NO973455L - Dermatologisk anvendelse av Vitamin-D-derivater - Google Patents
Dermatologisk anvendelse av Vitamin-D-derivaterInfo
- Publication number
- NO973455L NO973455L NO973455A NO973455A NO973455L NO 973455 L NO973455 L NO 973455L NO 973455 A NO973455 A NO 973455A NO 973455 A NO973455 A NO 973455A NO 973455 L NO973455 L NO 973455L
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- ester
- seco
- pregna
- dihydroxy
- Prior art date
Links
- 150000003710 vitamin D derivatives Chemical class 0.000 title description 8
- 150000001875 compounds Chemical class 0.000 claims description 47
- 239000002253 acid Substances 0.000 claims description 33
- -1 isopropyl ester Chemical class 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 24
- 150000004702 methyl esters Chemical class 0.000 claims description 15
- 230000000699 topical effect Effects 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000004494 ethyl ester group Chemical group 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 125000006239 protecting group Chemical group 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- 201000004681 Psoriasis Diseases 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 4
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 4
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims description 3
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 2
- 206010000496 acne Diseases 0.000 claims description 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
- 206010051246 Photodermatosis Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000003780 keratinization Effects 0.000 claims 1
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- 239000000126 substance Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 69
- 239000012230 colorless oil Substances 0.000 description 62
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 55
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 15
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- 235000011152 sodium sulphate Nutrition 0.000 description 13
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- 230000000694 effects Effects 0.000 description 5
- SRLXVFJOSYUTPC-UHFFFAOYSA-N (1-ethenylcyclopentyl)oxy-triethylsilane Chemical compound CC[Si](CC)(CC)OC1(C=C)CCCC1 SRLXVFJOSYUTPC-UHFFFAOYSA-N 0.000 description 4
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- UWJYXWZIVOHKCT-XOEOCAAJSA-N (1-triethylsilyloxycyclohexyl)methyl (2s)-2-[(1r,3ar,7ar)-7a-methyl-4-oxo-2,3,3a,5,6,7-hexahydro-1h-inden-1-yl]propanoate Chemical compound O=C([C@@H](C)[C@@H]1[C@]2(CCCC(=O)[C@@H]2CC1)C)OCC1(O[Si](CC)(CC)CC)CCCCC1 UWJYXWZIVOHKCT-XOEOCAAJSA-N 0.000 description 3
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Classifications
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95101030 | 1995-01-26 | ||
| PCT/EP1996/000176 WO1996022776A1 (en) | 1995-01-26 | 1996-01-17 | Dermatological use of vitamin d derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO973455D0 NO973455D0 (no) | 1997-07-25 |
| NO973455L true NO973455L (no) | 1997-09-25 |
Family
ID=8218936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO973455A NO973455L (no) | 1995-01-26 | 1997-07-25 | Dermatologisk anvendelse av Vitamin-D-derivater |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5827883A (de) |
| EP (1) | EP0805682B1 (de) |
| JP (1) | JP2908566B2 (de) |
| KR (1) | KR19980701671A (de) |
| CN (1) | CN1168103A (de) |
| AR (1) | AR003107A1 (de) |
| AT (1) | ATE273010T1 (de) |
| AU (1) | AU4536796A (de) |
| BR (1) | BR9606856A (de) |
| CA (1) | CA2210884A1 (de) |
| CO (1) | CO4700475A1 (de) |
| CZ (1) | CZ238497A3 (de) |
| DE (1) | DE69633106T2 (de) |
| EA (1) | EA199700263A1 (de) |
| ES (1) | ES2225865T3 (de) |
| FI (1) | FI973124A0 (de) |
| HU (1) | HUP9800697A3 (de) |
| IL (1) | IL116825A0 (de) |
| MA (1) | MA23783A1 (de) |
| NO (1) | NO973455L (de) |
| PE (1) | PE28297A1 (de) |
| PL (1) | PL321638A1 (de) |
| TR (1) | TR199700694T1 (de) |
| WO (1) | WO1996022776A1 (de) |
| ZA (1) | ZA96452B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69724646T2 (de) | 1996-12-20 | 2004-06-17 | Chugai Seiyaku K.K. | 16-ene-vitamin d derivate |
| US6184398B1 (en) * | 1996-12-20 | 2001-02-06 | Chugai Seiyaku Kabushiki Kaisha | 16-ene-vitamin D derivatives |
| CN100469764C (zh) | 2000-06-15 | 2009-03-18 | 中外制药株式会社 | 维生素d衍生物 |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| JP4795023B2 (ja) * | 2004-02-03 | 2011-10-19 | 中外製薬株式会社 | ビタミンｄ化合物及びそれらの合成中間体の合成方法 |
| KR20160012242A (ko) * | 2004-12-03 | 2016-02-02 | 니뽄 신야쿠 가부시키가이샤 | 9,10-세코프레그난 유도체 및 의약 |
| CN101460455B (zh) | 2006-06-02 | 2012-05-09 | 日本新药株式会社 | 9,10-断孕甾烷衍生物及医药品 |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| US20120184514A1 (en) * | 2009-07-01 | 2012-07-19 | Vitamin Derivatives Inc. | Vitamin d compounds and methods for preparing same |
| PL237571B1 (pl) * | 2017-05-23 | 2021-05-04 | Inst Farmaceutyczny | Kompozycja dermokosmetyczna do stosowania na skórę zawierająca syntetyczny prekursor analogu witaminy D |
| US20230065886A1 (en) * | 2019-11-27 | 2023-03-02 | Yonsung Fine Chemical Co., Ltd. | Method for producing maxacalcitol, and intermediate therefor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2522962B2 (ja) * | 1986-09-19 | 1996-08-07 | 中外製薬株式会社 | 乾癬治療剤 |
| US4927815A (en) * | 1988-04-29 | 1990-05-22 | Wisconsin Alumni Research Foundation | Compounds effective in inducing cell differentiation and process for preparing same |
| GB9004544D0 (en) * | 1990-03-01 | 1990-04-25 | Leo Pharm Prod Ltd | Novel treatment ii |
| JP2903240B2 (ja) * | 1990-03-23 | 1999-06-07 | 株式会社コーセー | 皮膚外用剤 |
-
1996
- 1996-01-15 PE PE1996000032A patent/PE28297A1/es not_active Application Discontinuation
- 1996-01-17 EA EA199700263A patent/EA199700263A1/ru unknown
- 1996-01-17 HU HU9800697A patent/HUP9800697A3/hu unknown
- 1996-01-17 CN CN96191478A patent/CN1168103A/zh active Pending
- 1996-01-17 DE DE69633106T patent/DE69633106T2/de not_active Expired - Fee Related
- 1996-01-17 JP JP8522596A patent/JP2908566B2/ja not_active Expired - Fee Related
- 1996-01-17 BR BR9606856A patent/BR9606856A/pt not_active Application Discontinuation
- 1996-01-17 EP EP96901286A patent/EP0805682B1/de not_active Expired - Lifetime
- 1996-01-17 WO PCT/EP1996/000176 patent/WO1996022776A1/en active IP Right Grant
- 1996-01-17 PL PL96321638A patent/PL321638A1/xx unknown
- 1996-01-17 CA CA002210884A patent/CA2210884A1/en not_active Abandoned
- 1996-01-17 CZ CZ972384A patent/CZ238497A3/cs unknown
- 1996-01-17 KR KR1019970705067A patent/KR19980701671A/ko not_active Application Discontinuation
- 1996-01-17 US US08/875,187 patent/US5827883A/en not_active Expired - Fee Related
- 1996-01-17 TR TR97/00694T patent/TR199700694T1/xx unknown
- 1996-01-17 ES ES96901286T patent/ES2225865T3/es not_active Expired - Lifetime
- 1996-01-17 AU AU45367/96A patent/AU4536796A/en not_active Abandoned
- 1996-01-17 AT AT96901286T patent/ATE273010T1/de not_active IP Right Cessation
- 1996-01-19 ZA ZA96452A patent/ZA96452B/xx unknown
- 1996-01-19 IL IL11682596A patent/IL116825A0/xx unknown
- 1996-01-23 MA MA24138A patent/MA23783A1/fr unknown
- 1996-01-24 AR ARP960101125A patent/AR003107A1/es unknown
- 1996-01-25 CO CO96003055A patent/CO4700475A1/es unknown
-
1997
- 1997-07-25 FI FI973124A patent/FI973124A0/fi unknown
- 1997-07-25 NO NO973455A patent/NO973455L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9606856A (pt) | 1997-11-25 |
| AU4536796A (en) | 1996-08-14 |
| HUP9800697A3 (en) | 1999-03-01 |
| JP2908566B2 (ja) | 1999-06-21 |
| WO1996022776A1 (en) | 1996-08-01 |
| KR19980701671A (ko) | 1998-06-25 |
| MX9705648A (es) | 1997-10-31 |
| DE69633106T2 (de) | 2005-09-15 |
| CO4700475A1 (es) | 1998-12-29 |
| MA23783A1 (fr) | 1996-10-01 |
| ZA96452B (en) | 1996-07-26 |
| ES2225865T3 (es) | 2005-03-16 |
| EP0805682B1 (de) | 2004-08-11 |
| FI973124A (fi) | 1997-07-25 |
| HUP9800697A2 (hu) | 1998-07-28 |
| NO973455D0 (no) | 1997-07-25 |
| EP0805682A1 (de) | 1997-11-12 |
| FI973124A0 (fi) | 1997-07-25 |
| EA199700263A1 (ru) | 1998-02-26 |
| JPH10502940A (ja) | 1998-03-17 |
| TR199700694T1 (xx) | 1998-02-21 |
| ATE273010T1 (de) | 2004-08-15 |
| IL116825A0 (en) | 1996-05-14 |
| CN1168103A (zh) | 1997-12-17 |
| PL321638A1 (en) | 1997-12-22 |
| PE28297A1 (es) | 1997-08-20 |
| AR003107A1 (es) | 1998-07-08 |
| US5827883A (en) | 1998-10-27 |
| CZ238497A3 (en) | 1997-11-12 |
| CA2210884A1 (en) | 1996-08-01 |
| DE69633106D1 (de) | 2004-09-16 |
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