ITMI931717A0 - Derivati (di)azacicloesanici e diazacicloeptanici - Google Patents
Derivati (di)azacicloesanici e diazacicloeptaniciInfo
- Publication number
- ITMI931717A0 ITMI931717A0 IT93MI1717A ITMI931717A ITMI931717A0 IT MI931717 A0 ITMI931717 A0 IT MI931717A0 IT 93MI1717 A IT93MI1717 A IT 93MI1717A IT MI931717 A ITMI931717 A IT MI931717A IT MI931717 A0 ITMI931717 A0 IT MI931717A0
- Authority
- IT
- Italy
- Prior art keywords
- diazacycloheptan
- azacyclohexane
- derivatives
- diazacycloheptan derivatives
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical class C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001717A IT1266582B1 (it) | 1993-07-30 | 1993-07-30 | Derivati (di)azacicloesanici e diazacicloeptanici |
| IL11034894A IL110348A0 (en) | 1993-07-30 | 1994-07-18 | Piperazine derivatives and pharmaceutical compositions containing them |
| AU75323/94A AU680037B2 (en) | 1993-07-30 | 1994-07-22 | Piperazine derivatives as alpha1a-adrenergic receptor antagonists |
| PCT/EP1994/002437 WO1995004049A1 (en) | 1993-07-30 | 1994-07-22 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS |
| SG1996002067A SG46281A1 (en) | 1993-07-30 | 1994-07-22 | Piperazine derivatives |
| CA002168443A CA2168443A1 (en) | 1993-07-30 | 1994-07-22 | Piperazine derivatives as .alpha.1a-adrenergic receptor antagonists |
| KR1019960700460A KR960703884A (ko) | 1993-07-30 | 1994-07-22 | α₁_A-아드레날린 수용체 길항제로써 피페라진 유도체들(PIPERAZINE DERIVATIV ES AS α₁_A-ADRENERGIC RECEPTOR ANTAGONISTS) |
| NZ271634A NZ271634A (en) | 1993-07-30 | 1994-07-22 | 1-phenyl-4-(substituted alkyl)piperazine derivatives; pharmaceutical compositions |
| EP94925382A EP0711288A1 (en) | 1993-07-30 | 1994-07-22 | Piperazine derivatives as alpha 1a-adrenergic receptor antagonists |
| JP7505546A JPH09500883A (ja) | 1993-07-30 | 1994-07-22 | α１Ａ−アドレナリン受容体アンタゴニストとしてのピペラジン誘導体 |
| CN94193622A CN1132508A (zh) | 1993-07-30 | 1994-07-22 | 哌嗪衍生物 |
| MXPA94005805A MXPA94005805A (es) | 1993-07-30 | 1994-07-29 | Derivados de piperazina. |
| ZA945625A ZA945625B (en) | 1993-07-30 | 1994-07-29 | Piperazine derivatives |
| NO960371A NO960371L (no) | 1993-07-30 | 1996-01-29 | Piperazinderivater som ter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001717A IT1266582B1 (it) | 1993-07-30 | 1993-07-30 | Derivati (di)azacicloesanici e diazacicloeptanici |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI931717A0 true ITMI931717A0 (it) | 1993-07-30 |
| ITMI931717A1 ITMI931717A1 (it) | 1995-01-30 |
| IT1266582B1 IT1266582B1 (it) | 1997-01-09 |
Family
ID=11366733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT93MI001717A IT1266582B1 (it) | 1993-07-30 | 1993-07-30 | Derivati (di)azacicloesanici e diazacicloeptanici |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0711288A1 (it) |
| JP (1) | JPH09500883A (it) |
| KR (1) | KR960703884A (it) |
| CN (1) | CN1132508A (it) |
| AU (1) | AU680037B2 (it) |
| CA (1) | CA2168443A1 (it) |
| IL (1) | IL110348A0 (it) |
| IT (1) | IT1266582B1 (it) |
| MX (1) | MXPA94005805A (it) |
| NO (1) | NO960371L (it) |
| NZ (1) | NZ271634A (it) |
| SG (1) | SG46281A1 (it) |
| WO (1) | WO1995004049A1 (it) |
| ZA (1) | ZA945625B (it) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5661163A (en) * | 1995-06-07 | 1997-08-26 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| US5620993A (en) * | 1995-06-07 | 1997-04-15 | Merck & Co., Inc. | Alpha-1a adrenergic receptor antagonists |
| US5659033A (en) * | 1995-09-13 | 1997-08-19 | Neurogen Corporation | N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands |
| US5807856A (en) * | 1995-11-15 | 1998-09-15 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonist |
| BR9611487A (pt) * | 1995-11-17 | 1999-01-19 | Warner Lambert Co | Inibidores de sulfonamida de metaloproteinases de matriz |
| US6288091B1 (en) | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
| PT871619E (pt) | 1995-12-29 | 2003-03-31 | Boehringer Ingelheim Pharma | Derivados de fenil-tiazol com propriedades anti-virus do herpesc |
| JP3845452B2 (ja) * | 1996-04-05 | 2006-11-15 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーシヨン・シヤンテイフイツク・（エス．セー．エール．アー．エス） | α１―交感神経受容体拮抗薬 |
| JP4150435B2 (ja) * | 1996-04-18 | 2008-09-17 | 株式会社資生堂 | アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤 |
| WO1998003505A2 (en) | 1996-07-19 | 1998-01-29 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| AU2002300904B2 (en) * | 1997-05-12 | 2004-12-23 | Ortho-Mcneil Pharmaceutical, Inc. | Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia |
| BR9809804A (pt) | 1997-05-12 | 2000-06-27 | Ortho Mcneil Pharm Inc | Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
| US6271234B1 (en) | 1997-08-01 | 2001-08-07 | Recordati S.A., Chemical And Pharmaceutical Company | 1,4-disubstituted piperazines |
| JP2001512110A (ja) * | 1997-08-01 | 2001-08-21 | レコルダチ エッセ．ア．，ケミカル アンド ファーマシューティカル カンパニー | １，４−ジ置換ピペラジン |
| ZA991315B (en) * | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
| WO2000008001A1 (en) | 1998-08-07 | 2000-02-17 | Chiron Corporation | Substituted isoxazole as estrogen receptor modulators |
| US6365591B1 (en) | 1999-10-18 | 2002-04-02 | Recordati, S.A., Chemical And Pharmacueticals Company | Isoxazolecarboxamide derivatives |
| IT1314191B1 (it) * | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
| AR027133A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de heteroarilo, su preparacion y uso. |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| EP1351936A1 (en) * | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| US7153858B2 (en) | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US8394954B2 (en) * | 2007-03-30 | 2013-03-12 | Council Of Scientific & Industrial Research | Benzophenone hybrids as anticancer agents and processes for the preparation thereof |
| JP4827986B2 (ja) | 2007-06-08 | 2011-11-30 | マンカインド コーポレ−ション | ＩＲＥ−１αインヒビター |
| MX2012014273A (es) | 2010-06-07 | 2013-03-22 | Novomedix Llc | Compuestos furanilo y su uso. |
| ES2631607T3 (es) * | 2011-12-09 | 2017-09-01 | Research Triangle Institute, International | 4-Arilpiperazinas 1-sustituidas como antagonistas del receptor opioide kappa |
| BR102012000187A2 (pt) * | 2012-01-05 | 2018-04-10 | Univ Rio De Janeiro | Derivados n-fenilpiperazínicos antagonistas de adrenoceptores a1a, a1d e de receptores 5-ht1a no tratamento da hiperplasia prostática benigna, composições farmacêuticas contendo os mesmos |
| WO2023044364A1 (en) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Protoporphyrinogen oxidase inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2997472A (en) * | 1961-08-22 | Certificate of correction | ||
| FR6452M (it) * | 1967-03-10 | 1968-11-12 | ||
| FR1543944A (fr) * | 1967-03-10 | 1968-10-31 | Bruneau & Cie Lab | Dérivés amidés de l'acide salicylique et leur préparation |
| US3557107A (en) * | 1967-05-01 | 1971-01-19 | Shulton Inc | Phenylpiperazinylalkyl alkoxy anthranilates |
| FR1537901A (fr) * | 1967-07-19 | 1968-08-30 | Bruneau & Cie Lab | Dérivés amidés d'acides halogéno et nitro benzoïques et leur préparation |
| FR6924M (it) * | 1967-10-18 | 1969-05-05 | ||
| US3846430A (en) * | 1968-01-12 | 1974-11-05 | Bruneau & Cie Lab | 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine |
| NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
| US4642291A (en) * | 1982-09-01 | 1987-02-10 | Sloan-Kettering Institute For Cancer Research | Cell surface antigens of human astrocytoma |
| JPS5955878A (ja) * | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JPS60169467A (ja) * | 1984-02-10 | 1985-09-02 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JP2556722B2 (ja) * | 1988-02-18 | 1996-11-20 | 興和株式会社 | 新規なスルホンアミド化合物 |
| US4857644A (en) * | 1988-06-09 | 1989-08-15 | American Home Products Corporation | Aryl sulfonopiperazines as anti-inflammatory agents |
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| HRP930210A2 (en) * | 1992-02-25 | 1995-06-30 | Recordati Chem Pharm | Heterobicyclic compounds and pharmaceutical preparations containing them |
| SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
-
1993
- 1993-07-30 IT IT93MI001717A patent/IT1266582B1/it active IP Right Grant
-
1994
- 1994-07-18 IL IL11034894A patent/IL110348A0/xx unknown
- 1994-07-22 SG SG1996002067A patent/SG46281A1/en unknown
- 1994-07-22 NZ NZ271634A patent/NZ271634A/en unknown
- 1994-07-22 AU AU75323/94A patent/AU680037B2/en not_active Ceased
- 1994-07-22 JP JP7505546A patent/JPH09500883A/ja active Pending
- 1994-07-22 WO PCT/EP1994/002437 patent/WO1995004049A1/en not_active Application Discontinuation
- 1994-07-22 KR KR1019960700460A patent/KR960703884A/ko not_active Application Discontinuation
- 1994-07-22 CN CN94193622A patent/CN1132508A/zh active Pending
- 1994-07-22 CA CA002168443A patent/CA2168443A1/en not_active Abandoned
- 1994-07-22 EP EP94925382A patent/EP0711288A1/en not_active Withdrawn
- 1994-07-29 MX MXPA94005805A patent/MXPA94005805A/es unknown
- 1994-07-29 ZA ZA945625A patent/ZA945625B/xx unknown
-
1996
- 1996-01-29 NO NO960371A patent/NO960371L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1266582B1 (it) | 1997-01-09 |
| SG46281A1 (en) | 1998-02-20 |
| NZ271634A (en) | 1996-09-25 |
| AU7532394A (en) | 1995-02-28 |
| IL110348A0 (en) | 1994-10-21 |
| AU680037B2 (en) | 1997-07-17 |
| ITMI931717A1 (it) | 1995-01-30 |
| EP0711288A1 (en) | 1996-05-15 |
| NO960371L (no) | 1996-03-29 |
| WO1995004049A1 (en) | 1995-02-09 |
| NO960371D0 (no) | 1996-01-29 |
| CN1132508A (zh) | 1996-10-02 |
| JPH09500883A (ja) | 1997-01-28 |
| ZA945625B (en) | 1995-03-07 |
| MXPA94005805A (es) | 2004-08-20 |
| CA2168443A1 (en) | 1995-02-09 |
| KR960703884A (ko) | 1996-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970129 |