NO921719L - Fosfono/biaryl-substituerte dipeptidderivater - Google Patents

Fosfono/biaryl-substituerte dipeptidderivater

Info

Publication number
NO921719L
NO921719L NO92921719A NO921719A NO921719L NO 921719 L NO921719 L NO 921719L NO 92921719 A NO92921719 A NO 92921719A NO 921719 A NO921719 A NO 921719A NO 921719 L NO921719 L NO 921719L
Authority
NO
Norway
Prior art keywords
alkyl
aryl
substituted
alkoxy
haloalkyl
Prior art date
Application number
NO92921719A
Other languages
English (en)
Other versions
NO921719D0 (no
Inventor
Mark D Erion
Stephane De Lombaert
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO921719D0 publication Critical patent/NO921719D0/no
Publication of NO921719L publication Critical patent/NO921719L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nye N-fosfonometyl-biarylsubstituerte dipeptidderivater med formel I o R - O - P - CHo- NH- CH- CONH- A -(CH)¿ COR3 . t- l m O-R' fi ^ R2 (D der R og R1 representerer uavhengig av hverandre hydrogen, karbocyklisk aryl, 6-tetrahydronaftyl, 5-indanyl, acyloksyrae- tyl eller acyloksymetylmonosubstituert på metylkarbon med C,- CJO-alkyl, med C5-C7-cykloalkyl, med aryl eller med aryl-lavere alkyl; A representerer en direkte binding, laverealkylen, fenylen eller cykloheksylen; m representerer l eller null, forutsatt at m representerer l når A er en direkte binding; R, representerer fenyl, fenyl substituert med en til tre sub- stituenter valgt blant laverealkyl, hydroksy, laverealkoksy, laverealkanoyloksy, halogen, cyano, trifluormetyl, laverealka- noylamino eller laverealkoksykarbonyl, naftyl, naftyl sub- stituert med laverealkyl, laverealkoksy eller halogen, tienyl, tienyl substituert med laverealkyl, furanyl, furanyl substitu- ert med laverealkyl, pyridyl, pyridyl substituert med lavere- alkyl, halogen eller cyano, pyrrolyl eller N-laverealkylpyrro- lyl; Rz representerer hydrogen, hydroksy, laverealkyl, aryl- laverealkyl, C5-C7-cykloalkyllaverealkyl, amino-laverealkyl, hydroksy-laverealkyl, laverealkyltio-laverealkyl, laverealkoksy-laverealkyl, aryl-laverealkyltio-laverealkyl eller aryl-laverealkoksy-laverealkyl; COR3 representerer karboksyl eller karboksylderivatisert i form av en farma- søytisk aksepterbar ester eller amid; og farmasøytisk aksep- terbare salter derav er nyttige som nøytrale endopeptidase- (NEP)-inhibitorer. Egnede fremgangsmåter for deres fremstil- ling er beskrevet.
NO92921719A 1991-05-01 1992-04-30 Fosfono/biaryl-substituerte dipeptidderivater NO921719L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/694,533 US5155100A (en) 1991-05-01 1991-05-01 Phosphono/biaryl substituted dipeptide derivatives

Publications (2)

Publication Number Publication Date
NO921719D0 NO921719D0 (no) 1992-04-30
NO921719L true NO921719L (no) 1992-11-02

Family

ID=24789228

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92921719A NO921719L (no) 1991-05-01 1992-04-30 Fosfono/biaryl-substituerte dipeptidderivater

Country Status (15)

Country Link
US (1) US5155100A (no)
EP (1) EP0511940A3 (no)
JP (1) JPH05170792A (no)
KR (1) KR920021578A (no)
AU (1) AU655252B2 (no)
CA (1) CA2067592A1 (no)
FI (1) FI921884A (no)
HU (1) HUT61032A (no)
IE (1) IE921401A1 (no)
IL (1) IL101633A (no)
MX (1) MX9201953A (no)
NO (1) NO921719L (no)
NZ (1) NZ242546A (no)
TW (1) TW208704B (no)
ZA (1) ZA923164B (no)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
JP3130938B2 (ja) * 1991-10-22 2001-01-31 オーストリア・タバクヴェルケ・アクチエンゲゼルシャフトヴォマー・オーシュターライヒッシェ・タバコレジー シガレットフィルター
US5273990A (en) * 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
JPH05148277A (ja) * 1991-11-05 1993-06-15 Banyu Pharmaceut Co Ltd アミノホスホン酸誘導体
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
WO1995013817A1 (en) * 1993-11-18 1995-05-26 Smithkline Beecham Corporation Endothelin converting enzyme inhibitors
IT1274673B (it) * 1994-04-14 1997-07-24 Zambon Spa Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari
IT1270260B (it) * 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
US5635103A (en) 1995-01-20 1997-06-03 The Procter & Gamble Company Bleaching compositions and additives comprising bleach activators having alpha-modified lactam leaving-groups
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
WO1997011717A1 (en) * 1995-09-27 1997-04-03 Novartis Ag Treatment of chronic progressive renal failure
JP3973748B2 (ja) * 1998-01-14 2007-09-12 花王株式会社 発毛抑制剤
RU2245147C2 (ru) * 1999-03-29 2005-01-27 Бристол-Маерс Сквибб Компани Применение ингибитора вазопептидазы для лечения стенокардии
JP2007191446A (ja) * 2006-01-20 2007-08-02 Sumitomo Chemical Co Ltd ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法
WO2007083774A1 (ja) * 2006-01-17 2007-07-26 Sumitomo Chemical Company, Limited ビフェニルメチルヒダントイン化合物、その製造方法、及びそれを用いるビフェニルアラニン化合物の製造方法
TW200838501A (en) * 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
JP2010538071A (ja) 2007-09-07 2010-12-09 セラヴァンス， インコーポレーテッド 二重作用性降圧剤
CA2705921A1 (en) 2007-12-11 2009-06-18 Theravance, Inc. Dual-acting benzoimidazole derivatives and their use as antihypertensive agents
WO2009134741A1 (en) 2008-04-29 2009-11-05 Theravance, Inc. Dual-acting antihypertensive agents
WO2010011821A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
US8372984B2 (en) 2009-07-22 2013-02-12 Theravance, Inc. Dual-acting oxazole antihypertensive agents
EP2526095A1 (en) 2010-01-19 2012-11-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
CA2817368C (en) 2010-12-15 2019-12-31 Theravance, Inc. Neprilysin inhibitors
JP5944922B2 (ja) 2010-12-15 2016-07-05 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
JP5959066B2 (ja) 2011-02-17 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
KR101854874B1 (ko) 2011-02-17 2018-05-04 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제로서 치환된 아미노부티릭 유도체
CA2835220A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
JP5885832B2 (ja) 2011-05-31 2016-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
EP2714662B1 (en) 2011-05-31 2017-10-11 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
US9045443B2 (en) 2012-05-31 2015-06-02 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
CA2873328A1 (en) 2012-06-08 2013-12-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
ME02698B (me) 2012-06-08 2017-10-20 Theravance Biopharma R&D Ip Llc Inhibitori neprilizina
PT2882716T (pt) 2012-08-08 2017-03-13 Theravance Biopharma R&D Ip Llc Inibidores da neprilisina
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
HUE034210T2 (hu) 2013-03-05 2018-02-28 Theravance Biopharma R&D Ip Llc Neprilizininhibitorok
MX2016001021A (es) 2013-07-25 2016-08-03 Novartis Ag Bioconjugados de polipeptidos de apelina sinteticos.
KR20160031551A (ko) 2013-07-25 2016-03-22 노파르티스 아게 심부전의 치료를 위한 시클릭 폴리펩티드
CA2934898A1 (en) 2014-01-30 2015-08-06 Theravance Biopharma R&D Ip, Llc 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
AU2015210983B2 (en) 2014-01-30 2018-10-04 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
SG11201704758XA (en) 2015-01-23 2017-08-30 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
KR102640906B1 (ko) 2015-02-11 2024-02-27 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 저해제로서 (2s,4r)-5-(5''-클로로-2''-플루오로비페닐-4-일)-4-(에톡시옥살릴아미노)-2-히드록시메틸-2-메틸펜타노익산
US9533962B2 (en) 2015-02-19 2017-01-03 Theravance Biopharma R&D Ip, Llc (2R,4R)-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid
DK3408260T3 (da) 2016-03-08 2021-08-02 Theravance Biopharma R&D Ip Llc Krystallinsk (2s,4r)-5-(5'-chlor-2-fluor-[1,1'-biphenyl]-4-yl)-2-(ethoxy¬methyl)-4-(3-hydroxyisoxazol-5-carboxamido)-2-methylpentansyre og anvendelser deraf
WO2020110008A1 (en) 2018-11-27 2020-06-04 Novartis Ag Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
CN113166204A (zh) 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE141930C (no) * 1900-01-01
US4053505A (en) * 1976-01-05 1977-10-11 Monsanto Company Preparation of n-phosphonomethyl glycine
EP0054862B1 (en) * 1980-12-18 1985-11-27 Schering Corporation Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4721726A (en) * 1980-12-18 1988-01-26 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
AU569719B2 (en) * 1983-01-28 1988-02-18 Schering Corporation Phosphorous compounds as inhibitors of enkephalinases
US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4963539A (en) * 1987-09-10 1990-10-16 E. R. Squibb & Sons, Inc. Phosphonate and phosphonamide endopeptidase inhibitors
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (en) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides with collagenase inhibiting activity
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.

Also Published As

Publication number Publication date
KR920021578A (ko) 1992-12-18
HUT61032A (en) 1992-11-30
AU1509192A (en) 1992-11-05
NZ242546A (en) 1994-08-26
TW208704B (no) 1993-07-01
NO921719D0 (no) 1992-04-30
MX9201953A (es) 1992-11-01
AU655252B2 (en) 1994-12-08
ZA923164B (en) 1992-11-25
JPH05170792A (ja) 1993-07-09
EP0511940A2 (en) 1992-11-04
HU9201430D0 (en) 1992-07-28
IL101633A0 (en) 1992-12-30
FI921884A0 (fi) 1992-04-27
EP0511940A3 (en) 1993-11-03
IL101633A (en) 1996-03-31
CA2067592A1 (en) 1992-11-02
US5155100A (en) 1992-10-13
IE921401A1 (en) 1992-11-04
FI921884A (fi) 1992-11-02

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