BR9809804A - Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata - Google Patents

Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata

Info

Publication number
BR9809804A
BR9809804A BR9809804-7A BR9809804A BR9809804A BR 9809804 A BR9809804 A BR 9809804A BR 9809804 A BR9809804 A BR 9809804A BR 9809804 A BR9809804 A BR 9809804A
Authority
BR
Brazil
Prior art keywords
treatment
aryl
substituted piperazines
benign prostatic
prostatic hyperplasia
Prior art date
Application number
BR9809804-7A
Other languages
English (en)
Inventor
Linda Jolliffe
William Murray
Vierginia Pulito
Alan Reite
Xiaobing Li
Linda Mulcahy
Cynthia Maryanoff
Frank Villani
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR9809804A publication Critical patent/BR9809804A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"PIPERAZINAS SUBSTITUìDAS COM ARILA úTEIS NO TRATAMENTO DE HIPERPLASIA BENIGNA DA PRóSTATA"<D>. Esta invenção refere-se a uma série de piperazinas substituídas com arila, da Fórmula (I), composições farmacêuticas que contém as mesmas e intermediários usados na fabricação das mesmas. Os compostos da invenção inibem de forma seletiva a ligação ao receptor adrenérgico alfa 1-a, um receptor que tem sido implicado na hiperplasia benigna da próstata. Como tal, os compostos são potencialmente úteis no tratamento desta e de outras doenças.
BR9809804-7A 1997-05-12 1998-05-08 Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata BR9809804A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4623697P 1997-05-12 1997-05-12
PCT/US1998/009023 WO1998051298A1 (en) 1997-05-12 1998-05-08 Arylsubstituted piperazines useful in the treatement of benign prostatic hyperlasia

Publications (1)

Publication Number Publication Date
BR9809804A true BR9809804A (pt) 2000-06-27

Family

ID=21942353

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809804-7A BR9809804A (pt) 1997-05-12 1998-05-08 Piperazinas substituìdas com arila úteis no tratamento de hiperplasia benigna da próstata

Country Status (28)

Country Link
US (4) US6071915A (pt)
EP (1) EP0984777B1 (pt)
JP (1) JP4189867B2 (pt)
KR (1) KR100440755B1 (pt)
CN (3) CN1269807C (pt)
AP (1) AP1349A (pt)
AR (1) AR012686A1 (pt)
AT (1) ATE250033T1 (pt)
AU (1) AU7366998A (pt)
BR (1) BR9809804A (pt)
CA (1) CA2289987C (pt)
CZ (1) CZ298217B6 (pt)
DE (1) DE69818255T2 (pt)
DK (1) DK0984777T3 (pt)
EA (1) EA001904B1 (pt)
ES (1) ES2206928T3 (pt)
HK (1) HK1024630A1 (pt)
HU (1) HUP0100048A3 (pt)
IL (1) IL132836A0 (pt)
MY (2) MY122095A (pt)
NO (1) NO314144B1 (pt)
NZ (1) NZ500992A (pt)
PL (1) PL192596B1 (pt)
PT (1) PT984777E (pt)
TR (1) TR199902971T2 (pt)
TW (1) TW512146B (pt)
WO (1) WO1998051298A1 (pt)
ZA (1) ZA983968B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768055A1 (fr) * 1997-09-11 1999-03-12 Synthelabo Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie
EP1346983A3 (en) * 1998-02-20 2003-12-03 Ortho-Mcneil Pharmaceutical, Inc. Phthalimido arylpiperazines as alpha 1A receptor antagonists useful in the treatment of benign prostatic hyperplasia
ZA991319B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia.
TW536538B (en) 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
US20020082421A1 (en) * 2000-09-14 2002-06-27 Abdel-Magid Ahmed F. Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide
EP1339682A1 (en) 2000-11-30 2003-09-03 Ranbaxy Laboratories, Ltd. 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers
WO2005118537A2 (en) * 2004-05-31 2005-12-15 Ranbaxy Laboratories Limited Arylpiperazine derivatives as adrenergic receptor antagonists
WO2006092710A1 (en) * 2005-03-02 2006-09-08 Ranbaxy Laboratories Limited Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione
WO2007029156A2 (en) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Isoindoledione derivatives as adrenergic receptor antagonists
CN102391169B (zh) * 2011-10-17 2015-10-28 上海化学试剂研究所 N-(5-甲氧基-3-吲哚乙基)-4-取代苯基哌嗪-1-乙酰胺的制备方法
CN103387531A (zh) * 2012-05-10 2013-11-13 广州医学院 酰胺类芳基哌嗪衍生物及其制备方法和在抗良性前列腺增生中的应用
CN103980195A (zh) * 2014-04-28 2014-08-13 广州医科大学 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用

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US4069336A (en) * 1976-02-25 1978-01-17 Chemisches Laboratorium Fritz-Walter Lange Gmbh & Co Kg (2-oxo-pyrrolidines)-acetic hydrazides
JPS5955878A (ja) 1982-09-24 1984-03-31 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
AU1475583A (en) * 1983-04-27 1984-11-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted picolinic acids, processes for their preparation,their use and medicaments containing them
JPS62135464A (ja) * 1985-12-10 1987-06-18 Nippon Kayaku Co Ltd フエニルピペラジン誘導体
GB8703749D0 (en) 1987-02-18 1987-03-25 Sandoz Ltd Piperazinecarboxylic acid
US5254552A (en) * 1988-05-24 1993-10-19 American Home Products Corporation Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors
FR2692894B1 (fr) * 1992-06-24 1994-10-14 Irceba Aryl-1-(o-alcoxy-phényl-4-pipérazinyl-1)-2, 3- ou 4-alcanols, leur procédé de préparation et leur utilisation pour la préparation de médicaments.
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
US5807856A (en) * 1995-11-15 1998-09-15 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonist
EP0881235A1 (fr) * 1997-05-26 1998-12-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles
US6218396B1 (en) * 1998-02-20 2001-04-17 Orth-Mcneil Pharmaceutical, Inc. Substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia
US6063785A (en) * 1999-02-17 2000-05-16 Ortho-Mcneil Pharmaceutical Inc. Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
TW536538B (en) * 1998-02-20 2003-06-11 Ortho Mcneil Pharm Inc Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia

Also Published As

Publication number Publication date
PL342518A1 (en) 2001-06-18
MY127385A (en) 2006-11-30
HK1024630A1 (en) 2000-10-20
CA2289987C (en) 2006-03-14
CZ399799A3 (cs) 2000-04-12
HUP0100048A3 (en) 2002-12-28
EP0984777A1 (en) 2000-03-15
US6890921B1 (en) 2005-05-10
CN1264300A (zh) 2000-08-23
US6071915A (en) 2000-06-06
CN1515563A (zh) 2004-07-28
US20030220493A1 (en) 2003-11-27
TW512146B (en) 2002-12-01
TR199902971T2 (xx) 2001-03-21
NO314144B1 (no) 2003-02-03
ES2206928T3 (es) 2004-05-16
CN1269807C (zh) 2006-08-16
EA199900928A1 (ru) 2000-08-28
KR20010012505A (ko) 2001-02-15
PL192596B1 (pl) 2006-11-30
EP0984777B1 (en) 2003-09-17
IL132836A0 (en) 2001-03-19
AR012686A1 (es) 2000-11-08
DK0984777T3 (da) 2003-12-08
EP0984777A4 (en) 2001-04-25
DE69818255T2 (de) 2004-12-23
EA001904B1 (ru) 2001-10-22
CN1515556A (zh) 2004-07-28
NO995518L (no) 2000-01-11
MY122095A (en) 2006-03-31
ATE250033T1 (de) 2003-10-15
CN1149081C (zh) 2004-05-12
AP9901684A0 (en) 1999-12-31
NO995518D0 (no) 1999-11-11
WO1998051298A1 (en) 1998-11-19
ZA983968B (en) 1999-11-11
CZ298217B6 (cs) 2007-07-25
DE69818255D1 (de) 2003-10-23
AP1349A (en) 2004-12-17
US6593474B1 (en) 2003-07-15
JP2002511065A (ja) 2002-04-09
KR100440755B1 (ko) 2004-07-21
CA2289987A1 (en) 1998-11-19
HUP0100048A2 (hu) 2001-07-30
AU7366998A (en) 1998-12-08
JP4189867B2 (ja) 2008-12-03
PT984777E (pt) 2004-01-30
NZ500992A (en) 2003-02-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 295/12, A61K 31/495, A61K 31/395, C07D 205/02, C07D 207/02, C07D 209/44, C07D 211/04, C07D 223/04, C07D 225/02

Ipc: A61K 31/33 (2009.01), A61K 31/395 (2009.01), A61K

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time