KR20010006390A - 삼환식 화합물 - Google Patents

삼환식 화합물 Download PDF

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Publication number
KR20010006390A
KR20010006390A KR1019997009477A KR19997009477A KR20010006390A KR 20010006390 A KR20010006390 A KR 20010006390A KR 1019997009477 A KR1019997009477 A KR 1019997009477A KR 19997009477 A KR19997009477 A KR 19997009477A KR 20010006390 A KR20010006390 A KR 20010006390A
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KR
South Korea
Prior art keywords
substituted
unsubstituted lower
formula
hydrogen
lower alkyl
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KR1019997009477A
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English (en)
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KR100447674B1 (ko
Inventor
쓰요시 야마가따
가오루 아쓰끼
도시아끼 구마자와
Original Assignee
히라타 다다시
교와 핫꼬 고교 가부시끼가이샤
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Publication of KR20010006390A publication Critical patent/KR20010006390A/ko
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Publication of KR100447674B1 publication Critical patent/KR100447674B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/12—[b,e]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Led Devices (AREA)
  • Surgical Instruments (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

빈뇨, 요실금의 치료에 유용한 화학식 I
[화학식 I]
[식 중, R1은 수소, 치환 또는 비치환의 저급 알킬 등을 나타낸다. X1-X2-X3는, CR5=CR6-CR7=CR8(식 중, R5, R6, R7및 R8은 동일하거나 다르게 수소, 치환 또는 비치환의 저급 알킬, 히드록시, 치환 또는 비치환의 저급알콕시 등을 나타낸다), N(O)m=CR5-CR6-CR7(식 중, R5, R6및 R7은 상기와 동일하다. m 은 0 또는 1 을 나타낸다), S-CR7=CR8(식 중, R7및 R8은 상기와 동일한 의미이다) 등을 나타낸다.
R2가 수소, 치환 또는 비치환의 저급 알킬, 치환 또는 비치환의 저급알콕시, 치환 또는 비치환의 N-치환의 복소환기 또는
(식 중, n 은 0 또는 1 이고, R3및 R4는, 동일하거나 다르게 수소, 치환 또는 비치환의 저급 알킬, 치환 또는 트리플루오로메틸을 나타내거나, R3및 R4가 함께 고리형상 알킬을 형성한다. Q 는 히드록시 또는 할로겐 등을 나타낸다) 등을 나타낼 때에, Y 는 -CH2SO2-, -SCH2, -SOCH2- 또는 -SO2CH2- 를 나타낸다] 로 표시되는 삼환식 화합물 또는 그것의 약리학적으로 허용되는 염을 제공한다.
KR10-1999-7009477A 1997-04-15 1998-04-15 삼환식 화합물 KR100447674B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9723397 1997-04-15
JP97-97233 1997-04-15

Publications (2)

Publication Number Publication Date
KR20010006390A true KR20010006390A (ko) 2001-01-26
KR100447674B1 KR100447674B1 (ko) 2004-09-08

Family

ID=14186913

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7009477A KR100447674B1 (ko) 1997-04-15 1998-04-15 삼환식 화합물

Country Status (19)

Country Link
US (1) US6211227B1 (ko)
EP (1) EP0979821B1 (ko)
JP (1) JP3283267B2 (ko)
KR (1) KR100447674B1 (ko)
CN (1) CN1260220C (ko)
AT (1) ATE339409T1 (ko)
AU (1) AU738757B2 (ko)
BR (1) BR9808552A (ko)
CA (1) CA2286723C (ko)
CY (1) CY1105821T1 (ko)
DE (1) DE69835877T2 (ko)
DK (1) DK0979821T3 (ko)
EA (1) EA002322B1 (ko)
ES (1) ES2273413T3 (ko)
HK (1) HK1025572A1 (ko)
HU (1) HUP0002461A3 (ko)
NO (1) NO994960L (ko)
PT (1) PT979821E (ko)
WO (1) WO1998046587A1 (ko)

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US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2319077A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU2335699A (en) 1998-01-21 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EP1182200B1 (en) * 1999-06-03 2005-08-31 Nippon Suisan Kaisha, Ltd. Tricyclic fused heterocycle compounds, process for preparing the same and use thereof
EP1372630A4 (en) * 2001-03-30 2005-03-23 Kyowa Hakko Kogyo Kk AGENT FOR THE TREATMENT OF THE HYPERACTIVE BLADDER
WO2002078710A1 (fr) * 2001-03-30 2002-10-10 Kyowa Hakko Kogyo Co., Ltd. Medicaments contre l'hyperactivite vesicale
US20040106671A1 (en) * 2001-03-30 2004-06-03 Tsuyoshi Yamagata Remedies for vesical hyperesthesia
JP4104986B2 (ja) * 2001-03-30 2008-06-18 協和醗酵工業株式会社 前立腺肥大症に伴う膀胱刺激症状治療剤
CA2442452A1 (en) * 2001-03-30 2002-10-10 Kyowa Hakko Kogyo Co., Ltd. Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia
CA2466790A1 (en) * 2001-11-13 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Preventive or therapeutic agent for pruritus
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US20040132803A1 (en) * 2002-03-29 2004-07-08 Tsuyoshi Yamagata Agent for the treatment of overactive bladder
EP1611888A1 (en) * 2003-03-31 2006-01-04 Kyowa Hakko Kogyo Co., Ltd. Antitussives
AR044870A1 (es) * 2003-06-27 2005-10-05 Kyowa Hakko Kogyo Kk Compuesto azufrado triciclico y su uso como agente terapeutico para la vejiga hiperactiva
US20060148885A1 (en) * 2003-07-16 2006-07-06 Kyowa Hakko Kogyo Co., Ltd. Medicinal composition
JPWO2005007191A1 (ja) * 2003-07-16 2006-08-31 協和醗酵工業株式会社 医薬組成物
WO2005007154A1 (ja) * 2003-07-16 2005-01-27 Kyowa Hakko Kogyo Co., Ltd. 疼痛の予防及び／または治療剤
JPWO2005011674A1 (ja) * 2003-08-05 2006-09-14 協和醗酵工業株式会社 気管支喘息の予防及び／または治療剤
TW200522943A (en) * 2003-12-11 2005-07-16 Kyowa Hakko Kogyo Kk Fine crystallites and a pharmaceutical composition comprising them
JPWO2006013965A1 (ja) * 2004-08-06 2008-05-01 協和醗酵工業株式会社 三環系スルホンの製造法
TW200827367A (en) * 2006-10-26 2008-07-01 Kyowa Hakko Kogyo Kk A therapeutic agent for irritable bowel syndrome
WO2009131200A1 (ja) * 2008-04-25 2009-10-29 協和発酵キリン株式会社 過敏性腸症候群治療剤
WO2009131201A1 (ja) * 2008-04-25 2009-10-29 協和発酵キリン株式会社 間欠性跛行症治療剤
EP2206534A1 (de) * 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
EP2325040B1 (en) * 2009-11-23 2018-01-03 Faurecia Automotive Seating, Inc. Controllable comfort shell for vehicle seat
CN107233682B (zh) * 2017-07-04 2019-08-06 李烨 以压缩空气为动力的发射装置
CN110357850A (zh) * 2018-03-26 2019-10-22 广东东阳光药业有限公司 一种含硫杂环化合物的制备方法

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DK467274A (ko) 1973-09-13 1975-05-12 Sandoz Ag
SE8500273D0 (sv) * 1985-01-22 1985-01-22 Leo Ab Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
US4645748A (en) 1985-02-01 1987-02-24 Charles Hurwitz Protein which is characteristic of rheumatoid arthritis
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
GB9214120D0 (en) 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
ATE201195T1 (de) * 1995-10-16 2001-06-15 Kyowa Hakko Kogyo Kk Tricyclische verbindungen

Also Published As

Publication number Publication date
JP3283267B2 (ja) 2002-05-20
CY1105821T1 (el) 2011-02-02
DK0979821T3 (da) 2007-01-29
AU6851598A (en) 1998-11-11
DE69835877T2 (de) 2007-05-16
ES2273413T3 (es) 2007-05-01
PT979821E (pt) 2007-01-31
HK1025572A1 (en) 2000-11-17
CN1255129A (zh) 2000-05-31
EP0979821A1 (en) 2000-02-16
EA199900927A1 (ru) 2000-08-28
NO994960L (no) 1999-12-09
ATE339409T1 (de) 2006-10-15
CA2286723A1 (en) 1998-10-22
WO1998046587A1 (fr) 1998-10-22
HUP0002461A3 (en) 2003-01-28
NO994960D0 (no) 1999-10-12
US6211227B1 (en) 2001-04-03
DE69835877D1 (de) 2006-10-26
AU738757B2 (en) 2001-09-27
KR100447674B1 (ko) 2004-09-08
CN1260220C (zh) 2006-06-21
BR9808552A (pt) 2000-05-23
EP0979821A4 (en) 2002-04-24
HUP0002461A2 (hu) 2001-06-28
CA2286723C (en) 2007-01-30
EA002322B1 (ru) 2002-04-25
EP0979821B1 (en) 2006-09-13

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