NO972190L - Hydrat for medisinsk anvendelse - Google Patents
Hydrat for medisinsk anvendelseInfo
- Publication number
- NO972190L NO972190L NO972190A NO972190A NO972190L NO 972190 L NO972190 L NO 972190L NO 972190 A NO972190 A NO 972190A NO 972190 A NO972190 A NO 972190A NO 972190 L NO972190 L NO 972190L
- Authority
- NO
- Norway
- Prior art keywords
- hydrate
- dimethoxy
- chloro
- ethyl
- methylphenyl
- Prior art date
Links
- 239000013078 crystal Substances 0.000 claims abstract description 54
- 238000002441 X-ray diffraction Methods 0.000 claims abstract description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 98
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 49
- KSWPGVNFLOBEBO-UHFFFAOYSA-N 3-[2-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]ethyl]-1-(1h-imidazol-5-ylmethyl)-5,6-dimethoxyindazole Chemical compound N=1N(CC=2N=CNC=2)C=2C=C(OC)C(OC)=CC=2C=1CCN(CC1)CCN1C1=CC=CC(Cl)=C1C KSWPGVNFLOBEBO-UHFFFAOYSA-N 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 18
- NSCWUFNNLDMDJJ-UHFFFAOYSA-N 3-[2-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]ethyl]-1-(1h-imidazol-5-ylmethyl)-5,6-dimethoxyindazole;hydrate;hydrochloride Chemical compound O.Cl.N=1N(CC=2N=CNC=2)C=2C=C(OC)C(OC)=CC=2C=1CCN(CC1)CCN1C1=CC=CC(Cl)=C1C NSCWUFNNLDMDJJ-UHFFFAOYSA-N 0.000 claims description 12
- IHRBZSIEWFFJQW-UHFFFAOYSA-N 3-[2-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]ethyl]-1-(1h-imidazol-5-ylmethyl)-5,6-dimethoxyindazole;dihydrochloride Chemical compound Cl.Cl.N=1N(CC=2N=CNC=2)C=2C=C(OC)C(OC)=CC=2C=1CCN(CC1)CCN1C1=CC=CC(Cl)=C1C IHRBZSIEWFFJQW-UHFFFAOYSA-N 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- IWKCLHUCYFCZJQ-UHFFFAOYSA-N 3-[2-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]ethyl]-1-(1h-imidazol-5-ylmethyl)-5,6-dimethoxyindazole;hydrochloride Chemical compound Cl.N=1N(CC=2N=CNC=2)C=2C=C(OC)C(OC)=CC=2C=1CCN(CC1)CCN1C1=CC=CC(Cl)=C1C IWKCLHUCYFCZJQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 abstract description 12
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- 229910052739 hydrogen Inorganic materials 0.000 description 77
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- 238000006243 chemical reaction Methods 0.000 description 18
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 3
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- 230000000971 hippocampal effect Effects 0.000 description 1
- 210000004295 hippocampal neuron Anatomy 0.000 description 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 description 1
- 229960004135 idebenone Drugs 0.000 description 1
- 150000002473 indoazoles Chemical class 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- GKKCIDNWFBPDBW-UHFFFAOYSA-M potassium cyanate Chemical compound [K]OC#N GKKCIDNWFBPDBW-UHFFFAOYSA-M 0.000 description 1
- 238000001144 powder X-ray diffraction data Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 229960003912 probucol Drugs 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- SAALQYKUFCIMHR-UHFFFAOYSA-N propan-2-ol;2-propan-2-yloxypropane Chemical compound CC(C)O.CC(C)OC(C)C SAALQYKUFCIMHR-UHFFFAOYSA-N 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- YDLQKLWVKKFPII-UHFFFAOYSA-N timiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC(N2C(NC3=CC=CC=C32)=S)CC1 YDLQKLWVKKFPII-UHFFFAOYSA-N 0.000 description 1
- 229950000809 timiperone Drugs 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
- 229960000363 trapidil Drugs 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27820494 | 1994-11-14 | ||
| PCT/JP1995/002317 WO1996015124A1 (fr) | 1994-11-14 | 1995-11-14 | Hydrate a usage medicinal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO972190D0 NO972190D0 (no) | 1997-05-13 |
| NO972190L true NO972190L (no) | 1997-07-14 |
Family
ID=17594052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO972190A NO972190L (no) | 1994-11-14 | 1997-05-13 | Hydrat for medisinsk anvendelse |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5948913A (es) |
| EP (1) | EP0792879B1 (es) |
| KR (1) | KR100372188B1 (es) |
| CN (1) | CN1067998C (es) |
| AT (1) | ATE199375T1 (es) |
| AU (1) | AU698464B2 (es) |
| CA (1) | CA2205206A1 (es) |
| DE (1) | DE69520225T2 (es) |
| DK (1) | DK0792879T3 (es) |
| ES (1) | ES2156605T3 (es) |
| FI (1) | FI972035A (es) |
| GR (1) | GR3035820T3 (es) |
| NO (1) | NO972190L (es) |
| PT (1) | PT792879E (es) |
| RU (1) | RU2152941C1 (es) |
| WO (1) | WO1996015124A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| ES2222614T3 (es) | 1997-11-12 | 2005-02-01 | Mitsubishi Chemical Corporation | Derivados de purina y medicina que los contiene como ingrediente activo. |
| DE60006663T2 (de) * | 1999-05-11 | 2004-10-07 | Mitsubishi Chem Corp | Dihydrat eines purinderivates, medikamente die dieses als aktiven wirkstoff enthalten und zwischenprodukte zu dessen herstellung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| CA2121596A1 (en) * | 1992-10-06 | 1994-04-14 | Martin Missbach | Novel thiosemicarbazonethiones |
| RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| JPH0741431A (ja) * | 1993-05-25 | 1995-02-10 | Dai Ichi Seiyaku Co Ltd | 脳保護薬 |
| PH31213A (en) * | 1993-05-25 | 1998-05-05 | Daiichi Seiyaku Co | Drug for neuroprotection. |
-
1995
- 1995-11-14 EP EP95936786A patent/EP0792879B1/en not_active Expired - Lifetime
- 1995-11-14 KR KR1019970703310A patent/KR100372188B1/ko not_active IP Right Cessation
- 1995-11-14 AT AT95936786T patent/ATE199375T1/de not_active IP Right Cessation
- 1995-11-14 ES ES95936786T patent/ES2156605T3/es not_active Expired - Lifetime
- 1995-11-14 AU AU38565/95A patent/AU698464B2/en not_active Ceased
- 1995-11-14 CN CN95197248A patent/CN1067998C/zh not_active Expired - Fee Related
- 1995-11-14 WO PCT/JP1995/002317 patent/WO1996015124A1/ja active IP Right Grant
- 1995-11-14 RU RU97110091/04A patent/RU2152941C1/ru not_active IP Right Cessation
- 1995-11-14 CA CA002205206A patent/CA2205206A1/en not_active Abandoned
- 1995-11-14 US US08/836,583 patent/US5948913A/en not_active Expired - Fee Related
- 1995-11-14 DK DK95936786T patent/DK0792879T3/da active
- 1995-11-14 PT PT95936786T patent/PT792879E/pt unknown
- 1995-11-14 DE DE69520225T patent/DE69520225T2/de not_active Expired - Fee Related
-
1997
- 1997-05-13 NO NO972190A patent/NO972190L/no not_active Application Discontinuation
- 1997-05-13 FI FI972035A patent/FI972035A/fi not_active IP Right Cessation
-
2001
- 2001-04-30 GR GR20010400668T patent/GR3035820T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE199375T1 (de) | 2001-03-15 |
| RU2152941C1 (ru) | 2000-07-20 |
| DE69520225T2 (de) | 2001-10-11 |
| KR970707118A (ko) | 1997-12-01 |
| ES2156605T3 (es) | 2001-07-01 |
| NO972190D0 (no) | 1997-05-13 |
| WO1996015124A1 (fr) | 1996-05-23 |
| PT792879E (pt) | 2001-08-30 |
| FI972035A (fi) | 1997-07-11 |
| EP0792879A1 (en) | 1997-09-03 |
| EP0792879B1 (en) | 2001-02-28 |
| CN1171786A (zh) | 1998-01-28 |
| AU3856595A (en) | 1996-06-06 |
| KR100372188B1 (ko) | 2003-05-12 |
| GR3035820T3 (en) | 2001-07-31 |
| US5948913A (en) | 1999-09-07 |
| FI972035A0 (fi) | 1997-05-13 |
| AU698464B2 (en) | 1998-10-29 |
| CA2205206A1 (en) | 1996-05-23 |
| CN1067998C (zh) | 2001-07-04 |
| EP0792879A4 (en) | 1998-02-25 |
| DK0792879T3 (da) | 2001-03-26 |
| DE69520225D1 (de) | 2001-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |