NO950404D0 - Prolegemidler av imidazolcarboxylsyrer som angiotensin II receptorantagonister - Google Patents

Prolegemidler av imidazolcarboxylsyrer som angiotensin II receptorantagonister

Info

Publication number
NO950404D0
NO950404D0 NO950404A NO950404A NO950404D0 NO 950404 D0 NO950404 D0 NO 950404D0 NO 950404 A NO950404 A NO 950404A NO 950404 A NO950404 A NO 950404A NO 950404 D0 NO950404 D0 NO 950404D0
Authority
NO
Norway
Prior art keywords
angiotensin
promoters
carboxylic acids
receptor antagonists
imidazole carboxylic
Prior art date
Application number
NO950404A
Other languages
English (en)
Norwegian (no)
Inventor
Robert John Ardecky
Carol Lee Ensinger
James Russell Pruitt
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of NO950404D0 publication Critical patent/NO950404D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO950404A 1992-08-06 1995-02-03 Prolegemidler av imidazolcarboxylsyrer som angiotensin II receptorantagonister NO950404D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
PCT/US1993/007103 WO1994003435A1 (en) 1992-08-06 1993-08-02 Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists

Publications (1)

Publication Number Publication Date
NO950404D0 true NO950404D0 (no) 1995-02-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950404A NO950404D0 (no) 1992-08-06 1995-02-03 Prolegemidler av imidazolcarboxylsyrer som angiotensin II receptorantagonister

Country Status (18)

Country Link
US (1) US5310929A (cs)
EP (1) EP0654027A1 (cs)
JP (1) JP2892838B2 (cs)
CN (1) CN1090275A (cs)
AU (1) AU688735B2 (cs)
BR (1) BR9306911A (cs)
CA (1) CA2141692C (cs)
FI (1) FI950485L (cs)
HU (1) HU9500349D0 (cs)
IL (1) IL106553A0 (cs)
MX (1) MX9304787A (cs)
NO (1) NO950404D0 (cs)
PL (1) PL307309A1 (cs)
SG (1) SG47108A1 (cs)
SK (1) SK13195A3 (cs)
TW (1) TW239131B (cs)
WO (1) WO1994003435A1 (cs)
ZA (1) ZA935693B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
DE69533045T2 (de) * 1994-03-16 2005-01-27 Sankyo Co., Ltd. Okulares Hypotonikum
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
US5965738A (en) * 1994-09-20 1999-10-12 Wakunaga Seiyaku Kabushiki Kaisha Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
CN1529697B (zh) 2001-05-31 2010-09-22 维科尔药物公司 用作血管紧张素ⅱ激动剂的三环化合物
US7019148B2 (en) 2003-01-16 2006-03-28 Teva Pharmaceutical Industries, Ltd. Synthesis of irbesartan
US7619058B2 (en) 2004-01-20 2009-11-17 Aichi Prefecture Epitope/peptide recognized by HLA-A2402-restricted Ep-CAM-specific CTL and use of the same
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006029057A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries, Ltd. Purification of olmesartan medoxomil
EP1874302A4 (en) * 2005-04-20 2009-12-16 Merck & Co Inc ANTAGONISTS OF ANGIOTENSIN II RECEPTORS
US20080103312A1 (en) * 2006-08-29 2008-05-01 Kansal Vinod K Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole
WO2008043996A2 (en) * 2006-10-09 2008-04-17 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
ATE525371T1 (de) * 2006-12-06 2011-10-15 Shanghai Allist Pharmaceutical Inc Salze von imidazol-5-carbonsäure-derivaten, herstellungsverfahren und verwendung davon
EP2521545B1 (en) * 2010-01-07 2019-11-27 Alkermes Pharma Ireland Limited Prodrugs of heteroaromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN109320501B (zh) * 2013-11-01 2021-06-01 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
US20220257698A1 (en) 2019-08-02 2022-08-18 Lanthiopep B.V. Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
SG50669A1 (en) * 1989-06-30 1998-07-20 Du Pont Fused-ring aryl subtituted imidazoles
CA2060656A1 (en) * 1989-06-30 1990-12-31 Robert John Ardecky Substituted imidazoles
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
PT573218E (pt) * 1992-06-02 2001-06-29 Sankyo Co 4-carbonilimidazoles como antagonistas de angiotensina ii e sua utilizacao terapeutica

Also Published As

Publication number Publication date
US5310929A (en) 1994-05-10
AU4790393A (en) 1994-03-03
JPH08500103A (ja) 1996-01-09
HU9500349D0 (en) 1995-03-28
CA2141692C (en) 2006-05-30
CA2141692A1 (en) 1994-02-17
MX9304787A (es) 1995-01-31
FI950485A7 (fi) 1995-02-03
FI950485A0 (fi) 1995-02-03
CN1090275A (zh) 1994-08-03
BR9306911A (pt) 1998-12-08
SK13195A3 (en) 1995-07-11
WO1994003435A1 (en) 1994-02-17
FI950485L (fi) 1995-02-03
TW239131B (cs) 1995-01-21
PL307309A1 (en) 1995-05-15
SG47108A1 (en) 1998-03-20
EP0654027A1 (en) 1995-05-24
ZA935693B (en) 1995-02-06
IL106553A0 (en) 1993-12-08
JP2892838B2 (ja) 1999-05-17
AU688735B2 (en) 1998-03-19

Similar Documents

Publication Publication Date Title
NO950404D0 (no) Prolegemidler av imidazolcarboxylsyrer som angiotensin II receptorantagonister
DK0569013T3 (da) Quinolinforbindelser som angiotensin II antagonister
FI943948L (fi) Heterosykliset hiilihappojohdannaiset
KR100345626B1 (ko) 안지오텐신ii길항물질로서의치환된인돌및아자인돌
EP0574787A3 (en) Benzimidazole derivatives as angiotensin ii antagonists
DE69213276D1 (de) Substituierte Piperidimylmethyl-Ester von 3-Indolcarbonsäure
NO994595L (no) Salt av naftyridin-karboksylsyrederivat
FI950089A7 (fi) Dioksosyklobuteenijohdannaiset angiotensiini-II-antagonisteina
NO20002637L (no) FremgangsmÕte for fremstilling av 8-metoksy-kinolon- karboksylsyrer
AU4261293A (en) 1-piperazineacetic derivatives as fibrinogen receptor antagonists
AU5455194A (en) Substituted phthalazinones as nerotensin antagonists
FI943933A0 (fi) Menetelmä fibrinogeenireseptoriantagonistien valmistamiseksi
NO961333D0 (no) Nye pyrazolderivater som angiotensin-II-antagonister
FI943807L (fi) Pyratsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vastavaikuttajina
FI951798A0 (fi) Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
FI953104L (fi) Diaryyli-5,6-kondensoidut heterosykliset hapot leukotrieeniantagonisteina
PL334014A1 (en) Heterocyclic derivatives of carboxylic acids, their preduction and application as antagonists of endothelin receptors
NO940623D0 (no) Fremgangsmåte for fremstilling av karboksylsyreanhydrider
EP0591891A3 (en) Benzimidazole derivatives as angiotensin ii antagonists
NO308465B1 (no) FremgangsmÕte for fremstilling av karboksylsyrederivater
FI943359A7 (fi) Atsasykliset-heterosykliset yhdisteet angiotensiini II reseptoriantagonisteina
NO950684L (no) Nye imidazopyridinderivater som angiotensin II-antagonister
FI944606A0 (fi) Menetelmä 4-pyridyyli- ja 4-piperidinyyli-imidatsolien valmistamiseksi, jotka ovat käyttökelpoisia histamiinireseptoriantagonistien synteesin välituotteina
DE69617010D1 (de) Isazole derivate als fibrinogen-rezeptor-antagonisten
AU5376194A (en) Heterocyclic compounds as angiotensin ii antagonists