EA199700263A1 - Применение производных витамина d в дерматологии - Google Patents

Применение производных витамина d в дерматологии

Info

Publication number
EA199700263A1
EA199700263A1 EA199700263A EA199700263A EA199700263A1 EA 199700263 A1 EA199700263 A1 EA 199700263A1 EA 199700263 A EA199700263 A EA 199700263A EA 199700263 A EA199700263 A EA 199700263A EA 199700263 A1 EA199700263 A1 EA 199700263A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
derivatives
application
vitamin
dermatology
Prior art date
Application number
EA199700263A
Other languages
English (en)
Inventor
Пьерр Барбье
Марк Мюллер
Йозеф Штадльвизер
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA199700263A1 publication Critical patent/EA199700263A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описаны производные витамина D формулы (I)где X обозначает =CH или H, H; Y обозначает фрагмент -CH(CH)-(A)-C(O)-OR(а), -CH(CH)-CHO-C(O)-R(б) или -C(O)-OR(в); A обозначает -CH=CH- или CH-CH-; Rобозначает (низший)алкил, циклоалкил, циклоалкилметил, -CHRили -CH-CHR; Rобозначает (низший)алкил, циклоалкил или R; Rобозначает гидрокси(низший)алкил, гидроксициклоалкил или трифторметилгидрокси(низший)алкил; n равно 0 или 1; и обозначенная пунктиром связь в пятичленном кольце является необязательной; которые могут применяться для лечения дерматологических состояний, в частности нарушений кератинизации.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700263A 1995-01-26 1996-01-17 Применение производных витамина d в дерматологии EA199700263A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95101030 1995-01-26
PCT/EP1996/000176 WO1996022776A1 (en) 1995-01-26 1996-01-17 Dermatological use of vitamin d derivatives

Publications (1)

Publication Number Publication Date
EA199700263A1 true EA199700263A1 (ru) 1998-02-26

Family

ID=8218936

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700263A EA199700263A1 (ru) 1995-01-26 1996-01-17 Применение производных витамина d в дерматологии

Country Status (25)

Country Link
US (1) US5827883A (ru)
EP (1) EP0805682B1 (ru)
JP (1) JP2908566B2 (ru)
KR (1) KR19980701671A (ru)
CN (1) CN1168103A (ru)
AR (1) AR003107A1 (ru)
AT (1) ATE273010T1 (ru)
AU (1) AU4536796A (ru)
BR (1) BR9606856A (ru)
CA (1) CA2210884A1 (ru)
CO (1) CO4700475A1 (ru)
CZ (1) CZ238497A3 (ru)
DE (1) DE69633106T2 (ru)
EA (1) EA199700263A1 (ru)
ES (1) ES2225865T3 (ru)
FI (1) FI973124A (ru)
HU (1) HUP9800697A3 (ru)
IL (1) IL116825A0 (ru)
MA (1) MA23783A1 (ru)
NO (1) NO973455L (ru)
PE (1) PE28297A1 (ru)
PL (1) PL321638A1 (ru)
TR (1) TR199700694T1 (ru)
WO (1) WO1996022776A1 (ru)
ZA (1) ZA96452B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184398B1 (en) * 1996-12-20 2001-02-06 Chugai Seiyaku Kabushiki Kaisha 16-ene-vitamin D derivatives
IL130484A (en) * 1996-12-20 2004-07-25 Chugai Pharmaceutical Co Ltd History of -16N-Vitamin-D
CN100469764C (zh) 2000-06-15 2009-03-18 中外制药株式会社 维生素d衍生物
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US9221753B2 (en) 2004-02-03 2015-12-29 Chugai Seiyaku Kabushiki Kaisha Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
KR20160012242A (ko) * 2004-12-03 2016-02-02 니뽄 신야쿠 가부시키가이샤 9,10-세코프레그난 유도체 및 의약
KR20090017640A (ko) 2006-06-02 2009-02-18 니뽄 신야쿠 가부시키가이샤 9,10-세코프레그난 유도체 및 의약
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
US20120184514A1 (en) * 2009-07-01 2012-07-19 Vitamin Derivatives Inc. Vitamin d compounds and methods for preparing same
PL237571B1 (pl) * 2017-05-23 2021-05-04 Inst Farmaceutyczny Kompozycja dermokosmetyczna do stosowania na skórę zawierająca syntetyczny prekursor analogu witaminy D
WO2021107646A1 (ko) * 2019-11-27 2021-06-03 연성정밀화학(주) 막사칼시톨의 제조방법 및 그를 위한 중간체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2522962B2 (ja) * 1986-09-19 1996-08-07 中外製薬株式会社 乾癬治療剤
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
JP2903240B2 (ja) * 1990-03-23 1999-06-07 株式会社コーセー 皮膚外用剤

Also Published As

Publication number Publication date
JP2908566B2 (ja) 1999-06-21
CN1168103A (zh) 1997-12-17
CO4700475A1 (es) 1998-12-29
ZA96452B (en) 1996-07-26
IL116825A0 (en) 1996-05-14
TR199700694T1 (xx) 1998-02-21
NO973455L (no) 1997-09-25
DE69633106D1 (de) 2004-09-16
DE69633106T2 (de) 2005-09-15
WO1996022776A1 (en) 1996-08-01
AR003107A1 (es) 1998-07-08
CZ238497A3 (en) 1997-11-12
BR9606856A (pt) 1997-11-25
EP0805682B1 (en) 2004-08-11
MX9705648A (es) 1997-10-31
MA23783A1 (fr) 1996-10-01
KR19980701671A (ko) 1998-06-25
AU4536796A (en) 1996-08-14
CA2210884A1 (en) 1996-08-01
ES2225865T3 (es) 2005-03-16
EP0805682A1 (en) 1997-11-12
PL321638A1 (en) 1997-12-22
PE28297A1 (es) 1997-08-20
ATE273010T1 (de) 2004-08-15
HUP9800697A2 (hu) 1998-07-28
NO973455D0 (no) 1997-07-25
FI973124A0 (fi) 1997-07-25
HUP9800697A3 (en) 1999-03-01
FI973124A (fi) 1997-07-25
US5827883A (en) 1998-10-27
JPH10502940A (ja) 1998-03-17

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