IL106553A0 - Substituted imidazoles and pharmaceutical compositions containing them - Google Patents
Substituted imidazoles and pharmaceutical compositions containing themInfo
- Publication number
- IL106553A0 IL106553A0 IL106553A IL10655393A IL106553A0 IL 106553 A0 IL106553 A0 IL 106553A0 IL 106553 A IL106553 A IL 106553A IL 10655393 A IL10655393 A IL 10655393A IL 106553 A0 IL106553 A0 IL 106553A0
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- substituted imidazoles
- imidazoles
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/926,795 US5310929A (en) | 1992-08-06 | 1992-08-06 | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL106553A0 true IL106553A0 (en) | 1993-12-08 |
Family
ID=25453732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL106553A IL106553A0 (en) | 1992-08-06 | 1993-08-02 | Substituted imidazoles and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5310929A (cs) |
| EP (1) | EP0654027A1 (cs) |
| JP (1) | JP2892838B2 (cs) |
| CN (1) | CN1090275A (cs) |
| AU (1) | AU688735B2 (cs) |
| BR (1) | BR9306911A (cs) |
| CA (1) | CA2141692C (cs) |
| FI (1) | FI950485A7 (cs) |
| HU (1) | HU9500349D0 (cs) |
| IL (1) | IL106553A0 (cs) |
| MX (1) | MX9304787A (cs) |
| NO (1) | NO950404D0 (cs) |
| PL (1) | PL307309A1 (cs) |
| SG (1) | SG47108A1 (cs) |
| SK (1) | SK13195A3 (cs) |
| TW (1) | TW239131B (cs) |
| WO (1) | WO1994003435A1 (cs) |
| ZA (1) | ZA935693B (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| TW259786B (cs) * | 1992-12-17 | 1995-10-11 | Sankyo Co | |
| ES2163501T3 (es) * | 1994-03-16 | 2002-02-01 | Sankyo Co | Agente para la disminucion de la tension ocular. |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5510495A (en) * | 1994-09-19 | 1996-04-23 | The Du Pont Merck Pharmaceutical Company | Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis |
| ATE176784T1 (de) * | 1994-09-20 | 1999-03-15 | Wakunaga Seiyaku Kk | Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen |
| IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
| IT1295405B1 (it) | 1997-09-30 | 1999-05-12 | Merck Sharp & Dohme Italia S P | Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di |
| DE19820064A1 (de) * | 1998-05-06 | 1999-11-11 | Hoechst Marion Roussel De Gmbh | Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19832428A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ES2154191B1 (es) * | 1998-11-24 | 2001-10-16 | Ferrer Int | Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos. |
| GR20000100281A (el) * | 2000-08-17 | 2002-05-24 | Ιωαννης Ματσουκας | Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων |
| ES2295339T3 (es) | 2001-05-31 | 2008-04-16 | Vicore Pharma Ab | Compuestos tricilicos utiles como agonistas de la angiotensina ii. |
| EP2039693A3 (en) * | 2003-01-16 | 2009-06-17 | Teva Pharmaceutical Industries Limited | Novel synthesis of irbesartan |
| JP4779067B2 (ja) | 2004-01-20 | 2011-09-21 | 愛知県 | ＨＬＡ−Ａ２４０２拘束性Ｅｐ−ＣＡＭ特異的ＣＴＬが認識するエピトープ・ペプチド及びその用途 |
| US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| JP4437141B2 (ja) * | 2004-09-02 | 2010-03-24 | テバ ファーマシューティカル インダストリーズ リミティド | オルメサルタンメドキソミルの精製法 |
| US20070054948A1 (en) * | 2004-09-02 | 2007-03-08 | Lilach Hedvati | Purification of olmesartan medoxomil |
| JP2008538561A (ja) * | 2005-04-20 | 2008-10-30 | メルク エンド カムパニー インコーポレーテッド | アンジオテンシンｉｉ受容体アンタゴニスト |
| WO2008027385A2 (en) * | 2006-08-29 | 2008-03-06 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 5-phenyl -1 trityl-1h-tetrazole |
| CA2663981C (en) * | 2006-10-09 | 2014-05-27 | Cipla Limited | Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil |
| JP5290190B2 (ja) * | 2006-12-06 | 2013-09-18 | サルブリス・アセット・マネイジメント・カンパニー・リミテッド | イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物 |
| ES2768295T3 (es) * | 2010-01-07 | 2020-06-22 | Alkermes Pharma Ireland Ltd | Profármacos de compuestos heteroaromáticos |
| EP2455388A1 (en) | 2010-11-23 | 2012-05-23 | LanthioPep B.V. | Novel angiotensin type 2 (AT2) receptor agonists and uses thereof. |
| CN104610232B (zh) * | 2013-11-01 | 2019-09-20 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
| EP4007592A1 (en) | 2019-08-02 | 2022-06-08 | LanthioPep B.V. | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| KR0163595B1 (ko) * | 1989-06-30 | 1998-12-01 | 미리암디, 메코너헤이 | 치환된 이미다졸 |
| FI916130A0 (fi) * | 1989-06-30 | 1991-12-27 | Du Pont | Arylsubstituerade imidazoler. |
| GB8927277D0 (en) * | 1989-12-01 | 1990-01-31 | Glaxo Group Ltd | Chemical compounds |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5137902A (en) * | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
| ATE199548T1 (de) * | 1992-06-02 | 2001-03-15 | Sankyo Co | 4-carboxyimidazolderivate als angiotensin-ii- antagonisten und ihre therapeutische verwendung |
-
1992
- 1992-08-06 US US07/926,795 patent/US5310929A/en not_active Expired - Lifetime
-
1993
- 1993-08-02 HU HU9500349A patent/HU9500349D0/hu unknown
- 1993-08-02 JP JP6505415A patent/JP2892838B2/ja not_active Expired - Lifetime
- 1993-08-02 IL IL106553A patent/IL106553A0/xx unknown
- 1993-08-02 EP EP93918463A patent/EP0654027A1/en not_active Withdrawn
- 1993-08-02 SK SK131-95A patent/SK13195A3/sk unknown
- 1993-08-02 FI FI950485A patent/FI950485A7/fi not_active Application Discontinuation
- 1993-08-02 AU AU47903/93A patent/AU688735B2/en not_active Ceased
- 1993-08-02 BR BR9306911A patent/BR9306911A/pt not_active Application Discontinuation
- 1993-08-02 CA CA002141692A patent/CA2141692C/en not_active Expired - Lifetime
- 1993-08-02 PL PL93307309A patent/PL307309A1/xx unknown
- 1993-08-02 SG SG1996008109A patent/SG47108A1/en unknown
- 1993-08-02 WO PCT/US1993/007103 patent/WO1994003435A1/en not_active Application Discontinuation
- 1993-08-05 ZA ZA935693A patent/ZA935693B/xx unknown
- 1993-08-06 MX MX9304787A patent/MX9304787A/es unknown
- 1993-08-06 TW TW082106302A patent/TW239131B/zh active
- 1993-08-06 CN CN93117634A patent/CN1090275A/zh active Pending
-
1995
- 1995-02-03 NO NO950404A patent/NO950404D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI950485A0 (fi) | 1995-02-03 |
| SG47108A1 (en) | 1998-03-20 |
| MX9304787A (es) | 1995-01-31 |
| SK13195A3 (en) | 1995-07-11 |
| EP0654027A1 (en) | 1995-05-24 |
| AU688735B2 (en) | 1998-03-19 |
| FI950485L (fi) | 1995-02-03 |
| WO1994003435A1 (en) | 1994-02-17 |
| JP2892838B2 (ja) | 1999-05-17 |
| PL307309A1 (en) | 1995-05-15 |
| JPH08500103A (ja) | 1996-01-09 |
| CA2141692C (en) | 2006-05-30 |
| HU9500349D0 (en) | 1995-03-28 |
| CA2141692A1 (en) | 1994-02-17 |
| FI950485A7 (fi) | 1995-02-03 |
| BR9306911A (pt) | 1998-12-08 |
| US5310929A (en) | 1994-05-10 |
| CN1090275A (zh) | 1994-08-03 |
| ZA935693B (en) | 1995-02-06 |
| NO950404D0 (no) | 1995-02-03 |
| AU4790393A (en) | 1994-03-03 |
| TW239131B (cs) | 1995-01-21 |
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