NO970174L - 2-okso- og 2-tio-1,2-dihydrochinolinyl-oksazolidinoner - Google Patents

2-okso- og 2-tio-1,2-dihydrochinolinyl-oksazolidinoner

Info

Publication number
NO970174L
NO970174L NO970174A NO970174A NO970174L NO 970174 L NO970174 L NO 970174L NO 970174 A NO970174 A NO 970174A NO 970174 A NO970174 A NO 970174A NO 970174 L NO970174 L NO 970174L
Authority
NO
Norway
Prior art keywords
carbon atoms
straight chain
dihydroquinolinyl
oxazolidinones
thio
Prior art date
Application number
NO970174A
Other languages
English (en)
Other versions
NO970174D0 (no
Inventor
Dieter Haebich
Andreas Stolle
Bernd Riedl
Martin Ruppelt
Stephan Bartel
Walter Guarnieri
Rainer Endermann
Hein-Peter Kroll
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO970174D0 publication Critical patent/NO970174D0/no
Publication of NO970174L publication Critical patent/NO970174L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Det blir beskrevet 2-okso- og 2-tio-l,2-dihydrochinoli- nyl-oksazolidinoner med den generelle formel (I) (I), hvor A står for et oksygen- eller svovelatom, D står for hydrogen eller for cykloalkyl med 3 til 6 karbonatomer, eller rettkjedet eller forgrenet alkoksykarbonyl med opp til 4 karbonatomer, eller eventuelt substituert rettkjedet eller forgrenet alkyl eller alkenyl med opp til 9 karbonatomer, eller for eventuelt substituert rettkjedet eller forgrenet acyl med opp til 5 karbonatomer, eller for en av gruppene med formelene -( CT )jj-NR10r11 , -( C0)c-NR^2-C0-Nr13r14 _ -Nr15-S02R^^, r1'7r18-N-S02-, 51*^-5(0);, eller -C0-R20 , E og L er like eller forskjellige og står for hydrogen, karboksy, halogen, cyano, formyl, trifluormetyl, nitro eller rettkjedet eller forgrenet alkyl med opp til 4 karbonatomer, R^ står for azido, hydroksy, eller for en gruppe med formel -OR^l, O-SOaR^^ eller -KR^SrS"! ^ og deres salter og isomerer. Det blir dessuten beskrevet en fremgangsmåte for fremstilling av forbindelsene samt deres anvendelse i legemidler, spesielt i antibakterielle legemidler.
NO970174A 1996-01-16 1997-01-15 2-okso- og 2-tio-1,2-dihydrochinolinyl-oksazolidinoner NO970174L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601265A DE19601265A1 (de) 1996-01-16 1996-01-16 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone

Publications (2)

Publication Number Publication Date
NO970174D0 NO970174D0 (no) 1997-01-15
NO970174L true NO970174L (no) 1997-07-17

Family

ID=7782816

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970174A NO970174L (no) 1996-01-16 1997-01-15 2-okso- og 2-tio-1,2-dihydrochinolinyl-oksazolidinoner

Country Status (28)

Country Link
US (1) US5861413A (no)
EP (1) EP0785197A3 (no)
JP (1) JPH09194478A (no)
KR (1) KR970059174A (no)
AR (1) AR005458A1 (no)
AU (1) AU711924B2 (no)
BG (1) BG62257B1 (no)
BR (1) BR9700688A (no)
CA (1) CA2194945A1 (no)
CO (1) CO4520188A1 (no)
CZ (1) CZ12897A3 (no)
DE (1) DE19601265A1 (no)
EE (1) EE9700019A (no)
HN (1) HN1996000124A (no)
HR (1) HRP960614A2 (no)
HU (1) HUP9700126A3 (no)
IL (1) IL119994A0 (no)
NO (1) NO970174L (no)
NZ (1) NZ314057A (no)
PE (1) PE35398A1 (no)
PL (1) PL317930A1 (no)
SG (1) SG46764A1 (no)
SK (1) SK5897A3 (no)
SV (1) SV1997000002A (no)
TN (1) TNSN97009A1 (no)
TR (1) TR199601002A1 (no)
YU (1) YU1097A (no)
ZA (1) ZA97302B (no)

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GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
KR20010015910A (ko) 1998-01-23 2001-02-26 로렌스 티. 마이젠헬더 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법
KR20010052615A (ko) 1998-06-05 2001-06-25 다비드 에 질레스 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
JP2004501965A (ja) 2000-06-30 2004-01-22 ファルマシア・アンド・アップジョン・カンパニー 細菌感染を治療するための組成物および方法
ATE319710T1 (de) * 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
CA2491287A1 (en) * 2002-08-12 2004-02-19 Pharmacia & Upjohn Company N-aryl-2-oxazolidinones and their derivatives
AU2002339721A1 (en) * 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
BR0316483A (pt) * 2002-11-21 2005-10-11 Upjohn Co Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianos
ES2312839T3 (es) * 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
BRPI0407304A (pt) * 2003-02-07 2006-01-10 Warner Lambert Co Agentes antibacterianos
US20040204463A1 (en) * 2003-04-01 2004-10-14 Harris Christina Renee N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
CA2529347C (en) 2003-04-30 2011-09-06 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005058888A2 (en) 2003-12-18 2005-06-30 Morphochem Aktiengesellschaft für kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US7494578B2 (en) * 2004-03-01 2009-02-24 Atotech Deutschland Gmbh Iron-phosphorus electroplating bath and method
EP1781642A1 (en) * 2004-08-06 2007-05-09 Pharmacia & Upjohn Company LLC Oxazolidinones containing oxindoles as antibacterial agents
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
TW200831517A (en) * 2006-12-15 2008-08-01 Astrazeneca Ab Chemical compounds
US20100144717A1 (en) * 2006-12-15 2010-06-10 Janelle Comita-Prevoir 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents
US8349826B2 (en) * 2008-02-22 2013-01-08 Actelion Pharmaceuticals Ltd. Oxazolidinone derivatives
JP2017523213A (ja) * 2014-08-06 2017-08-17 ノバルティス アーゲー 抗菌薬としてのキノロン誘導体
KR20220055171A (ko) * 2020-10-26 2022-05-03 주식회사 아이비스바이오 포말리도마이드로부터 3,6'-디티오포말리도마이드를 선택적으로 합성하는 방법

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US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
CA1320730C (en) * 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US4942183A (en) * 1987-10-16 1990-07-17 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
WO1990002744A1 (en) 1988-09-15 1990-03-22 The Upjohn Company In position 3 substituted-5-beta-amidomethyl-oxazolidin-2-ones
JP2669579B2 (ja) * 1991-10-23 1997-10-29 エーザイ株式会社 オキサゾリドン誘導体
DE4332384A1 (de) * 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
TW286317B (no) * 1993-12-13 1996-09-21 Hoffmann La Roche
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone

Also Published As

Publication number Publication date
EP0785197A2 (de) 1997-07-23
CA2194945A1 (en) 1997-07-17
EE9700019A (et) 1997-08-15
TR199601002A1 (tr) 1997-08-21
SG46764A1 (en) 1998-02-20
HRP960614A2 (en) 1998-02-28
DE19601265A1 (de) 1997-07-17
AU1009797A (en) 1997-07-24
BG62257B1 (bg) 1999-06-30
BG101131A (en) 1998-04-30
YU1097A (sh) 1999-12-27
IL119994A0 (en) 1997-04-15
PE35398A1 (es) 1998-08-29
EP0785197A3 (de) 1999-02-10
HU9700126D0 (en) 1997-02-28
SK5897A3 (en) 1997-09-10
AU711924B2 (en) 1999-10-21
MX9700419A (es) 1997-07-31
NZ314057A (en) 1998-11-25
TNSN97009A1 (fr) 2005-03-15
BR9700688A (pt) 1998-09-01
JPH09194478A (ja) 1997-07-29
KR970059174A (ko) 1997-08-12
CZ12897A3 (en) 1997-08-13
HUP9700126A2 (hu) 1998-12-28
HN1996000124A (es) 1997-06-18
US5861413A (en) 1999-01-19
HUP9700126A3 (en) 1999-05-28
CO4520188A1 (es) 1997-10-15
PL317930A1 (en) 1997-07-21
ZA97302B (en) 1997-07-17
AR005458A1 (es) 1999-06-23
SV1997000002A (es) 1997-08-29
NO970174D0 (no) 1997-01-15

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