NO985039L - Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler - Google Patents
Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midlerInfo
- Publication number
- NO985039L NO985039L NO985039A NO985039A NO985039L NO 985039 L NO985039 L NO 985039L NO 985039 A NO985039 A NO 985039A NO 985039 A NO985039 A NO 985039A NO 985039 L NO985039 L NO 985039L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- independently
- nr8r1
- trifluoromethyl
- Prior art date
Links
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000011368 organic material Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/637,968 US5608095A (en) | 1996-04-30 | 1996-04-30 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
| PCT/US1997/003335 WO1997041129A1 (en) | 1996-04-30 | 1997-03-03 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO985039D0 NO985039D0 (no) | 1998-10-29 |
| NO985039L true NO985039L (no) | 1998-12-21 |
Family
ID=24558107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO985039A NO985039L (no) | 1996-04-30 | 1998-10-29 | Alkyl-4-silyl-fenoler og estere derav som antiatherosklerotiske midler |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5608095A (https=) |
| EP (1) | EP0900225B1 (https=) |
| JP (1) | JP4309473B2 (https=) |
| KR (1) | KR100503181B1 (https=) |
| CN (1) | CN1216993A (https=) |
| AR (1) | AR006890A1 (https=) |
| AT (1) | ATE212639T1 (https=) |
| AU (1) | AU711322B2 (https=) |
| BR (1) | BR9709190A (https=) |
| CA (1) | CA2251991C (https=) |
| DE (1) | DE69710191T2 (https=) |
| DK (1) | DK0900225T3 (https=) |
| ES (1) | ES2167716T3 (https=) |
| IL (1) | IL126758A0 (https=) |
| NO (1) | NO985039L (https=) |
| PT (1) | PT900225E (https=) |
| TW (1) | TW474940B (https=) |
| WO (1) | WO1997041129A1 (https=) |
| ZA (1) | ZA973503B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
| CN1216921A (zh) * | 1996-04-30 | 1999-05-19 | 赫彻斯特马里恩鲁斯公司 | 用2,6－二烷基－4－甲硅烷基－苯酚诱导血管细胞粘着分子－1和治疗慢性炎症疾病的方法 |
| CN1275596C (zh) * | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
| US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| CA2295232A1 (en) * | 1997-06-25 | 1998-12-30 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol |
| WO1999001118A2 (en) * | 1997-07-01 | 1999-01-14 | Atherogenics, Inc. | Antioxidant enhancement of therapy for hyperproliferative conditions |
| JP2002529740A (ja) * | 1998-11-09 | 2002-09-10 | アセロジエニクス・インコーポレイテツド | 血漿コレステロールレベルを低下させるための方法及び組成物 |
| US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6020383A (en) * | 1999-01-11 | 2000-02-01 | Eastman Chemicals Company | Method for reducing blood cholesterol and/or blood triglycerides |
| WO2002040021A2 (en) | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| US20030064967A1 (en) * | 2001-04-11 | 2003-04-03 | Jayraz Luchoomun | Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters |
| JP2005514344A (ja) * | 2001-10-25 | 2005-05-19 | アセロジエニクス・インコーポレイテツド | 移植拒絶治療のための化合物と方法 |
| AU2002352826B2 (en) * | 2001-11-09 | 2009-05-28 | Atherogenics, Inc. | Methods of reversing and preventing cardiovascular pathologies |
| IL162533A0 (en) * | 2001-12-19 | 2005-11-20 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
| US6960683B2 (en) * | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
| AU2003266165A1 (en) * | 2002-09-13 | 2004-04-30 | Hossein Dovlatabadi | Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels |
| WO2004056727A2 (en) * | 2002-12-19 | 2004-07-08 | Atherogenics, Inc. | Process of making chalcone derivatives |
| CN101391972A (zh) * | 2003-01-13 | 2009-03-25 | 阿特罗吉尼克斯公司 | 制备普罗布考及其衍生物的酯和醚的方法 |
| US7173129B2 (en) * | 2003-06-06 | 2007-02-06 | Athero Genics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| JP2007509054A (ja) * | 2003-10-17 | 2007-04-12 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 血管健康を促進するシリルフェノール |
| US20070260087A1 (en) | 2004-04-20 | 2007-11-08 | Atherogenics, Inc. | Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
| EP1768660A4 (en) * | 2004-07-01 | 2009-05-13 | Atherogenics Inc | COMPOUNDS AND METHOD FOR THE TREATMENT OF DIABETIC VASCULAR DISEASES |
| EP2139320A4 (en) * | 2007-03-26 | 2010-09-08 | Salutria Pharmaceuticals Llc | METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES |
| WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
| EP2558433B1 (en) * | 2010-04-15 | 2014-06-18 | Merck Patent GmbH | Process for the preparation of hydroquinones |
| JP6447858B2 (ja) * | 2016-07-08 | 2019-01-09 | Ｙａｎｃｈｅｒｓ株式会社 | 固形癌治療剤 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129262A (en) * | 1962-10-08 | 1964-04-14 | Consolidation Coal Co | Reduction of organic thiocyanates |
| US3862332A (en) * | 1967-05-11 | 1975-01-21 | Dow Chemical Co | Method of lowering serum cholesterol |
| US3576883A (en) * | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
| US3897500A (en) * | 1971-12-10 | 1975-07-29 | Continental Oil Co | Alkylidenedithiobisphenols |
| US3786100A (en) * | 1971-12-10 | 1974-01-15 | Continental Oil Co | Keto substituted alkylidenedithiobisphenols |
| JPS61263988A (ja) * | 1985-05-16 | 1986-11-21 | Shionogi & Co Ltd | シリル置換エ−テル類および殺虫・殺ダニ剤 |
| US5356917A (en) * | 1985-08-09 | 1994-10-18 | Eli Lilly And Company | Aryl-substituted rhodanine derivatives |
| US4719237A (en) * | 1986-01-28 | 1988-01-12 | Merrell Dow Pharmaceuticals Inc. | Cardiac antiarrythmic method employing probucol |
| US4734527A (en) * | 1986-10-17 | 1988-03-29 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol |
| US4772363A (en) * | 1987-01-14 | 1988-09-20 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol by electrocatalysis |
| US4861443A (en) * | 1987-01-14 | 1989-08-29 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol) by electrocatalysis |
| US5401883A (en) * | 1987-01-20 | 1995-03-28 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol and 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol) |
| US4975467A (en) * | 1987-03-17 | 1990-12-04 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions |
| JPH0813824B2 (ja) * | 1988-10-27 | 1996-02-14 | 北興化学工業株式会社 | 有機ケイ素化合物 |
| US4900757A (en) * | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
| US5047555A (en) * | 1988-12-13 | 1991-09-10 | Tanabe Seiyaku Co., Ltd. | 4-aminophenol derivatives and processes for preparing the same |
| US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
| US5217870A (en) * | 1989-04-28 | 1993-06-08 | Biogen, Inc. | Monoclonal antibodies against CDX |
| US5008421A (en) * | 1989-07-05 | 1991-04-16 | Aristech Chemical Corporation | Silyl derivatives of 2,6-dimethyl-4-allyl phenol |
| DE3935638A1 (de) * | 1989-10-26 | 1991-05-02 | Consortium Elektrochem Ind | Organosilylalkylaromaten |
| US5061734A (en) * | 1990-05-09 | 1991-10-29 | Merrell Dow Pharmaceuticals Inc. | Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis |
| US5112870A (en) * | 1990-05-09 | 1992-05-12 | Merrell Dow Pharmaceuticals Inc. | Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis |
| JP2899064B2 (ja) * | 1990-05-23 | 1999-06-02 | キヤノン株式会社 | 液晶性化合物、これを含む液晶組成物およびこれを使用した液晶素子 |
| US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| NZ238807A (en) * | 1990-07-05 | 1994-03-25 | Merrell Dow Pharma | Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions |
| US5304668A (en) * | 1990-07-05 | 1994-04-19 | Merrell Dow Pharmaceuticals | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents |
| US5254549A (en) * | 1991-12-19 | 1993-10-19 | Merz & Co. Gmbh & Co. | New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs |
| US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
| KR0178958B1 (ko) * | 1992-09-02 | 1999-03-20 | 데이비드 제이.엑커 | 세포 흡착의 올리고누클레오티드 조절 |
| US5380747A (en) * | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| DE69309487T2 (de) * | 1992-11-13 | 1997-10-23 | Univ Washington | Peripheralisierung hämatopoietischer stammzellen |
| CA2152394A1 (en) * | 1992-12-22 | 1994-07-07 | Ronald Joseph King | Piperidine derivatives as calcium channel antagonists |
| DE69419721T2 (de) * | 1993-01-12 | 2000-04-27 | Biogen, Inc. | Rekombinante anti-vla4 antikörpermoleküle |
| ATE161730T1 (de) * | 1993-02-09 | 1998-01-15 | Biogen Inc | Antikörper zur behandlung von insulinabhängigen diabetes |
| AU7559894A (en) * | 1993-08-05 | 1995-02-28 | Isis Pharmaceuticals, Inc. | Oligomers for modulating metabolic function |
| JP3650144B2 (ja) * | 1994-06-08 | 2005-05-18 | 花王株式会社 | 細胞接着抑制剤 |
-
1996
- 1996-04-30 US US08/637,968 patent/US5608095A/en not_active Expired - Fee Related
-
1997
- 1997-03-03 BR BR9709190A patent/BR9709190A/pt active Search and Examination
- 1997-03-03 DE DE69710191T patent/DE69710191T2/de not_active Expired - Fee Related
- 1997-03-03 JP JP53886297A patent/JP4309473B2/ja not_active Expired - Fee Related
- 1997-03-03 CN CN97194267A patent/CN1216993A/zh active Pending
- 1997-03-03 CA CA002251991A patent/CA2251991C/en not_active Expired - Fee Related
- 1997-03-03 IL IL12675897A patent/IL126758A0/xx unknown
- 1997-03-03 DK DK97907998T patent/DK0900225T3/da active
- 1997-03-03 PT PT97907998T patent/PT900225E/pt unknown
- 1997-03-03 ES ES97907998T patent/ES2167716T3/es not_active Expired - Lifetime
- 1997-03-03 AT AT97907998T patent/ATE212639T1/de not_active IP Right Cessation
- 1997-03-03 EP EP97907998A patent/EP0900225B1/en not_active Expired - Lifetime
- 1997-03-03 AU AU19854/97A patent/AU711322B2/en not_active Ceased
- 1997-03-03 KR KR1019980708692A patent/KR100503181B1/ko not_active Expired - Fee Related
- 1997-03-03 WO PCT/US1997/003335 patent/WO1997041129A1/en not_active Ceased
- 1997-04-23 ZA ZA9703503A patent/ZA973503B/xx unknown
- 1997-04-23 TW TW086105269A patent/TW474940B/zh active
- 1997-04-29 AR ARP970101749A patent/AR006890A1/es unknown
-
1998
- 1998-10-29 NO NO985039A patent/NO985039L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69710191T2 (de) | 2002-07-25 |
| AU711322B2 (en) | 1999-10-14 |
| CA2251991A1 (en) | 1997-11-06 |
| US5608095A (en) | 1997-03-04 |
| DE69710191D1 (de) | 2002-03-14 |
| KR20000065101A (ko) | 2000-11-06 |
| EP0900225B1 (en) | 2002-01-30 |
| AR006890A1 (es) | 1999-09-29 |
| ES2167716T3 (es) | 2002-05-16 |
| BR9709190A (pt) | 1999-08-10 |
| DK0900225T3 (da) | 2002-05-13 |
| TW474940B (en) | 2002-02-01 |
| IL126758A0 (en) | 1999-08-17 |
| JP2001509782A (ja) | 2001-07-24 |
| AU1985497A (en) | 1997-11-19 |
| ZA973503B (en) | 1997-10-30 |
| PT900225E (pt) | 2002-06-28 |
| ATE212639T1 (de) | 2002-02-15 |
| CN1216993A (zh) | 1999-05-19 |
| CA2251991C (en) | 2002-05-14 |
| EP0900225A1 (en) | 1999-03-10 |
| WO1997041129A1 (en) | 1997-11-06 |
| NO985039D0 (no) | 1998-10-29 |
| JP4309473B2 (ja) | 2009-08-05 |
| KR100503181B1 (ko) | 2006-03-03 |
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