UA41952C2 - Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії - Google Patents

Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії

Info

Publication number
UA41952C2
UA41952C2 UA96041333A UA96041333A UA41952C2 UA 41952 C2 UA41952 C2 UA 41952C2 UA 96041333 A UA96041333 A UA 96041333A UA 96041333 A UA96041333 A UA 96041333A UA 41952 C2 UA41952 C2 UA 41952C2
Authority
UA
Ukraine
Prior art keywords
atoms
carbon
psycosis
schizophrenia
treatment
Prior art date
Application number
UA96041333A
Other languages
English (en)
Russian (ru)
Inventor
Франк Керріган
Франк Керриган
Девід Джон Хіл
Дэвид Джон ХИЛ
Кіт Франк Мартін
Кеит Франк Мартин
Original Assignee
Кноль Акцієнгезельшафт
Кноль Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кноль Акцієнгезельшафт, Кноль Акциенгезельшафт filed Critical Кноль Акцієнгезельшафт
Publication of UA41952C2 publication Critical patent/UA41952C2/uk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Цей винахід належить до нових фторвмісних органічних сполук, конкретніше, до похідних аміну, що мають біологічну активність. Похідні аміну загальної формули (I): де R - галоїд, гідроксил, алкіл з 1 - 3 атомами вуглецю, алкоксил з 1 - 3 атомами вуглецю Q - двовалентна група формули (IIа) (IIб) де V - метилен або етилен Х - алкіленоий ланцюг з 0 - 2 атомами вуглецю X' - алкіленовий ланцюг з 1 - 4 атомами вуглецю при цьому загальне число атомів вуглецю в залишках Х і X' складає 3 або 4 Т - феніл, піридил, піразінил, бензо[b]фураніл, 1,4-бензодиоксаніл і хіназолініл, незаміщені або заміщені галоїдом, метоксилом або трифторметилом m - 0, 1, та їх фармацевтично прийнятні солі.
UA96041333A 1993-09-06 1994-09-01 Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії UA41952C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939318431A GB9318431D0 (en) 1993-09-06 1993-09-06 Therapeutic agents
PCT/EP1994/002904 WO1995007274A1 (en) 1993-09-06 1994-09-01 Bicyclic aromatic compounds as therapeutic agents

Publications (1)

Publication Number Publication Date
UA41952C2 true UA41952C2 (uk) 2001-10-15

Family

ID=10741568

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96041333A UA41952C2 (uk) 1993-09-06 1994-09-01 Похідні аміну, фармацевтична композиція на їх основі та спосіб лікування психозів і шизофренії

Country Status (31)

Country Link
US (1) US5767116A (uk)
EP (1) EP0717739B1 (uk)
JP (1) JPH09502431A (uk)
KR (1) KR100325964B1 (uk)
CN (1) CN1052723C (uk)
AT (1) ATE191214T1 (uk)
AU (1) AU689802B2 (uk)
BG (1) BG63272B1 (uk)
BR (1) BR9407413A (uk)
CA (1) CA2170056A1 (uk)
CZ (1) CZ61496A3 (uk)
DE (1) DE69423767T2 (uk)
DK (1) DK0717739T3 (uk)
ES (1) ES2144528T3 (uk)
FI (1) FI961016A (uk)
GB (1) GB9318431D0 (uk)
GR (1) GR3033575T3 (uk)
HU (1) HUT75875A (uk)
IL (1) IL110844A (uk)
NO (1) NO308536B1 (uk)
NZ (1) NZ273581A (uk)
PL (1) PL178270B1 (uk)
PT (1) PT717739E (uk)
RO (1) RO116811B1 (uk)
RU (1) RU2136680C1 (uk)
SI (1) SI9420058B (uk)
SK (1) SK27196A3 (uk)
TW (1) TW311137B (uk)
UA (1) UA41952C2 (uk)
WO (1) WO1995007274A1 (uk)
ZA (1) ZA946798B (uk)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
GB9526495D0 (en) * 1995-12-23 1996-02-28 Knoll Ag Therapeutic agents
DE19624154A1 (de) 1996-06-18 1998-01-08 Hoechst Ag Ringannelierte Dihydropyrane, Verfahren zur Herstellung sowie deren Verwendung
GB9627006D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
GB9627005D0 (en) * 1996-12-27 1997-02-12 Knoll Ag Therapeutic agents
FR2760014B1 (fr) * 1997-02-27 1999-04-09 Adir Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9704948D0 (en) 1997-03-11 1997-04-30 Knoll Ag Therapeutic agents
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6077850A (en) 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
GB9811879D0 (en) * 1998-06-03 1998-07-29 Knoll Ag Therapeutic agents
FR2780057B1 (fr) * 1998-06-18 2002-09-13 Sanofi Sa Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
GB9915616D0 (en) * 1999-07-05 1999-09-01 Knoll Ag Therapeutic agents
GB0007376D0 (en) * 2000-03-28 2000-05-17 Knoll Ag Therapeutic agents
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6656951B2 (en) * 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
WO2002088129A1 (en) * 2001-04-26 2002-11-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
US6667322B2 (en) 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1888548B1 (en) 2005-05-26 2012-08-22 Neuron Systems, Inc Quinoline derivative for the treatment of retinal diseases
TWI457122B (zh) * 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
MX2018015872A (es) 2016-06-29 2019-04-22 Orion Corp Derivados de benzodioxano y su uso farmaceutico.
CN117580569A (zh) * 2021-07-02 2024-02-20 奥尔德拉医疗公司 杂环型醛捕获化合物和其用途

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JPS58154574A (ja) * 1982-03-09 1983-09-14 Mitsubishi Chem Ind Ltd アルキレンジオキシベンゼン誘導体およびその酸付加塩
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DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
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SI9300097B (en) * 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

Also Published As

Publication number Publication date
BR9407413A (pt) 1996-11-12
JPH09502431A (ja) 1997-03-11
TW311137B (uk) 1997-07-21
HUT75875A (en) 1997-05-28
ZA946798B (en) 1995-04-06
RU2136680C1 (ru) 1999-09-10
US5767116A (en) 1998-06-16
CA2170056A1 (en) 1995-03-16
AU7692894A (en) 1995-03-27
NO960888L (no) 1996-03-05
DK0717739T3 (da) 2000-07-10
DE69423767D1 (de) 2000-05-04
SK27196A3 (en) 1996-10-02
RO116811B1 (ro) 2001-06-29
CN1133043A (zh) 1996-10-09
BG100388A (bg) 1996-07-31
FI961016A0 (fi) 1996-03-05
IL110844A (en) 1999-10-28
GB9318431D0 (en) 1993-10-20
GR3033575T3 (en) 2000-09-29
IL110844A0 (en) 1995-01-24
ES2144528T3 (es) 2000-06-16
FI961016A (fi) 1996-03-05
NZ273581A (en) 1998-05-27
HU9600552D0 (en) 1996-05-28
PT717739E (pt) 2000-07-31
EP0717739B1 (en) 2000-03-29
PL313347A1 (en) 1996-06-24
BG63272B1 (bg) 2001-08-31
SI9420058A (en) 1996-12-31
CN1052723C (zh) 2000-05-24
SI9420058B (sl) 2002-02-28
NO308536B1 (no) 2000-09-25
WO1995007274A1 (en) 1995-03-16
NO960888D0 (no) 1996-03-05
PL178270B1 (pl) 2000-03-31
ATE191214T1 (de) 2000-04-15
DE69423767T2 (de) 2000-07-20
EP0717739A1 (en) 1996-06-26
CZ61496A3 (en) 1996-09-11
AU689802B2 (en) 1998-04-09
KR100325964B1 (ko) 2002-07-27

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