100362080B1 (ko) * 2000-03-29 2002-11-23 광주과학기술원 고리 올리고당과 그들의 유도체를 이용한 조영제의 새로운포접 착체
KR20050035137A (ko) * 2001-10-12 2005-04-15 다우 글로벌 테크놀로지스 인크. 아미드 연결기를 보유하는 폴리에폭시 화합물
US7300986B2 (en) * 2001-10-12 2007-11-27 Dow3Global Technologies Inc. Polyepoxy compounds having an amide linkage
KR100700701B1 (ko) 2004-10-28 2007-03-28 동국정밀화학(주) 이오딕사놀의 제조방법
US20070148096A1 (en) * 2005-12-15 2007-06-28 Lars-Goran Wistrand Contrast Agents
KR101098553B1 (ko) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법
CN101921209B (zh) * 2010-09-09 2013-01-30 江苏省原子医学研究所 5-硝基-n,n′-双（2，3-二羟丙基）-1,3-苯二甲酰胺的制备方法
US9006486B2 (en) * 2013-01-15 2015-04-14 Liebel-Flarsheim Company Llc Synthesis of N1,N3-bis(2,3-dihydroxypropyl)-5-nitroisophthalamide
CN107635431B (zh) 2015-06-08 2022-01-11 化妆品科技有限责任公司 化妆品样品的自动分配系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2720968C2 (de) * 1977-05-10 1986-05-07 Kali-Chemie Pharma Gmbh, 3000 Hannover N↓1↓-Acyl-2-hydroxy-1,3-diaminopropane und Arzneimittel
ES469020A1 (es) * 1977-05-10 1979-09-01 Kali Chemie Pharma Gmbh Procedimiento para la preparacion de nuevos 1-acil-2-hidroxi-1,3-diaminopropanos
US4115350A (en) * 1977-07-27 1978-09-19 Allied Chemical Corporation Production of thermally stabilized polyester
DE3014109A1 (de) * 1980-04-12 1981-10-22 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von 1-aminopropandiol-2,3 (ii)
JPS59191720A (ja) * 1983-04-14 1984-10-30 Unitika Ltd 耐熱性ポリエステルの製造法
JPS6042376A (ja) * 1983-08-18 1985-03-06 Mitsubishi Chem Ind Ltd Ν−（２，３−エポキシプロピレン）スルホンアミド誘導体及びそれを有効成分とする選択性除草剤
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation

Also Published As

Publication number Publication date
PL334954A1 (en) 2000-03-27
HUP0000845A3 (en) 2002-07-29
SK106799A3 (en) 2000-01-18
EP0968173B1 (en) 2003-04-16
JP2001511173A (ja) 2001-08-07
EP0968173A1 (en) 2000-01-05
BR9807154A (pt) 2000-01-25
ATE237578T1 (de) 2003-05-15
CN1246844A (zh) 2000-03-08
IL131423A0 (en) 2001-01-28
CA2280235A1 (en) 1998-08-13
US5824821A (en) 1998-10-20
NO993806D0 (no) 1999-08-06
US6153771A (en) 2000-11-28
HUP0000845A2 (hu) 2002-02-28
DE69813534D1 (de) 2003-05-22
WO1998034905A1 (en) 1998-08-13
AU5996498A (en) 1998-08-26

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application