FI953104L - Diaryyli-5,6-kondensoidut heterosykliset hapot leukotrieeniantagonisteina - Google Patents

Diaryyli-5,6-kondensoidut heterosykliset hapot leukotrieeniantagonisteina Download PDF

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Publication number
FI953104L
FI953104L FI953104A FI953104A FI953104L FI 953104 L FI953104 L FI 953104L FI 953104 A FI953104 A FI 953104A FI 953104 A FI953104 A FI 953104A FI 953104 L FI953104 L FI 953104L
Authority
FI
Finland
Prior art keywords
diaryl
fused heterocyclic
leukotriene antagonists
heterocyclic acids
acids
Prior art date
Application number
FI953104A
Other languages
English (en)
Swedish (sv)
Other versions
FI953104A0 (fi
FI111368B (fi
Inventor
Robert N Young
Marc Labelle
Yves Leblanc
Yi Bin Xiang
Cheuk L Lau
Claude Dufresne
Yves Gareau
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of FI953104A0 publication Critical patent/FI953104A0/fi
Publication of FI953104L publication Critical patent/FI953104L/fi
Application granted granted Critical
Publication of FI111368B publication Critical patent/FI111368B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
FI953104A 1992-12-22 1995-06-21 Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi FI111368B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99486992A 1992-12-22 1992-12-22
US99486992 1992-12-22
PCT/CA1993/000541 WO1994014815A1 (en) 1992-12-22 1993-12-15 Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists
CA9300541 1993-12-15

Publications (3)

Publication Number Publication Date
FI953104A0 FI953104A0 (fi) 1995-06-21
FI953104L true FI953104L (fi) 1995-06-21
FI111368B FI111368B (fi) 2003-07-15

Family

ID=25541163

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953104A FI111368B (fi) 1992-12-22 1995-06-21 Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi

Country Status (23)

Country Link
EP (1) EP0604114B1 (fi)
KR (1) KR100310552B1 (fi)
CN (1) CN1040213C (fi)
AT (1) ATE192448T1 (fi)
AU (1) AU672837B2 (fi)
CA (1) CA2111372C (fi)
CZ (1) CZ290829B6 (fi)
DE (1) DE69328540T2 (fi)
DK (1) DK0604114T3 (fi)
ES (1) ES2145765T3 (fi)
FI (1) FI111368B (fi)
GR (1) GR3033985T3 (fi)
HU (1) HU222274B1 (fi)
IL (1) IL108050A (fi)
MX (1) MX9400022A (fi)
NO (1) NO313831B1 (fi)
NZ (1) NZ258835A (fi)
PL (1) PL177967B1 (fi)
PT (1) PT604114E (fi)
RU (1) RU2154065C2 (fi)
SK (1) SK282409B6 (fi)
WO (1) WO1994014815A1 (fi)
ZA (1) ZA939560B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472964A (en) * 1992-12-22 1995-12-05 Merck Frosst Canada, Inc. Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
US5491077A (en) * 1994-07-20 1996-02-13 Merck & Co., Inc. Microbial method
US5427933A (en) * 1994-07-20 1995-06-27 Merck & Co., Inc. Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
RU2196772C1 (ru) * 2001-10-08 2003-01-20 Кубанский государственный технологический университет 6-МЕТИЛ-8-МЕТОКСИМЕТИЛ-3-ФЕНИЛИЗОКСАЗОЛО[3',4':4,5]ТИЕНО-[2,3-b]ПИРИДИН, ПРОЯВЛЯЮЩИЙ РОСТОРЕГУЛИРУЮЩУЮ И АНТИСТРЕССОВУЮ АКТИВНОСТЬ
EP1474386B1 (en) * 2002-02-06 2006-12-27 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
RU2449807C2 (ru) * 2009-11-16 2012-05-10 Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию" Способ лечения эндотоксикоза при хроническом пиелонефрите

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001576A1 (fr) * 1982-10-07 1984-04-26 Takeda Chemical Industries Ltd Derives de pyrrolidone fondus
US4957932A (en) * 1987-11-25 1990-09-18 Merck Frosst Canada, Inc. Benzoheterazoles
HU222344B1 (hu) * 1990-10-12 2003-06-28 Merck Frosst Canada & Co. Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására
US5428033A (en) * 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis

Also Published As

Publication number Publication date
IL108050A (en) 1998-06-15
HU222274B1 (hu) 2003-05-28
KR100310552B1 (ko) 2001-12-17
NO313831B1 (no) 2002-12-09
PL177967B1 (pl) 2000-02-29
SK282409B6 (sk) 2002-01-07
WO1994014815A1 (en) 1994-07-07
CZ165395A3 (en) 1996-01-17
NZ258835A (en) 1997-06-24
ES2145765T3 (es) 2000-07-16
FI953104A0 (fi) 1995-06-21
HUT71810A (en) 1996-02-28
ATE192448T1 (de) 2000-05-15
EP0604114B1 (en) 2000-05-03
MX9400022A (es) 1995-01-31
RU2154065C2 (ru) 2000-08-10
PL309408A1 (en) 1995-10-02
SK82295A3 (en) 1995-12-06
CN1094051A (zh) 1994-10-26
KR950704325A (ko) 1995-11-17
CA2111372A1 (en) 1994-06-23
NO952495L (no) 1995-08-22
FI111368B (fi) 2003-07-15
PT604114E (pt) 2000-09-29
CA2111372C (en) 2007-01-16
NO952495D0 (no) 1995-06-21
EP0604114A1 (en) 1994-06-29
HU9501842D0 (en) 1995-08-28
DK0604114T3 (da) 2000-08-07
DE69328540D1 (de) 2000-06-08
RU95113598A (ru) 1997-06-10
CZ290829B6 (cs) 2002-10-16
AU5257993A (en) 1994-07-07
AU672837B2 (en) 1996-10-17
GR3033985T3 (en) 2000-11-30
CN1040213C (zh) 1998-10-14
ZA939560B (en) 1994-08-11
DE69328540T2 (de) 2001-01-04
IL108050A0 (en) 1994-04-12

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Owner name: MERCK FROSST CANADA & CO.