NO973335L - Fremgangsmåte for fremstilling av et flertall kjemiske stoffer i en tabelloppstilling - Google Patents

Fremgangsmåte for fremstilling av et flertall kjemiske stoffer i en tabelloppstilling

Info

Publication number
NO973335L
NO973335L NO973335A NO973335A NO973335L NO 973335 L NO973335 L NO 973335L NO 973335 A NO973335 A NO 973335A NO 973335 A NO973335 A NO 973335A NO 973335 L NO973335 L NO 973335L
Authority
NO
Norway
Prior art keywords
preparation
chemical substances
table arrangement
arrangement
substances
Prior art date
Application number
NO973335A
Other languages
English (en)
Norwegian (no)
Other versions
NO973335D0 (no
Inventor
Robert A Zambias
David A Bolten
Joseph C Hogan
Paul Furth
David S Casebier
Cheng Tu
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of NO973335D0 publication Critical patent/NO973335D0/no
Publication of NO973335L publication Critical patent/NO973335L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/774—Exhibiting three-dimensional carrier confinement, e.g. quantum dots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/778—Nanostructure within specified host or matrix material, e.g. nanocomposite films
    • Y10S977/779—Possessing nanosized particles, powders, flakes, or clusters other than simple atomic impurity doping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/789—Of specified organic or carbon-based composition in array format
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/789—Of specified organic or carbon-based composition in array format
    • Y10S977/79—Of specified organic or carbon-based composition in array format with heterogeneous nanostructures
    • Y10S977/791—Molecular array

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Structural Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
NO973335A 1995-01-20 1997-07-18 Fremgangsmåte for fremstilling av et flertall kjemiske stoffer i en tabelloppstilling NO973335L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/375,838 US5712171A (en) 1995-01-20 1995-01-20 Method of generating a plurality of chemical compounds in a spatially arranged array
PCT/US1996/001005 WO1996022529A1 (fr) 1995-01-20 1996-01-19 Procede de production de differents composes chimiques constituant un reseau spatial

Publications (2)

Publication Number Publication Date
NO973335D0 NO973335D0 (no) 1997-07-18
NO973335L true NO973335L (no) 1997-08-21

Family

ID=23482579

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973335A NO973335L (no) 1995-01-20 1997-07-18 Fremgangsmåte for fremstilling av et flertall kjemiske stoffer i en tabelloppstilling

Country Status (13)

Country Link
US (4) US5712171A (fr)
EP (1) EP0804726A4 (fr)
JP (1) JPH11503720A (fr)
KR (1) KR100414424B1 (fr)
AU (1) AU719584C (fr)
CA (1) CA2210949A1 (fr)
CZ (1) CZ232297A3 (fr)
HU (1) HUP9802293A3 (fr)
IL (1) IL116838A0 (fr)
NO (1) NO973335L (fr)
NZ (1) NZ301594A (fr)
PL (1) PL327437A1 (fr)
WO (1) WO1996022529A1 (fr)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
EP0874625B1 (fr) 1996-01-22 2005-03-16 Eli Lilly And Company Derives d'indane destines a des compositions antipsychotiques
US6528324B1 (en) * 1996-03-22 2003-03-04 Ontogen Corporation Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports
WO1998008839A1 (fr) * 1996-08-26 1998-03-05 Eli Lilly And Company Procede combinatoire de preparation d'echantillotheques de thiophene substitue
US6042789A (en) * 1996-10-23 2000-03-28 Glaxo Group Limited System for parallel synthesis of organic compounds
US6149869A (en) * 1996-10-23 2000-11-21 Glaxo Wellcome Inc. Chemical synthesizers
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
EP0935789A1 (fr) 1996-11-04 1999-08-18 3-Dimensional Pharmaceuticals, Inc. Systeme, procede et produit programme informatique pour visualiser, traiter et analyser de fa on interactive des donnees chimiques
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6054325A (en) * 1996-12-02 2000-04-25 Glaxo Wellcom Inc. Method and apparatus for transferring and combining distinct chemical compositions with reagents
JP4704317B2 (ja) * 1996-12-26 2011-06-15 株式会社日本触媒 樹脂粒子の製造方法
US5976894A (en) * 1997-04-14 1999-11-02 Pharmacopeia, Inc. Combinatorial amide alcohol libraries
AU7135598A (en) * 1997-04-16 1998-11-11 Arqule, Inc. Synthesis and use of biased arrays
CA2293593A1 (fr) * 1997-06-03 1998-12-10 Arqule, Inc. Procede automatise a haut debit permettant de cribler une pluralite de composes par spectrometrie de masse
JP2001510797A (ja) 1997-07-22 2001-08-07 イーライ・リリー・アンド・カンパニー 医薬化合物
GB9724784D0 (en) * 1997-11-24 1998-01-21 Biofocus Plc Method of designing chemical substances
AU1818199A (en) * 1997-12-11 1999-06-28 President & Fellows Of Harvard College, The Anti-picornaviral ligands via a combinatorial computational and synthetic appro ach
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
AU2083499A (en) * 1997-12-31 1999-07-19 Amersham Biosciences Ab Method for binding albumin and means to be used in the method
US5968361A (en) * 1998-02-24 1999-10-19 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
US6497820B1 (en) 1998-02-03 2002-12-24 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
AU2774199A (en) 1998-02-19 1999-09-06 Washington University Beta-lactam-like chaperone inhibitors
DE19812210C1 (de) 1998-03-19 1999-05-06 Siemens Ag Vorrichtung und Verfahren zum Sichern eines Kraftfahrzeugs gegen unberechtigte Benutzung
AU767185B2 (en) 1998-03-23 2003-11-06 President And Fellows Of Harvard College Synthesis of compounds and libraries of compounds
US6872535B2 (en) 1998-05-20 2005-03-29 Aventis Pharmaceuticals Inc. Three-dimensional array of supports for solid-phase parallel synthesis and method of use
US6541211B1 (en) * 1998-05-20 2003-04-01 Selectide Corporation Apparatus and method for synthesizing combinational libraries
US5993662A (en) * 1998-08-28 1999-11-30 Thetagen, Inc. Method of purifying and identifying a large multiplicity of chemical reaction products simultaneously
US6827979B2 (en) * 1999-01-07 2004-12-07 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or produced thereby
US20020122873A1 (en) * 2000-01-05 2002-09-05 Mirkin Chad A. Nanolithography methods and products therefor and produced thereby
US6635311B1 (en) * 1999-01-07 2003-10-21 Northwestern University Methods utilizing scanning probe microscope tips and products therefor or products thereby
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
DE60045474D1 (de) * 1999-01-13 2011-02-17 Univ New York State Res Found Neues verfahren zum erschaffen von proteinkinase-inhibitoren
US7070936B1 (en) 1999-01-13 2006-07-04 The Research Foundation Of State University Of New York Method for designing protein kinase inhibitors
US6500609B1 (en) * 1999-02-11 2002-12-31 Scynexis Chemistry & Automation, Inc. Method and apparatus for synthesizing characterizing and assaying combinatorial libraries
US6355641B1 (en) 1999-03-17 2002-03-12 Syntex (U.S.A.) Llc Oxazolone derivatives and uses thereof
US6824987B1 (en) 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
US7932213B2 (en) * 1999-05-11 2011-04-26 President And Fellows Of Harvard College Small molecule printing
FR2795022A1 (fr) * 1999-06-21 2000-12-22 Michelin Soc Tech Ensemble d'un pneumatique, d'une jante et d'un adaptateur
US6362342B1 (en) 1999-06-29 2002-03-26 Lion Bioscience Ag Triazole compounds and methods of making same
US6524863B1 (en) 1999-08-04 2003-02-25 Scynexis Chemistry & Automation, Inc. High throughput HPLC method for determining Log P values
US6413431B1 (en) 1999-08-10 2002-07-02 Scynexis Chemistry & Automation, Inc. HPLC method for purifying organic compounds
EP1212128A1 (fr) 1999-08-27 2002-06-12 Scynexis Chemistry and Automation, Inc. Preparation d'echantillons pour purification a grand debit
US20030044846A1 (en) 2001-04-03 2003-03-06 Gary Eldridge Screening of chemical compounds purified from biological sources
ES2592507T3 (es) 1999-09-03 2016-11-30 The Brigham And Women's Hospital, Inc. Métodos y composiciones para el tratamiento de enfermedad inflamatoria mediante el uso de agentes moduladores de cadherina-11
EP1216037A2 (fr) * 1999-09-21 2002-06-26 Emory University Procedes et compositions pour le traitement de troubles lies aux plaquettes au moyen d'agents inhibiteurs de trajet de mpl
AU1591301A (en) 1999-11-09 2001-06-06 Sri International Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
SG121902A1 (en) * 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US7039621B2 (en) 2000-03-22 2006-05-02 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method, and computer program product for representing object relationships in a multidimensional space
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US20050070578A1 (en) * 2000-03-30 2005-03-31 Baxter Anthony David Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7139739B2 (en) 2000-04-03 2006-11-21 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for representing object relationships in a multidimensional space
US6339182B1 (en) 2000-06-20 2002-01-15 Chevron U.S.A. Inc. Separation of olefins from paraffins using ionic liquid solutions
US6834239B2 (en) * 2000-08-22 2004-12-21 Victor S. Lobanov Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
WO2002025504A2 (fr) * 2000-09-20 2002-03-28 Lobanov Victor S Procede, systeme, et produit de programme informatique permettant de coder et d'elaborer des produits d'une bibliotheque combinatoire virtuelle
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
WO2002045215A2 (fr) * 2000-10-20 2002-06-06 Northwestern University Procedes nanolithographiques et produits associes obtenus par ces procedes
WO2002061419A1 (fr) * 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Procede, systeme et progiciel permettant d'analyser les banques combinatoires
CA2383094A1 (fr) * 2001-04-24 2002-10-24 Nitech S.A. Cellule electrochimique
EP1461605A4 (fr) * 2001-10-02 2009-10-21 Univ Northwestern Nanoreseaux de proteines et de peptides
US7005445B2 (en) * 2001-10-22 2006-02-28 The Research Foundation Of State University Of New York Protein kinase and phosphatase inhibitors and methods for designing them
US7129225B2 (en) * 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss
US6846846B2 (en) * 2001-10-23 2005-01-25 The Trustees Of Columbia University In The City Of New York Gentle-acting skin disinfectants
US7361310B1 (en) 2001-11-30 2008-04-22 Northwestern University Direct write nanolithographic deposition of nucleic acids from nanoscopic tips
US20040023248A1 (en) * 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
US20040009495A1 (en) * 2001-12-07 2004-01-15 Whitehead Institute For Biomedical Research Methods and products related to drug screening using gene expression patterns
US6849774B2 (en) * 2001-12-31 2005-02-01 Chevron U.S.A. Inc. Separation of dienes from olefins using ionic liquids
AU2003209054A1 (en) * 2002-02-07 2003-09-02 Discovery Genomics, Inc. Factors for angiogenesis, vasculogenesis, cartilage formation, bone formation and methods of use thereof
EP1496905B1 (fr) 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulateurs de voies de signalisation hedgehog, compositions et utilisations associees
JP2005531540A (ja) 2002-04-30 2005-10-20 トラスティーズ・オブ・タフツ・カレッジ セリンプロテアーゼ阻害剤のスマートプロドラッグ
MXPA04011769A (es) * 2002-05-31 2005-07-26 Indian Agricultural Council Deteccion rapida de toxinas cry de bacillus thuringiensis.
US7108992B2 (en) * 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
US7683003B2 (en) 2004-06-16 2010-03-23 Dow Global Technologies, Inc. Method for identifying Ziegler-Natta cocatalysts
WO2006007093A1 (fr) 2004-06-16 2006-01-19 Dow Global Technologies Inc. Appareil et procede de recherche ziegler-natta
EP3009459B1 (fr) * 2004-06-16 2017-08-02 Dow Global Technologies LLC Procédé de polymérisation d'oléfine employant un modificateur
WO2006039569A1 (fr) * 2004-09-30 2006-04-13 The University Of Chicago Polytherapie d'inhibiteurs hedgehog, de rayonnement et d'agents chimiotherapeutiques
US7803790B2 (en) 2005-05-09 2010-09-28 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US7333907B2 (en) * 2005-07-29 2008-02-19 Agilent Technologies, Inc. System and methods for characterization of chemical arrays for quality control
EP1945202A2 (fr) * 2005-11-11 2008-07-23 Licentia OY Inhibiteurs de signalisation du herisson des mammiferes
CN101384757A (zh) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 小分子印渍
WO2008005290A2 (fr) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Procédés de test d'agents anti-thrombotiques
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
US20080103116A1 (en) * 2006-11-01 2008-05-01 Jennings-Spring Barbara L Method of treatment and compositions of D-chiro inositol and phosphates thereof
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20080242559A1 (en) * 2007-03-28 2008-10-02 Northwestern University Protein and peptide arrays
US7928202B2 (en) 2007-04-12 2011-04-19 The Brigham And Women's Hospital, Inc. Targeting ABCB5 for cancer therapy
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
JP5576790B2 (ja) * 2007-06-11 2014-08-20 アール ロッチ マクドナルド 脳血管れん縮の予防用薬物送達システム
RU2492232C2 (ru) 2007-08-31 2013-09-10 Уайтхэд Инститьют Фор Байомедикал Рисерч СТИМУЛЯЦИЯ ПУТИ Wnt ПРИ ПЕРЕПРОГРАММИРОВАНИИ СОМАТИЧЕСКИХ КЛЕТОК
WO2009089380A2 (fr) * 2008-01-08 2009-07-16 The Trustees Of Columbia University In The City Of New York Procédés pour la régulation médiée par p2ry5 de la pousse de cheveux et des mutants de ceux-ci
CA2737146A1 (fr) 2008-07-25 2010-01-28 The Regents Of The University Of Colorado Inhibiteurs de clip et procedes de modulation de la fonction immune
WO2010074783A1 (fr) 2008-12-23 2010-07-01 The Trustees Of Columbia University In The City Of New York Inhibiteurs de la phosphodiestérase et utilisations de ces derniers
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
US20110045053A1 (en) * 2009-08-18 2011-02-24 Shen Michael M Isolated population of luminal stem cells that give rise to prostate cancer and methods of using same
WO2011072243A1 (fr) 2009-12-10 2011-06-16 The Trustees Of Columbia University In The City Of New York Activateurs d'histone acétyltransférase et utilisation de ceux-ci
US10640457B2 (en) 2009-12-10 2020-05-05 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
BR112013009196A2 (pt) 2010-10-15 2020-08-25 The Trustees Of Columbia University In The City Of New York usos de polipeptídeo para redução da aquisição de ácido graxo e da ingestão de alimento, bem como para promoção de saciedade relacionados à obesidade
WO2012061537A2 (fr) 2010-11-02 2012-05-10 The Trustees Of Columbia University In The City Of New York Méthodes de traitement de troubles capillaires
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
WO2012088420A1 (fr) 2010-12-22 2012-06-28 The Trustees Of Columbia University In The City Of New York Modulateurs de l'histone acétyltransférase et leurs utilisations
SG10201602665UA (en) 2011-04-05 2016-05-30 Edge Therapeutics Intraventricular Drug Delivery System For Improving Outcome After A Brain Injury Affecting Cerebral Blood Flow
CN103930165B (zh) 2011-09-02 2018-05-25 纽约市哥伦比亚大学理事会 用以治疗肥胖症的代谢紊乱的CaMKII、IP3R、钙调神经磷酸酶、P38和MK2/3抑制剂
WO2013109738A1 (fr) 2012-01-17 2013-07-25 The Trustees Of Columbia University In The City Of New York Nouveaux inhibiteurs de la phosphodiestérase et utilisations de ceux-ci
PL2830662T3 (pl) 2012-03-29 2019-02-28 The Trustees Of Columbia University In The City Of New York Sposoby leczenia zaburzeń utraty włosów
US9399019B2 (en) 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
WO2014082096A1 (fr) 2012-11-26 2014-05-30 The Trustees Of Columbia University In The City Of New York Procédé pour la culture d'organoïdes de prostate humaine et murine et utilisations correspondantes
EP3022205B1 (fr) 2013-07-17 2020-02-05 The Trustees of Columbia University in the City of New York Nouveaux inhibiteurs de la phosphodiestérase et utilisations de ceux-ci
CN112229834A (zh) * 2015-04-14 2021-01-15 亿明达股份有限公司 用于改进对光发射的检测的结构化基底及涉及其的方法

Family Cites Families (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1809950U (de) 1959-12-29 1960-04-21 Kabelwerke Reinshagen G M B H Isolierte elektrische leitung.
US3410880A (en) * 1963-10-30 1968-11-12 Procter & Gamble N-trialkylammonium imides of higher fatty acids
DE1545810A1 (de) 1965-05-06 1969-12-11 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden
US3450673A (en) * 1965-09-07 1969-06-17 Ashland Oil Inc Polyurethane compositions from diaminimides
US3488389A (en) * 1965-09-07 1970-01-06 Ashland Oil Inc Perfluoroimides
NL131743C (fr) 1965-12-17
DE1745348A1 (de) * 1967-12-01 1971-09-09 Roehm Gmbh Azlactongruppen enthaltende Mischpolymerisate
US3598790A (en) * 1966-07-01 1971-08-10 Roehm & Haas Gmbh Azlactone copolymers
US3488327A (en) * 1967-06-30 1970-01-06 Roehm & Haas Gmbh Preparation of coating materials
DE1645225C3 (de) * 1966-09-10 1974-08-29 Roehm Gmbh, 6100 Darmstadt Verfahren zur Herstellung von Pfropfpolymerisaten
DE1618399A1 (de) 1967-04-05 1970-11-05 Hoechst Ag Verfahren zur Herstellung von N-Sulfonyl-N'-alkyl-harnstoffen
US3499032A (en) * 1967-04-25 1970-03-03 Ashland Oil Inc Hydroxyl-,mercapto-,and amino-substituted aminimides
US3527802A (en) * 1967-05-05 1970-09-08 Ashland Oil Inc Acrylic aminimides
US3664990A (en) * 1967-05-05 1972-05-23 Ashland Oil Inc Acrylic aminimides and polymers thereof
US3756994A (en) * 1967-08-23 1973-09-04 Ashland Oil Inc Vinyl aromatic aminimides and polymers thereof
US3641145A (en) * 1967-08-23 1972-02-08 Ashland Oil Inc Vinyl aromatic aminimides
US3485806A (en) * 1968-02-07 1969-12-23 Ashland Oil Inc Hydroxy substituted aminimides
US3671473A (en) * 1968-03-19 1972-06-20 Ashland Oil Inc Polymers formed from the reaction of a mixture of a polyepoxide and a polyester and an unsymmetrical disubstituted hydrazine
US3565868A (en) * 1968-03-19 1971-02-23 Ashland Oil Inc Polymers of unsymmetrical disubstituted hydrazine
US3555095A (en) * 1968-03-19 1971-01-12 Ashland Oil Inc Hydroxy aminimines
US3676453A (en) * 1968-11-07 1972-07-11 Merck & Co Inc Oxazole and oxazol-5-one derivatives
DE1809950A1 (de) 1968-11-20 1970-06-11 Basf Ag Substituierte Hydrazinderivate und diese enthaltende Mittel zur Regulierung des Pflanzenwachstums
US3567725A (en) * 1968-11-20 1971-03-02 Merck & Co Inc Process for preparation of 1h-imidazo-(4,5-b)pyrazin-2-ones
JPS494853B1 (fr) * 1969-03-14 1974-02-04
US3706797A (en) * 1969-08-06 1972-12-19 Ashland Oil Inc Bisacyl aminimides
US3706800A (en) * 1970-02-26 1972-12-19 Ashland Oil Inc Process for the preparation of aminimides
DE2009218C3 (de) * 1970-02-27 1980-07-17 Roehm Gmbh, 6100 Darmstadt Verfahren zur Perlpolymerisation von äthylenisch ungesättigten Monomeren
US3781319A (en) * 1970-09-28 1973-12-25 Univ Iowa Process for preparing isocyanates
JPS4843809B1 (fr) * 1970-12-18 1973-12-20
US3811887A (en) * 1970-12-18 1974-05-21 Konishiroku Photo Ind Photographic material comprising bisacylhydrazinium compounds
US3803220A (en) * 1971-03-02 1974-04-09 Kendall & Co Mono aminimide derivatives of unsaturated dicarboxylic acids
US3893974A (en) * 1971-04-20 1975-07-08 Permachem Asia Co Ltd Epoxy resin compositions containing aminimide compound
US3850969A (en) * 1971-05-28 1974-11-26 Ashland Oil Inc Process for the preparation of hydroxy substituted aminimides
US3715343A (en) * 1971-08-11 1973-02-06 Ashland Oil Inc Polymers of vinyl aminimides
US3963703A (en) * 1971-09-13 1976-06-15 Ashland Oil, Inc. Trialkylammonium -N-[β(1-aziridinyl)] propionoylimines
US3904749A (en) * 1971-10-22 1975-09-09 Ashland Oil Inc Hair setting preparations
US3818065A (en) * 1971-12-22 1974-06-18 Basf Ag Production of aminoacid precursors
US3828007A (en) * 1972-02-18 1974-08-06 Ashland Oil Inc Process of reacting isocyanate or isothiocyanate and compositions therefor
US3728387A (en) * 1972-03-17 1973-04-17 Ashland Oil Inc Acrylamide of methacrylamide monomer with n-substituted amininmide residues
US4070348A (en) * 1973-07-25 1978-01-24 Rohm Gmbh Water-swellable, bead copolymer
US3969298A (en) * 1973-08-24 1976-07-13 The Kendall Company Selected lipophilic aminimides and polymers derived therefrom useful for making stable emulsions
US3983166A (en) * 1974-03-18 1976-09-28 The Kendall Company Monomeric emulsion stabilizers
US3934035A (en) * 1974-04-29 1976-01-20 Michigan State University Certain aminimides used to control bacteria and fungi
US3934029A (en) * 1974-04-29 1976-01-20 Michigan State University Certain aminimides used to control bacteria and fungi
US3934031A (en) * 1974-04-29 1976-01-20 Michigan State University Certain aminimides used to control bacteria and fungi
US3946131A (en) * 1974-05-06 1976-03-23 Owens-Corning Fiberglas Corporation Glass fibers coated with silicon containing aminimide compounds
US3898087A (en) * 1974-06-14 1975-08-05 Ball Corp Photopolymerizable compositions containing aminimides
US3925284A (en) * 1974-06-24 1975-12-09 Upjohn Co Polyisocyanate-based foam process using aminimides as catalyst
US3963776A (en) * 1974-06-24 1976-06-15 E. I. Du Pont De Nemours And Company Amine fluoroacylimide surfactants
US4080206A (en) * 1974-12-30 1978-03-21 Polaroid Corporation Photographic processing composition containing polyvinyl aminimide
US3968065A (en) * 1974-12-30 1976-07-06 The B. F. Goodrich Company Vulcanizable polymer blends of a halogen-containing polymer and a carboxyl-containing polymer
US3985807A (en) * 1975-03-31 1976-10-12 Ashland Oil, Inc. Alkoxy derivatives of hydroxy aminimides
US4005055A (en) * 1975-05-22 1977-01-25 Skeist Laboratories, Incorporated Anaerobic aminimide curing compositions
US4016340A (en) * 1975-08-07 1977-04-05 Polaroid Corporation Hydroxyl-containing polymers having aminimide groups attached thereto through an ether linkage
US4046658A (en) * 1975-08-15 1977-09-06 General Motors Corporation Process for electrocoating aminimide containing compositions
US4022623A (en) * 1975-10-28 1977-05-10 Polaroid Corporation Photosensitive emulsion containing polyvinyl aminimide polymers
US4217364A (en) * 1975-11-18 1980-08-12 Michigan State University Antimicrobial compositions
US4189481A (en) * 1975-11-18 1980-02-19 Michigan State University Antimicrobial compositions
DE2608482C2 (de) * 1976-03-02 1978-03-30 Hoechst Ag, 6000 Frankfurt Verfahren zum Farben von wasserunlöslichen, thermoplastischen Polymerisaten und Polykondensaten in der Masse
US4067830A (en) * 1976-03-29 1978-01-10 Ashland Oil, Inc. Catalytic trimerization of polyisocyanates
US4260705A (en) * 1976-06-30 1981-04-07 Board Of Regents, For And On Behalf Of The University Of Florida Addition copolymers of aminimides useful for affinity chromatography
US4212905A (en) * 1976-06-30 1980-07-15 Board of Reagents, for and on behalf of the University of Florida Method of coating supports using addition copolymers of aminimides
US4213860A (en) * 1976-06-30 1980-07-22 Board of Regents, State of Florida for and on behalf of the University of Florida Affinity chromatography and substrate useful therefor
US4162355A (en) * 1976-06-30 1979-07-24 Board Of Regents, For And On Behalf Of The University Of Florida Copolymers of (a) aminimides and (b) vinyl pendant primary halomethy monomers useful for affinity chromatography
US4102916A (en) * 1976-12-02 1978-07-25 Ciba-Geigy Corporation Perfluoroalkylthioaminimide derivatives
US4078901A (en) * 1976-12-20 1978-03-14 Texaco Inc. Detergent fuel composition
US4140680A (en) * 1976-12-22 1979-02-20 Polaroid Corporation 2-Acrylamido-2-methylpropane sulfonic acid vinyl aminimide/copolymer
US4280008A (en) * 1976-12-24 1981-07-21 Basf Aktiengesellschaft Chirally substituted 2-imidazolin-5-ones
FR2381813A1 (fr) * 1977-02-24 1978-09-22 Oreal Composition moussante pour recipient pressurise du type " bombe aerosol "
US4378411A (en) * 1980-01-02 1983-03-29 Minnesota Mining And Manufacturing Company Radiation-curable polymers
US4304705A (en) * 1980-01-02 1981-12-08 Minnesota Mining And Manufacturing Company Radiation-curable polymers containing pendant unsaturated peptide groups derived from azlactone polymers
US4424272A (en) * 1981-08-03 1984-01-03 Polaroid Corporation Temporary polymeric mordants and elements containing same
US4777276A (en) * 1981-10-29 1988-10-11 Minnesota Mining And Manufacturing Company Acrylamidoacylated oligomers
US4485236A (en) * 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
US4451619A (en) * 1982-09-30 1984-05-29 Minnesota Mining And Manufacturing Company Method of hydrophilizing or hydrophobizing polymers
FR2540870A1 (fr) * 1983-02-15 1984-08-17 Provesan Sa Nouveaux derives de betaines n-iminopyridinium, leur preparation et leur application en tant que medicaments
US4548981A (en) * 1983-07-01 1985-10-22 Polaroid Corporation Compositions and articles containing polymeric vinyl aromatic aminimides
US4695608A (en) * 1984-03-29 1987-09-22 Minnesota Mining And Manufacturing Company Continuous process for making polymers having pendant azlactone or macromolecular moieties
US4617253A (en) * 1984-06-06 1986-10-14 Polaroid Corporation Polymeric pyridinium ylides and products prepared from same
US4667012A (en) * 1984-12-14 1987-05-19 Minnesota Mining And Manufacturing Company Imidazolinone-containing polymer and copolymer
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4740568A (en) * 1985-04-09 1988-04-26 Minnesota Mining And Manufacturing Company Triazolinethione-containing polymer
US4624995A (en) * 1985-04-09 1986-11-25 Minnesota Mining And Manufacturing Company Triazolinethione-containing polymer
CA1325222C (fr) 1985-08-23 1993-12-14 Lederle (Japan), Ltd. Procede pour la production d'acide 4-biphenylylacetique
US4645711A (en) * 1985-08-26 1987-02-24 Minnesota Mining And Manufacturing Company Removable pressure-sensitive adhesive tape
US4705824A (en) * 1986-02-14 1987-11-10 W. R. Grace & Co. Poly(5-imidazolone) and process therefor
US4777217A (en) * 1987-02-26 1988-10-11 Minnesota Mining And Manufacturing Company Methacrylamide functional polymers and method
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US4737560A (en) * 1987-03-13 1988-04-12 Minnesota Mining And Manufacturing Company Polymer beads
US4816554A (en) * 1987-05-27 1989-03-28 Minnesota Mining And Manufacturing Company Poly(amido methyl-benzazole)
US5300425A (en) 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US4841021A (en) * 1987-11-30 1989-06-20 Minnesota Mining And Manufacturing Company Polypyridinium
US4898923A (en) * 1987-11-30 1990-02-06 Minnesota Mining And Manufacturing Company Polypyridinium copolymer
GB8803416D0 (en) * 1988-02-15 1988-03-16 Minnesota Mining & Mfg Polymeric polymethine dyes & optical data storage media containing same
US4852969A (en) * 1988-03-17 1989-08-01 Minnesota Mining And Manufacturing Company Silyl 2-amidoacetate and silyl 3-amidopropionate compositions and optical fiber made therefrom
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5225533A (en) 1988-05-02 1993-07-06 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE3831716A1 (de) 1988-09-17 1990-03-22 Basf Ag Verfahren zur herstellung von dipeptiden mit c-terminalen nicht-proteinogenen aminosaeuren
DE3831717A1 (de) * 1988-09-17 1990-03-22 Basf Ag Verfahren zur herstellung von dipeptiden mit n-terminalen nicht-proteinogenen aminosaeuren
US5049656A (en) 1988-12-21 1991-09-17 Board Of Regents Of The University Of Nebraska Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
US5053454A (en) 1989-02-15 1991-10-01 Sri International Multiple polymer synthesizer
US5013795A (en) * 1989-04-10 1991-05-07 Minnesota Mining And Manufacturing Company Azlactone graft copolymers
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5185102A (en) 1989-06-08 1993-02-09 Minnesota Mining And Manufacturing Company Polymeric charge transfer complexes for nonlinear optical applications
US4981933A (en) * 1989-06-23 1991-01-01 Polaroid Corporation Azlactone copolymers
US5075352A (en) * 1989-08-15 1991-12-24 Minnesota Mining And Manufacturing Company Stabilized polymeric dispersions
US5147957A (en) * 1989-09-22 1992-09-15 Minnesota Mining And Manufacturing Company Hydrosilated azlactone functional silicon containing compounds and derivatives thereof
US5157108A (en) 1989-12-12 1992-10-20 Minnesota Mining And Manufacturing Company Thermally sensitive linkages
US5066559A (en) * 1990-01-22 1991-11-19 Minnesota Mining And Manufacturing Company Liquid electrophotographic toner
US5149806A (en) 1990-03-28 1992-09-22 Minnesota Mining And Manufacturing Company Azlactone michael adducts
US5039813A (en) * 1990-06-29 1991-08-13 Polaroid Corporation 2-(4-alkenylphenyl)-5-oxazolones and polymers thereof
US5094766A (en) * 1990-07-02 1992-03-10 Texaco Inc. Dispersant-antioxidant viscosity index improver
US5175081A (en) 1990-08-31 1992-12-29 Minnesota Mining And Manufacturing Company Post-processsing stabilization of photothermographic emulsions
US5194623A (en) 1990-08-31 1993-03-16 Minnesota Mining And Manufacturing Company Azlactone based photographic reagents
US5091489A (en) * 1990-10-23 1992-02-25 Minnesota Mining And Manufacturing Company Oligo (2-alkenyl azlactones)
US5081197A (en) * 1990-10-23 1992-01-14 Minnesota Mining And Manufacturing Company Oligo(2-alkenyl azlactones)
US5200471A (en) 1990-11-05 1993-04-06 Minnesota Mining And Manufacturing Company Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same
US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
US5359115A (en) 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5324483B1 (en) 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5367053A (en) 1993-05-19 1994-11-22 Houghten Pharmaceuticals, Inc. Opioid peptide inhibitors
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties

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IL116838A0 (en) 1996-07-23
EP0804726A1 (fr) 1997-11-05
KR19980703097A (ko) 1998-10-15
WO1996022529A1 (fr) 1996-07-25
US5712171A (en) 1998-01-27
US6878557B1 (en) 2005-04-12
KR100414424B1 (ko) 2004-07-07
PL327437A1 (en) 1998-12-07
HUP9802293A3 (en) 1999-03-29
AU719584C (en) 2001-07-26
HUP9802293A2 (hu) 1999-02-01
AU719584B2 (en) 2000-05-11
NO973335D0 (no) 1997-07-18
US5962736A (en) 1999-10-05
US5736412A (en) 1998-04-07
JPH11503720A (ja) 1999-03-30
CZ232297A3 (cs) 1998-06-17
AU4705996A (en) 1996-08-07
CA2210949A1 (fr) 1996-07-25
EP0804726A4 (fr) 2004-07-07
NZ301594A (en) 1999-01-28

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