NO974270L - Insulinderivater - Google Patents

Insulinderivater

Info

Publication number
NO974270L
NO974270L NO974270A NO974270A NO974270L NO 974270 L NO974270 L NO 974270L NO 974270 A NO974270 A NO 974270A NO 974270 A NO974270 A NO 974270A NO 974270 L NO974270 L NO 974270L
Authority
NO
Norway
Prior art keywords
insulin derivatives
group
chain
amino acid
terminal amino
Prior art date
Application number
NO974270A
Other languages
English (en)
Other versions
NO974270D0 (no
Inventor
Jan Markussen
Ib Jonassen
Svend Havelund
Jakob Brandt
Peter Kurtzhals
Peter Hertz Hansen
Niels Christian Kaarsholm
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO974270D0 publication Critical patent/NO974270D0/no
Publication of NO974270L publication Critical patent/NO974270L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Insulinderivater hvor en lipofil gruppe som har fra 12 til 40 karbon- atomer, er bundet til a-aminogruppen i den N-terminale aminosyre i B-kjeden eller til karboksygruppen i den C- terminale aminosyre i B-kjeden, har en langvarig virkningsprofil.
NO974270A 1995-03-17 1997-09-16 Insulinderivater NO974270L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK27695 1995-03-17
PCT/DK1996/000107 WO1996029344A1 (en) 1995-03-17 1996-03-18 Insulin derivatives

Publications (2)

Publication Number Publication Date
NO974270D0 NO974270D0 (no) 1997-09-16
NO974270L true NO974270L (no) 1997-11-14

Family

ID=8091725

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974270A NO974270L (no) 1995-03-17 1997-09-16 Insulinderivater

Country Status (14)

Country Link
EP (1) EP0871665B1 (no)
JP (1) JP3872105B2 (no)
KR (1) KR19980703039A (no)
CN (1) CN1196061A (no)
AT (1) ATE245659T1 (no)
AU (1) AU720966B2 (no)
BR (1) BR9607647A (no)
CA (1) CA2215694A1 (no)
CZ (1) CZ289343B6 (no)
DE (1) DE69629210T2 (no)
HU (1) HUP9800523A3 (no)
NO (1) NO974270L (no)
PL (1) PL183698B1 (no)
WO (1) WO1996029344A1 (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
AU1111799A (en) 1997-10-24 1999-05-17 Eli Lilly And Company Fatty acid-acylated insulin analogs
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
ATE352559T1 (de) * 1998-12-08 2007-02-15 Biovation Ltd Verfahren zur verminderung der immunogenität von proteinen
TWI242000B (en) * 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
ATE496064T1 (de) 2002-05-07 2011-02-15 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
CN1247616C (zh) * 2002-07-19 2006-03-29 上海中科生龙达生物技术（集团）有限公司 新的单体胰岛素，药物组合物及其制法
EP2107069B1 (en) 2003-08-05 2013-01-16 Novo Nordisk A/S Novel insulin derivatives
JP2007532096A (ja) * 2003-11-14 2007-11-15 ノボ　ノルディスク　アクティーゼルスカブ アシル化されたインスリンの製造方法
AU2005205867A1 (en) 2004-01-21 2005-08-04 Novo Nordisk Health Care Ag Transglutaminase mediated conjugation of peptides
JP2007529463A (ja) 2004-03-17 2007-10-25 ７ティーエム ファーマ エイ／エス 治療的介入のためのｙ４選択性レセプターアゴニスト
EA011860B1 (ru) 2004-03-17 2009-06-30 7ТиЭм ФАРМА А/С Селективные агонисты рецептора y2 для терапевтического воздействия
EP2256130B1 (en) 2005-02-02 2013-09-25 Novo Nordisk A/S Novel insulin derivatives
WO2006082205A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
ATE519780T1 (de) 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
US8933021B2 (en) 2006-05-09 2015-01-13 Novo Nordisk A/S Insulin derivative
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
EP2058330A1 (en) * 2007-11-08 2009-05-13 Novo Nordisk A/S Insulin derivative
CN101932601B (zh) * 2007-11-08 2016-08-03 诺沃-诺迪斯克有限公司 胰岛素衍生物
EP2254905B1 (en) * 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910570B1 (en) 2008-03-18 2016-10-12 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
SI3554534T1 (sl) 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin
PL3474820T3 (pl) 2017-08-24 2024-05-13 Novo Nordisk A/S Kompozycje glp-1 i ich zastosowania
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CA3122632A1 (en) 2018-12-11 2020-06-18 Sanofi Insulin conjugates
KR20220143037A (ko) 2020-02-18 2022-10-24 노보 노르디스크 에이/에스 Glp-1 조성물 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
AU682061B2 (en) * 1993-09-17 1997-09-18 Novo Nordisk A/S Acylated insulin

Also Published As

Publication number Publication date
AU4939696A (en) 1996-10-08
HUP9800523A2 (hu) 1998-06-29
JPH11502110A (ja) 1999-02-23
CA2215694A1 (en) 1996-09-26
EP0871665A1 (en) 1998-10-21
ATE245659T1 (de) 2003-08-15
WO1996029344A1 (en) 1996-09-26
JP3872105B2 (ja) 2007-01-24
PL183698B1 (pl) 2002-06-28
DE69629210D1 (de) 2003-08-28
HUP9800523A3 (en) 1998-09-28
DE69629210T2 (de) 2004-04-22
BR9607647A (pt) 1999-04-06
NO974270D0 (no) 1997-09-16
CZ289343B6 (cs) 2002-01-16
CN1196061A (zh) 1998-10-14
MX9707056A (es) 1997-11-29
KR19980703039A (ko) 1998-09-05
AU720966B2 (en) 2000-06-22
EP0871665B1 (en) 2003-07-23
CZ289997A3 (cs) 1998-01-14
PL322299A1 (en) 1998-01-19

Similar Documents

Publication Publication Date Title
NO974270L (no) Insulinderivater
NO974269L (no) Lipofile peptidhormonderivater
NO20061026L (no) Nye insulinderivater
ATE399177T1 (de) Derivate therapeutischer peptide
DE69728149D1 (de) Modifizierte liganden für den tie-2-rezeptor
HUP0100928A2 (hu) Humán inzulin B láncának részletét tartalmazó peptidanalógok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
NO974514L (no) Syntetisk HPV6/11 hybrid L1 DNA som koder for humant papillomavirus Type 11 L1-protein
ATE245435T1 (de) Totalsynthese des amino hip analogen von didemnin a
ATE364079T1 (de) Peptide mit gdp-austauschfaktorartiger wirkung, dafür kodierende nukleinsäuresequenzen, ihre herstellung und verwendung
ES2038675T3 (es) Un procedimiento para preparar compuestos peptidicos.
FR2703054B1 (fr) Promoteur vegetal inductible au stress et cellules vegetales contenant une unite d'expression d'une proteine d'interet comprenant ledit promoteur.
DE69834929D1 (de) Verwendung eines organspezifischen ernährungmittels
ES8605769A1 (es) Un procedimiento para la preparacion de un peptido
DE69518246T2 (de) Aminosäuren konjugaten
MX9206732A (es) Nuevas proteinas inhibidoras de trombina a partir de sanguijuelas de tierra.
IT1277391B1 (it) Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
MX9802268A (es) Nuevos derivados de la substancia pf1022 de ciclodepsipeptido.
GT199300023A (es) Derivados de aminoacidos

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application