NO960371L - Piperazinderivater som ter - Google Patents
Piperazinderivater som terInfo
- Publication number
- NO960371L NO960371L NO960371A NO960371A NO960371L NO 960371 L NO960371 L NO 960371L NO 960371 A NO960371 A NO 960371A NO 960371 A NO960371 A NO 960371A NO 960371 L NO960371 L NO 960371L
- Authority
- NO
- Norway
- Prior art keywords
- group
- compounds
- ter
- piperazine derivatives
- sonh
- Prior art date
Links
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 abstract 1
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical group C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000003708 urethra Anatomy 0.000 abstract 1
- 210000001635 urinary tract Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001717A IT1266582B1 (it) | 1993-07-30 | 1993-07-30 | Derivati (di)azacicloesanici e diazacicloeptanici |
| PCT/EP1994/002437 WO1995004049A1 (fr) | 1993-07-30 | 1994-07-22 | DERIVES DE PIPERAZINE UTILISES COMME ANTAGONISTES DES RECEPTEURS α1A-ADRENERGIQUES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960371D0 NO960371D0 (no) | 1996-01-29 |
| NO960371L true NO960371L (no) | 1996-03-29 |
Family
ID=11366733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960371A NO960371L (no) | 1993-07-30 | 1996-01-29 | Piperazinderivater som ter |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0711288A1 (fr) |
| JP (1) | JPH09500883A (fr) |
| KR (1) | KR960703884A (fr) |
| CN (1) | CN1132508A (fr) |
| AU (1) | AU680037B2 (fr) |
| CA (1) | CA2168443A1 (fr) |
| IL (1) | IL110348A0 (fr) |
| IT (1) | IT1266582B1 (fr) |
| MX (1) | MXPA94005805A (fr) |
| NO (1) | NO960371L (fr) |
| NZ (1) | NZ271634A (fr) |
| SG (1) | SG46281A1 (fr) |
| WO (1) | WO1995004049A1 (fr) |
| ZA (1) | ZA945625B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5661163A (en) * | 1995-06-07 | 1997-08-26 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| US5620993A (en) * | 1995-06-07 | 1997-04-15 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| US5659033A (en) * | 1995-09-13 | 1997-08-19 | Neurogen Corporation | N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands |
| US5807856A (en) * | 1995-11-15 | 1998-09-15 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonist |
| NZ321293A (en) * | 1995-11-17 | 2001-04-27 | Warner Lambert Co | Sulfonamide inhibitors of matrix metalloproteinases |
| SK89398A3 (en) | 1995-12-29 | 1998-11-04 | Boehringer Ingelheim Pharma | Phenyl thiazole derivatives with anti herpes virus properties |
| US6288091B1 (en) | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
| DK0891344T3 (da) * | 1996-04-05 | 2003-04-07 | Sod Conseils Rech Applic | Antagonister til alpha-1-adrenergisk receptor |
| JP4150435B2 (ja) * | 1996-04-18 | 2008-09-17 | 株式会社資生堂 | アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤 |
| CA2260999C (fr) | 1996-07-19 | 2006-07-11 | Takeda Chemical Industries, Ltd. | Composes heterocycliques, leur production et leur utilisation en tant qu'inhibiteurs de tyrosine kinase |
| TR199902971T2 (xx) * | 1997-05-12 | 2001-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | Selim prostat hiperplazisinin tedavisinde yararl� aril ikameli piperazinler. |
| AU2002300904B2 (en) * | 1997-05-12 | 2004-12-23 | Ortho-Mcneil Pharmaceutical, Inc. | Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| JP2001512110A (ja) * | 1997-08-01 | 2001-08-21 | レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー | １，４−ジ置換ピペラジン |
| IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
| US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| US6218396B1 (en) * | 1998-02-20 | 2001-04-17 | Orth-Mcneil Pharmaceutical, Inc. | Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia |
| WO2000008001A1 (fr) | 1998-08-07 | 2000-02-17 | Chiron Corporation | Isoxazoles substitues comme modulateurs de recepteur d'oestrogenes |
| IT1314191B1 (it) * | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| US6365591B1 (en) | 1999-10-18 | 2002-04-02 | Recordati, S.A., Chemical And Pharmacueticals Company | Isoxazolecarboxamide derivatives |
| AR027133A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de heteroarilo, su preparacion y uso. |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| WO2002055496A1 (fr) * | 2001-01-15 | 2002-07-18 | Glaxo Group Limited | Derives aryle de piperidine et de piperazine comme inducteurs de l'expression du recepteur ldl |
| US7153858B2 (en) | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US8394954B2 (en) * | 2007-03-30 | 2013-03-12 | Council Of Scientific & Industrial Research | Benzophenone hybrids as anticancer agents and processes for the preparation thereof |
| US7858666B2 (en) | 2007-06-08 | 2010-12-28 | Mannkind Corporation | IRE-1α inhibitors |
| MX2012014273A (es) | 2010-06-07 | 2013-03-22 | Novomedix Llc | Compuestos furanilo y su uso. |
| WO2013086496A2 (fr) | 2011-12-09 | 2013-06-13 | Research Triangle Institute | 4-arylpipérazine 1-substitué à titre d'antagoniste du récepteur opioïde kappa |
| BR102012000187A2 (pt) * | 2012-01-05 | 2018-04-10 | Univ Rio De Janeiro | Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos |
| WO2023044364A1 (fr) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Inhibiteurs de protoporphyrinogène oxydase |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2997472A (en) * | 1961-08-22 | Certificate of correction | ||
| FR6452M (fr) * | 1967-03-10 | 1968-11-12 | ||
| FR1543944A (fr) * | 1967-03-10 | 1968-10-31 | Bruneau & Cie Lab | Dérivés amidés de l'acide salicylique et leur préparation |
| US3557107A (en) * | 1967-05-01 | 1971-01-19 | Shulton Inc | Phenylpiperazinylalkyl alkoxy anthranilates |
| FR1537901A (fr) * | 1967-07-19 | 1968-08-30 | Bruneau & Cie Lab | Dérivés amidés d'acides halogéno et nitro benzoïques et leur préparation |
| FR6924M (fr) * | 1967-10-18 | 1969-05-05 | ||
| US3846430A (en) * | 1968-01-12 | 1974-11-05 | Bruneau & Cie Lab | 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine |
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| US4642291A (en) * | 1982-09-01 | 1987-02-10 | Sloan-Kettering Institute For Cancer Research | Cell surface antigens of human astrocytoma |
| JPS5955878A (ja) * | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JPS60169467A (ja) * | 1984-02-10 | 1985-09-02 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JP2556722B2 (ja) * | 1988-02-18 | 1996-11-20 | 興和株式会社 | 新規なスルホンアミド化合物 |
| US4857644A (en) * | 1988-06-09 | 1989-08-15 | American Home Products Corporation | Aryl sulfonopiperazines as anti-inflammatory agents |
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| HRP930210A2 (en) * | 1992-02-25 | 1995-06-30 | Recordati Chem Pharm | Heterobicyclic compounds and pharmaceutical preparations containing them |
| SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
-
1993
- 1993-07-30 IT IT93MI001717A patent/IT1266582B1/it active IP Right Grant
-
1994
- 1994-07-18 IL IL11034894A patent/IL110348A0/xx unknown
- 1994-07-22 EP EP94925382A patent/EP0711288A1/fr not_active Withdrawn
- 1994-07-22 AU AU75323/94A patent/AU680037B2/en not_active Ceased
- 1994-07-22 WO PCT/EP1994/002437 patent/WO1995004049A1/fr not_active Application Discontinuation
- 1994-07-22 CN CN94193622A patent/CN1132508A/zh active Pending
- 1994-07-22 NZ NZ271634A patent/NZ271634A/en unknown
- 1994-07-22 KR KR1019960700460A patent/KR960703884A/ko not_active Application Discontinuation
- 1994-07-22 CA CA002168443A patent/CA2168443A1/fr not_active Abandoned
- 1994-07-22 SG SG1996002067A patent/SG46281A1/en unknown
- 1994-07-22 JP JP7505546A patent/JPH09500883A/ja active Pending
- 1994-07-29 MX MXPA94005805A patent/MXPA94005805A/es unknown
- 1994-07-29 ZA ZA945625A patent/ZA945625B/xx unknown
-
1996
- 1996-01-29 NO NO960371A patent/NO960371L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09500883A (ja) | 1997-01-28 |
| NZ271634A (en) | 1996-09-25 |
| ITMI931717A0 (it) | 1993-07-30 |
| ITMI931717A1 (it) | 1995-01-30 |
| AU7532394A (en) | 1995-02-28 |
| MXPA94005805A (es) | 2004-08-20 |
| IT1266582B1 (it) | 1997-01-09 |
| AU680037B2 (en) | 1997-07-17 |
| IL110348A0 (en) | 1994-10-21 |
| KR960703884A (ko) | 1996-08-31 |
| WO1995004049A1 (fr) | 1995-02-09 |
| CA2168443A1 (fr) | 1995-02-09 |
| ZA945625B (en) | 1995-03-07 |
| CN1132508A (zh) | 1996-10-02 |
| EP0711288A1 (fr) | 1996-05-15 |
| SG46281A1 (en) | 1998-02-20 |
| NO960371D0 (no) | 1996-01-29 |
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