AU4261293A - 1-piperazineacetic derivatives as fibrinogen receptor antagonists - Google Patents

1-piperazineacetic derivatives as fibrinogen receptor antagonists

Info

Publication number
AU4261293A
AU4261293A AU42612/93A AU4261293A AU4261293A AU 4261293 A AU4261293 A AU 4261293A AU 42612/93 A AU42612/93 A AU 42612/93A AU 4261293 A AU4261293 A AU 4261293A AU 4261293 A AU4261293 A AU 4261293A
Authority
AU
Australia
Prior art keywords
piperazineacetic
derivatives
receptor antagonists
fibrinogen receptor
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU42612/93A
Inventor
Colin David Eldred
Brian David Judkins
Henry Anderson Kelly
David Middlemiss
Barry Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU4261293A publication Critical patent/AU4261293A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
AU42612/93A 1992-04-23 1993-04-20 1-piperazineacetic derivatives as fibrinogen receptor antagonists Abandoned AU4261293A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929208740A GB9208740D0 (en) 1992-04-23 1992-04-23 Chemical compounds
GB9208740 1992-04-23

Publications (1)

Publication Number Publication Date
AU4261293A true AU4261293A (en) 1993-11-29

Family

ID=10714405

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42612/93A Abandoned AU4261293A (en) 1992-04-23 1993-04-20 1-piperazineacetic derivatives as fibrinogen receptor antagonists

Country Status (9)

Country Link
EP (1) EP0637304A1 (en)
JP (1) JPH07505897A (en)
CN (1) CN1083475A (en)
AU (1) AU4261293A (en)
GB (1) GB9208740D0 (en)
IL (1) IL105375A0 (en)
MX (1) MX9302283A (en)
WO (1) WO1993022303A1 (en)
ZA (1) ZA932790B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668765B2 (en) * 1992-10-12 1996-05-16 Dr. Karl Thomae Gmbh Carboxylic acid derivatives

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
TW276254B (en) * 1993-03-29 1996-05-21 Zeneca Ltd
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
GB9326232D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
USRE39263E1 (en) * 1994-05-04 2006-09-05 Bayer Aktiengesellschaft Substituted aromatic thiocarboxylic acid amides and their use as herbicides
EP0758324B1 (en) * 1994-05-04 2005-03-16 Bayer CropScience AG Substituted aromatic thiocarboxylic acid amides and their use as herbicides
AU3261097A (en) * 1996-06-21 1998-01-14 Glaxo Group Limited Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders
AR008245A1 (en) * 1996-06-21 1999-12-29 Glaxo Group Ltd DERIVATIVES OF ACETIC ACID, USE OF THE SAME IN THE MANUFACTURE OF A THERAPEUTIC AGENT AND PROCESS TO PREPARE SUCH DERIVATIVES
DE19743435A1 (en) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidine derivatives
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
IL163828A0 (en) * 2002-03-12 2005-12-18 Wyeth Corp Process for making chiral 1,4-disubstituted piperazines
AU2003280558A1 (en) * 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
CA2636929A1 (en) * 2005-12-21 2007-07-12 Decode Genetics, Ehf Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
CA3224732A1 (en) 2021-07-07 2023-01-12 Kevin M. Guckian Compounds for targeting degradation of irak4 proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668765B2 (en) * 1992-10-12 1996-05-16 Dr. Karl Thomae Gmbh Carboxylic acid derivatives

Also Published As

Publication number Publication date
JPH07505897A (en) 1995-06-29
MX9302283A (en) 1994-02-28
EP0637304A1 (en) 1995-02-08
CN1083475A (en) 1994-03-09
GB9208740D0 (en) 1992-06-10
IL105375A0 (en) 1993-08-18
ZA932790B (en) 1994-03-25
WO1993022303A1 (en) 1993-11-11

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