CA2257948A1 - Preparation pharmaceutique - Google Patents

Preparation pharmaceutique Download PDF

Info

Publication number
CA2257948A1
CA2257948A1 CA002257948A CA2257948A CA2257948A1 CA 2257948 A1 CA2257948 A1 CA 2257948A1 CA 002257948 A CA002257948 A CA 002257948A CA 2257948 A CA2257948 A CA 2257948A CA 2257948 A1 CA2257948 A1 CA 2257948A1
Authority
CA
Canada
Prior art keywords
phenyl
unsubstituted
substituted
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002257948A
Other languages
English (en)
Inventor
Joseph J. Lynch, Jr.
Joseph J. Salata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617894.2A external-priority patent/GB9617894D0/en
Application filed by Individual filed Critical Individual
Publication of CA2257948A1 publication Critical patent/CA2257948A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La présente invention a trait à une méthode de prévention, de traitement, de guérison et de protection concernant les arythmies cardiaques, telles que les ectopies de type auriculaire, supraventriculaire et ventriculaire, la tachycardie, le flutter ou la fibrillation, y compris les arythmies cardiaques auriculaires, supraventriculaires et ventriculaires résultant d'un traumatisme d'ischémie myocardiaque chez un patient nécessitant ledit traitement. La méthode comprend l'administration d'un antagoniste d'I¿Ks? sélectif et d'un bêta-bloquant, administrés selon une polythérapie simultanée, séparée ou séquentielle. En outre, l'invention concerne une préparation pharmaceutique comprenant un antagoniste d'I¿Ks? sélectif et un bêta-bloquant, ces composés étant administrés simultanément, séparément ou séquentiellement.
CA002257948A 1996-06-28 1997-06-25 Preparation pharmaceutique Abandoned CA2257948A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2074796P 1996-06-28 1996-06-28
US60/020,747 1996-06-28
GBGB9617894.2A GB9617894D0 (en) 1996-08-28 1996-08-28 Pharmaceutical preparation
GB9617894.2 1996-08-28
PCT/US1997/011131 WO1998000405A1 (fr) 1996-06-28 1997-06-25 Preparation pharmaceutique

Publications (1)

Publication Number Publication Date
CA2257948A1 true CA2257948A1 (fr) 1998-01-08

Family

ID=26309928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002257948A Abandoned CA2257948A1 (fr) 1996-06-28 1997-06-25 Preparation pharmaceutique

Country Status (5)

Country Link
EP (1) EP0907644A4 (fr)
JP (1) JP2000510155A (fr)
AU (1) AU722110B2 (fr)
CA (1) CA2257948A1 (fr)
WO (1) WO1998000405A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
EP1494685B1 (fr) * 2002-04-18 2008-12-31 Cv Therapeutics, Inc. Procede de traitement des arythmies consistant a administrer un agoniste d'adenosine a1 avec un betabloquant
KR20170091770A (ko) 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
EP2450039A1 (fr) 2010-11-08 2012-05-09 PAION UK Ltd. Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
GB201613942D0 (en) * 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
WO1989005812A1 (fr) * 1987-12-22 1989-06-29 Yoshitomi Pharmaceutical Industries, Ltd. Composes de thienodiazepine et leur utilisation en medecine
US4970207A (en) * 1988-07-07 1990-11-13 Fujisawa Pharmaceutical Company, Ltd. Benzodiazepine derivatives
US5324726A (en) * 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5220017A (en) * 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5153191A (en) * 1991-08-20 1992-10-06 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
CA2097285C (fr) * 1991-09-30 2000-03-14 Yoichi Naka Composes de thienodiazepine et leur utilisation
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
US5521175A (en) * 1992-07-29 1996-05-28 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
GB9218412D0 (en) * 1992-08-28 1992-10-14 Merck Sharp & Dohme Therapeutic agents
EP0730596A4 (fr) * 1993-11-22 1997-07-30 Merck & Co Inc Benzodiazepines
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
DE69513295T2 (de) * 1994-08-18 2000-06-08 Merck & Co., Inc. 2,3-dihydro-1-(2,2,2-trifluorethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepine
JP2000504306A (ja) * 1994-08-18 2000-04-11 メルク エンド カンパニー インコーポレーテッド Ｎ―２，３―ジヒドロ―１―（２―プロピル）―２―オキソ―５―フェニル―１ｈ―１，４―ベンゾジアゼピン
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives

Also Published As

Publication number Publication date
EP0907644A1 (fr) 1999-04-14
JP2000510155A (ja) 2000-08-08
EP0907644A4 (fr) 2003-02-05
AU3506697A (en) 1998-01-21
AU722110B2 (en) 2000-07-20
WO1998000405A1 (fr) 1998-01-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead