CA2168443A1 - Derives de la piperazine, antagonistes du recepteur .alpha.1a-adrenergique - Google Patents

Derives de la piperazine, antagonistes du recepteur .alpha.1a-adrenergique

Info

Publication number
CA2168443A1
CA2168443A1 CA002168443A CA2168443A CA2168443A1 CA 2168443 A1 CA2168443 A1 CA 2168443A1 CA 002168443 A CA002168443 A CA 002168443A CA 2168443 A CA2168443 A CA 2168443A CA 2168443 A1 CA2168443 A1 CA 2168443A1
Authority
CA
Canada
Prior art keywords
methoxyphenyl
piperazinyl
propyl
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002168443A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2168443A1 publication Critical patent/CA2168443A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés répondant à la formule générale (I), dans laquelle Y représente un groupe de liaison, choisi dans une large gamme, mais comprenant -COO-, -CH2COO-, -CONH-, -CON(CH3)-, -CH2CONH-, SO2NH-, -SO2N(CH3)- et -PO(OC2H5)NH-; W représente une chaîne alkylène; A représente un groupe phénylique substitué ou un groupe benzofurane ou benzodioxane; et R et R1 peuvent avoir plusieurs valeurs, mais R est de préférence un groupe volumineux. Ces composés et leurs promédicaments, énantiomères, diastéréoisomères, N-oxydes et leurs sels pharmaceutiquement acceptables bloquent les récepteurs alpha 1a-adrénergiques et sont de ce fait utilisables dans la prophylaxie des contractions de la prostate, de l'urètre et de la partie inférieure du tractus urinaire, et ce sans intervenir sur la tension artérielle.
CA002168443A 1993-07-30 1994-07-22 Derives de la piperazine, antagonistes du recepteur .alpha.1a-adrenergique Abandoned CA2168443A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93MI001717A IT1266582B1 (it) 1993-07-30 1993-07-30 Derivati (di)azacicloesanici e diazacicloeptanici
ITMI93A001717 1993-07-30

Publications (1)

Publication Number Publication Date
CA2168443A1 true CA2168443A1 (fr) 1995-02-09

Family

ID=11366733

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002168443A Abandoned CA2168443A1 (fr) 1993-07-30 1994-07-22 Derives de la piperazine, antagonistes du recepteur .alpha.1a-adrenergique

Country Status (14)

Country Link
EP (1) EP0711288A1 (fr)
JP (1) JPH09500883A (fr)
KR (1) KR960703884A (fr)
CN (1) CN1132508A (fr)
AU (1) AU680037B2 (fr)
CA (1) CA2168443A1 (fr)
IL (1) IL110348A0 (fr)
IT (1) IT1266582B1 (fr)
MX (1) MXPA94005805A (fr)
NO (1) NO960371L (fr)
NZ (1) NZ271634A (fr)
SG (1) SG46281A1 (fr)
WO (1) WO1995004049A1 (fr)
ZA (1) ZA945625B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
PL326700A1 (en) * 1995-11-17 1998-10-26 Warner Lambert Co Sulphonamide-based inhibitors of intercellular substance metaloproteinases
US6288091B1 (en) 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
WO1997024343A1 (fr) 1995-12-29 1997-07-10 Boehringer Ingelheim Pharmaceuticals, Inc. Derives de phenylthiazole dotes de proprietes anti virus de l'herpes
CZ315098A3 (cs) * 1996-04-05 1999-04-14 Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) Antagonisté alfa1-adrenergických receptorů
JP4150435B2 (ja) * 1996-04-18 2008-09-17 株式会社資生堂 アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
DE69736642T2 (de) 1996-07-19 2007-09-20 Takeda Pharmaceutical Co. Ltd. Heterocyclische Verbindungen, ihre Herstellung und Verwendung
AU2002300904B2 (en) * 1997-05-12 2004-12-23 Ortho-Mcneil Pharmaceutical, Inc. Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
PT984777E (pt) 1997-05-12 2004-01-30 Ortho Mcneil Pharm Inc Piperazinas arilsubstituidas uteis no tratamento da hiperplasia benigna da prostata
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
JP2001512110A (ja) * 1997-08-01 2001-08-21 レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー １，４−ジ置換ピペラジン
IT1293807B1 (it) * 1997-08-01 1999-03-10 Recordati Chem Pharm Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6271234B1 (en) 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
US6262098B1 (en) 1998-08-07 2001-07-17 Chiron Corporation Estrogen receptor modulators
IT1314191B1 (it) * 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati isossazolcarbossamidici
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
AR027133A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
SE0004780D0 (sv) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
JP3940290B2 (ja) * 2000-12-22 2007-07-04 ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド 新規化合物
US20040077654A1 (en) * 2001-01-15 2004-04-22 Bouillot Anne Marie Jeanne Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
JP5260627B2 (ja) * 2007-03-30 2013-08-14 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ ベンゾフェノン化合物及びその作製方法
CN102015606B (zh) 2007-06-08 2015-02-04 满康德股份有限公司 IRE-1α抑制剂
JP5855095B2 (ja) 2010-06-07 2016-02-09 ノボメディックス，エルエルシーＮｏｖｏｍｅｄｉｘ，Ｌｌｃ フラニル化合物およびその使用
WO2013086496A2 (fr) * 2011-12-09 2013-06-13 Research Triangle Institute 4-arylpipérazine 1-substitué à titre d'antagoniste du récepteur opioïde kappa
BR102012000187A2 (pt) * 2012-01-05 2018-04-10 Univ Rio De Janeiro Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos
WO2023044364A1 (fr) 2021-09-15 2023-03-23 Enko Chem, Inc. Inhibiteurs de protoporphyrinogène oxydase

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997472A (en) * 1961-08-22 Certificate of correction
FR6452M (fr) * 1967-03-10 1968-11-12
FR1543944A (fr) * 1967-03-10 1968-10-31 Bruneau & Cie Lab Dérivés amidés de l'acide salicylique et leur préparation
US3557107A (en) * 1967-05-01 1971-01-19 Shulton Inc Phenylpiperazinylalkyl alkoxy anthranilates
FR1537901A (fr) * 1967-07-19 1968-08-30 Bruneau & Cie Lab Dérivés amidés d'acides halogéno et nitro benzoïques et leur préparation
FR6924M (fr) * 1967-10-18 1969-05-05
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
NL8005133A (nl) * 1980-09-12 1982-04-01 Duphar Int Res Fenylpiperazinederivaten met antiagressieve werking.
US4642291A (en) * 1982-09-01 1987-02-10 Sloan-Kettering Institute For Cancer Research Cell surface antigens of human astrocytoma
JPS5955878A (ja) * 1982-09-24 1984-03-31 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS60169467A (ja) * 1984-02-10 1985-09-02 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JP2556722B2 (ja) * 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物
US4857644A (en) * 1988-06-09 1989-08-15 American Home Products Corporation Aryl sulfonopiperazines as anti-inflammatory agents
ES2027898A6 (es) * 1991-01-24 1992-06-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
EP0558245A1 (fr) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Composés hétérobicycliques comme antagonistes des récepteurs alpha-1 adrénergiques et 5HT1A
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines

Also Published As

Publication number Publication date
ITMI931717A0 (it) 1993-07-30
AU7532394A (en) 1995-02-28
EP0711288A1 (fr) 1996-05-15
JPH09500883A (ja) 1997-01-28
IT1266582B1 (it) 1997-01-09
NO960371L (no) 1996-03-29
NZ271634A (en) 1996-09-25
NO960371D0 (no) 1996-01-29
CN1132508A (zh) 1996-10-02
ITMI931717A1 (it) 1995-01-30
WO1995004049A1 (fr) 1995-02-09
AU680037B2 (en) 1997-07-17
SG46281A1 (en) 1998-02-20
KR960703884A (ko) 1996-08-31
MXPA94005805A (es) 2004-08-20
ZA945625B (en) 1995-03-07
IL110348A0 (en) 1994-10-21

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Legal Events

Date Code Title Description
FZDE Discontinued