ES2167716T3 - Alquil-4-silil-fenoles y esteres de los mismos como agentes antiescleroticos. - Google Patents

Alquil-4-silil-fenoles y esteres de los mismos como agentes antiescleroticos.

Info

Publication number
ES2167716T3
ES2167716T3 ES97907998T ES97907998T ES2167716T3 ES 2167716 T3 ES2167716 T3 ES 2167716T3 ES 97907998 T ES97907998 T ES 97907998T ES 97907998 T ES97907998 T ES 97907998T ES 2167716 T3 ES2167716 T3 ES 2167716T3
Authority
ES
Spain
Prior art keywords
rent
independently
hydrogen
inhibit
res
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97907998T
Other languages
English (en)
Spanish (es)
Inventor
Steven J Busch
Kim S Chen
Michael J Edwards
James E Matt Jr
Roger A Parker
Mark J Vaal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2167716T3 publication Critical patent/ES2167716T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES97907998T 1996-04-30 1997-03-03 Alquil-4-silil-fenoles y esteres de los mismos como agentes antiescleroticos. Expired - Lifetime ES2167716T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/637,968 US5608095A (en) 1996-04-30 1996-04-30 Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Publications (1)

Publication Number Publication Date
ES2167716T3 true ES2167716T3 (es) 2002-05-16

Family

ID=24558107

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97907998T Expired - Lifetime ES2167716T3 (es) 1996-04-30 1997-03-03 Alquil-4-silil-fenoles y esteres de los mismos como agentes antiescleroticos.

Country Status (19)

Country Link
US (1) US5608095A (https=)
EP (1) EP0900225B1 (https=)
JP (1) JP4309473B2 (https=)
KR (1) KR100503181B1 (https=)
CN (1) CN1216993A (https=)
AR (1) AR006890A1 (https=)
AT (1) ATE212639T1 (https=)
AU (1) AU711322B2 (https=)
BR (1) BR9709190A (https=)
CA (1) CA2251991C (https=)
DE (1) DE69710191T2 (https=)
DK (1) DK0900225T3 (https=)
ES (1) ES2167716T3 (https=)
IL (1) IL126758A0 (https=)
NO (1) NO985039L (https=)
PT (1) PT900225E (https=)
TW (1) TW474940B (https=)
WO (1) WO1997041129A1 (https=)
ZA (1) ZA973503B (https=)

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CN1216921A (zh) * 1996-04-30 1999-05-19 赫彻斯特马里恩鲁斯公司 用2,6－二烷基－4－甲硅烷基－苯酚诱导血管细胞粘着分子－1和治疗慢性炎症疾病的方法
CN1275596C (zh) * 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2295232A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[ (dimethyl-4-methoxyphenylsilyl) -methyloxy]phenol and 2,6-di-t-butyl-4-[ (dimethyl-2-methoxy-phenylsilyl) -methyloxy]phenol
WO1999001118A2 (en) * 1997-07-01 1999-01-14 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
JP2002529740A (ja) * 1998-11-09 2002-09-10 アセロジエニクス・インコーポレイテツド 血漿コレステロールレベルを低下させるための方法及び組成物
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6020383A (en) * 1999-01-11 2000-02-01 Eastman Chemicals Company Method for reducing blood cholesterol and/or blood triglycerides
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
US20030064967A1 (en) * 2001-04-11 2003-04-03 Jayraz Luchoomun Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters
JP2005514344A (ja) * 2001-10-25 2005-05-19 アセロジエニクス・インコーポレイテツド 移植拒絶治療のための化合物と方法
AU2002352826B2 (en) * 2001-11-09 2009-05-28 Atherogenics, Inc. Methods of reversing and preventing cardiovascular pathologies
IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US6960683B2 (en) * 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
WO2004056727A2 (en) * 2002-12-19 2004-07-08 Atherogenics, Inc. Process of making chalcone derivatives
CN101391972A (zh) * 2003-01-13 2009-03-25 阿特罗吉尼克斯公司 制备普罗布考及其衍生物的酯和醚的方法
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US20060063828A1 (en) * 2004-06-28 2006-03-23 Weingarten M D 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof
EP1768660A4 (en) * 2004-07-01 2009-05-13 Atherogenics Inc COMPOUNDS AND METHOD FOR THE TREATMENT OF DIABETIC VASCULAR DISEASES
EP2139320A4 (en) * 2007-03-26 2010-09-08 Salutria Pharmaceuticals Llc METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
EP2558433B1 (en) * 2010-04-15 2014-06-18 Merck Patent GmbH Process for the preparation of hydroquinones
JP6447858B2 (ja) * 2016-07-08 2019-01-09 Ｙａｎｃｈｅｒｓ株式会社 固形癌治療剤

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Also Published As

Publication number Publication date
DE69710191T2 (de) 2002-07-25
AU711322B2 (en) 1999-10-14
CA2251991A1 (en) 1997-11-06
US5608095A (en) 1997-03-04
DE69710191D1 (de) 2002-03-14
KR20000065101A (ko) 2000-11-06
EP0900225B1 (en) 2002-01-30
AR006890A1 (es) 1999-09-29
BR9709190A (pt) 1999-08-10
DK0900225T3 (da) 2002-05-13
TW474940B (en) 2002-02-01
IL126758A0 (en) 1999-08-17
JP2001509782A (ja) 2001-07-24
AU1985497A (en) 1997-11-19
ZA973503B (en) 1997-10-30
PT900225E (pt) 2002-06-28
ATE212639T1 (de) 2002-02-15
CN1216993A (zh) 1999-05-19
CA2251991C (en) 2002-05-14
EP0900225A1 (en) 1999-03-10
WO1997041129A1 (en) 1997-11-06
NO985039D0 (no) 1998-10-29
NO985039L (no) 1998-12-21
JP4309473B2 (ja) 2009-08-05
KR100503181B1 (ko) 2006-03-03

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