MX9302283A - DERIVATIVES OF ACETIC ACID, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM. - Google Patents

DERIVATIVES OF ACETIC ACID, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM.

Info

Publication number
MX9302283A
MX9302283A MX9302283A MX9302283A MX9302283A MX 9302283 A MX9302283 A MX 9302283A MX 9302283 A MX9302283 A MX 9302283A MX 9302283 A MX9302283 A MX 9302283A MX 9302283 A MX9302283 A MX 9302283A
Authority
MX
Mexico
Prior art keywords
preparation
acetic acid
derivatives
pharmaceutical composition
iib
Prior art date
Application number
MX9302283A
Other languages
Spanish (es)
Inventor
Barry Porter
Henry Anderson Kelly
David Middlemiss
Brian David Judkins
Colin David Eldred
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX9302283A publication Critical patent/MX9302283A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invención se refiere a derivados de ácido acético, a los procedimientos para su preparación a las composiciones farmacéuticas que contienen tales compuestos y a su uso en la medicina. Se acepta ampliamente que el complejo de glicoproteína Gp IIb/IIIa es el sito de enlace de fibrinógeno en las plaquetas, que media o interviene en la función adhesiva requerida para la agregación de las plaquetas y la formación del trombo. Ahora se ha encontrado un grupo compuesto no péptidicos que inhiben la agregación de las plaquetas dependientes de fibrinógeno al bloquear el enlace del fibrinógeno al complejo de Gp IIb/IIIa receptor de fibrigéno, supuesto.This invention relates to acetic acid derivatives, to the processes for their preparation to pharmaceutical compositions containing such compounds and to their use in medicine. It is widely accepted that the Gp IIb / IIIa glycoprotein complex is the site of fibrinogen binding in platelets, which mediates or intervenes in the adhesive function required for platelet aggregation and thrombus formation. A non-peptidic compound group has now been found to inhibit fibrinogen dependent platelet aggregation by blocking fibrinogen binding to the putative fibrigen receptor Gp IIb / IIIa complex.

MX9302283A 1992-04-23 1993-04-20 DERIVATIVES OF ACETIC ACID, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM. MX9302283A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929208740A GB9208740D0 (en) 1992-04-23 1992-04-23 Chemical compounds

Publications (1)

Publication Number Publication Date
MX9302283A true MX9302283A (en) 1994-02-28

Family

ID=10714405

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302283A MX9302283A (en) 1992-04-23 1993-04-20 DERIVATIVES OF ACETIC ACID, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM.

Country Status (9)

Country Link
EP (1) EP0637304A1 (en)
JP (1) JPH07505897A (en)
CN (1) CN1083475A (en)
AU (1) AU4261293A (en)
GB (1) GB9208740D0 (en)
IL (1) IL105375A0 (en)
MX (1) MX9302283A (en)
WO (1) WO1993022303A1 (en)
ZA (1) ZA932790B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4234295A1 (en) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carboxylic acid derivatives, medicaments containing these compounds and process for their preparation
PL310889A1 (en) * 1993-03-29 1996-01-08 Zeneca Ltd Heterocyclic derivatives as inhibitors of thrombocytes aggregation
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
GB9326232D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
GB9326373D0 (en) * 1993-12-23 1994-02-23 Zeneca Ltd Chemical compounds
BR9507598A (en) 1994-05-04 1997-10-07 Bayer Ag Aromatic substituted thiocarboxamides and their use as herbicides
USRE39263E1 (en) * 1994-05-04 2006-09-05 Bayer Aktiengesellschaft Substituted aromatic thiocarboxylic acid amides and their use as herbicides
AR008245A1 (en) * 1996-06-21 1999-12-29 Glaxo Group Ltd DERIVATIVES OF ACETIC ACID, USE OF THE SAME IN THE MANUFACTURE OF A THERAPEUTIC AGENT AND PROCESS TO PREPARE SUCH DERIVATIVES
AU3261097A (en) * 1996-06-21 1998-01-14 Glaxo Group Limited Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders
DE19743435A1 (en) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidine derivatives
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
NZ535169A (en) 2002-03-12 2006-03-31 Wyeth Corp Process for making chiral 1,4-disubstituted piperazines
AU2003280558A1 (en) * 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
EP1968961A2 (en) 2005-12-21 2008-09-17 Decode Genetics EHF Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
KR20240035526A (en) 2021-07-07 2024-03-15 바이오젠 엠에이 인코포레이티드 Compounds that target degradation of the IRAK4 protein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility

Also Published As

Publication number Publication date
JPH07505897A (en) 1995-06-29
CN1083475A (en) 1994-03-09
GB9208740D0 (en) 1992-06-10
IL105375A0 (en) 1993-08-18
ZA932790B (en) 1994-03-25
EP0637304A1 (en) 1995-02-08
AU4261293A (en) 1993-11-29
WO1993022303A1 (en) 1993-11-11

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