ATE186463T1 - 2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5- phenyl-1h-1,4-benzodiazepine - Google Patents

2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5- phenyl-1h-1,4-benzodiazepine

Info

Publication number
ATE186463T1
ATE186463T1 AT95930197T AT95930197T ATE186463T1 AT E186463 T1 ATE186463 T1 AT E186463T1 AT 95930197 T AT95930197 T AT 95930197T AT 95930197 T AT95930197 T AT 95930197T AT E186463 T1 ATE186463 T1 AT E186463T1
Authority
AT
Austria
Prior art keywords
trifluorethyl
benzodiazepines
dihydro
oxo
phenyl
Prior art date
Application number
AT95930197T
Other languages
English (en)
Inventor
David A Claremon
Nigel Liverton
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE186463T1 publication Critical patent/ATE186463T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
AT95930197T 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5- phenyl-1h-1,4-benzodiazepine ATE186463T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29244794A 1994-08-18 1994-08-18

Publications (1)

Publication Number Publication Date
ATE186463T1 true ATE186463T1 (de) 1999-11-15

Family

ID=23124712

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95930197T ATE186463T1 (de) 1994-08-18 1995-08-17 2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5- phenyl-1h-1,4-benzodiazepine

Country Status (24)

Country Link
US (1) US5658901A (de)
EP (1) EP0776208B1 (de)
JP (1) JPH10504570A (de)
KR (1) KR970705395A (de)
CN (1) CN1158568A (de)
AT (1) ATE186463T1 (de)
AU (1) AU692300B2 (de)
BG (1) BG63032B1 (de)
BR (1) BR9508608A (de)
CA (1) CA2195974C (de)
CZ (1) CZ285008B6 (de)
DE (1) DE69513295T2 (de)
DK (1) DK0776208T3 (de)
ES (1) ES2139933T3 (de)
FI (1) FI970668A0 (de)
GR (1) GR3032592T3 (de)
HU (1) HU220635B1 (de)
MX (1) MX9701195A (de)
NO (1) NO970731L (de)
NZ (1) NZ291988A (de)
PL (1) PL319104A1 (de)
RU (1) RU2149161C1 (de)
SK (1) SK282019B6 (de)
WO (1) WO1996005839A1 (de)

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US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP4410328B2 (ja) * 1998-12-14 2010-02-03 久光製薬株式会社 オキソクアゼパムの製造方法
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US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
CU20090172A6 (es) 2009-10-09 2011-10-05 Facultad De Quimica Universidad De La Habana Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

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Also Published As

Publication number Publication date
MX9701195A (es) 1997-05-31
FI970668A (fi) 1997-02-17
CN1158568A (zh) 1997-09-03
PL319104A1 (en) 1997-07-21
KR970705395A (ko) 1997-10-09
BG63032B1 (bg) 2001-02-28
SK282019B6 (sk) 2001-10-08
EP0776208A4 (de) 1997-12-29
AU692300B2 (en) 1998-06-04
DE69513295D1 (de) 1999-12-16
CZ285008B6 (cs) 1999-04-14
AU3366795A (en) 1996-03-14
JPH10504570A (ja) 1998-05-06
US5658901A (en) 1997-08-19
NZ291988A (en) 1998-11-25
BG101227A (en) 1998-03-31
NO970731D0 (no) 1997-02-17
ES2139933T3 (es) 2000-02-16
HUT76811A (en) 1997-11-28
CA2195974A1 (en) 1996-02-29
FI970668A0 (fi) 1997-02-17
EP0776208A1 (de) 1997-06-04
NO970731L (no) 1997-02-17
EP0776208B1 (de) 1999-11-10
CA2195974C (en) 2000-12-05
DE69513295T2 (de) 2000-06-08
BR9508608A (pt) 1997-12-30
HU220635B1 (hu) 2002-03-28
WO1996005839A1 (en) 1996-02-29
SK22297A3 (en) 1997-09-10
CZ48597A3 (en) 1997-09-17
GR3032592T3 (en) 2000-05-31
RU2149161C1 (ru) 2000-05-20
DK0776208T3 (da) 2000-05-01

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Legal Events

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