PE35398A1 - 2-oxo y 2-tio-1,2-dihidroquinolinil-oxazolidinonas - Google Patents
2-oxo y 2-tio-1,2-dihidroquinolinil-oxazolidinonasInfo
- Publication number
- PE35398A1 PE35398A1 PE1997000019A PE00001997A PE35398A1 PE 35398 A1 PE35398 A1 PE 35398A1 PE 1997000019 A PE1997000019 A PE 1997000019A PE 00001997 A PE00001997 A PE 00001997A PE 35398 A1 PE35398 A1 PE 35398A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- vii
- hydrogen
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIEREN A ANTIBACTERIANOS DE FORMULA (I), EN DONDE: "A" ES OXIGENO O AZUFRE; "D" ES HIDROGENO, ALQUILO O ALQUENILO C1-C9 (OPCIONALMENTE SUSTITUIDOS POR CIANO O HIDROXILO), -(CO)a-NR2R3, -(CT)d-NR10R11, -(CO)e-NR12-CO-NR13R14 o -CO-R20, ENTRE OTROS, EN DONDE: "T" ES OXIGENO O AZUFRE; a, d Y e SON 0 o 1; R2, R3, R10, R11, R12, R13 Y R14 SON H o ALQUILO C1-C5, ENTRE OTROS; R20 ES ARILO C6-C10 OPCIONALMENTE SUSTITUIDO POR HALOGENO; "E" Y "L" PREFERENTEMENTE SON HIDROGENO; R1 ES AZIDO, HIDROXILO, -OR21, -O-SO2R22 o -NR23R24, EN DONDE: R21 ES ACILO C1-C6 o UN GRUPO PROTECTOR OH; R22 ES ALQUILO C1-C5, FENILO o TOLILO; R23 Y R24 SON HIDROGENO, ALCOXI C1-C6 o -CT`-R25, ENTRE OTROS, EN DONDE: T' ES COMO "T"; R25 ES CICLOALQUILO C3-C6, ALQUILO C1-C6, TIOALQUILO C1-C5 o ACILO C1-C5, ENTRE OTROS. TAMBIEN SE REFIERE A LOS COMPUESTOS INTERMEDIOS DE FORMULA (VII), A LOS N-1-OXIDOS DEL COMPUESTO (VII) Y AL COMPUESTO DE FORMULA (IV). ADEMAS SE REFIERE A LOS PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I), QUE COMPRENDE: a) TRANSFORMAR LOS N-1-OXIDOS DEL COMPUESTO DE FORMULA (VII) MEDIANTE REACCION CON Ac2O o p-TsCl/CO3K2 EN DISOLVENTES INERTES, o b) TRANSFORMAR (IV) MEDIANTE REACCION CON ALQUIL-LITIO EN ETERES Y BUTIRATO DE R-GLICIDILO, Y OTROS PROCESOS PARA OBTENER LOS SUSTITUYENTES EN R1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19601265A DE19601265A1 (de) | 1996-01-16 | 1996-01-16 | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
Publications (1)
Publication Number | Publication Date |
---|---|
PE35398A1 true PE35398A1 (es) | 1998-08-29 |
Family
ID=7782816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000019A PE35398A1 (es) | 1996-01-16 | 1997-01-14 | 2-oxo y 2-tio-1,2-dihidroquinolinil-oxazolidinonas |
Country Status (28)
Country | Link |
---|---|
US (1) | US5861413A (es) |
EP (1) | EP0785197A3 (es) |
JP (1) | JPH09194478A (es) |
KR (1) | KR970059174A (es) |
AR (1) | AR005458A1 (es) |
AU (1) | AU711924B2 (es) |
BG (1) | BG62257B1 (es) |
BR (1) | BR9700688A (es) |
CA (1) | CA2194945A1 (es) |
CO (1) | CO4520188A1 (es) |
CZ (1) | CZ12897A3 (es) |
DE (1) | DE19601265A1 (es) |
EE (1) | EE9700019A (es) |
HN (1) | HN1996000124A (es) |
HR (1) | HRP960614A2 (es) |
HU (1) | HUP9700126A3 (es) |
IL (1) | IL119994A0 (es) |
NO (1) | NO970174L (es) |
NZ (1) | NZ314057A (es) |
PE (1) | PE35398A1 (es) |
PL (1) | PL317930A1 (es) |
SG (1) | SG46764A1 (es) |
SK (1) | SK5897A3 (es) |
SV (1) | SV1997000002A (es) |
TN (1) | TNSN97009A1 (es) |
TR (1) | TR199601002A1 (es) |
YU (1) | YU1097A (es) |
ZA (1) | ZA97302B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
DE19802239A1 (de) * | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
KR20010015910A (ko) | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
KR20010052615A (ko) | 1998-06-05 | 2001-06-25 | 다비드 에 질레스 | 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물 |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
JP2004501965A (ja) | 2000-06-30 | 2004-01-22 | ファルマシア・アンド・アップジョン・カンパニー | 細菌感染を治療するための組成物および方法 |
ATE319710T1 (de) * | 2000-12-21 | 2006-03-15 | Pharmacia & Upjohn Co Llc | Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
WO2003031441A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
CA2491287A1 (en) * | 2002-08-12 | 2004-02-19 | Pharmacia & Upjohn Company | N-aryl-2-oxazolidinones and their derivatives |
AU2002339721A1 (en) * | 2002-09-20 | 2004-04-08 | Lupin Limited | Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents |
BR0316483A (pt) * | 2002-11-21 | 2005-10-11 | Upjohn Co | Derivados de n-(4-(piperazin-1-il)-fenil-2-oxazolidinona-5-carboxami da e compostos relacionados como agentes antibacterianos |
ES2312839T3 (es) * | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
CA2515311A1 (en) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Antibacterial agents |
BRPI0407304A (pt) * | 2003-02-07 | 2006-01-10 | Warner Lambert Co | Agentes antibacterianos |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
CA2529347C (en) | 2003-04-30 | 2011-09-06 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
WO2005058888A2 (en) | 2003-12-18 | 2005-06-30 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
US7494578B2 (en) * | 2004-03-01 | 2009-02-24 | Atotech Deutschland Gmbh | Iron-phosphorus electroplating bath and method |
EP1781642A1 (en) * | 2004-08-06 | 2007-05-09 | Pharmacia & Upjohn Company LLC | Oxazolidinones containing oxindoles as antibacterial agents |
MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
TW200831517A (en) * | 2006-12-15 | 2008-08-01 | Astrazeneca Ab | Chemical compounds |
US20100144717A1 (en) * | 2006-12-15 | 2010-06-10 | Janelle Comita-Prevoir | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents |
US8349826B2 (en) * | 2008-02-22 | 2013-01-08 | Actelion Pharmaceuticals Ltd. | Oxazolidinone derivatives |
JP2017523213A (ja) * | 2014-08-06 | 2017-08-17 | ノバルティス アーゲー | 抗菌薬としてのキノロン誘導体 |
KR20220055171A (ko) * | 2020-10-26 | 2022-05-03 | 주식회사 아이비스바이오 | 포말리도마이드로부터 3,6'-디티오포말리도마이드를 선택적으로 합성하는 방법 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US4942183A (en) * | 1987-10-16 | 1990-07-17 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
WO1990002744A1 (en) | 1988-09-15 | 1990-03-22 | The Upjohn Company | In position 3 substituted-5-beta-amidomethyl-oxazolidin-2-ones |
JP2669579B2 (ja) * | 1991-10-23 | 1997-10-29 | エーザイ株式会社 | オキサゾリドン誘導体 |
DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
TW286317B (es) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
-
1996
- 1996-01-16 DE DE19601265A patent/DE19601265A1/de not_active Withdrawn
- 1996-12-12 TR TR96/01002A patent/TR199601002A1/xx unknown
- 1996-12-23 HR HR19601265.1A patent/HRP960614A2/hr not_active Application Discontinuation
- 1996-12-27 HN HN1996000124A patent/HN1996000124A/es unknown
-
1997
- 1997-01-03 EP EP97100026A patent/EP0785197A3/de not_active Withdrawn
- 1997-01-09 US US08/781,002 patent/US5861413A/en not_active Expired - Fee Related
- 1997-01-09 AU AU10097/97A patent/AU711924B2/en not_active Ceased
- 1997-01-13 CA CA002194945A patent/CA2194945A1/en not_active Abandoned
- 1997-01-13 JP JP9015889A patent/JPH09194478A/ja active Pending
- 1997-01-13 IL IL11999497A patent/IL119994A0/xx unknown
- 1997-01-13 NZ NZ314057A patent/NZ314057A/en unknown
- 1997-01-14 PL PL97317930A patent/PL317930A1/xx unknown
- 1997-01-14 YU YU1097A patent/YU1097A/sh unknown
- 1997-01-14 AR ARP970100134A patent/AR005458A1/es unknown
- 1997-01-14 BG BG101131A patent/BG62257B1/bg unknown
- 1997-01-14 PE PE1997000019A patent/PE35398A1/es not_active Application Discontinuation
- 1997-01-15 NO NO970174A patent/NO970174L/no unknown
- 1997-01-15 EE EE9700019A patent/EE9700019A/xx unknown
- 1997-01-15 SG SG1997000088A patent/SG46764A1/en unknown
- 1997-01-15 BR BR9700688A patent/BR9700688A/pt not_active Application Discontinuation
- 1997-01-15 ZA ZA97302A patent/ZA97302B/xx unknown
- 1997-01-15 KR KR1019970001029A patent/KR970059174A/ko not_active Application Discontinuation
- 1997-01-15 CZ CZ97128A patent/CZ12897A3/cs unknown
- 1997-01-15 HU HU9700126A patent/HUP9700126A3/hu unknown
- 1997-01-15 SK SK58-97A patent/SK5897A3/sk unknown
- 1997-01-15 TN TNTNSN97009A patent/TNSN97009A1/fr unknown
- 1997-01-15 CO CO97001471A patent/CO4520188A1/es unknown
- 1997-01-16 SV SV1997000002A patent/SV1997000002A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP0785197A2 (de) | 1997-07-23 |
CA2194945A1 (en) | 1997-07-17 |
EE9700019A (et) | 1997-08-15 |
TR199601002A1 (tr) | 1997-08-21 |
SG46764A1 (en) | 1998-02-20 |
HRP960614A2 (en) | 1998-02-28 |
DE19601265A1 (de) | 1997-07-17 |
AU1009797A (en) | 1997-07-24 |
BG62257B1 (bg) | 1999-06-30 |
BG101131A (en) | 1998-04-30 |
YU1097A (sh) | 1999-12-27 |
IL119994A0 (en) | 1997-04-15 |
EP0785197A3 (de) | 1999-02-10 |
NO970174L (no) | 1997-07-17 |
HU9700126D0 (en) | 1997-02-28 |
SK5897A3 (en) | 1997-09-10 |
AU711924B2 (en) | 1999-10-21 |
MX9700419A (es) | 1997-07-31 |
NZ314057A (en) | 1998-11-25 |
TNSN97009A1 (fr) | 2005-03-15 |
BR9700688A (pt) | 1998-09-01 |
JPH09194478A (ja) | 1997-07-29 |
KR970059174A (ko) | 1997-08-12 |
CZ12897A3 (en) | 1997-08-13 |
HUP9700126A2 (hu) | 1998-12-28 |
HN1996000124A (es) | 1997-06-18 |
US5861413A (en) | 1999-01-19 |
HUP9700126A3 (en) | 1999-05-28 |
CO4520188A1 (es) | 1997-10-15 |
PL317930A1 (en) | 1997-07-21 |
ZA97302B (en) | 1997-07-17 |
AR005458A1 (es) | 1999-06-23 |
SV1997000002A (es) | 1997-08-29 |
NO970174D0 (no) | 1997-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |