NO970731D0 - 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner - Google Patents

2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner

Info

Publication number
NO970731D0
NO970731D0 NO970731A NO970731A NO970731D0 NO 970731 D0 NO970731 D0 NO 970731D0 NO 970731 A NO970731 A NO 970731A NO 970731 A NO970731 A NO 970731A NO 970731 D0 NO970731 D0 NO 970731D0
Authority
NO
Norway
Prior art keywords
benzodiazepine
trifluoroethyl
dihydro
oxo
phenyl
Prior art date
Application number
NO970731A
Other languages
English (en)
Norwegian (no)
Other versions
NO970731L (no
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO970731L publication Critical patent/NO970731L/no
Publication of NO970731D0 publication Critical patent/NO970731D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO970731A 1994-08-18 1997-02-17 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner NO970731D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29244794A 1994-08-18 1994-08-18
PCT/US1995/010500 WO1996005839A1 (fr) 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines

Publications (2)

Publication Number Publication Date
NO970731L NO970731L (no) 1997-02-17
NO970731D0 true NO970731D0 (no) 1997-02-17

Family

ID=23124712

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970731A NO970731D0 (no) 1994-08-18 1997-02-17 2,3-dihydro-1-(2,2,2-trifluoretyl)-2-okso-5-fenyl-1H-1,4-benzodiazepiner

Country Status (24)

Country Link
US (1) US5658901A (fr)
EP (1) EP0776208B1 (fr)
JP (1) JPH10504570A (fr)
KR (1) KR970705395A (fr)
CN (1) CN1158568A (fr)
AT (1) ATE186463T1 (fr)
AU (1) AU692300B2 (fr)
BG (1) BG63032B1 (fr)
BR (1) BR9508608A (fr)
CA (1) CA2195974C (fr)
CZ (1) CZ285008B6 (fr)
DE (1) DE69513295T2 (fr)
DK (1) DK0776208T3 (fr)
ES (1) ES2139933T3 (fr)
FI (1) FI970668A0 (fr)
GR (1) GR3032592T3 (fr)
HU (1) HU220635B1 (fr)
MX (1) MX9701195A (fr)
NO (1) NO970731D0 (fr)
NZ (1) NZ291988A (fr)
PL (1) PL319104A1 (fr)
RU (1) RU2149161C1 (fr)
SK (1) SK282019B6 (fr)
WO (1) WO1996005839A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
CA2257948A1 (fr) * 1996-06-28 1998-01-08 Merck & Co., Inc. Preparation pharmaceutique
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6262068B1 (en) 1997-02-21 2001-07-17 Bristol-Myers Squibb Company Lactam derivatives as antiarrhythmic agents
US6048877A (en) * 1997-02-21 2000-04-11 Bristol-Myers Squibb Company Tetralone derivatives as antiarrhythmic agents
WO1998037068A1 (fr) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques
US5817658A (en) * 1997-03-14 1998-10-06 Merck & Company, Inc. Method for treating Meniere's disease
GB2328942A (en) * 1997-09-05 1999-03-10 Merck & Co Inc Side chain synthesis for an antiarrythmic compound
US6214823B1 (en) 1997-10-17 2001-04-10 Merck & Co., Inc. Benzodiazepine derivatives as antiarrhythmic agents
ES2148057B1 (es) * 1998-01-05 2001-05-16 Univ Murcia Nuevo uso del diacepam como potenciador del efecto de los inhibidores pde 3
US6664250B2 (en) 1998-01-20 2003-12-16 Bristol-Myers Squibb Co. Lactam derivatives as antiarrhythmic agents
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP4410328B2 (ja) * 1998-12-14 2010-02-03 久光製薬株式会社 オキソクアゼパムの製造方法
GB0221923D0 (en) * 2002-09-20 2002-10-30 Arrow Therapeutics Ltd Chemical compounds
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT75373B (en) * 1981-08-12 1986-06-18 Agripat Sa Process for the preparation of tinted contact lenses
DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (fr) * 1982-09-30 1987-09-09 Merck & Co. Inc. 1-N-carboxyalkyl-benzolactames utiles comme agents antihypertensifs
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
CS249146B2 (en) * 1984-01-19 1987-03-12 Hoffmann La Roche Method of new imidazodiazepine's derivatives production
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5004741A (en) * 1984-06-26 1991-04-02 Merck & Co., Inc. Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4847248A (en) * 1986-12-23 1989-07-11 Merck & Co., Inc. 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
WO1989005812A1 (fr) * 1987-12-22 1989-06-29 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thienodiazepine et leur utilisation en medecine
EP0322779A3 (fr) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Composés de benzolactame et leur utilisation pharmaceutique
US5166151A (en) * 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
US5324726A (en) * 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
US5220018A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
CA2068355A1 (fr) * 1991-05-14 1992-11-15 Mark S. Chambers Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique
GB9116113D0 (en) * 1991-07-25 1991-09-11 Merck Sharp & Dohme Therapeutic agents
DE4125457A1 (de) * 1991-08-01 1993-02-04 Bayer Ag Verfahren zur herstellung von n-substituierten lactamen
ATE188702T1 (de) * 1991-09-30 2000-01-15 Yoshitomi Pharmaceutical Thienodiazepinverbindungen und ihre verwendung
WO1993007131A1 (fr) * 1991-10-10 1993-04-15 Merck Sharp & Dohme Limited Derives de benzodiazepine et leur utilisation comme antagonistes de recepteurs de cholecystokinine et/ou de gastrine
WO1993008175A1 (fr) * 1991-10-24 1993-04-29 Glaxo Group Limited Derives de benzodiazepine utilises comme antagonistes de la gastrine et/ou de la cholecystokinine
EP0609306A1 (fr) * 1991-10-24 1994-08-10 MERCK SHARP & DOHME LTD. Derives de benzodiazepine et leur utilisation comme antagonistes de recepteurs de cholecystikinine et/ou de gastrine
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
DE69204040T2 (de) * 1991-12-20 1996-03-28 Merck Sharp & Dohme 3-Phenylureido-1,4-Benzodiazepinone und ihre Verwendung als Cholecystokinin- oder Gastrinantagonisten.
ZA93436B (en) * 1992-01-24 1993-08-25 Chugai Pharmaceutical Co Ltd Benzopyran derivatives
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
CA2130195A1 (fr) * 1992-03-16 1993-09-30 Mark Gary Bock Derives de benzodiazepine; compositions a base de ces derives et leur utilisation comme agents therapeutiques
IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
GB9209518D0 (en) * 1992-05-01 1992-06-17 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
GB9218412D0 (en) * 1992-08-28 1992-10-14 Merck Sharp & Dohme Therapeutic agents
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5438055A (en) * 1993-11-22 1995-08-01 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5428157A (en) * 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
US5441950A (en) * 1994-06-09 1995-08-15 G. D. Searle & Co. Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
JPH10504570A (ja) 1998-05-06
NO970731L (no) 1997-02-17
EP0776208B1 (fr) 1999-11-10
BR9508608A (pt) 1997-12-30
SK282019B6 (sk) 2001-10-08
ATE186463T1 (de) 1999-11-15
DE69513295D1 (de) 1999-12-16
AU3366795A (en) 1996-03-14
EP0776208A1 (fr) 1997-06-04
DE69513295T2 (de) 2000-06-08
HUT76811A (en) 1997-11-28
ES2139933T3 (es) 2000-02-16
KR970705395A (ko) 1997-10-09
CN1158568A (zh) 1997-09-03
FI970668A (fi) 1997-02-17
FI970668A0 (fi) 1997-02-17
CZ285008B6 (cs) 1999-04-14
WO1996005839A1 (fr) 1996-02-29
MX9701195A (es) 1997-05-31
BG101227A (en) 1998-03-31
SK22297A3 (en) 1997-09-10
US5658901A (en) 1997-08-19
EP0776208A4 (fr) 1997-12-29
BG63032B1 (bg) 2001-02-28
CA2195974A1 (fr) 1996-02-29
HU220635B1 (hu) 2002-03-28
GR3032592T3 (en) 2000-05-31
DK0776208T3 (da) 2000-05-01
NZ291988A (en) 1998-11-25
RU2149161C1 (ru) 2000-05-20
CA2195974C (fr) 2000-12-05
AU692300B2 (en) 1998-06-04
CZ48597A3 (en) 1997-09-17
PL319104A1 (en) 1997-07-21

Similar Documents

Publication Publication Date Title
FI970668A (fi) 2,3-dihydro-1-(2,2,2-trifluorietyyli)-2-okso-5-fenyyli-1H-1,4-bentsodiatsepiinejä
ES2163638T3 (es) Nuevas n-(1-alquil-5-fenil-2,3,4,5-tetrahidro-1h-benzo(b)(1,5)diacepin-3-il)acetamidas.
NO800657L (no) Ikke-ionogent roentgenkontrastmiddel.
LV12258A (lv) Diaminociklobuten-3,4-dioni ka gludo muskulu relaksanti
PT83713A (de) Neue 4-benzyl-1-(2h)-phthalazinon-derivate
DE69433984D1 (de) Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
DK0730581T3 (da) 3-acylaminobezazepiner
EP0833819A4 (fr) Nouveaux n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepine-3yle)-3-amides
DE69610628D1 (de) N-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
DE69412016T2 (de) Substituierte arylalkoxybenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
ES2194102T3 (es) Nuevas n-(2,4-dioxo-2,3,4,5-tetrahidro-1h-1,5-benzodiazepin-3-il)-3-amidas.
ECSP941124A (es) 3-(heterociclico biciclicos) -6 fluoroalquiluracilos
DE69402935T2 (de) Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
ES2103794T3 (es) Pirazolinas, pirazolidinas e hidrazinas artropodicidas.
DK0625982T3 (da) 4-Oxo- og 4H-imidazo(5,1-c)(1,4)benzoxaziner anvendelige som benzodiazepinreceptor-bindemidler
DE69309900T2 (de) Substituierte benzylcarbamate mit herbiziden eigenschaften
DK428087A (da) Dihydropyridin-5-phosphonsyre-cyclopropylenester
SE8700566L (sv) Tetracykliska kinazolinoner
TR21967A (tr) Organo-kalay bilesikleri
SE7904162L (sv) 1,5-disubstituerad-1,2-dihydro-2h-1,4-benzodiazepin-2-oner

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application